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1. 发明申请

US20110117552A1 METHODS OF USING A NOD2/CARD15 HAPLOTYPE TO DIAGNOSE CROHN'S DISEASE 审中-公开
标题翻译：使用NOD2 / CARD15 HAPLOTYPE诊断CROHN病的方法
公开(公告)号：US20110117552A1
公开(公告)日：2011-05-19
申请号：US12902111
申请日：2010-10-11
申请人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Kazuhito Sugimura , Stephan R. Targan
发明人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Kazuhito Sugimura , Stephan R. Targan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172
摘要： The present invention provides a method of diagnosing or predicting susceptibility to Crohn's disease in an individual by determining the presence or absence in the individual of a disease-predisposing haplotype containing a JW1 variant allele at the NOD2/CARD15 locus, where the presence of the disease-predisposing haplotype is diagnostic of or predictive of susceptibility to Crohn's disease.
摘要翻译：本发明提供了一种诊断或预测个体中克罗恩病易感性的方法，其通过确定个体存在或不存在在NOD2 / CARD15基因座处含有JW1变体等位基因的疾病易感单倍体，其中存在疾病 - 反义单倍型是克罗恩病易感性的诊断或预测。

2. 发明授权

US07790370B2 Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease 有权
标题翻译： NOD2的突变与克罗恩病患者的纤维化疾病有关
公开(公告)号：US07790370B2
公开(公告)日：2010-09-07
申请号：US10526256
申请日：2003-07-30
申请人： Maria T. Abreu , Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Stephan R. Targan
发明人： Maria T. Abreu , Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Stephan R. Targan
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease characterized by fibrostenosing disease by determining the presence or absence in an individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, where the presence of the fibrostenosis-predisposing allele is diagnostic of or predictive of susceptibility to the clinical subtype of Crohn's disease characterized by fibrostenosing disease. In a method of the invention, the clinical subtype of Crohn's disease can be, for example, characterized by fibrostenosing disease independent of small bowel involvement. The invention also provides a method of optimizing therapy in an individual by determining the presence or absence in the individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, diagnosing individuals in which the fibrostenosis-predisposing allele is present as having a fibrostenosing subtype of Crohn's disease, and treating the individual having a fibrostenosing subtype of Crohn's disease based on the diagnosis.
摘要翻译：本发明提供一种诊断或预测以特征在于纤维化疾病的克罗恩病的临床亚型的易感性的方法，其通过确定个体中存在或不存在与NOD2 / CARD15基因座连锁的纤维化狭窄等位基因，其中存在纤维狭窄 - 易感性等位基因是以特征为纤维化疾病的克罗恩病的临床亚型的易感性的诊断或预测。在本发明的方法中，克罗恩病的临床亚型可以是例如独立于小肠受累的纤维化疾病的特征。本发明还提供了一种通过确定个体中存在或不存在与NOD2 / CARD15基因座连锁的纤维化狭窄等位基因来诊断个体的方法，其中存在纤维狭窄 - 倾向性等位基因的个体具有纤维化克罗恩病的亚型，并基于诊断治疗患有克罗恩病的纤维化亚型的个体。

3. 发明授权

US07662569B2 Methods of assessing Crohn's disease patient phenotype by I2 serologic response 有权
标题翻译：通过I2血清学反应评估克罗恩病患者表型的方法
公开(公告)号：US07662569B2
公开(公告)日：2010-02-16
申请号：US10413501
申请日：2003-04-11
申请人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
发明人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
IPC分类号： G01N33/53 , G01N33/542 , G01N33/00
CPC分类号： G01N33/686 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2469/20 , G01N2800/065
摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.
摘要翻译：本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明该受试者具有克罗恩病的临床亚型。在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法）。本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型结肠炎。

4. 发明授权

US06884590B1 Methods of screening for ulcerative colitis and crohn's disease 失效
标题翻译：筛查溃疡性结肠炎和克罗恩病的方法
公开(公告)号：US06884590B1
公开(公告)日：2005-04-26
申请号：US09419408
申请日：1999-10-15
申请人： Jerome I. Rotter , Stephan R. Targan , Huiying Yang , Arthur L. Beaudet , Devendra Vora
发明人： Jerome I. Rotter , Stephan R. Targan , Huiying Yang , Arthur L. Beaudet , Devendra Vora
IPC分类号： C07K14/705 , C07K16/28 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6883 , C07K14/70525 , C07K16/2821 , C12Q2600/156
摘要： A novel association between IBD and a polymorphism at amino acid residue 241 of ICAM-1 has been discovered. In accordance with the present invention there is provided methods of screening for IBD, methods for treating IBD, antibodies specifically reactive with ICAM-1 encoded by, R241 allele and kits which exploit the inventive methods.
摘要翻译：已经发现了IBD与ICAM-1氨基酸残基241之间的多态性的新型关联。根据本发明，提供了筛选IBD的方法，用于治疗IBD的方法，与由R241等位基因编码的ICAM-1特异性反应的抗体以及利用本发明方法的试剂盒。

5. 发明授权

US06534263B1 Methods of screening for Crohn's disease using TNF microsatellite alleles 有权
标题翻译：使用TNF微卫星等位基因筛选克罗恩病的方法
公开(公告)号：US06534263B1
公开(公告)日：2003-03-18
申请号：US09419406
申请日：1999-10-15
申请人： Scott E. Plevy , Jerome I. Rotter , Stephan R. Targan , Hiroo Toyoda , Huiying Yang
发明人： Scott E. Plevy , Jerome I. Rotter , Stephan R. Targan , Hiroo Toyoda , Huiying Yang
IPC分类号： C12Q1568
CPC分类号： C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： A novel association between certain tumor necrosis factor microsatellite alleles and Crohn's disease has been discovered. In accordance with the present invention, there is provided methods for screening for Crohn's disease comprising detecting the presence or absence of nucleic acid of a subject encoding TNF microsatellite alleles associated with Crohn's disease, wherein the presence of nucleic acid encoding three or more of the alleles is indicative of Crohn's disease. Kits useful for screening for Crohn's disease are also provided which comprise nucleic acid encoding TNF microsatellite alleles associated with Crohn's disease.
摘要翻译：已经发现了某些肿瘤坏死因子微卫星等位基因与克罗恩病之间的关联。根据本发明，提供了用于筛选克罗恩病的方法，包括检测编码与克罗恩病相关的TNF微卫星等位基因的受试者的核酸的存在或不存在，其中编码三个或更多个等位基因的核酸的存在表明克罗恩病。还提供了用于筛选克罗恩病的试剂盒，其包含编码与克罗恩病相关的TNF微卫星等位基因的核酸。

6. 发明申请

US20100240077A1 METHODS OF ASSESSING CROHN'S DISEASE PATIENT PHENOTYPE BY I2 SEROLOGIC RESPONSE 有权
标题翻译：通过I2感染反应评估冠心病患者的方法
公开(公告)号：US20100240077A1
公开(公告)日：2010-09-23
申请号：US12645394
申请日：2009-12-22
申请人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
发明人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
IPC分类号： G01N33/53
CPC分类号： G01N33/686 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2469/20 , G01N2800/065
摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.
摘要翻译：本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明该受试者具有克罗恩病的临床亚型。在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法）。本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型结肠炎。

7. 发明授权

US5681699A Methods of diagnosing ulcerative colitis and Crohn's disease 失效
标题翻译：诊断溃疡性结肠炎和克罗恩病的方法
公开(公告)号：US5681699A
公开(公告)日：1997-10-28
申请号：US196003
申请日：1994-02-11
申请人： Jerome I. Rotter , Stephan R. Targan , Huiying Yang , Arthur L. Beaudet , Devendra Vora
发明人： Jerome I. Rotter , Stephan R. Targan , Huiying Yang , Arthur L. Beaudet , Devendra Vora
IPC分类号： C07K14/705 , C07K16/28 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C07K16/2821 , C07K14/70525 , C12Q1/6883 , C12Q2600/156
摘要： A novel association between IBD and a polymorphism at amino acid residue 241 of ICAM-1 has been discovered. In accordance with the present invention there is provided methods of screening for IBD, methods for treating IBD, antibodies specifically reactive wish ICAM-1 encoded by R241 allele and kits which exploit the inventive methods.
摘要翻译：已经发现了IBD与ICAM-1氨基酸残基241之间的多态性的新型关联。根据本发明，提供了筛选IBD的方法，用于治疗IBD的方法，由R241等位基因编码的抗体特异性反应性愿望ICAM-1和利用本发明方法的试剂盒。

8. 发明申请

US20120208212A1 METHODS OF ASSESSING CROHN'S DISEASE PATIENT PHENOTYPE BY I2, OMPC AND ASCA SEROLOGIC RESPONSE 审中-公开
标题翻译：通过I2，OMPC和ASCA行为反应来评估冠心病患者的方法
公开(公告)号：US20120208212A1
公开(公告)日：2012-08-16
申请号：US13312960
申请日：2011-12-06
申请人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
发明人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
IPC分类号： G01N33/566
CPC分类号： G01N33/686 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2469/20 , G01N2800/065
摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.
摘要翻译：本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明该受试者具有克罗恩病的临床亚型。在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法）。本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型结肠炎。

9. 发明授权

US6008335A Methods of screening for ulcerative colitis and Crohn's disease 失效
标题翻译：筛查溃疡性结肠炎和克罗恩病的方法
公开(公告)号：US6008335A
公开(公告)日：1999-12-28
申请号：US933824
申请日：1997-09-19
申请人： Jerome I. Rotter , Stephan R. Targan , Huiying Yang , Arthur L. Beaudet , Devendra Vora
发明人： Jerome I. Rotter , Stephan R. Targan , Huiying Yang , Arthur L. Beaudet , Devendra Vora
IPC分类号： C07K14/705 , C07K16/28 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C07K16/2821 , C07K14/70525 , C12Q1/6883 , C12Q2600/156
摘要： A novel association between IBD and a polymorphism at amino acid residue 241 of ICAM-1 has been discovered. In accordance with the present invention there is provided methods of screening for IBD, methods for treating IBD, antibodies specifically reactive with ICAM-1 encoded by R241 allele and kits which exploit the inventive methods.
摘要翻译：已经发现了IBD与ICAM-1氨基酸残基241之间的多态性的新型关联。根据本发明，提供了筛选IBD的方法，用于治疗IBD的方法，与由R241等位基因编码的ICAM-1特异性反应的抗体以及利用本发明方法的试剂盒。

10. 发明授权

US6001569A Methods of screening for Crohn's disease using TNF microsatellite alleles 失效
公开(公告)号：US6001569A
公开(公告)日：1999-12-14
申请号：US798668
申请日：1997-02-11
申请人： Scott E. Plevy , Jerome I. Rotter , Stephan R. Targan , Hiroo Toyoda , Huiying Yang
发明人： Scott E. Plevy , Jerome I. Rotter , Stephan R. Targan , Hiroo Toyoda , Huiying Yang
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： A novel association between certain tumor necrosis factor microsatellite alleles and Crohn's disease has been discovered. In accordance with the present invention, there is provided methods for screening for Crohn's disease comprising detecting the presence or absence of nucleic acid of a subject encoding TNF microsatellite alleles associated with Crohn's disease, wherein the presence of nucleic acid encoding three or more of the alleles is indicative of Crohn's disease. Kits useful for screening for Crohn's disease are also provided which comprise nucleic acid encoding TNF microsatellite alleles associated with Crohn's disease.

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