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1. 发明授权

US09980774B2 Methods and devices for delivering microwave energy 有权
公开(公告)号：US09980774B2
公开(公告)日：2018-05-29
申请号：US12829222
申请日：2010-07-01
申请人： Chun Yiu Chu , Ketan Shroff , Dinesh I. Mody , Clarence Emmons , Amrish Jayprakash Walke
发明人： Chun Yiu Chu , Ketan Shroff , Dinesh I. Mody , Clarence Emmons , Amrish Jayprakash Walke
IPC分类号： A61B18/04 , A61B18/18 , A61B18/00 , A61N5/04
CPC分类号： A61B18/18 , A61B18/1815 , A61B2018/00196 , A61B2018/1861 , A61N5/045
摘要： The invention comprises novel microwave antennas wherein the microwave field profile generated by an antenna is tailored and optimized for a particular clinical application. The antennas disclosed herein incorporate one or more additional elements called shaping elements that use unique properties of microwaves such as interaction of a microwave field with one or more conductive or non-conductive elements to shape or redistribute the microwave field. Such shaping elements may be used to reduce the undesired backward coupling of the emitted microwave field to the transmission line. Such shaping elements may be used to increase the power efficiency of the antenna. The invention also discloses devices and methods for treating tissue with microwave energy emitted from the antennas for use in applications such as destroying a soil tissue by microwave ablation.

2. 发明授权

US09993293B2 Methods and devices for applying energy to bodily tissues 有权
公开(公告)号：US09993293B2
公开(公告)日：2018-06-12
申请号：US12603349
申请日：2009-10-21
申请人： Chun Yiu Chu , Ketan Shroff , Clarence Emmons , Amrish Jayprakash Walke , Dinesh I. Mody
发明人： Chun Yiu Chu , Ketan Shroff , Clarence Emmons , Amrish Jayprakash Walke , Dinesh I. Mody
IPC分类号： A61B18/18 , A61B18/00 , A61N5/04
CPC分类号： A61B18/18 , A61B18/1815 , A61B2018/00982 , A61B2018/1861 , A61N5/045
摘要： Devices and methods are disclosed for treating tissue with microwave energy. Such devices and methods are able to treat cavities or surface tissue by creating one or more area or volumetric lesions. Also disclosed are flexible, low-profile devices that can be inserted non-invasively or minimally invasively near or into the target tissue as well as microwave antennas designed to generate ablation profiles that can ablate a large area or a large volume of target tissue in a single ablation. The devices include antennas wherein the field profile generated by an antenna is tailored and optimized for a particular clinical application. The antennas use unique properties of microwaves such as interaction of a microwave field with a metallic object and the use of additional shaping elements to shape the microwave field.

3. 发明授权

US08808281B2 Microwave treatment devices and methods 有权
标题翻译：微波处理装置及方法
公开(公告)号：US08808281B2
公开(公告)日：2014-08-19
申请号：US12603134
申请日：2009-10-21
申请人： Clarence Emmons , Chun Yiu Chu , Amrish Jayprakash Walke , Dinesh I. Mody , Ketan Shroff
发明人： Clarence Emmons , Chun Yiu Chu , Amrish Jayprakash Walke , Dinesh I. Mody , Ketan Shroff
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/1815 , A61B2018/00351 , A61B2018/00422 , A61B2018/00452 , A61B2018/00488 , A61B2018/00494 , A61B2018/00505 , A61B2018/00511 , A61B2018/00517 , A61B2018/00523 , A61B2018/00529 , A61B2018/00547 , A61B2018/00559 , A61B2018/00577 , A61B2018/00702 , A61B2018/00726 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/00982 , A61B2018/00994 , A61B2018/1846 , A61B2018/1853 , A61B2018/1861 , A61B2018/1869
摘要： The present invention discloses medical systems and methods adapted for the delivery of various medical components such as microwave antennas within or on a body for performing one or more medical procedures. Several embodiments herein disclose medical systems comprising a combination of one or more medical components and one or more elongate steerable or non-steerable arms that are adapted to mechanically manipulate the one or more medical components. Several embodiments of microwave antennas are disclosed that comprise an additional diagnostic or therapeutic modality located on or in the vicinity of the microwave antennas.
摘要翻译：本发明公开了适用于在身体内部或身体上递送诸如微波天线的各种医疗部件以执行一个或多个医疗程序的医疗系统和方法。本文中的几个实施方案公开了医疗系统，其包括一个或多个医疗部件和适于机械地操纵所述一个或多个医疗部件的一个或多个细长的可转向或不可操纵的臂的组合。公开了微波天线的几个实施例，其包括位于微波天线上或附近的附加诊断或治疗模态。

4. 发明授权

US08968287B2 Methods and devices for applying energy to bodily tissues 有权
标题翻译：向身体组织施加能量的方法和装置
公开(公告)号：US08968287B2
公开(公告)日：2015-03-03
申请号：US12603077
申请日：2009-10-21
申请人： Ketan Shroff , Chun Yiu Chu , Dinesh I. Mody , Clarence Emmons , Amrish Jayprakash Walke
发明人： Ketan Shroff , Chun Yiu Chu , Dinesh I. Mody , Clarence Emmons , Amrish Jayprakash Walke
IPC分类号： A61B18/18 , A61B18/00
CPC分类号： A61B18/18 , A61B18/1815 , A61B2018/00351 , A61B2018/00422 , A61B2018/00452 , A61B2018/00488 , A61B2018/00511 , A61B2018/00517 , A61B2018/00523 , A61B2018/00529 , A61B2018/00547 , A61B2018/00559 , A61B2018/00577 , A61B2018/00702 , A61B2018/00726 , A61B2018/00761 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/00982 , A61B2018/00994 , A61B2018/1846 , A61B2018/1853 , A61B2018/1861 , A61B2018/1869
摘要： Devices and methods for treating tissue with microwave energy used in applications such as destroying a soft tissue by microwave ablation and/or creating point, line, area or volumetric lesions. Various embodiments of flexible, low-profile devices are also disclosed where such device can be inserted non-invasively or minimally invasively near or into the target tissue such as cardiac tissue. The devices disclosed herein comprise antennas wherein the field profile generated by an antenna is tailored and optimized for a particular clinical application. The antennas use unique properties of microwaves such as interaction of a microwave field with one or more conductive or non-conductive shaping elements to shape or redistribute the microwave field.
摘要翻译：用微波能量处理组织的装置和方法，例如通过微波消融破坏软组织和/或产生点，线，面积或体积损伤的应用。还公开了柔性的低轮廓装置的各种实施例，其中这样的装置可以非侵入地或最小程度地侵入附近或进入靶组织例如心脏组织。本文公开的装置包括其中由天线产生的场分布针对特定临床应用进行定制和优化的天线。这些天线使用微波的独特性质，例如微波场与一个或多个导电或非导电成形元件的相互作用以形成或重新分布微波场。

5. 发明授权

US08657815B2 Delivery system for delivering a medical device to a location within a patient's body 有权
标题翻译：用于将医疗设备递送到患者体内的位置的递送系统
公开(公告)号：US08657815B2
公开(公告)日：2014-02-25
申请号：US12027215
申请日：2008-02-06
申请人： Dinesh I. Mody , Ketan Shroff , Dany Berube
发明人： Dinesh I. Mody , Ketan Shroff , Dany Berube
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00279 , A61B2018/00375 , A61B2018/00839 , A61B2018/1407 , A61B2018/1467 , A61M2025/0163
摘要： Devices, systems and methods are provided for deployment of one or more functional devices, such as therapeutic or diagnostic medical devices, or positioning devices, at various locations relative to a defined operative path. The devices, systems, and methods can include a guide system and a positioning element. The guide system defines the operative path when deployed within a patient's body. The positioning element cooperates with the guide system to define one or more positions relative the defined operative path from which the one or more functional devices are deployed. The present inventions allow for the accurate and reliable placement of the one or more functional devices at the one or more positions relative the operative path. In one embodiment, the functional device is an ablation device adapted to ablate cardiac tissue for the treatment of cardiac arrhythmias, such as atrial fibrillation.
摘要翻译：设备，系统和方法被提供用于在相对于限定的操作路径的不同位置处部署一个或多个功能装置，例如治疗或诊断医疗装置或定位装置。设备，系统和方法可以包括引导系统和定位元件。引导系统定义在部署在患者体内时的手术路径。所述定位元件与所述引导系统协作以相对于所述一个或多个功能装置从所述限定的操作路径定义一个或多个位置。本发明允许在相对于操作路径的一个或多个位置处准确和可靠地放置一个或多个功能装置。在一个实施例中，功能装置是适于消融心脏组织以用于治疗心律失常（例如心房颤动）的消融装置。

6. 发明申请

US20070219546A1 Devices and methods for creating continuous lesions 有权
标题翻译：用于创建连续病变的装置和方法
公开(公告)号：US20070219546A1
公开(公告)日：2007-09-20
申请号：US11725086
申请日：2007-03-16
申请人： Dinesh I. Mody , Dany Berube , Ross M. Carothers
发明人： Dinesh I. Mody , Dany Berube , Ross M. Carothers
IPC分类号： A61B18/04 , A61N5/00 , A61B18/14
CPC分类号： A61B18/1815 , A61B18/14 , A61B18/1492 , A61B18/18 , A61B2018/00214 , A61B2018/00375 , A61B2018/00839 , A61B2018/1475 , A61B2018/1861 , A61B2090/065
摘要： The present invention discloses devices and methods for creating multiple lesions using ablation devices in anatomical regions such as the heart, for example to treat cardiac arrhythmias. The present invention discloses methods and devices to create continuous lesions using area ablation devices. The present invention discloses various embodiments of reference assemblies for accurately positioning ablation devices having ablating portions, especially deployable ablation portions adapted for area ablation. The ablation devices are positioned using the reference assemblies in the anatomy to create one or more lesions. The present invention also discloses several method embodiments for creating continuous lesions using deployable ablating portions to produce two or more overlapping lesions.
摘要翻译：本发明公开了使用解剖区域（例如心脏）中的消融装置来产生多个病变的装置和方法，例如用于治疗心律失常。本发明公开了使用区域消融装置产生连续病变的方法和装置。本发明公开了用于精确地定位具有烧蚀部分的消融装置的参考组件的各种实施例，特别是适用于区域消融的可展开的消融部分。使用解剖学中的参考组件来定位消融装置以产生一个或多个损伤。本发明还公开了使用可展开的消融部分产生两个或更多个重叠病变的多个创建连续病变的方法实施例。

7. 发明授权

US4640821A Analysis apparatus 失效
标题翻译：分析仪
公开(公告)号：US4640821A
公开(公告)日：1987-02-03
申请号：US756149
申请日：1985-07-16
申请人： Dinesh I. Mody , James E. Rasmussen , Mikhail Y. Ryaboy
发明人： Dinesh I. Mody , James E. Rasmussen , Mikhail Y. Ryaboy
IPC分类号： G01N35/08 , G01N27/26
CPC分类号： G01N35/08 , Y10T436/117497
摘要： A system for analyzing a biological fluid or the like includes a series flow loop that extends between an inlet valve array and an outlet valve array. The flow loop includes an analysis region to which a measuring system is connected in sensing relation and an accumulator chamber connected to the outlet of the analysis region. The inlet valve array is arranged to selectively and alternately connect a sample inlet port and an auxiliary fluid reservoir to the flow loop while the outlet valve array is arranged to selectively connect a controlled source of reduced pressure to the flow loop. The volume of the accumulator chamber is at least as great as the volume of the flow loop (including the analysis region) between the inlet valve array and the accumulator chamber and the system is arranged to capture reduced pressure in the flow loop, the captured reduced pressure then being used to provide the sole transfer force to gently and reliably transfer a minute quantity of fluid to be analyzed from the sample inlet port through the analysis region and at least partially fill the accumulator chamber.
摘要翻译：用于分析生物流体等的系统包括在入口阀阵列和出口阀阵列之间延伸的串联流动回路。流动回路包括测量系统以感测关系连接的分析区域和连接到分析区域的出口的蓄液室。入口阀阵列布置成选择性地和交替地将样品入口端口和辅助流体容器连接到流动回路，同时出口阀阵列被布置成选择性地将受控的减压源连接到流动回路。蓄能器室的容积至少与入口阀阵列和蓄能室之间的流动回路（包括分析区域）的体积一样大，并且系统被设置成在流动回路中捕获减压，所捕获的减少压力然后被用于提供唯一的转印力，以便将来自待分析的微量流体从样品入口通过分析区域轻轻地和可靠地传递并且至少部分地填充储存室。

8. 发明授权

US4299794A Analytical system for analyzing CO.sub.2 content of a fluid 失效
标题翻译：用于分析液体二氧化碳含量的分析系统
公开(公告)号：US4299794A
公开(公告)日：1981-11-10
申请号：US161375
申请日：1980-06-20
申请人： Thomas F. Kelley , Dinesh I. Mody , Charles F. Mountain
发明人： Thomas F. Kelley , Dinesh I. Mody , Charles F. Mountain
IPC分类号： G01N7/18 , G01N7/14 , G01N33/483 , G01N33/84 , G01N33/50 , G01N1/10
CPC分类号： G01N33/84 , G01N7/14 , Y10T436/204998
摘要： A total carbon dioxide analyzer system has a reaction chamber that includes a tube and a piston mounted for sliding movement in the tube to change the volume of the chamber. A valve coupled to the chamber has a sample inlet port and a reagent inlet port, and is movable between a first state in which the sample inlet port is connected to the chamber, a second state in which the reagent inlet port is connected to the chamber, and a third state in which the reaction chamber is sealed. A system controller coordinately operates the valve and moves the piston to increase the volume of said chamber to draw sample into the chamber for mixing with an acid reagent in the chamber, and then seals the chamber and increases the volume of the chamber to facilitate the release of carbon dioxide. A transducer then senses the pressure of carbon dioxide in the reaction chamber.
摘要翻译：总的二氧化碳分析仪系统具有包括管和活塞的反应室，该活塞安装成用于在管中滑动以改变腔的体积。联接到所述室的阀具有样品入口和试剂入口，并且可以在样品入口与腔室连接的第一状态和第二状态之间移动，其中试剂入口连接到腔室和第三状态，其中反应室被密封。系统控制器协调地操作阀并移动活塞以增加所述室的体积以将样品抽入室中以与室中的酸试剂混合，然后密封室并增加室的体积以便于释放的二氧化碳。传感器然后感测反应室中二氧化碳的压力。

9. 发明授权

US4245509A Sampling apparatus 失效
标题翻译：取样装置
公开(公告)号：US4245509A
公开(公告)日：1981-01-20
申请号：US21069
申请日：1979-03-16
申请人： Dinesh I. Mody , Carolyn Bergkvist , Gustav H. Dreier
发明人： Dinesh I. Mody , Carolyn Bergkvist , Gustav H. Dreier
IPC分类号： G01N1/00 , G01N1/38 , G01N1/14
CPC分类号： G01N35/1097 , G01N1/38 , G01N2001/382
摘要： Sampling apparatus designed for aspirating, diluting and mixing a small sample of fluid in precise amounts and delivering the mixture to a scientific apparatus at a place remote from the place of aspiration. Operation of the device may be manual but is preferably automatic. The apparatus is designed to process a plurality of sample fluids with no cross-contamination between samples. In essence, the apparatus is a fluid handling system including a sample pick-up assembly in fluid communication with an automatic valve assembly having two operative positions. The automatic valve assembly is in fluid communication with a dilutor assembly having a sample pump and a diluent pump operable by a common means. A mixing and delivery assembly is also in fluid communication with the automatic valve assembly and includes a cup designed for bidirectional rotation with an annular space about the cup. A dispensing probe dispenses into the cup precise amounts of sample and diluent in a predetermined ratio to each other and, following rotation of the cup to achieve the mixture of sample and diluent, an aspirator probe enters the mixture and delivers an amount thereof to an adjacent scientific instrument. The apparatus further includes a means for expelling the remainder of the mixture from the cup into the annular space surrounding the cup, and from there through a valve, to waste.
摘要翻译：采样设备设计用于精确量吸入，稀释和混合小样本的流体，并将混合物输送到远离抽吸位置的地方的科学仪器。设备的操作可以是手动的，但是优选是自动的。该设备被设计成在样品之间没有交叉污染的情况下处理多个样品流体。实质上，该装置是一种流体处理系统，其包括与具有两个操作位置的自动阀组件流体连通的样品拾取组件。自动阀组件与具有可由常用装置操作的样品泵和稀释剂泵的稀释器组件流体连通。混合和输送组件还与自动阀组件流体连通，并且包括设计成用于围绕杯的环形空间进行双向旋转的杯。分配探针以预定的比例将精确量的样品和稀释剂分配到杯中，并且在杯的旋转以实现样品和稀释剂的混合物之后，吸气探针进入混合物并将其量递送到相邻的科学仪器。该装置还包括将混合物的剩余部分从杯子排出到围绕杯子的环形空间中并从那里通过阀排出的装置，以浪费。

10. 发明授权

US06802840B2 Medical instrument positioning tool and method 失效
标题翻译：医疗仪器定位工具及方法
公开(公告)号：US06802840B2
公开(公告)日：2004-10-12
申请号：US09872652
申请日：2001-06-01
申请人： Sing Fatt Chin , Dany Berube , Dinesh I. Mody , Nancy Norris
发明人： Sing Fatt Chin , Dany Berube , Dinesh I. Mody , Nancy Norris
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B18/02 , A61B18/18 , A61B18/1815 , A61B2017/00243 , A61B2018/00375 , A61B2018/00839 , A61B2018/0212 , A61B2018/1407 , A61B2018/1497
摘要： A system and method for positioning a medical instrument at a desired biological target tissue site is provided. The system includes an elongated sheath having a deflectable distal end configured to deflect or otherwise position at least a portion of a medical instrument during a surgical procedure allowing for the placement of the deflected portion adjacent or proximate to a predetermined target tissue surface. The positioning system may be incorporated into the medical instrument. The medical instrument may be an ablation system.
摘要翻译：提供了一种用于将医疗器械定位在期望的生物靶组织部位的系统和方法。该系统包括细长护套，其具有可偏转的远端，所述远端构造成在手术过程期间偏转或以其他方式定位医疗器械的至少一部分，从而允许偏转部分邻近或接近预定的靶组织表面。定位系统可以并入到医疗器械中。医疗器械可以是消融系统。

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