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1. 发明申请

US20090098193A1 HEMOSTATIC COMPOSITIONS AND METHODS FOR CONTROLLING BLEEDING 审中-公开
标题翻译：化学成分及其控制方法
公开(公告)号：US20090098193A1
公开(公告)日：2009-04-16
申请号：US12340159
申请日：2008-12-19
申请人： Kent C. Cochrum , Susan Jemtrud
发明人： Kent C. Cochrum , Susan Jemtrud
IPC分类号： A61L15/22 , A61L17/00
CPC分类号： A61K31/717 , A61L15/225 , A61L15/28 , A61L15/44 , A61L24/0015 , A61L24/043 , A61L24/08 , A61L26/0023 , A61L26/0066 , A61L31/041 , A61L31/042 , A61L31/16 , A61L2300/232 , A61L2300/418 , A61L2400/04 , C08L1/28
摘要： The disclosure provides hemostatic compositions useful to promote hemostasis at active bleeding wound sites. The hemostatic compositions include an article containing cellulose, e.g., cotton gauze, and a cross-linked polysaccharide ionically linked to the cellulose. Methods of making and using the hemostatic compositions are also provided.
摘要翻译：本公开提供了可用于促进活动性出血伤口部位止血的止血组合物。止血组合物包括含有纤维素的制品，例如棉纱布，和与纤维素离子连接的交联多糖。还提供了制备和使用止血组合物的方法。

2. 发明授权

US07101862B2 Hemostatic compositions and methods for controlling bleeding 失效
公开(公告)号：US07101862B2
公开(公告)日：2006-09-05
申请号：US10334864
申请日：2002-12-31
申请人： Kent C. Cochrum , Susan Jemtrud
发明人： Kent C. Cochrum , Susan Jemtrud
IPC分类号： A61K31/729 , A61K31/721 , A61K31/718 , A61L15/00
CPC分类号： A61L33/08 , A61L15/225 , A61L15/28 , A61L15/44 , A61L2300/232 , A61L2300/418 , A61L2400/04 , C08L5/04 , C08L1/26 , C08L5/02
摘要： The invention provides hemostatic compositions useful to promote hemostasis at active bleeding wound sites. The hemostatic compositions typically include an article containing cellulose, e.g., cotton gauze, and a polysaccharide covalently linked to the cellulose, or a polysaccharide ionically cross-linked and in association with the article. Methods of making and using the hemostatic compositions are also provided.

3. 发明授权

US5876742A Biological tissue transplant coated with stabilized multilayer alginate coating suitable for transplantation and method of preparation thereof 失效
标题翻译：用适于移植的稳定化的多层藻酸盐包衣的生物组织移植及其制备方法
公开(公告)号：US5876742A
公开(公告)日：1999-03-02
申请号：US757025
申请日：1996-11-26
申请人： Kent C. Cochrum , Susan A. Jemtrud
发明人： Kent C. Cochrum , Susan A. Jemtrud
IPC分类号： A01N1/02 , A61K9/00 , A61K9/16 , A61K9/50 , A61K35/12 , A61L27/20 , A61L27/34 , A61L27/36 , A61L27/38 , B01J2/00 , C12N5/00 , C12N5/071 , C12N11/04 , A61F2/02 , C12N5/08
CPC分类号： A61K9/0024 , A01N1/02 , A01N1/0205 , A01N1/0231 , A61K9/1652 , A61K9/5031 , A61K9/5073 , A61K9/5089 , A61L27/20 , A61L27/34 , A61L27/36 , A61L27/3604 , A61L27/3687 , A61L27/38 , A61L27/3804 , A61L27/3839 , B01J2/003 , C12N11/04 , C12N5/0012 , C12N5/0677 , A61K2035/128 , A61L2420/08 , C12N2500/12 , C12N2533/74
摘要： A biological tissue transplant coated with a stabilized multilayer alginate coating and a method for preparation of the stabilized multilayer coating. Coating has three primary layers of the alginate with a polyamino acid barrier emplaced between a primary and a secondary layer. The secondary "halo" layer of soft gel is formed by a gel gradient created between weakly bound cross-linking gelling divalent cations of an alginate used for the primary layer of the coating and non-gelling counter ions of a non-ionic alginate of the secondary layer of the coating.
摘要翻译：涂覆有稳定的多层藻酸盐涂层的生物组织移植物和制备稳定的多层涂层的方法。涂层具有三个主要的藻酸盐层，其中聚氨基酸屏障放置在初级和次级层之间。柔性凝胶的次级“卤素”层由在用于涂层主要层的藻酸盐的弱结合交联胶凝二价阳离子和非离子藻酸盐的非胶凝抗衡离子之间产生的凝胶梯度形成二次涂层。

4. 发明授权

US5643594A Spin encapsulation apparatus and method of use 失效
标题翻译：旋转封装装置及其使用方法
公开(公告)号：US5643594A
公开(公告)日：1997-07-01
申请号：US237290
申请日：1994-05-03
申请人： Randel E. Dorian , Kent C. Cochrum , Richard David Antanavich
发明人： Randel E. Dorian , Kent C. Cochrum , Richard David Antanavich
IPC分类号： A01N1/02 , A61K9/16 , A61K9/50 , A61K35/12 , A61L27/20 , A61L27/34 , A61L27/36 , A61L27/38 , B01J2/00 , B01J13/04 , B29B9/10 , C12N5/00 , C12N5/071 , C12N11/04 , A61F2/02 , C12N11/02 , B29C39/10
CPC分类号： A01N1/0231 , A01N1/02 , A01N1/0242 , A01N1/0278 , A61K9/1652 , A61K9/5073 , A61K9/5089 , A61L27/20 , A61L27/34 , A61L27/36 , A61L27/38 , B01J13/04 , B01J2/003 , B29B9/10 , C12N11/04 , C12N5/0012 , C12N5/0677 , A61K2035/128 , C12N2500/12 , C12N2533/74 , Y10S264/37 , Y10S425/804
摘要： A coating apparatus includes a rotary cup for forming beads and projecting them radially outwardly, and one or more collection basins surrounding the bead forming cup. The cup is adjustably rotatable about its central axis, and the collection basins are independently rotatable and positioned to collect the beads projected from the cup. The coating apparatus further includes an elevation adjustment system for axially adjusting the alignment of the cup with respect to the selected collection basins. The rotational speeds of the cup and the collection basins are selected so as to minimize the impact of the beads against a gelling solution in the collection basins. In use, a supply mixture is introduced into a mixing chamber of the cup. As the cup spins, the coated particles are propelled upwardly by the centrifugal force from the mixing chamber along the inner surface of the cup, and are projected radially outwardly, as beads, into the gelling solution in one of the selected basins. Since the cup and the basin are simultaneously rotated, the impact of the beads against the capture solution is significantly reduced.
摘要翻译：涂覆装置包括用于形成珠并且径向向外突出的旋转杯和围绕珠形杯的一个或多个收集池。杯子可围绕其中心轴线可调节地旋转，并且收集池可独立地旋转和定位成收集从杯子突出的小珠。涂覆装置还包括用于相对于所选择的收集池轴向调节杯的对准的仰角调节系统。选择杯子和收集盆的旋转速度，以便最小化珠子抵抗收集池中的胶凝溶液的影响。在使用中，将供给混合物引入杯的混合室。当杯子旋转时，涂覆的颗粒通过来自混合室的沿着杯的内表面的离心力被向上推动，并且作为小珠径向向外突出到所选盆地之一中的胶凝溶液中。由于杯和盆同时旋转，珠子对捕获溶液的影响显着降低。

5. 发明授权

US5510102A Plasma and polymer containing surgical hemostatic adhesives 失效
标题翻译：含血浆和聚合物的手术止血粘合剂
公开(公告)号：US5510102A
公开(公告)日：1996-04-23
申请号：US377775
申请日：1995-01-23
申请人： Kent C. Cochrum
发明人： Kent C. Cochrum
IPC分类号： A61K35/16 , A61K38/39 , A61L24/04 , A61K38/36 , A61L25/00
CPC分类号： A61K38/39 , A61K35/16 , A61L24/043 , A61L2400/04 , Y10S128/22
摘要： Autologous platelet-rich plasma and a biocompatible polymer containing hemostatic adhesive agents. The agents have strong hemostatic properties when applied to a bleeding wound or vessel.
摘要翻译：自体富血小板血浆和含有止血粘合剂的生物相容性聚合物。当应用于出血的伤口或血管时，这些药剂具有强的止血特性。

6. 发明授权

US5521079A Microcapsule generating system containing an air knife and method of encapsulating 失效
标题翻译：含有气刀的微胶囊生成系统及其封装方法
公开(公告)号：US5521079A
公开(公告)日：1996-05-28
申请号：US185709
申请日：1994-01-24
申请人： Randel E. Dorian , Kent C. Cochrum
发明人： Randel E. Dorian , Kent C. Cochrum
IPC分类号： A01N1/02 , A61K9/50 , A61K35/12 , B01J2/00 , B01J13/04 , C12M1/40 , C12M3/06 , C12N5/00 , C12N5/071 , C12N11/04 , C12N11/00 , C12N11/10
CPC分类号： A01N1/0242 , A01N1/02 , A01N1/0231 , A61K9/5089 , B01J13/04 , B01J2/003 , C12M45/22 , C12N11/04 , C12N5/0012 , C12N5/0671 , C12N5/0677 , A61K2035/128 , C12N2533/74 , Y10T428/2984
摘要： Spherical microcapsules containing biological material such as tissue or living cells are formed with a diameter of less than 300 .mu.m using a microcapsule generating system containing an air knife. The air knife is formed by an air sleeve positioned eccentrically around a needle. An encapsulating material such as an alginate solution containing the biological material to be encapsulated is forced through the needle, while pressurized air is introduced into the air sleeve and flows out an end opening of the sleeve in which the needle is positioned. The pressurized air breaks up the alginate being discharged from the needle. The resultant alginate droplets fall into a collecting tank where they contact a gelling medium, such as CaCl.sub.2, so that the outer surface of these droplets harden and microcapsules are formed. In addition to being eccentrically positioned to facilitate very small droplet formation, the needle preferably has a beveled, pointed discharge end surface to enhance droplet size reduction. The beveled end surface of the needle preferably extends beyond the end opening of the sleeve and is positioned facing the center of the air sleeve. The end opening of the air sleeve may also be beveled.
摘要翻译：使用包含气刀的微胶囊生成系统，使用含有小于300μm的直径的生物材料如组织或活细胞的球形微胶囊。气刀由围绕针定位的空气套筒形成。将包含待包封的生物材料的藻酸盐溶液的包封材料强制通过针，同时加压的空气被引入空气套筒中并流出针定位在其中的套筒的端部开口。加压空气破坏从针排出的藻酸盐。所得的藻酸盐液滴落入收集罐中，在其中它们接触诸如CaCl 2的胶凝介质，使得这些液滴的外表面变硬并形成微胶囊。除了偏心地定位以促进非常小的液滴形成之外，针优选地具有倾斜的尖端的排出端面，以增强液滴尺寸的减小。针的倾斜端面优选地延伸超出套筒的端部开口并且面向空气套筒的中心定位。空气套筒的端部开口也可以是斜面的。

7. 发明授权

US4696286A Coated transplants and method for making same 失效
标题翻译：涂层移植物及其制备方法
公开(公告)号：US4696286A
公开(公告)日：1987-09-29
申请号：US866167
申请日：1986-05-22
申请人： Kent C. Cochrum
发明人： Kent C. Cochrum
IPC分类号： A01N1/02 , A61F2/02 , A61K9/16 , A61K9/50 , A61K35/12 , A61K35/39 , A61L27/34 , A61B19/00
CPC分类号： A61K9/5073 , A61F2/022 , A61K9/1611 , A61K9/5031 , A61L27/34 , Y10S930/29
摘要： Transplants, such as pancreatic islets, are made suitable for transplantation into a genetically dissimilar individual by coating the transplant with a surface-conforming bonding bridge layer of a multifunctional material that binds chemically to a surface component of the transplant followed by a semipermeable, biologically compatible layer of a polymer that binds chemically to the bonding bridge layer.
摘要翻译：移植物，例如胰岛，适合于移植到遗传上不同的个体中，通过用表面依附的多功能材料的结合桥接层涂覆移植物，所述多层功能材料的化学结合与移植物的表面组分结合，然后是半透性的，生物相容的层与化学键合到结合桥接层的聚合物层。

8. 发明授权

US5773033A Fibrinogen/chitosan hemostatic agents 失效
标题翻译：纤维蛋白原/壳聚糖止血剂
公开(公告)号：US5773033A
公开(公告)日：1998-06-30
申请号：US636247
申请日：1996-04-23
申请人： Kent C. Cochrum , Harold R. Parker , Maggie M. C. Chiu
发明人： Kent C. Cochrum , Harold R. Parker , Maggie M. C. Chiu
IPC分类号： A61K35/16 , A61K38/39 , A61L24/04 , A61L25/00
CPC分类号： A61K38/39 , A61K35/16 , A61L24/043 , A61L2400/04 , Y10S128/22
摘要： Autologous fibrinogen and chitosan containing hemostatic adhesive agents having strong hemostatic properties when applied to a bleeding wound or vessel. Fibrinogen is isolated and purified using ammonium sulphate precipitation in slow incremental portions.
摘要翻译：含有止血性粘合剂的自体纤维蛋白原和壳聚糖应用于出血性伤口或血管时具有强止血特性。使用缓慢增量部分的硫酸铵沉淀分离和纯化纤维蛋白原。

9. 发明授权

US5656468A Cells or tissue coated with non-fibrogenic alginate less than 200 .mu.m thick 失效
标题翻译：用不超过200μm厚的非纤维形成藻酸盐涂覆的细胞或组织
公开(公告)号：US5656468A
公开(公告)日：1997-08-12
申请号：US403348
申请日：1995-03-14
申请人： Randel E. Dorian , Kent C. Cochrum
发明人： Randel E. Dorian , Kent C. Cochrum
IPC分类号： A61K9/16 , A61K35/12 , C12N5/00 , C12N5/071 , C12N11/04 , C12N11/10 , C12N11/00 , C12N13/00
CPC分类号： C12N5/0012 , A61K9/1652 , A61K9/1694 , C12N11/04 , C12N5/0677 , A61K2035/128 , C12N2533/74
摘要： An electrostatic process is used for coating a biological material with a uniform, continuous polymer layer by discharging a suspension of the biological material in a gelable coating polymer solution in a continuous stream through an orifice into an electrostatic field. The stream is attenuated to form droplets by maintaining an electrostatic voltage between the needle and the gelling solution which is sufficient to maintain an attraction of at least 1.times.10.sup.-6 newtons on the stream of liquid leaving the needle, and the droplets are collected in a gelling solution. A preferred product is pancreatic islets having a continuous, smooth coating of high polymannuronate non-fibrogenic alginate having a thickness less than 200 .mu.m such as about 20-200 .mu.m. The alginate preferably contains less than 1 wt. % fucose, less than 0.5 wt. % sulfate and less than 0.01 wt. % phloroglucinol, is free of fibrinoogenic concentration of protein, and has a mannuronate to guluronate ratio of from 1.2 to 6. Preferably, the electrostatic field is formed by applying an electrostatic continuous DC voltage to each the needle and gelling solution so that the needle and solution have opposite charges.
摘要翻译：通过将连续流中的生物材料的悬浮液通过孔喷射到静电场中，将静电过程用于通过将生物材料的悬浮液排出到可凝胶涂层聚合物溶液中，以均匀连续的聚合物层来涂覆生物材料。通过保持针和胶凝溶液之间的静电电压来使流减弱以形成液滴，其足以在离开针的液体流上保持至少1×10 -6牛顿的吸引力，并且将液滴收集在胶凝中解。优选的产品是具有厚度小于200μm（例如约20-200μm）的高聚甘露糖醛酸盐非纤维形成藻酸盐的连续光滑涂层的胰岛。藻酸盐优选含有少于1wt。％岩藻糖，小于0.5wt。％硫酸盐和小于0.01重量％％的间苯三酚不含蛋白质的纤维蛋白原浓度，并且甘露糖醛酸盐与古洛糖酸的比例为1.2〜6。优选地，静电场是通过向针和胶凝溶液施加静电连续的直流电压形成的，解决方案有相反的收费。

10. 发明授权

US5514377A In situ dissolution of alginate coatings of biological tissue transplants 失效
标题翻译：原位溶解生物组织移植藻酸盐涂层
公开(公告)号：US5514377A
公开(公告)日：1996-05-07
申请号：US207937
申请日：1994-03-08
申请人： Kent C. Cochrum , Susan A. Jemtrud
发明人： Kent C. Cochrum , Susan A. Jemtrud
IPC分类号： A61K9/00 , A61K9/16 , A61K31/194 , A61L27/38 , A61F2/00
CPC分类号： A61K9/0024 , A61K31/194 , A61K9/1652 , A61L27/3687 , A61L27/3804 , Y10S623/915
摘要： A method for in situ dissolution of an alginate coating from transplants containing biological tissue cores by administering to a transplant's recipient a physiologically acceptable chelating agent in an amount sufficient to dissolve the alginate coating. The method allows in situ removal of the coating and deactivation of the transplant by rejection of its core by the host immune system without the necessity to perform a surgery.
摘要翻译：一种通过向移植受体施用足以溶解藻酸盐包衣的量的生理上可接受的螯合剂来原位溶解含有生物组织芯的移植物的藻酸盐包衣的方法。该方法允许通过宿主免疫系统排除其核心而原位去除包被和去活化移植物，而无需进行手术。

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