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1. 发明授权

US10118927B2 Substituted piperidin-4-amino-type compounds and uses thereof 有权
公开(公告)号：US10118927B2
公开(公告)日：2018-11-06
申请号：US14655882
申请日：2013-12-23
申请人： SHIONOGI & CO., LTD. , Kevin Brown , Dawit Tadesse , Naoki Tsuno , Nobuyuki Tanaka , Xiaoming Zhou
发明人： Kevin Brown , Dawit Tadesse , Nobuyuki Tanaka , Naoki Tsuno , Xiaoming Zhou
IPC分类号： C07D471/08 , C07D211/58 , C07C235/74
摘要： The disclosure relates to Substituted Piperidin-4-amino-Type Compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof wherein R1, R2, R3, Q1, Q2, E1, E2, A, B, D, W, Z, a, b, n, and x are as defined herein, compositions comprising an effective amount of a Substituted Piperidin-4-amino-Type Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted Piperidin-4-amino-Type Compound.

2. 发明申请

US20160272640A1 SUBSTITUTED PIPERIDIN-4-AMINO-TYPE COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：取代的哌啶-4-氨基型化合物及其用途
公开(公告)号：US20160272640A1
公开(公告)日：2016-09-22
申请号：US14655882
申请日：2013-12-23
申请人： Kevin BROWN , Dawit TADESSE , Naoki TSUNO , Nobuyuki TANAKA , Xiaoming Zhou , SHIONOGI & CO., LTD.
发明人： Kevin Brown , Dawit Tadesse , Nobuyuki Tanaka , Naoki Tsuno , Xiaoming Zhou
IPC分类号： C07D471/08 , C07D211/58 , C07C235/74
CPC分类号： C07D471/08 , C07C235/74 , C07C2602/46 , C07D211/58
摘要： The disclosure relates to Substituted Piperidin-4-amino-Type Compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof wherein R1, R2, R3, Q1, Q2, E1, E2, A, B, D, W, Z, a, b, n, and x are as defined herein, compositions comprising an effective amount of a Substituted Piperidin-4-amino-Type Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted Piperidin-4-amino-Type Compound.

3. 发明授权

US09182486B2 Sonar rendering systems and associated methods 有权
标题翻译：声纳渲染系统及相关方法
公开(公告)号：US09182486B2
公开(公告)日：2015-11-10
申请号：US13313574
申请日：2011-12-07
申请人： Kevin Brown , Aaron Coleman
发明人： Kevin Brown , Aaron Coleman
IPC分类号： G01S15/00 , G01S15/89 , G01S7/62 , G01S15/02 , G01S15/50
CPC分类号： G01S15/8902 , G01S7/6281 , G01S7/629 , G01S15/025 , G01S15/50
摘要： Sonar rendering systems and methods are described herein. One example is an apparatus that includes a transducer element, position sensing circuitry, processing circuitry, and a display device. The processing circuitry may be configured to receive raw sonar data and positioning data, convert the raw sonar data into range cell data based at least on amplitudes of the return echoes, make a location-based association between the raw sonar data and the positioning data, plot the range cell data based on respective positions derived from the positioning data and rotate the range cell data based on a direction of movement of the watercraft to generate adjusted range cell data. The processing circuitry may be further configured to convert the adjusted range cell data into sonar image data, and cause the display device to render the sonar image data with a presentation of a geographic map.
摘要翻译：本文描述了声纳渲染系统和方法。一个示例是包括换能器元件，位置感测电路，处理电路和显示装置的装置。处理电路可以被配置为接收原始声纳数据和定位数据，至少基于返回回波的幅度将原始声纳数据转换成范围单元数据，在原始声纳数据和定位数据之间进行基于位置的关联，基于从定位数据导出的相应位置绘制范围单元数据，并且基于船舶的运动方向旋转范围单元数据以生成调整范围单元数据。处理电路还可以被配置为将调整的范围单元数据转换成声纳图像数据，并且使得显示设备用地图的呈现来呈现声纳图像数据。

4. 发明申请

US20140039582A1 APPARATUS AND METHOD FOR USING ULTRAVIOLET LIGHT WITH PULSATILE LAVAGE 审中-公开
标题翻译：装置和方法，用于使用具有柔性拉链的超紫外线
公开(公告)号：US20140039582A1
公开(公告)日：2014-02-06
申请号：US13960589
申请日：2013-08-06
申请人： Jay Wilson , Kevin Brown , Ringo Wan Chan Yen , Isaac Odim
发明人： Jay Wilson , Kevin Brown , Ringo Wan Chan Yen , Isaac Odim
IPC分类号： A61L2/00
CPC分类号： A61L2/0047 , A61L2202/21
摘要： An illumination device comprises a housing, a power supply and at least one light source powered by the power supply. The at least one light source is adapted to emit radiation from the housing at one or more therapeutic wavelengths. The illumination device is positioned in proximity to an area for applying radiation to the area for a time and intensity sufficient to have a bacteriocidal effect.
摘要翻译：照明装置包括壳体，电源和由电源供电的至少一个光源。所述至少一个光源适于以一个或多个治疗波长从壳体发射辐射。照明装置位于靠近用于向该区域施加辐射足以具有杀菌效果的时间和强度的区域附近。

5. 发明申请

US20130289796A1 VISION SYSTEM FOR RADIOTHERAPY MACHINE CONTROL 有权
标题翻译：放射治疗机器视觉系统
公开(公告)号：US20130289796A1
公开(公告)日：2013-10-31
申请号：US13458207
申请日：2012-04-27
申请人： Per H. Bergfjord , Dan Thompson , Kevin Brown , Christopher Knox , Andrew Long , Stephen Young
发明人： Per H. Bergfjord , Dan Thompson , Kevin Brown , Christopher Knox , Andrew Long , Stephen Young
IPC分类号： G05D3/00 , G08B21/18
CPC分类号： A61N5/1048 , A61B90/36 , A61N5/1067 , A61N2005/1059
摘要： In various embodiments, a system for controlling radiotherapy equipment in a treatment environment includes a controller for receiving, from one or more image capture devices, data indicating the position of one or more objects in the treatment environment. Based on the position data, the controller defines one or more exclusionary zones from which the radiotherapy equipment is excluded. Each zone has a buffer area surrounding one or more of the objects. The controller further directs the radiotherapy equipment such that a radiotherapy treatment plan is delivered without the equipment entering into the exclusionary zones.
摘要翻译：在各种实施例中，用于在治疗环境中控制放射治疗设备的系统包括用于从一个或多个图像捕获设备接收指示治疗环境中的一个或多个物体的位置的数据的控制器。基于位置数据，控制器定义一个或多个排除区域，排除放射治疗设备。每个区域具有围绕一个或多个对象的缓冲区。控制器进一步指导放射治疗设备，使得在没有设备进入排除区域的情况下传送放射治疗计划。

6. 发明授权

US08458273B2 Content rights management for document contents and systems, structures, and methods therefor 有权
标题翻译：文件内容和系统的内容权限管理，结构及其方法
公开(公告)号：US08458273B2
公开(公告)日：2013-06-04
申请号：US12967965
申请日：2010-12-14
申请人： Chris Graham , Jason Cahill , Kevin Brown
发明人： Chris Graham , Jason Cahill , Kevin Brown
IPC分类号： G06F15/16
CPC分类号： G06F21/10 , G06Q10/107 , H04L9/0825 , H04L2209/603
摘要： A document comprises a body having at least one defined portion therein, each defined portion being represented in the body of the document as a body object, each of the document and each body object therein being rights-managed as protected content based on license terms specified in a digital license. A recipient of the document can render the protected content of each of the document and each body object therein by acquiring the digital license and satisfying the license terms set forth in the digital license.
摘要翻译：文件包括其中具有至少一个限定部分的主体，每个限定部分在文档的主体中表示为身体对象，其中每个文档及其每个身体对象基于指定的许可条款进行受保护内容的受权管理在数字许可证。文件的收件人可以通过获取数字许可证并满足数字许可证中规定的许可条款，将文档和每个身体对象中的每一个的受保护内容呈现。

7. 发明授权

US08446994B2 Gain control in a communication channel 有权
标题翻译：在通信通道中增益控制
公开(公告)号：US08446994B2
公开(公告)日：2013-05-21
申请号：US12634233
申请日：2009-12-09
申请人： Gregory S. Rawlins , Kevin Brown , Michael W. Rawlins , David F. Sorrells
发明人： Gregory S. Rawlins , Kevin Brown , Michael W. Rawlins , David F. Sorrells
IPC分类号： H04L27/08
CPC分类号： H03G3/20 , H04B1/30
摘要： Methods and apparatuses for reducing DC offsets in a communication system are described. In a first aspect, a feedback loop circuit reduces DC offset in a wireless local area network (WLAN) receiver channel. The frequency response of the feedback loop circuit can be variable. In a second aspect, a circuit provides gain control in a WLAN receiver channel. The stored DC offset is subtracted from the receiver channel. First and second automatic gain control (AGC) amplifiers are coupled in respective portions of the receiver channel. In a third aspect, a feedback loop circuit reduces DC offset in a WLAN receiver channel. The feedback loop circuit includes a storage element that samples and stores receiver channel DC offset. The loop is opened, and the DC offset stored in the storage element is subtracted from the receiver channel. Circuits for monitoring DC offset, and for providing control signals for controlling the frequency response of the DC offset reducing circuits are also provided.
摘要翻译：描述用于减少通信系统中的DC偏移的方法和装置。在第一方面，反馈回路电路减少无线局域网（WLAN）接收机信道中的DC偏移。反馈回路电路的频率响应是可变的。在第二方面，电路在WLAN接收机信道中提供增益控制。从接收机通道中减去存储的直流偏移。第一和第二自动增益控制（AGC）放大器耦合在接收机通道的相应部分中。在第三方面，反馈回路电路减少WLAN接收机信道中的DC偏移。反馈回路电路包括采样和存储接收机通道DC偏移的存储元件。打开该循环，并从接收器通道中减去存储在存储元件中的DC偏移。还提供了用于监控DC偏移的电路，以及用于提供用于控制DC偏移减小电路的频率响应的控制信号。

8. 发明授权

US08401175B2 Internet protocol telephone system 有权
公开(公告)号：US08401175B2
公开(公告)日：2013-03-19
申请号：US12461354
申请日：2009-08-10
申请人： Siavash Fallahi , Kevin Brown
发明人： Siavash Fallahi , Kevin Brown
IPC分类号： H04M1/00 , H04M9/00
CPC分类号： H04M1/2535 , H03H7/06 , H03H7/075 , H03H7/38 , H04M11/066
摘要： An internet protocol telephone includes a substrate having an input and an output that are capable of being connected to the internet protocol (IP) network. A relay is disposed on the substrate and is connected between the input and the output of the substrate. The relay includes first and second native FETs that have a threshold voltage of approximately zero volts. Therefore, the relay is nominally turned-on, even when little or no voltage (or power) is applied to the IP telephone substrate, as during the discovery mode of IP telephone operation. During discovery mode, The IP phone is configured to be responsive to extended link pulses and block data packets that are associated with legacy devices. Data packets have a higher signal duration and are more continuous than extended link pulses. The IP phone includes a switchable ground that is connected to the gates of the native devices, and is controlled by a rectifier and filter circuit that are connected to the substrate input. If the IP phone receives legacy data packets during discovery mode, then the high signal duration and continuous nature of the data packets are sufficient to cause the rectifier to generate a rectified signal having sufficient amplitude to activate the switchable ground, so as to ground the gates of the native devices and therefore turn-off the native devices. Therefore, the data packets are rejected and are not passed back to the switch. Extended link pulses have a frequency that is too low to generate a rectified signal that is sufficient to activate the switchable ground, and therefore the native devices remain turned-on. Accordingly, the extended link pulses are passed back to the switch.

9. 发明申请

US20120224582A1 Method and System for Asymmetric Operation in a Network Node in an Energy Efficient Network 有权
标题翻译：节能网络网络节点不对称操作方法与系统
公开(公告)号：US20120224582A1
公开(公告)日：2012-09-06
申请号：US13471763
申请日：2012-05-15
申请人： Wael William Diab , Kevin Brown
发明人： Wael William Diab , Kevin Brown
IPC分类号： H04L12/56
CPC分类号： H04L12/40136 , H04L43/0823 , H04L43/0894 , Y02D50/10
摘要： An Ethernet network comprising multi-rate link partners that may be operable to communicate symmetrically and/or asymmetrically via any of a plurality of channels. The multi-rate link partners may monitor one or more factors that may affect their power consumption and/or energy efficiency. During operation, an uplink and/or downlink communication rate may be configured, based on the monitoring, to enable asymmetrical data rate operation. The monitored factors may comprise prior or current data rates, bit error rate, packet error rate, latency, queued data and/or tasks, for example. The multi-rate link partners may comprise a twisted pair PHY, an optical PHY or a backplane PHY. In order to reduce power consumption and/or improve energy efficiency, one or more of the uplink communication rate and/or the downlink communication rate may be lowered. The power consumption may be reduced for a multi-rate PHY, a host computer and/or a MAC controller.
摘要翻译：一种包括多速率链路伙伴的以太网，其可操作以经由多个信道中的任一个对称和/或不对称地通信。多速率链路伙伴可以监视可能影响其功率消耗和/或能量效率的一个或多个因素。在操作期间，可以基于监视来配置上行链路和/或下行链路通信速率，以实现非对称数据速率操作。受监视的因素可以包括例如先前的或当前的数据速率，误码率，分组错误率，等待时间，排队的数据和/或任务。多速率链路伙伴可以包括双绞线PHY，光学PHY或背板PHY。为了降低功率消耗和/或提高能量效率，可以降低上行链路通信速率和/或下行链路通信速率中的一个或多个。对于多速率PHY，主机和/或MAC控制器，功耗可能会降低。

10. 发明授权

US08139718B2 Radiotherapy apparatus 有权
标题翻译：放射治疗仪
公开(公告)号：US08139718B2
公开(公告)日：2012-03-20
申请号：US12740291
申请日：2007-10-30
申请人： Kevin Brown , Ralph Streamer , Duncan Bourne
发明人： Kevin Brown , Ralph Streamer , Duncan Bourne
IPC分类号： G21K1/04 , A61N5/10
CPC分类号： A61N5/1049 , A61N5/1042 , A61N5/1067 , A61N2005/1061
摘要： Realtime beam shape adjustment in response to (for example) online CT scanning of a patient during treatment is assisted by the radiotherapy apparatus comprising a source adapted to emit a beam of therapeutic radiation, a collimator for delimiting the radiation beam, the collimator comprising a plurality of leaves arranged alongside each other and be moveable longitudinally so that the tips of the leaves define a variable edge of the collimator, the leaves being mounted on a support that is moveable laterally with respect to the leaves. In this way, movements of the tumor that are perpendicular to the direction of leaf motion can be accommodated by simply moving the collimator bodily so as to accommodate this. It is preferred that the apparatus also includes a control means adapted to receive information as to the location of the target volume, and, on the basis of that information, control the longitudinal positions of the leaves and the lateral position of the support. It is also preferred that the support tilts as it moves laterally along a path. This can be achieved, by example, by bearings that are moveable on suitable guides, or by mounting the support on a plurality of pivot arms of unequal lengths. The lengths of such pivot arms can be adjusted as necessary.
摘要翻译：响应于（例如）治疗期间患者的在线CT扫描的实时波束形状调整由包括适于发射治疗辐射束的源的放射治疗装置辅助，用于限定辐射束的准直器，准直器包括多个的叶片彼此并排设置并且可纵向移动，使得叶片的尖端限定准直器的可变边缘，叶片安装在相对于叶片横向移动的支撑件上。以这种方式，垂直于叶片运动方向的肿瘤的运动可以通过简单地移动准直器以适应这一点来适应。优选地，该装置还包括适于接收关于目标体积的位置的信息的控制装置，并且基于该信息控制叶片的纵向位置和支撑件的横向位置。还优选的是，当支撑件沿着路径横向移动时，支撑件倾斜。这可以通过例如通过在合适的导轨上可移动的轴承，或者通过将支撑件安装在不等长度的多个枢轴臂上来实现。这种枢转臂的长度可以根据需要进行调节。

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