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1. 发明授权

US07803828B2 Functionally selective alpha2C adrenoreceptor agonists 有权
标题翻译：功能选择性α2C肾上腺素受体激动剂
公开(公告)号：US07803828B2
公开(公告)日：2010-09-28
申请号：US11508458
申请日：2006-08-23
申请人： Kevin D. McCormick , Christopher W. Boyce , Robert G. Aslanian , Neng-Yang Shih , Salem Fevrier , Pietro Mangiaracina , Chia-Yu Huang , Bo Liang , Rong-Qiang Liu , Huagang Lu
发明人： Kevin D. McCormick , Christopher W. Boyce , Robert G. Aslanian , Neng-Yang Shih , Salem Fevrier , Pietro Mangiaracina , Chia-Yu Huang , Bo Liang , Rong-Qiang Liu , Huagang Lu
IPC分类号： A01N43/50 , C07D233/00
CPC分类号： C07D403/02 , C07D401/06 , C07D403/06
摘要： In its many embodiments, the present invention provides a novel class of indolines as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明提供了作为α2C肾上腺素能受体激动剂抑制剂的新一类中和体，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与α2C肾上腺素能受体相关的一种或多种病症的方法。

2. 发明授权

US07700592B2 α2C adrenoreceptor agonists 失效
标题翻译： α2C肾上腺素受体激动剂
公开(公告)号：US07700592B2
公开(公告)日：2010-04-20
申请号：US11705673
申请日：2007-02-13
申请人： Kevin D. McCormick , Christopher W. Boyce , Neng-Yang Shih , Chia-Yu Huang , Robert G. Aslanian , Salem Fevrier , Bo Liang , Rong-qiang Liu , Ruiyan Liu , Pietro Mangiaracina , Manuel de Lera Ruiz , Younong Yu , Lisa Guise-Zawacki , Junying Zheng
发明人： Kevin D. McCormick , Christopher W. Boyce , Neng-Yang Shih , Chia-Yu Huang , Robert G. Aslanian , Salem Fevrier , Bo Liang , Rong-qiang Liu , Ruiyan Liu , Pietro Mangiaracina , Manuel de Lera Ruiz , Younong Yu , Lisa Guise-Zawacki , Junying Zheng
IPC分类号： C07D498/04 , A61K31/538
CPC分类号： C07D413/14 , C07D241/36 , C07D279/06 , C07D403/06 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04 , C07D498/04
摘要： In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the α2C adrenergic receptor agonists using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明涉及可用作α2C肾上腺素能受体激动剂的新一类苯基吗啉和苯硫基吗啉化合物，含有该化合物的药物组合物，以及治疗，预防，抑制或改善一种或多种与 α2C肾上腺素能受体激动剂，使用这些化合物或药物组合物。

3. 发明授权

US07985748B2 ALPHA2C adrenoreceptor agonists 失效
标题翻译： ALPHA2C肾上腺素受体激动剂
公开(公告)号：US07985748B2
公开(公告)日：2011-07-26
申请号：US12722879
申请日：2010-03-12
申请人： Kevin D. McCormick , Christopher W. Boyce , Neng-Yang Shih , Robert G. Aslanian , Pietro Mangiaracina , Manuel de Lera Ruiz , Younong Yu , Purakkattle Biju , Chia-Yu Huang , Bo Liang , Ruiyan Liu , Rong-Qiang Liu , Lisa Guise-Zawacki
发明人： Kevin D. McCormick , Christopher W. Boyce , Neng-Yang Shih , Robert G. Aslanian , Pietro Mangiaracina , Manuel de Lera Ruiz , Younong Yu , Purakkattle Biju , Chia-Yu Huang , Bo Liang , Ruiyan Liu , Rong-Qiang Liu , Lisa Guise-Zawacki
IPC分类号： C07D413/06 , A61K31/538
CPC分类号： C07D413/06 , C07D403/06 , C07D413/04 , C07D413/14 , C07D417/06 , C07D471/04 , C07D487/04 , C07D498/04
摘要： In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the α2C adrenergic receptor agonists using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明涉及可用作α2C肾上腺素能受体激动剂的新一类苯基吗啉和苯硫基吗啉化合物，含有该化合物的药物组合物，以及治疗，预防，抑制或改善一种或多种与 α2C肾上腺素能受体激动剂，使用这些化合物或药物组合物。

4. 发明申请

US20100173823A1 ALPHA2C ADRENORECEPTOR AGONISTS 失效
公开(公告)号：US20100173823A1
公开(公告)日：2010-07-08
申请号：US12722879
申请日：2010-03-12
申请人： Kevin D. McCormick , Christopher W. Boyce , Neng-Yang Shih , Robert G. Aslanian , Pietro Mangiaracina , Manuel de Lera Ruiz , Younong Yu , Purakkattle Biju , Chia-Yu Huang , Bo Liang , Ruiyan Liu , Rong-Qiang Liu , Lisa Guise-Zawacki
发明人： Kevin D. McCormick , Christopher W. Boyce , Neng-Yang Shih , Robert G. Aslanian , Pietro Mangiaracina , Manuel de Lera Ruiz , Younong Yu , Purakkattle Biju , Chia-Yu Huang , Bo Liang , Ruiyan Liu , Rong-Qiang Liu , Lisa Guise-Zawacki
IPC分类号： A61K31/553 , C07D265/36 , A61K31/538 , C12N5/00 , C07D279/16 , A61K31/5415 , C07D241/36 , A61K31/498 , C07D267/14 , C07D471/04 , A61K31/56 , A61K38/02 , A61P11/00 , A61P37/08 , A61P9/00 , A61P25/00 , A61P29/00 , A61P13/00
CPC分类号： C07D413/06 , C07D403/06 , C07D413/04 , C07D413/14 , C07D417/06 , C07D471/04 , C07D487/04 , C07D498/04
摘要： In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the α2C adrenergic receptor agonists using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明涉及可用作α2C肾上腺素能受体激动剂的新一类苯基吗啉和苯硫基吗啉化合物，含有该化合物的药物组合物，以及治疗，预防，抑制或改善一种或多种与 α2C肾上腺素能受体激动剂，使用这些化合物或药物组合物。

5. 发明申请

US20070099872A1 Functionally selective alpha2C adrenoreceptor agonists 有权
标题翻译：功能选择性α2C肾上腺素受体激动剂
公开(公告)号：US20070099872A1
公开(公告)日：2007-05-03
申请号：US11508458
申请日：2006-08-23
申请人： Kevin McCormick , Christopher Boyce , Robert Aslanian , Neng-Yang Shih , Salem Fevrier , Pietro Mangiaracina , Chia-Yu Huang , Bo Liang , Rong-Qiang Liu , Huagang Lu
发明人： Kevin McCormick , Christopher Boyce , Robert Aslanian , Neng-Yang Shih , Salem Fevrier , Pietro Mangiaracina , Chia-Yu Huang , Bo Liang , Rong-Qiang Liu , Huagang Lu
IPC分类号： A61K31/675 , A61K31/4709 , A61K31/4178 , C07D403/02
CPC分类号： C07D403/02 , C07D401/06 , C07D403/06
摘要： In its many embodiments, the present invention provides a novel class of indolines as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明提供了作为α2C肾上腺素能受体激动剂抑制剂的新一类中和体，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与α2C肾上腺素能受体相关的一种或多种病症的方法。

6. 发明申请

US20080027100A1 Functionally selective alpha2C adrenoreceptor agonists 失效
标题翻译：功能选择性α2C肾上腺素受体激动剂
公开(公告)号：US20080027100A1
公开(公告)日：2008-01-31
申请号：US11705683
申请日：2007-02-13
申请人： Kevin McCormick , Christopher Boyce , Neng-Yang Shih , Chia-Yu Huang , Robert Aslanian , Jianhua Chao , Salem Fevrier , Bo Liang , Huagang Lu , Pietro Mangiaracina , Rong-Qiang Liu , Younong Yu
发明人： Kevin McCormick , Christopher Boyce , Neng-Yang Shih , Chia-Yu Huang , Robert Aslanian , Jianhua Chao , Salem Fevrier , Bo Liang , Huagang Lu , Pietro Mangiaracina , Rong-Qiang Liu , Younong Yu
IPC分类号： A61K31/4178 , A61K31/4709 , A61P1/12 , A61P13/00 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/24 , A61P27/14 , A61P37/00 , A61P9/00 , C07D215/00 , C07D403/06 , C12N5/00
CPC分类号： C07D403/02 , C07D401/14 , C07D403/06 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： In its many embodiments, the present invention provides a novel class of indolines as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明提供了作为α2C肾上腺素能受体激动剂抑制剂的新一类中和体，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与α2C肾上腺素能受体相关的一种或多种病症的方法。

7. 发明申请

US20080039439A1 Alpha2C adrenoreceptor agonists 失效
标题翻译： α2C肾上腺素受体激动剂
公开(公告)号：US20080039439A1
公开(公告)日：2008-02-14
申请号：US11705673
申请日：2007-02-13
申请人： Kevin McCormick , Christopher Boyce , Neng-Yang Shih , Chia-Yu Huang , Robert Aslanian , Salem Fevrier , Bo Liang , Rong-qiang Liu , Ruiyan Liu , Pietro Mangiaracina , Manuel de Lera Ruiz , Younong Yu , Lisa Guise-Zawacki , Junying Zheng
发明人： Kevin McCormick , Christopher Boyce , Neng-Yang Shih , Chia-Yu Huang , Robert Aslanian , Salem Fevrier , Bo Liang , Rong-qiang Liu , Ruiyan Liu , Pietro Mangiaracina , Manuel de Lera Ruiz , Younong Yu , Lisa Guise-Zawacki , Junying Zheng
IPC分类号： A61K31/535 , A61K31/502 , A61K31/54 , A61K31/553 , A61P1/00 , A61P25/00 , A61P37/00 , A61P9/00 , C07D241/36 , C07D279/06 , C07D498/04 , C12N5/06
CPC分类号： C07D413/14 , C07D241/36 , C07D279/06 , C07D403/06 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04 , C07D498/04
摘要： In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the α2C adrenergic receptor agonists using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明涉及可用作α2C肾上腺素能受体激动剂的新型苯基吗啉和苯硫基吗啉化合物，含有该化合物的药物组合物，以及治疗，预防，抑制或改善一种或多种与 α2C肾上腺素能受体激动剂，使用这些化合物或药物组合物。

8. 发明授权

US08501747B2 Functionally selective alpha2C adrenoreceptor agonists 失效
标题翻译：功能选择性α2C肾上腺素受体激动剂
公开(公告)号：US08501747B2
公开(公告)日：2013-08-06
申请号：US12525641
申请日：2008-02-11
申请人： Manuel de lera Ruiz , Kevin D. McCormick , Christopher W. Boyce , Robert G. Aslanian , Younong Yu , Pietro Mangiaracina , Junying Zheng , Michael Y. Berlin , Stephanie Louise Ciesla , Chia-Yu Huang , Bo Liang
发明人： Manuel de lera Ruiz , Kevin D. McCormick , Christopher W. Boyce , Robert G. Aslanian , Younong Yu , Pietro Mangiaracina , Junying Zheng , Michael Y. Berlin , Stephanie Louise Ciesla , Chia-Yu Huang , Bo Liang
IPC分类号： A61K31/404 , A61K31/4025 , A61K31/4178 , A61K31/4439 , A61K31/4709 , A61K31/506 , C07D401/04 , C07D401/14 , C07D403/02 , C07D403/14
CPC分类号： C07D403/14 , C07D233/10 , C07D401/14 , C07D403/06 , C07D403/10 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14
摘要： In its many embodiments, the present invention provides a novel class of biaryl compounds as inhibitors of ÿ2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the ÿ2C adrenergic receptors using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明提供了一类新颖的联芳基化合物作为ÿ2C肾上腺素能受体激动剂的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与ÿ2C肾上腺素能受体相关的一种或多种病症的方法。

9. 发明申请

US20070093477A1 Alpha2C adrenoreceptor agonists 审中-公开
标题翻译： α2C肾上腺素受体激动剂
公开(公告)号：US20070093477A1
公开(公告)日：2007-04-26
申请号：US11508467
申请日：2006-08-23
申请人： Kevin McCormick , Christopher Boyce , Neng-Yang Shih , Robert Aslanian , Pietro Mangiaracina , Manuel de Lera Ruiz , Younong Yu , Purakkattle Biju , Chia-Yu Huang , Bo Liang , Ruiyan Liu , Rong-Qiang Liu , Lisa Guise-Zawacki
发明人： Kevin McCormick , Christopher Boyce , Neng-Yang Shih , Robert Aslanian , Pietro Mangiaracina , Manuel de Lera Ruiz , Younong Yu , Purakkattle Biju , Chia-Yu Huang , Bo Liang , Ruiyan Liu , Rong-Qiang Liu , Lisa Guise-Zawacki
IPC分类号： A61K31/5415 , A61K31/538 , A61K31/498 , C07D413/02 , C07D417/02
CPC分类号： C07D413/06 , C07D403/06 , C07D413/04 , C07D413/14 , C07D417/06 , C07D471/04 , C07D487/04 , C07D498/04
摘要： In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the α2C adrenergic receptor agonists using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明涉及可用作α2C肾上腺素能受体激动剂的新型苯基吗啉和苯硫基吗啉化合物，含有该化合物的药物组合物，以及治疗，预防，抑制或改善一种或多种与 α2C肾上腺素能受体激动剂，使用这些化合物或药物组合物。

10. 发明申请

US20130260969A1 RESISTANCE ADJUSTABLE ROTATIONAL EXERCISER 有权
标题翻译：电阻可调式旋转练习器
公开(公告)号：US20130260969A1
公开(公告)日：2013-10-03
申请号：US13435921
申请日：2012-03-30
申请人： Chia-Yu Huang
发明人： Chia-Yu Huang
IPC分类号： A63B21/02
CPC分类号： A63B21/0608 , A63B21/00069 , A63B21/015 , A63B21/0724 , A63B21/4035 , A63B21/4049 , A63B23/03525 , A63B23/03541 , A63B2244/102
摘要： A resistance adjustable rotational exerciser includes a body, two rotary members and an adjustment device. The body has two outer rings with a connection plate connected therebetween. The two rotary members are rotatably connected to the outer rings and each have a handle. The adjustment device has front and rear plates respectively connected to the front and rear sides of the connection plate. The front and rear plates have resistance strips. Springs are located between the connection plate and the front and rear plates. A knob is located at the front plate and connected to connection rods connected between the front and rear plates. The user holds the handles to operate the exerciser in different directions to exercise the muscles and joints. By operation of the knob, the distance between the front and rear plates is adjusted to obtain desired resistance.
摘要翻译：电阻可调节旋转锻炼器包括主体，两个旋转构件和调节装置。主体具有两个连接在其间的连接板的外圈。两个旋转构件可旋转地连接到外圈并且每个具有把手。调节装置具有分别连接到连接板的前侧和后侧的前板和后板。前后板有电阻条。弹簧位于连接板和前后板之间。一个旋钮位于前板，并连接到连接在前板和后板之间的连接杆。用户握住手柄以在不同方向操作锻炼者以锻炼肌肉和关节。通过旋钮的操作，调整前板和后板之间的距离以获得所需的阻力。

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