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    • 3. 发明授权
    • Alph-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
    • US06255349B1
    • 2001-07-03
    • US09444734
    • 1999-11-22
    • Jonathan BloomKevin CurranMartin DiGrandiRussell DushinStanley LangEmily NortonAdma RossBryan O'Hara
    • Jonathan BloomKevin CurranMartin DiGrandiRussell DushinStanley LangEmily NortonAdma RossBryan O'Hara
    • A61K3117
    • C07D211/96C07C335/20
    • Compounds having the formula:  wherein  R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, —CN, —NO2, —CO2R6, —COR6, —OR6, —SR6, —SOR6, —SO2R6, —CONR7R8, —NR6N(R7R8), —N(R7R8) or W—Y—(CH2)n—Z provided that at least one of R1-R5 is not hydrogen; or R2 and R3or R3 and R4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl;  R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl;  R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or  R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl;  W is O, NR6, or is absent;  Y is —(CO)— or —(CO2)—, or is absent;  Z is alkyl of 1 to 4 carbon atoms, —CN, —CO2R6, COR6, —CONR7R8, —OCOR6, —NR6COR7, —OCONR6, —OR6, —SR6, —SOR6, —SO2R6, SR6N(R7R8), —N(R7R8) or phenyl;  G is aryl or fused bicyclic heteroaryl;  X is a bond, —NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J;  J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and  n is an integer from 1 to 6; or a pharmaceutically acceptable salt thereof, useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.
    • 5. 发明申请
    • SYSTEM AND METHOD FOR STREAMING MUSIC REPAIR AND ERROR CONCEALMENT
    • 用于流动音乐修复和错误隐藏的系统和方法
    • US20120269354A1
    • 2012-10-25
    • US13321795
    • 2010-05-20
    • Jonathan Paul DohertyKevin CurranPaul Mckevitt
    • Jonathan Paul DohertyKevin CurranPaul Mckevitt
    • G10L19/02
    • G10L19/005G10L19/167
    • A method is provided for analysing the self-similarity of an audio file. The method involves obtaining the audio spectrum envelope data of an audio file to be analysed; performing a clustering operation on the spectrum envelope data to produce a clustered set of data; for a first portion of the clustered data, performing a string matching operation on at least one other portion of the clustered data; and based on the results of the string matching operation, determining the at least one other portion of the clustered data most similar to said first portion of the clustered data. There is also provided a method of repairing an audio stream received over a network using similarity data to replace damaged or missing portions of data with similar “good” portions of data.
    • 提供了一种用于分析音频文件的自相似性的方法。 该方法涉及获得要分析的音频文件的音频频谱包络数据; 对频谱包络数据执行聚类操作以产生一组聚集的数据; 对于所述聚类数据的第一部分,对所述聚集数据的至少一个其他部分执行字符串匹配操作; 并且基于所述字符串匹配操作的结果,确定与所述聚集数据的所述第一部分最相似的所述聚类数据的所述至少一个其他部分。 还提供了一种使用相似性数据来修复通过网络接收的音频流的方法,以用数据的相似好部分来代替数据的损坏或丢失部分。