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1. 发明授权

US06544520B1 Hepatitis B virus inhibitors 有权
标题翻译：新型乙型肝炎病毒抑制剂
公开(公告)号：US06544520B1
公开(公告)日：2003-04-08
申请号：US09302087
申请日：1999-04-29
申请人： Kenneth Murray , Michael Richard Dyson
发明人： Kenneth Murray , Michael Richard Dyson
IPC分类号： A61K3900
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2730/10122
摘要： Peptides and other molecules which inhibit the assembly of the hepatitis B virus, methods of treatment, and pharmaceutical compositions comprising them.
摘要翻译：抑制乙型肝炎病毒组装的肽和其它分子，治疗方法和包含它们的药物组合物。

2. 发明申请

US20120321659A1 HBV CORE ANTIGEN PARTICLES WITH MULTIPLE IMMUNOGENIC COMPONENTS ATTACHED VIA PEPTIDE LIGANDS 审中-公开
标题翻译：通过肽配体连接多种免疫组分的HBV核心抗原颗粒
公开(公告)号：US20120321659A1
公开(公告)日：2012-12-20
申请号：US13456996
申请日：2012-04-26
申请人： Kenneth Murray
发明人： Kenneth Murray
IPC分类号： A61K39/39 , C07K17/10 , C07K19/00 , G01N33/53 , A61P31/04 , A61P33/02 , A61P31/20 , A61P33/06 , A61P37/08 , A61P31/22 , A61P31/10 , A61P33/00 , C07K17/02 , A61P31/14
CPC分类号： A61K39/385 , A61K39/00 , A61K39/12 , A61K39/29 , A61K39/292 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , A61K2039/64 , C07K14/005 , C07K2319/00 , C07K2319/70 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , G01N33/56983 , G01N2333/02 , G01N2469/20 , Y02A50/386 , Y02A50/388 , Y02A50/396 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/484 , Y02A50/53 , Y02A50/54 , Y02A50/58 , Y02A50/59 , Y02A50/60 , Y10S530/806 , Y10S530/81
摘要： This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core antigen particles comprising immunogens, epitopes, or other related structures, crosslinked thereto by ligands which are HBV capsid-binding peptides that selectively bind to HBV core protein. Such particles may be used as delivery systems for a diverse range of immunogenic epitopes, including the HBV capsid-binding peptides, which advantageously also inhibit and interfere with HBV viral assembly by blocking the interaction between HBV core protein and HBV surface proteins. Mixtures of different immunogens and/or capsid-binding peptide ligands may be crosslinked to the same HBV core particle. Such resulting multicomponent or multivalent HBV core particles may be advantageously used in therapeutic and prophylactic vaccines and compositions, as well as in diagnostic compositions and methods using them.
摘要翻译：本发明涉及以多种免疫原特异性为特征的乙型肝炎病毒（HBV）核心抗原颗粒。更具体地，本发明涉及包含免疫原，表位或其它相关结构的HBV核心抗原颗粒，其通过配体选择性地结合HBV核心蛋白的配体进行交联。这样的颗粒可以用作各种免疫原性表位的递送系统，包括HBV衣壳结合肽，其有利地还通过阻断HBV核心蛋白和HBV表面蛋白之间的相互作用来抑制和干扰HBV病毒组装。不同免疫原和/或衣壳结合肽配体的混合物可以交联到相同的HBV核心颗粒。这样得到的多组分或多价HBV核心颗粒可以有利地用于治疗和预防性疫苗和组合物，以及使用它们的诊断组合物和方法中。

3. 发明授权

US5395643A Method of and apparatus for depositing solder on a printed circuit board 失效
标题翻译：在印刷电路板上沉积焊料的方法和装置
公开(公告)号：US5395643A
公开(公告)日：1995-03-07
申请号：US190700
申请日：1994-02-02
申请人： John Brown , Kenneth Murray , James McNee , Brian Robertson
发明人： John Brown , Kenneth Murray , James McNee , Brian Robertson
IPC分类号： B23K3/06 , H05K3/12 , H05K3/34 , B05D1/00
CPC分类号： H05K3/3457 , B23K3/06 , H05K2203/0126 , H05K2203/0557 , H05K3/1216 , H05K3/1233
摘要： Solder is deposited on a printed circuit board by melting the solder in a container. The container has a slot for passage of solder, therethrough and control means actuable to alternately allow and prevent passage of solder through the slot. The slot is placed in contact with a stencil and the control means is actuated to allow passage of solder through the slot. The stencil is moved relative to the container in a direction transverse of the slot to deposit solder on the printed circuit board via the stencil.
摘要翻译：焊料通过将焊料熔化在容器中而沉积在印刷电路板上。容器具有用于通过焊料的插槽和可操作的控制装置，以交替地允许和防止焊料通过狭槽。槽被放置成与模板接触，并且控制装置被致动以允许焊料通过槽。模板在横向于槽的方向上相对于容器移动，以通过模板将焊料沉积在印刷电路板上。

4. 发明申请

US20160042202A1 Secure Shell for Electronic Devices 审中-公开
标题翻译：电子设备安全壳
公开(公告)号：US20160042202A1
公开(公告)日：2016-02-11
申请号：US14821660
申请日：2015-08-07
申请人： Kenneth Murray , Deborah Peppers , James Aikins , Michael T. Adams
发明人： Kenneth Murray , Deborah Peppers , James Aikins , Michael T. Adams
IPC分类号： G06F21/88 , H02J7/02 , A45C13/10 , H05K9/00 , A45C11/00 , G06F21/86 , H05K7/20
CPC分类号： G06F21/88 , A45C11/00 , A45C13/10 , A45C13/18 , A45C2011/002 , A45C2011/003 , A45C2200/10 , G06F1/203 , G06F21/86 , H01F38/14 , H02J7/0042 , H02J7/025 , H02J50/10 , H04B1/3888 , H04M1/04
摘要： An apparatus serving as a portable, lockable secure shell that prevents unauthorized physical and electrical signal access to a device enclosed within the shell. The apparatus comprises a case, a lid, a locking mechanism, cooling means, and charging means. When closed, the apparatus provides Faraday cage protection to an enclosed device to block external electronic, electromagnetic, and radio frequency signals from reaching the enclosed device, which preserves data stored in the device in its original form. In addition, the apparatus prevents clandestine access to an electronic device, which creates an obstacle to unauthorized access of information stored on the device.
摘要翻译：用作便携式可锁定安全壳的装置，其防止未经授权的物理和电信号访问封装在壳体内的装置。该装置包括壳体，盖子，锁定机构，冷却装置和充电装置。关闭时，该设备为封闭式设备提供法拉第笼式保护，以阻止外部电子，电磁和射频信号到达封闭式设备，从而保留原始形式存储在设备中的数据。此外，该装置防止秘密访问电子设备，这造成对存储在设备上的信息的未经授权的访问的障碍。

5. 发明申请

US20080233204A1 Anti-Microbial Paint Films 审中-公开
标题翻译：抗微生物漆膜
公开(公告)号：US20080233204A1
公开(公告)日：2008-09-25
申请号：US11915789
申请日：2006-06-09
申请人： Susan M. Horley , Colin Pearce , Kenneth Murray
发明人： Susan M. Horley , Colin Pearce , Kenneth Murray
IPC分类号： A01N59/16 , A01P1/00 , A01N25/00 , C09D5/14
CPC分类号： C09D5/14 , A01N59/16 , A01N25/10 , A01N25/08 , A01N25/34 , A01N2300/00
摘要： An anti-microbial, solid architectural paint film produced by applying a liquid paint composition to a work surface, wall, ceiling or floor and allowing it to dry wherein the paint film comprises i) a film forming polymer and ii) an anti-microbial substance, comprising a metal or metal compound deposited on a particulate inorganic material, in an effective amount to kill microbes or prevent their growth on the surface of the solid coating and wherein the paint film is free of metallic copper and zinc and their alloys.
摘要翻译：通过将液体涂料组合物施加到工作表面，墙壁，天花板或地板上并使其干燥并且允许其干燥的抗微生物固体建筑漆膜，其中所述漆膜包括i）成膜聚合物和ii）抗微生物物质包含沉积在颗粒状无机材料上的金属或金属化合物，有效量杀死微生物或防止其在固体涂层的表面上生长，并且其中漆膜不含金属铜和锌及其合金。

6. 发明申请

US20050282983A1 Polymers for use in optical devices 有权
标题翻译：聚合物用于光学器件
公开(公告)号：US20050282983A1
公开(公告)日：2005-12-22
申请号：US11184178
申请日：2005-07-18
申请人： Andrew Holmes , Xiao-Chang Li , Stephen Moratti , Kenneth Murray , Richard Friend
发明人： Andrew Holmes , Xiao-Chang Li , Stephen Moratti , Kenneth Murray , Richard Friend
IPC分类号： C08F4/04 , C08F126/06 , C08F220/36 , C08G61/00 , C08G61/02 , C08G61/12 , C09K11/06 , H01L51/00 , H01L51/30 , H01L51/50 , H05B33/10 , H05B33/14
CPC分类号： H05B33/14 , C08F128/06 , C08F220/18 , C08F220/30 , C08F220/36 , C08F228/06 , C08G61/00 , C08G61/02 , C08G61/12 , C08G61/126 , C09K11/06 , H01L51/0003 , H01L51/0035 , H01L51/0036 , H01L51/0038 , H01L51/004 , H01L51/0043 , H01L51/007 , H01L51/5012 , H01L51/5048 , H05B33/10
摘要： Optical devices fabricated from solvent processible polymers suffer from susceptibility to solvents and morphological changes. A semiconductive polymer capable of luminescence in an optical device is provided. The polymer comprises a luminescent film-forming solvent processible polymer which contains cross-linking so as to increase its molar mass and to resist solvent dissolution, the cross-linking being such that the polymer retains semiconductive and luminescent properties.
摘要翻译：由溶剂可加工聚合物制成的光学器件易受溶剂和形态的影响。提供了能够在光学装置中发光的半导体聚合物。该聚合物包含含有交联以增加其摩尔质量和抵抗溶剂溶解的发光成膜溶剂可加工聚合物，交联使得聚合物保持半导体和发光性质。

7. 发明授权

US07226603B2 HBV core antigen particles with multiple immunogenic components attached via peptide ligands 有权
标题翻译：具有通过肽配体连接的多种免疫原性组分的HBV核心抗原颗粒
公开(公告)号：US07226603B2
公开(公告)日：2007-06-05
申请号：US10872550
申请日：2004-06-21
申请人： Kenneth Murray
发明人： Kenneth Murray
IPC分类号： A61K39/29
CPC分类号： A61K39/385 , A61K39/00 , A61K39/12 , A61K39/29 , A61K39/292 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , A61K2039/64 , C07K14/005 , C07K2319/00 , C07K2319/70 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , G01N33/56983 , G01N2333/02 , G01N2469/20 , Y02A50/386 , Y02A50/388 , Y02A50/396 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/472 , Y02A50/484 , Y02A50/52 , Y02A50/53 , Y02A50/54 , Y02A50/58 , Y02A50/59 , Y02A50/60 , Y10S530/806 , Y10S530/81
摘要： This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core antigen particles comprising immunogens, epitopes, or other related structures, crosslinked thereto by ligands which are HBV capsid-binding peptides that selectively bind to HBV core protein. Such particles may be used as delivery systems for a diverse range of immunogenic epitopes, including the HBV capsid-binding peptides, which advantageously also inhibit and interfere with HBV viral assembly by blocking the interaction between HBV core protein and HBV surface proteins. Mixtures of different immunogens and/or capsid-binding peptide ligands may be crosslinked to the same HBV core particle. Such resulting multicomponent or multivalent HBV core particles may be advantageously used in therapeutic and prophylactic vaccines and compositions, as well as in diagnostic compositions and methods using them.
摘要翻译：本发明涉及以多种免疫原特异性为特征的乙型肝炎病毒（“HBV”）核心抗原颗粒。更具体地，本发明涉及包含免疫原，表位或其它相关结构的HBV核心抗原颗粒，其通过配体选择性地结合HBV核心蛋白的配体进行交联。这样的颗粒可以用作各种免疫原性表位的递送系统，包括HBV衣壳结合肽，其有利地还通过阻断HBV核心蛋白和HBV表面蛋白之间的相互作用来抑制和干扰HBV病毒组装。不同免疫原和/或衣壳结合肽配体的混合物可以交联到相同的HBV核心颗粒。这样得到的多组分或多价HBV核心颗粒可以有利地用于治疗和预防性疫苗和组合物，以及使用它们的诊断组合物和方法中。

8. 发明授权

US06627202B2 HBV core antigen particles with multiple immunogenic components attached via peptide ligands 有权
标题翻译：具有通过肽配体连接的多种免疫原性组分的HBV核心抗原颗粒
公开(公告)号：US06627202B2
公开(公告)日：2003-09-30
申请号：US09873459
申请日：2001-06-04
申请人： Kenneth Murray
发明人： Kenneth Murray
IPC分类号： A61K3929
CPC分类号： A61K39/385 , A61K39/00 , A61K39/12 , A61K39/29 , A61K39/292 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , A61K2039/64 , C07K14/005 , C07K2319/00 , C07K2319/70 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , G01N33/56983 , G01N2333/02 , G01N2469/20 , Y02A50/386 , Y02A50/388 , Y02A50/396 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/472 , Y02A50/484 , Y02A50/52 , Y02A50/53 , Y02A50/54 , Y02A50/58 , Y02A50/59 , Y02A50/60 , Y10S530/806 , Y10S530/81
摘要： This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV cote antigen particles comprising immunogens, epitopes, or other related structures, crosslinked thereto by ligands which are HBV capsid-binding peptides that selectively bind to HBV core protein. Such particles may be used as delivery systems for a diverse range of immunogenic epitopes, including the HBV capsid-binding peptides, which advantageously also inhibit and interfere with HBV viral assembly by blocking the interaction between HBV core protein and HBV surface proteins. Mixtures of different immunogens and/or capsid-binding peptide ligands may be crosslinked to the same HBV core particle. Such resulting multicomponent or multivalent HBV core particles may be advantageously used in therapeutic and prophylactic vaccines and compositions, as well as in diagnostic compositions and methods using them.
摘要翻译：本发明涉及以多种免疫原特异性为特征的乙型肝炎病毒（“HBV”）核心抗原颗粒。更具体地，本发明涉及包含免疫原，表位或其它相关结构的HBV cote抗原颗粒，其通过配体选择性地结合HBV核心蛋白的配体进行交联。这样的颗粒可以用作各种免疫原性表位的递送系统，包括HBV衣壳结合肽，其有利地还通过阻断HBV核心蛋白和HBV表面蛋白之间的相互作用来抑制和干扰HBV病毒组装。不同免疫原和/或衣壳结合肽配体的混合物可以交联到相同的HBV核心颗粒。这样得到的多组分或多价HBV核心颗粒可以有利地用于治疗和预防性疫苗和组合物，以及使用它们的诊断组合物和方法中。

9. 发明授权

US06270955B1 Pharmaceutical compositions and methods for producing antibodies to hepatitis b virus and kits and methods for detecting antibodies to hepatitis b virus 失效
标题翻译：用于生产乙型肝炎病毒抗体的药物组合物和方法，试剂盒和用于检测乙型肝炎病毒抗体的方法
公开(公告)号：US06270955B1
公开(公告)日：2001-08-07
申请号：US08486592
申请日：1995-06-07
申请人： Kenneth Murray
发明人： Kenneth Murray
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N15/70 , C12N2730/10122 , G01N33/5761 , G01N33/5764
摘要： Recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying HBV anti-genicity and genes coding therefor and methods of making and using these molecules, hosts, genes and polypeptides. The recombinant DNA molecules of this invention are characterized by structural genes that code for at least one polypeptide displaying HBV antigenicity. In appropriate hosts these recombinant DNA molecules permit the production and identification of genes and polypeptides characteristic of HBV antigenicity and their use in compositions and methods for detecting HBV virus infections in humans and stimulating the production of antibodies against this infection.
摘要翻译：用它们转化的重组DNA分子和宿主，其产生显示HBV抗生殖因子的多肽和编码该基因的基因以及制备和使用这些分子，宿主，基因和多肽的方法。本发明的重组DNA分子的特征在于编码显示HBV抗原性的至少一种多肽的结构基因。在适当的宿主中，这些重组DNA分子允许产生和鉴定HBV抗原性特征的基因和多肽，以及它们在用于检测人类HBV病毒感染的组合物和方法中的用途，并刺激针对该感染的抗体产生。

10. 发明授权

US5404258A Hard disk drive precision head positioner having a self-aligning head positioner/magnetic coil bobbin interface 失效
标题翻译：硬盘驱动器精密头定位器具有自动对准头定位器/电磁线圈线轴接口
公开(公告)号：US5404258A
公开(公告)日：1995-04-04
申请号：US41676
申请日：1993-04-01
申请人： Haldun Arin , Kenneth Murray
发明人： Haldun Arin , Kenneth Murray
IPC分类号： G11B5/48 , G11B5/55 , G11B21/08
CPC分类号： G11B5/5569 , G11B5/4813
摘要： A precision magnetic head positioner assembly for a Winchester-type hard disk drive storage system includes a main rotatable integral head positioner body and an integral magnetic coil assembly. The positioner body includes outwardly extending integral head positioning arms and a seating surface comprised of two angled lateral seating surfaces. The integral magnetic coil assembly comprises a coil frame and a mounting surface having two angled lateral mounting faces which engage the positioner angled seating surfaces for mounting with fasteners. Precision self-alignment of the positioner seating and bobbin mounting surfaces is provided by an alignment ledge protruding outwardly from the positioner seating surface which engages the lower edge of the bobbin mounting surface. An interference between the positioner seating surface and bobbin mounting surface angles improves mounting alignment and stability.
摘要翻译：一种用于温彻斯特型硬盘驱动器存储系统的精密磁头定位器组件，包括主旋转一体式头部定位器本体和整体式电磁线圈组件。定位器主体包括向外延伸的整体头部定位臂和由两个倾斜的侧面座面组成的座面。整体式电磁线圈组件包括线圈框架和安装表面，该安装表面具有两个成角度的侧向安装面，该侧面安装面与定位器成角度的座面接合，用于与紧固件一起安装。定位器座和筒管安装表面的精确自对准由从定位器座表面向外突出的对准凸缘提供，定位器座表面接合筒管安装表面的下边缘。定位器座表面和筒管安装表面角度之间的干涉改善了安装对准和稳定性。

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