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1. 发明申请

US20110262381A1 FORMULATION FOR TREATMENT OF VAGINAL DRYNESS 有权
标题翻译：用于治疗阴道干燥的配方
公开(公告)号：US20110262381A1
公开(公告)日：2011-10-27
申请号：US12998393
申请日：2009-10-29
申请人： Ketil Andre Hansen , Tore Fagerland , John Afseth , Mathew Leigh , Elsa Kung , Peter Van Hoogevest
发明人： Ketil Andre Hansen , Tore Fagerland , John Afseth , Mathew Leigh , Elsa Kung , Peter Van Hoogevest
IPC分类号： A61K31/765 , A61P15/02
CPC分类号： A61K9/0034 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44
摘要： The present invention is directed to a composition for treating vaginal dryness and lack of lubrication comprising: a poloxamer component; a phospholipid component; an optional oil component; and a non-aqueous carrier; wherein the composition is substantially anhydrous. In another aspect, the present invention is directed to a method of treating vaginal dryness comprising the step of administering to a patient suffering from vaginal dryness the above composition.
摘要翻译：本发明涉及用于治疗阴道干燥和缺乏润滑的组合物，其包含：泊洛沙姆组分; 磷脂成分; 可选的油成分; 和非水载体; 其中所述组合物基本上是无水的。另一方面，本发明涉及一种治疗阴道干燥的方法，包括向患有阴道干燥的患者施用上述组合物的步骤。

2. 发明授权

US09005597B2 Formulation for treatment of vaginal dryness 有权
标题翻译：治疗阴道干燥的配方
公开(公告)号：US09005597B2
公开(公告)日：2015-04-14
申请号：US12998393
申请日：2009-10-29
申请人： Ketil Andre Hansen , Tore Fagerland , John Afseth , Matthew Leigh , Elsa Kung , Peter van Hoogevest
发明人： Ketil Andre Hansen , Tore Fagerland , John Afseth , Matthew Leigh , Elsa Kung , Peter van Hoogevest
IPC分类号： A61K31/765 , A61P15/02 , A61K9/14 , A61K9/00 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44
CPC分类号： A61K9/0034 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44
摘要： The present invention is directed to a composition for treating vaginal dryness and lack of lubrication comprising: a poloxamer component; a phospholipid component; an optional oil component; and a non-aqueous carrier; wherein the composition is substantially anhydrous. In another aspect, the present invention is directed to a method of treating vaginal dryness comprising the step of administering to a patient suffering from vaginal dryness the above composition.
摘要翻译：本发明涉及用于治疗阴道干燥和缺乏润滑的组合物，其包含：泊洛沙姆组分; 磷脂成分; 可选的油成分; 和非水载体; 其中所述组合物基本上是无水的。另一方面，本发明涉及一种治疗阴道干燥的方法，包括向患有阴道干燥的患者施用上述组合物的步骤。

3. 发明申请

US20120141563A1 PHARMACEUTICAL COMPOSITION INCLUDING A DHA ESTER TO BE ADMINISTERED PARENTERALLY 失效
标题翻译：药物组合物，包括必须配制的DHA产品
公开(公告)号：US20120141563A1
公开(公告)日：2012-06-07
申请号：US13389970
申请日：2010-08-11
申请人： Elie Leverd , Peter Van Hoogevest , Elsa Kung , Mathew Leigh
发明人： Elie Leverd , Peter Van Hoogevest , Elsa Kung , Mathew Leigh
IPC分类号： A61K9/00 , A61P9/00 , A61K31/16
CPC分类号： A61K47/14 , A61K9/0019 , A61K9/1075 , A61K31/232 , A61K31/455
摘要： The present invention relates to a pharmaceutical composition to be parenterally administered, including submicronic ester particles of docosahexaenoic acid, dispersed in an aqueous phase using a mixture of at least two surfactants selected from among a) at least one polyoxyethylene fatty acid ester and b) at least one phospholipid derivative. The present invention also relates to the method for preparing said pharmaceutical composition.
摘要翻译：本发明涉及一种药物组合物，其包括使用至少两种选自a）至少一种聚氧乙烯脂肪酸酯和b）之间的混合物在水相中分散二十二碳六烯酸的亚微米酯颗粒，至少一种磷脂衍生物。本发明还涉及制备所述药物组合物的方法。

4. 发明授权

US08753652B2 Pharmaceutical composition including a DHA ester to be administered parenterally 失效
标题翻译：药物组合物，包括非肠道给药的DHA酯
公开(公告)号：US08753652B2
公开(公告)日：2014-06-17
申请号：US13389970
申请日：2010-08-11
申请人： Elie Leverd , Peter Van Hoogevest , Elsa Kung , Mathew Leigh
发明人： Elie Leverd , Peter Van Hoogevest , Elsa Kung , Mathew Leigh
IPC分类号： A61K9/00 , A61K47/14
CPC分类号： A61K47/14 , A61K9/0019 , A61K9/1075 , A61K31/232 , A61K31/455
摘要： The present invention relates to a pharmaceutical composition to be parenterally administered, including submicronic ester particles of docosahexaenoic acid, dispersed in an aqueous phase using a mixture of at least two surfactants selected from among a) at least one polyoxyethylene fatty acid ester and b) at least one phospholipid derivative. The present invention also relates to the method for preparing said pharmaceutical composition.
摘要翻译：本发明涉及一种药物组合物，其包括使用至少两种选自a）至少一种聚氧乙烯脂肪酸酯和b）之间的混合物在水相中分散二十二碳六烯酸的亚微米酯颗粒，至少一种磷脂衍生物。本发明还涉及制备所述药物组合物的方法。

5. 发明申请

US20060153886A1 Ambiphilic porous matrix 审中-公开
标题翻译：亲脂多孔基质
公开(公告)号：US20060153886A1
公开(公告)日：2006-07-13
申请号：US10547193
申请日：2004-02-27
申请人： Mathew Leigh , Steve Leigh , Elsa Kung , Peter Van Hoogevest
发明人： Mathew Leigh , Steve Leigh , Elsa Kung , Peter Van Hoogevest
IPC分类号： A61K8/19
CPC分类号： A61K8/0279 , A61K8/24 , A61K8/26 , A61K8/553 , A61K8/731 , A61K8/922 , A61K2800/56 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q19/00
摘要： Compositions are described which are capable of forming external reservoirs comprising a polymeric matrix for adsorbing sebum in exchange for beneficial oils and transfer of hydrating components to the skin. The compositions may be lotions, creams, gels, pastes, lip sticks and water and oil systems. There is also described a method of preparing said lotions, creams, etc containing an ambiphilic powder mixture or complex comprising synthetic porous agglomerates, a lipophilic component, hydrophilioc attractant/polymer, optionally biologically active compound and excipients.
摘要翻译：描述了能够形成外部储存器的组合物，其包含用于吸收皮脂的聚合物基质，以换取有益的油并将保湿组分转移至皮肤。组合物可以是洗剂，霜剂，凝胶剂，糊剂，唇膏和水和油系统。还描述了一种制备含有含有合成多孔附聚物，亲脂性组分，亲水引诱剂/聚合物，任选的生物活性化合物和赋形剂的两性粉末混合物或复合物的所述洗剂，霜剂等的方法。

6. 发明申请

US20060233846A1 Microdispersion and method of producing same 审中-公开
标题翻译：微分散体及其生产方法
公开(公告)号：US20060233846A1
公开(公告)日：2006-10-19
申请号：US10532309
申请日：2003-10-28
申请人： Steve Leigh , Mathew Louis Leigh , Peter Van Hoogevest , Elsa Kung
发明人： Steve Leigh , Mathew Louis Leigh , Peter Van Hoogevest , Elsa Kung
IPC分类号： A61K8/02
CPC分类号： A61K8/06 , A61K8/345 , A61K8/37 , A61K8/375 , A61K8/553 , A61K2800/21 , A61Q19/00 , A61Q19/08
摘要： The invention describes homogeneous microdispersions comprising at least one hydrogenated or partially hydrogenated membrane lipid with or without enzyme hydrolysis, dispersed in substantially non aqueous, non volatile hydrophilic medium with boiling point above 40° C. More preferably the compositions comprise a mixture of hydrogenated monoacyl and hydrogenated diacyl-lipids and at least one oil. The phospholipid mixture is obtained by controlled enzyme hydrolysis of lecithin or a specific phospholipid, followed by hydrogenation. The compositions have improved rheology, physical and chemical properties, functionality and industrial applicability. The microdispersions are used as such in all types of applications and as functional components with active compounds in products, particularly for improving skin function and facilitating skin repair due to UV damage and aging, in cosmetics and other topical products.
摘要翻译：本发明描述了均匀的微分散体，其包含至少一种具有或不具有酶水解的氢化或部分氢化的膜脂质，分散在沸点高于40℃的基本上非水性的非挥发性亲水介质中。更优选地，组合物包含氢化单酰基和氢化二酰基 - 脂质和至少一种油。磷脂混合物通过卵磷脂或特定磷脂的受控酶水解，然后氢化而获得。组合物具有改善的流变性，物理和化学性质，功能性和工业适用性。在所有类型的应用中以及在产品中具有活性化合物的功能组分，特别是用于改善皮肤功能并促进由于紫外线损伤和老化引起的皮肤修复，在化妆品和其它局部产品中使用微分散体。

7. 发明申请

US20060128665A1 Marine lipid compositions 审中-公开
标题翻译：海洋脂质组成
公开(公告)号：US20060128665A1
公开(公告)日：2006-06-15
申请号：US10536450
申请日：2003-11-26
申请人： Steve Leigh , Elsa Kung , Peter Van Hoogevest , Henricus Tiemessen
发明人： Steve Leigh , Elsa Kung , Peter Van Hoogevest , Henricus Tiemessen
IPC分类号： A61K31/685 , A61K31/66 , C07F9/02
CPC分类号： A23D9/013 , A23J7/00 , A23K20/147 , A23K40/10 , A23K40/30 , A23K50/80 , A23L33/115 , A23L33/12 , A23L33/17 , A23V2002/00 , C11B1/10 , C11B1/104 , Y02A40/818 , A23V2200/224 , A23V2250/192 , A23V2250/182 , A23V2250/05 , A23V2250/1842
摘要： There is described marine phospholipids (MPL) compositions suitable for human, aquaculture applications comprising a dry composition comprising nutritional components selected from the group consisting of marine phospholipids, marine proteins and amino acid blends obtainable by fluid extraction of a dried marine raw material. The compositions have low amounts of neutral lipids and particularly low amounts of cholesterol and cholesterol esters. They may be used either as such in powder form and for preparing purified MPL compositions by ethanol extraction. Both forms may be used as nutritional supplements, ingredients for functional foods and to optimise the delivery and containment of nutritional components in multicomponent fish feed compositions. There is further described a blend of the purified, ethanol extracted MPL compositions mixed with marine, vegetable, microbial or MCT oils to form liquid preparations for hard or soft gel encapsulation. There is further described MPL concentrates comprising purified and clearly defined phospholipid types dispersed in hydrophilic medium which are nutritionally essential in larvae feed. Still further there is described MPL compositions in unit dosage forms as supplements to supply highly bioavailable omega-3 fatty acids for human use, optionally with biologically active compounds.
摘要翻译：描述了适用于人，水产养殖应用的海洋磷脂（MPL）组合物，其包含干组合物，其包含选自海洋磷脂，海洋蛋白质和通过干燥的海洋原料的流体萃取获得的氨基酸混合物的营养成分。组合物具有低量的中性脂质，特别是低量的胆固醇和胆固醇酯。它们可以以粉末形式使用，也可以通过乙醇提取制备纯化的MPL组合物。两种形式可以用作营养补充剂，功能食品的成分，并优化多组分鱼饲料组合物中营养成分的输送和遏制。进一步描述了与海洋，植物，微生物或MCT油混合的纯化的乙醇提取的MPL组合物的混合物，以形成用于硬或软凝胶包封的液体制剂。进一步描述了MPL浓缩物，其包含分散在亲水介质中的纯化和明确定义的磷脂类型，其在幼虫饲料中是营养必需的。此外，还描述了单位剂型中的MPL组合物作为补充剂，为人类提供高度生物可利用的ω-3脂肪酸，任选地具有生物活性化合物。

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