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1. 发明申请

US20060229614A1 Instruments and methods for stabilization of bony structures 有权
公开(公告)号：US20060229614A1
公开(公告)日：2006-10-12
申请号：US11338405
申请日：2006-01-24
申请人： Kevin Foley , Michael Sherman , Jeff Justis
发明人： Kevin Foley , Michael Sherman , Jeff Justis
IPC分类号： A61F2/30
CPC分类号： A61B17/7086 , A61B17/00234 , A61B17/1671 , A61B17/7038 , A61B17/7089 , A61B17/88 , A61B17/8872 , A61B17/8897 , A61B2017/681 , A61B2017/90
摘要： The present invention relates to a brace installation instrument placement that is mounted to anchors secured in an animal subject. The installation instrument includes anchor extensions coupled to the anchors. The instrument is movable with respect to the anchors to position a brace in a position more proximate the anchors. The brace can be indexed for insertion at a predetermined orientation with respect to the installation instrument. Methods and techniques for using the installation instrument are also provided.

2. 发明申请

US20070198015A1 Instruments and methods for stabilization of bony structures 有权
标题翻译：用于稳定骨骼结构的仪器和方法
公开(公告)号：US20070198015A1
公开(公告)日：2007-08-23
申请号：US11656852
申请日：2007-01-23
申请人： Kevin Foley , Michael Sherman , Jeff Justis
发明人： Kevin Foley , Michael Sherman , Jeff Justis
IPC分类号： A61F2/30
CPC分类号： A61B17/7086 , A61B17/00234 , A61B17/1671 , A61B17/7038 , A61B17/7089 , A61B17/88 , A61B17/8872 , A61B17/8897 , A61B2017/681 , A61B2017/90
摘要： The present invention relates to methods and instruments for placing a brace or connecting element into an animal subject for engagement with anchors secured in the animal subject. The installation instrument includes anchor extensions coupled to the anchors. The instrument is movable with respect to the anchors to position the connecting element in a position more proximate the anchors.
摘要翻译：本发明涉及用于将支架或连接元件放置在动物对象中用于与固定在动物对象中的锚固件接合的方法和装置。安装仪器包括连接到锚固件的锚固件延伸件。仪器可相对于锚固件移动，以将连接元件定位在更接近锚定件的位置。

3. 发明申请

US20070185491A1 Instruments and methods for stabilization of bony structures 有权
标题翻译：用于稳定骨骼结构的仪器和方法
公开(公告)号：US20070185491A1
公开(公告)日：2007-08-09
申请号：US11656716
申请日：2007-01-23
申请人： Kevin Foley , Michael Sherman , Jeff Justis
发明人： Kevin Foley , Michael Sherman , Jeff Justis
IPC分类号： A61F2/30
CPC分类号： A61B17/7086 , A61B17/00234 , A61B17/1671 , A61B17/7038 , A61B17/7089 , A61B17/88 , A61B17/8872 , A61B17/8897 , A61B2017/681 , A61B2017/90
摘要： The present invention relates to methods and instruments for placing a brace or connecting element into an animal subject for engagement with anchors secured in the animal subject. The installation instrument includes anchor extensions coupled to the anchors. The instrument is movable with respect to the anchors to position the conencting element in a position more proximate the anchors.
摘要翻译：本发明涉及用于将支架或连接元件放置在动物对象中用于与固定在动物对象中的锚固件接合的方法和装置。安装仪器包括连接到锚固件的锚固件延伸件。仪器可相对于锚固件移动，以将连接元件定位在更靠近锚固件的位置。

4. 发明申请

US20060200135A1 Instruments and methods for stabilization of bony structures 有权
公开(公告)号：US20060200135A1
公开(公告)日：2006-09-07
申请号：US11338412
申请日：2006-01-24
申请人： Michael Sherman , Kevin Foley , Jeff Justis
发明人： Michael Sherman , Kevin Foley , Jeff Justis
IPC分类号： A61F2/30
CPC分类号： A61B17/7086 , A61B17/00234 , A61B17/1671 , A61B17/7038 , A61B17/7089 , A61B17/88 , A61B17/8872 , A61B17/8897 , A61B2017/681 , A61B2017/90
摘要： The present invention relates to a brace installation instrument placement that is mounted to anchors secured in an animal subject. The installation instrument includes anchor extensions coupled to the anchors. The instrument is movable with respect to the anchors to position a brace in a position more proximate the anchors. The brace can be indexed for insertion at a predetermined orientation with respect to the installation instrument. Methods and techniques for using the installation instrument are also provided.

5. 发明申请

US20050021031A1 Instruments and methods for stabilization of bony structures 有权
标题翻译：用于稳定骨骼结构的仪器和方法
公开(公告)号：US20050021031A1
公开(公告)日：2005-01-27
申请号：US10922639
申请日：2004-08-20
申请人： Kevin Foley , Michael Sherman , Jeff Justis
发明人： Kevin Foley , Michael Sherman , Jeff Justis
IPC分类号： A61B17/58 , A61B17/00 , A61B17/16 , A61B17/88 , A61B17/90 , A61B17/56
CPC分类号： A61B17/7086 , A61B17/00234 , A61B17/1671 , A61B17/7038 , A61B17/7089 , A61B17/88 , A61B17/8872 , A61B17/8897 , A61B2017/681 , A61B2017/90
摘要： The present invention relates to methods and instruments for placing a brace or connecting element into an animal subject for engagement with anchors secured in the animal subject. The installation instrument includes anchor extensions coupled to the anchors. The instrument is movable with respect to the anchors to position the conencting element in a position more proximate the anchors.
摘要翻译：本发明涉及用于将支架或连接元件放置在动物对象中用于与固定在动物对象中的锚固件接合的方法和装置。安装仪器包括连接到锚固件的锚固件延伸件。仪器可相对于锚固件移动，以将连接元件定位在更靠近锚固件的位置。

6. 发明申请

US20070198013A1 Surgical instrumentation and method for treatment of the spine 审中-公开
标题翻译：手术器械及脊柱治疗方法
公开(公告)号：US20070198013A1
公开(公告)日：2007-08-23
申请号：US11786595
申请日：2007-04-12
申请人： Kevin Foley , Jeff Justis
发明人： Kevin Foley , Jeff Justis
IPC分类号： A61B17/00 , A61B17/56 , A61F5/00
CPC分类号： A61B17/025 , A61B17/8858 , A61B2017/00867 , A61B2017/0256 , A61F2/44 , A61F2/4601 , A61F2002/4602
摘要： Instrumentation for treatment of the spine, including an elongate member having a deformable distal end portion at least partially formed of a flexible and preferably elastic material. The distal end portion has an initial configuration for placement adjacent a vertebral body and a deformed configuration defining at least one outwardly extending projection for displacement of at least a portion of the vertebral body. The elongate member preferably comprises a rod member, a sleeve member and an actuator mechanism for imparting relative linear displacement between the rod and sleeve members to effect outward deformation of the distal end portion of the sleeve member. In one embodiment, the instrumentation is used to compact cancellous bone to form a cavity within a vertebral body. In another embodiment, the instrumentation is used to reduce a compression fracture. In yet another embodiment, the instrumentation is used to distract a disc space between adjacent vertebral bodies.
摘要翻译：用于治疗脊柱的装置，包括具有至少部分地由柔性和优选弹性材料形成的可变形远端部分的细长构件。远端部分具有用于邻近椎体放置的初始构型和限定至少一个向外延伸的突起的变形构型，用于移位至少一部分椎体。细长构件优选地包括杆构件，套筒构件和致动器机构，用于在杆和套筒构件之间施加相对的线性位移以实现套筒构件的远端部分的向外变形。在一个实施例中，仪器用于压制松质骨以在椎体内形成腔。在另一个实施例中，仪器用于减少压缩断裂。在另一个实施例中，仪器用于分散相邻椎体之间的椎间盘空间。

7. 发明申请

US20050277832A1 Percutaneous registration apparatus and method for use in computer-assisted surgical navigation 审中-公开
标题翻译：用于计算机辅助外科导航的经皮注册装置和方法
公开(公告)号：US20050277832A1
公开(公告)日：2005-12-15
申请号：US11199419
申请日：2005-08-08
申请人： Kevin Foley , John Clayton , Anthony Melkent , Michael Sherman
发明人： Kevin Foley , John Clayton , Anthony Melkent , Michael Sherman
IPC分类号： A61B17/70 , A61B17/88 , A61B19/00 , A61B5/05
CPC分类号： A61B17/70 , A61B17/7032 , A61B17/7083 , A61B34/10 , A61B34/20 , A61B90/11 , A61B2017/00477 , A61B2034/2055 , A61B2034/2072 , A61B2090/363 , A61B2090/3945 , A61B2090/3983
摘要： An apparatus and procedures for percutaneous placement of surgical implants and instruments such as, for example, screws, rods, wires and plates into various body parts using image guided surgery. An apparatus for use with a surgical navigation system, an attaching device rigidly connected to a body part, such as the spinous process of a vertebrae, with an identification superstructure rigidly but removably connected to the attaching device. This identification superstructure, for example, is a reference arc and fiducial array which accomplishes the function of identifying the location of the superstructure, and, therefore, the body part to which it is fixed, during imaging by CAT scan or MRI, and later during medical procedures.
摘要翻译：使用图像引导手术将外科植入物和器械（例如螺钉，杆，线和板）经皮放置到各种身体部位中的装置和程序。一种与外科导航系统一起使用的装置，刚性地连接到身体部位的附接装置，例如椎骨的棘突，具有刚性但可拆卸地连接到附接装置的识别上部结构。该识别超结构例如是参考电弧和基准阵列，其在通过CAT扫描或MRI进行成像期间实现识别上部结构的位置以及因此固定的身体部位的功能，并且稍后在医疗程序。

8. 发明申请

US20060009780A1 Percutaneous registration apparatus and method for use in computer-assisted surgical navigation 审中-公开
标题翻译：用于计算机辅助外科导航的经皮注册装置和方法
公开(公告)号：US20060009780A1
公开(公告)日：2006-01-12
申请号：US11199418
申请日：2005-08-08
申请人： Kevin Foley , John Clayton , Anthony Melkent , Michael Sherman
发明人： Kevin Foley , John Clayton , Anthony Melkent , Michael Sherman
IPC分类号： A61B17/58
CPC分类号： A61B17/70 , A61B17/7032 , A61B17/7083 , A61B34/10 , A61B34/20 , A61B90/11 , A61B2017/00477 , A61B2034/2055 , A61B2034/2072 , A61B2090/363 , A61B2090/3945 , A61B2090/3983
摘要： An apparatus and procedures for percutaneous placement of surgical implants and instruments such as, for example, screws, rods, wires and plates into various body parts using image guided surgery. An apparatus for use with a surgical navigation system, an attaching device rigidly connected to a body part, such as the spinous process of a vertebrae, with an identification superstructure rigidly but removably connected to the attaching device. This identification superstructure, for example, is a reference arc and fiducial array which accomplishes the function of identifying the location of the superstructure, and, therefore, the body part to which it is fixed, during imaging by CAT scan or MRI, and later during medical procedures.
摘要翻译：使用图像引导手术将外科植入物和器械（例如螺钉，杆，线和板）经皮放置到各种身体部位中的装置和程序。一种与外科导航系统一起使用的装置，刚性地连接到身体部位的附接装置，例如椎骨的棘突，具有刚性但可拆卸地连接到附接装置的识别上部结构。该识别超结构例如是参考电弧和基准阵列，其在通过CAT扫描或MRI进行成像期间实现识别上部结构的位置以及因此固定的身体部位的功能，并且稍后在医疗程序。

9. 发明申请

US20060241643A1 Minimally invasive expanding spacer and method 有权
标题翻译：微创扩张垫片和方法
公开(公告)号：US20060241643A1
公开(公告)日：2006-10-26
申请号：US11451862
申请日：2006-06-13
申请人： Roy Lim , Michael Sherman , Kevin Foley
发明人： Roy Lim , Michael Sherman , Kevin Foley
IPC分类号： A61B17/58
CPC分类号： A61B17/025 , A61B17/0206 , A61B17/2804 , A61B2017/0256 , A61B2090/061 , A61F2/4455 , A61F2002/30471 , A61F2002/3055 , A61F2002/30579 , A61F2002/30624 , A61F2220/0091
摘要： A minimaly invasive spacer for positioning between vertebral members. The spacer is adjustable between a first orientation having a reduced size to facilitate insertion between the vertebral members. A second orientation has an enlarged size for contacting the vertebral members. The spacer includes linkages that are attached to a pair of plates. A pull arm is operatively connected to the linkages for adjusting the spacer from the first orientation to the second orientation. A indicator gauge indicates the height of the spacer.
摘要翻译：用于在椎骨构件之间定位的最小侵入间隔物。间隔件可在具有减小的尺寸的第一取向之间调节以便于椎骨构件之间的插入。第二方向具有用于接触椎骨构件的放大尺寸。间隔件包括连接到一对板的连接件。拉臂可操作地连接到连杆上，用于将间隔件从第一方向调整到第二方向。指示器表示间隔件的高度。

10. 发明申请

US20140094436A1 IMIDAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
标题翻译：调节HSP90活性的咪唑化合物
公开(公告)号：US20140094436A1
公开(公告)日：2014-04-03
申请号：US14103420
申请日：2013-12-11
申请人： Weiwen Ying , Zhenjian Du , Kevin Foley
发明人： Weiwen Ying , Zhenjian Du , Kevin Foley
IPC分类号： C07D233/84 , C07F9/6506 , C07D233/88 , C07D403/10
CPC分类号： A61K31/4164 , A61K31/4178 , A61K31/4184 , A61K31/428 , A61K31/4709 , A61K31/52 , A61K31/5377 , A61K31/675 , C07D233/70 , C07D233/84 , C07D233/88 , C07D403/02 , C07D403/04 , C07D403/10 , C07F9/6506
摘要： Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein.
摘要翻译：式（I）化合物，包含式（I）化合物的药物组合物和抑制细胞中Hsp90的方法，治疗或预防哺乳动物中的增殖病症并治疗哺乳动物的癌症，其包括给予式（I）化合物至患者或细胞。变量R5是任选取代的杂芳基; 任选取代的6至14元芳基; 任选在任何可取代的氮或碳原子上取代的双环9元杂环; 或本文定义的取代基R18。环A是除了R3之外任选进一步被一个或多个取代基取代的芳基或杂芳基。取代基R 3在本文中定义。

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