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1. 发明授权

US08853178B2 Antisense modulation of PTP1B expression 有权
标题翻译： PTP1B表达的反义调制
公开(公告)号：US08853178B2
公开(公告)日：2014-10-07
申请号：US13177462
申请日：2011-07-06
申请人： Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madelline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
发明人： Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madelline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
摘要翻译：提供化合物，组合物和方法用于调节PTP1B的表达。组合物包含靶向编码PTP1B的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节PTP1B表达和治疗与PTP1B表达相关的疾病的方法。

2. 发明申请

US20120029049A1 Antisense Modulation of Superoxide Dismutase 1, Soluble Expression 有权
标题翻译：超氧化物歧化酶1，可溶性表达的反义调制
公开(公告)号：US20120029049A1
公开(公告)日：2012-02-02
申请号：US12987929
申请日：2011-01-10
申请人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier
发明人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier
IPC分类号： A61K31/7088 , A61P25/00 , C07H21/00
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Y115/01001 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxide dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节超氧化物歧化酶1的表达，可溶性。组合物包含靶向编码超氧化物歧化酶1的核酸的可反应化合物，特别是反义寡核苷酸。提供了使用这些化合物调节超氧化物歧化酶1，可溶性表达和治疗与超氧化物歧化酶1表达相关的疾病的方法。

3. 发明授权

US08518904B2 Modulation of STAT 6 expression 失效
标题翻译： STAT 6表达调控
公开(公告)号：US08518904B2
公开(公告)日：2013-08-27
申请号：US13350691
申请日：2012-01-13
申请人： William R. Shanahan, Jr. , Susan M. Freier , Kenneth W. Dobie
发明人： William R. Shanahan, Jr. , Susan M. Freier , Kenneth W. Dobie
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： C12N15/113 , C07H21/04 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6886 , C12Q2600/136 , C12Q2600/16 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of STAT 6. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT 6. Methods of using these compounds for modulation of STAT 6 expression and for diagnosis and treatment of disease associated with expression of STAT 6 are provided.
摘要翻译：提供化合物，组合物和方法用于调节STAT6的表达。组合物包含靶向编码STAT6的核酸的寡核苷酸。使用这些化合物调节STAT6表达并用于诊断和治疗与表达相关的疾病提供STAT 6。

4. 发明授权

US07981868B2 Antisense modulation of p38 mitogen activated protein kinase expression 失效
标题翻译： p38丝裂原活化蛋白激酶表达的反义调制
公开(公告)号：US07981868B2
公开(公告)日：2011-07-19
申请号：US10568488
申请日：2004-08-12
申请人： Brett P. Monia , Kenneth W. Dobie , Susan M. Freier , Ian Popoff , James G. Karras
发明人： Brett P. Monia , Kenneth W. Dobie , Susan M. Freier , Ian Popoff , James G. Karras
IPC分类号： C07H21/00 , C07H21/02 , C12N15/11 , A61K48/00
CPC分类号： C12N15/1137 , A61K31/7052 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/11024 , Y02P20/582 , C12N2310/3525
摘要： Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for decreasing airway hyperresponsiveness or airway inflammation in an animal are also provided.
摘要翻译：提供了用于治疗和诊断适于通过调节编码p38丝裂原活化蛋白激酶（p38MAPK）的基因的表达进行治疗的疾病或病症的组合物和方法。还提供了降低动物气道高反应性或气道炎症的方法。

5. 发明授权

US07902163B2 Antisense modulation of superoxide dismutase 1, soluble expression 有权
标题翻译：反义调制超氧化物歧化酶1，可溶性表达
公开(公告)号：US07902163B2
公开(公告)日：2011-03-08
申请号：US11449446
申请日：2006-06-07
申请人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier
发明人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier
IPC分类号： C07H21/02 , C07H21/04 , A01N43/04 , A61K31/70
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Y115/01001 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxide dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节超氧化物歧化酶1的表达，可溶性。组合物包含靶向编码超氧化物歧化酶1的核酸的可反应化合物，特别是反义寡核苷酸。提供了使用这些化合物调节超氧化物歧化酶1，可溶性表达和治疗与超氧化物歧化酶1表达相关的疾病的方法。

6. 发明授权

US07759479B1 Compositions and their uses directed to Gemin Genes 失效
标题翻译：组合及其用途针对Gemin Genes
公开(公告)号：US07759479B1
公开(公告)日：2010-07-20
申请号：US11226884
申请日：2005-09-13
申请人： Kenneth W. Dobie , Susan M. Freier
发明人： Kenneth W. Dobie , Susan M. Freier
IPC分类号： C07H21/04 , A61K48/00
CPC分类号： C12N15/113 , C07H21/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/342 , C12N2310/343 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of a Gemin Gene. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译：本文公开了用于调节Gemin基因表达的化合物，组合物和方法。还提供了目标验证的方法。还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。

7. 发明申请

US20090156526A1 COMPOSITIONS AND METHODS FOR MODULATION OF LMNA EXPRESSION 有权
标题翻译： LMNA表达调控的组成和方法
公开(公告)号：US20090156526A1
公开(公告)日：2009-06-18
申请号：US12090847
申请日：2006-10-17
申请人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
发明人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
IPC分类号： A61K31/711 , C12Q1/68 , C12N5/00 , C07H21/04
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2320/33
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Further provided are methods of identifying cis splicing regulatory elements of a selected mRNA using the disclosed compounds.
摘要翻译：本文公开了用于调节细胞，组织或动物中LMNA表达的化合物，组合物和方法。还提供了目标验证的方法。还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。还提供了使用所公开的化合物鉴定所选mRNA的顺式剪接调节元件的方法。

8. 发明授权

US08921331B2 Methods for slowing familial ALS disease progression 有权
标题翻译：减慢家族性ALS疾病进展的方法
公开(公告)号：US08921331B2
公开(公告)日：2014-12-30
申请号：US13406256
申请日：2012-02-27
申请人： C. Frank Bennett , Susan M. Freier , Kenneth W. Dobie
发明人： C. Frank Bennett , Susan M. Freier , Kenneth W. Dobie
IPC分类号： A61K48/00 , C12N15/113 , A61K38/00
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y115/01001 , Y02P20/582 , C12N2310/3525
摘要： Methods for slowing disease progression in an individual suffering from familial ALS are provided. Also provided are methods of increasing the survival time of an individual suffering from familial ALS. These methods employ antisense oligonucleotides targeted to SOD1, for use in inhibiting the expression of SOD1 in the central nervous system of an individual suffering from familial ALS.
摘要翻译：提供了减轻患有家族性ALS的个体疾病进展的方法。还提供了增加患有家族性ALS的个体的存活时间的方法。这些方法使用靶向SOD1的反义寡核苷酸，用于抑制患有家族性ALS的个体的中枢神经系统中SOD1的表达。

9. 发明授权

US08791088B2 Compositions and methods for modulation of LMNA expression 有权
标题翻译： LMNA表达调控的组成和方法
公开(公告)号：US08791088B2
公开(公告)日：2014-07-29
申请号：US13566922
申请日：2012-08-03
申请人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
发明人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2320/33
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Further provided are methods of identifying cis splicing regulatory elements of a selected mRNA using the disclosed compounds.
摘要翻译：本文公开了用于调节细胞，组织或动物中LMNA表达的化合物，组合物和方法。还提供了目标验证的方法。还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。还提供了使用所公开的化合物鉴定所选mRNA的顺式剪接调节元件的方法。

10. 发明授权

US08669102B2 Modulation of prion expression 有权
标题翻译：调节朊病毒表达
公开(公告)号：US08669102B2
公开(公告)日：2014-03-11
申请号：US13059058
申请日：2009-08-14
申请人： C. Frank Bennett , Gene Hung , Susan M. Freier , Kenneth W. Dobie
发明人： C. Frank Bennett , Gene Hung , Susan M. Freier , Kenneth W. Dobie
IPC分类号： C12N15/85 , C07H21/04 , C07H21/02
CPC分类号： A61K31/7125
摘要： Disclosed herein are compounds and methods for decreasing PrP and preventing, ameliorating, or treating a prion disease or conformational neurodegenerative disorder, in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to PrP include Creutzfeldt-Jakob disease (CJD); variant Creutzfeldt-Jakob Disease (vCJD); Gerstmann-Straussler-Scheinker syndrome; fatal familial insomnia; kuru; Bovine Spongiform Encephalopathy (BSE), e.g. “mad cow disease”; Chronic Wasting Disease (CWD); scrapie; transmissible mink encephalopathy; feline spongiform encephalopathy; ungulate spongiform encephalopathy; Alzheimer's disease; Parkinson's disease; Huntington's disease; and Amyotrophic Lateral Sclerosis (ALS).
摘要翻译：本文公开了在有需要的个体中减少PrP并预防，改善或治疗朊病毒疾病或构象神经变性疾病的化合物和方法。通过施用针对PrP的反义化合物可以改善的疾病状况的实例包括克雅氏病（CJD）; 变异克雅氏病（vCJD）; Gerstmann-Straussler-Scheinker综合征; 致命性家族性失眠; 库鲁牛海绵状脑病（BSE），例如。 “疯牛病”; 慢性疾病（CWD）; scrap子传染性貂脑病猫海绵状脑病; 有蹄型海绵状脑病阿尔茨海默氏病; 帕金森病亨廷顿氏病和肌萎缩性侧索硬化（ALS）。

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