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1. 发明授权

US08383369B2 Intermittent detection during analytical reactions 有权
公开(公告)号：US08383369B2
公开(公告)日：2013-02-26
申请号：US12561221
申请日：2009-09-16
申请人： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers , Donald Gray , Robin Emig , Mark Chaisson , Benjamin Flusberg
发明人： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers , Donald Gray , Robin Emig , Mark Chaisson , Benjamin Flusberg
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： G01N21/6452 , C12Q1/6869 , G01N21/6428 , G01N2201/0635 , Y10T436/143333 , C12Q2525/119 , C12Q2521/125 , C12Q2537/149
摘要： Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.

2. 发明申请

US20100075327A1 INTERMITTENT DETECTION DURING ANALYTICAL REACTIONS 有权
标题翻译：分析反应期间的间接检测
公开(公告)号：US20100075327A1
公开(公告)日：2010-03-25
申请号：US12561221
申请日：2009-09-16
申请人： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers , Donald Gray , Robin Emig , Mark Chaisson , Benjamin Flusberg
发明人： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers , Donald Gray , Robin Emig , Mark Chaisson , Benjamin Flusberg
IPC分类号： C12Q1/68 , G01N21/76 , G01N33/00
CPC分类号： G01N21/6452 , C12Q1/6869 , G01N21/6428 , G01N2201/0635 , Y10T436/143333 , C12Q2525/119 , C12Q2521/125 , C12Q2537/149
摘要： Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.
摘要翻译：提供了在分析反应期间执行间歇检测的方法，装置和系统。这种方法有助于从不同的反应时间收集反应数据。此外，这样的方法可用于在给定的反应时间下降低照明分析反应中一种或多种反应物的光诱导损伤。在优选的实施方案中，将反应混合物经受至少一个照明和非照射期，并允许进行，使得反应混合物被照射的时间小于光诱导的损伤阈值期。

3. 发明申请

US20100075309A1 INTERMITTENT DETECTION DURING ANALYTICAL REACTIONS 有权
公开(公告)号：US20100075309A1
公开(公告)日：2010-03-25
申请号：US12413226
申请日：2009-03-27
申请人： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers
发明人： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers
IPC分类号： C12Q1/68 , G01N21/75 , C12Q1/48 , C12Q1/00 , C12Q1/44 , G01N33/48 , G01N21/76 , C12P19/34 , G06F19/00
CPC分类号： C12Q1/6869 , G01N2021/7786 , Y10T436/143333 , C12Q2525/301 , C12Q2533/101 , C12Q2537/149 , C12Q2565/631 , C12Q2525/307 , C12Q2525/191
摘要： Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.

4. 发明授权

US08143030B2 Intermittent detection during analytical reactions 有权
标题翻译：分析反应期间的间歇检测
公开(公告)号：US08143030B2
公开(公告)日：2012-03-27
申请号：US12413226
申请日：2009-03-27
申请人： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers
发明人： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6869 , G01N2021/7786 , Y10T436/143333 , C12Q2525/301 , C12Q2533/101 , C12Q2537/149 , C12Q2565/631 , C12Q2525/307 , C12Q2525/191
摘要： Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.
摘要翻译：提供了在分析反应期间执行间歇检测的方法，装置和系统。这种方法有助于从不同的反应时间收集反应数据。此外，这样的方法可用于在给定的反应时间下降低照明分析反应中的一种或多种反应物的光致损伤。在优选的实施方案中，将反应混合物经受至少一个照明和非照射期，并允许进行，使得反应混合物被照射的时间小于光诱导的损伤阈值期。

5. 发明授权

US08703422B2 Methods and processes for calling bases in sequence by incorporation methods 有权
标题翻译：通过并入方法顺序调用碱基的方法和方法
公开(公告)号：US08703422B2
公开(公告)日：2014-04-22
申请号：US13034199
申请日：2011-02-24
申请人： Austin Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
发明人： Austin Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02
CPC分类号： C12Q1/6874 , C12Q1/6844 , C12Q1/686 , C12Q1/6869 , G01N21/6428 , G01N2021/6421 , G01N2021/6441 , G01N2201/06113 , G01N2201/12 , G06F19/22 , Y10T436/143333 , C12Q2563/107
摘要： Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.
摘要翻译：计算机实现的方法和执行这种方法的系统用于处理来自分析操作和系统的信号数据，特别是处理来自逐个引入过程的信号数据，以鉴定模板核酸和较大核酸分子的核苷酸序列，例如基因组或片段。

6. 发明申请

US20090024331A1 METHODS AND PROCESSES FOR CALLING BASES IN SEQUENCE BY INCORPORATION METHODS 有权
标题翻译：通过并入方法对序列进行呼叫的方法和过程
公开(公告)号：US20090024331A1
公开(公告)日：2009-01-22
申请号：US12134186
申请日：2008-06-05
申请人： Austin B. Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
发明人： Austin B. Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
IPC分类号： G01N33/68 , G01J3/28
CPC分类号： C12Q1/6869 , G06F19/22 , C12Q2563/107
摘要： Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.
摘要翻译：计算机实现的方法和执行这种方法的系统用于处理来自分析操作和系统的信号数据，特别是处理来自逐个引入过程的信号数据，以鉴定模板核酸和较大核酸分子的核苷酸序列，例如基因组或片段。

7. 发明申请

US20110256631A1 METHODS AND PROCESSES FOR CALLING BASES IN SEQUENCE BY INCORPORATION METHODS 有权
标题翻译：通过并入方法对序列进行呼叫的方法和过程
公开(公告)号：US20110256631A1
公开(公告)日：2011-10-20
申请号：US13034199
申请日：2011-02-24
申请人： Austin Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
发明人： Austin Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
IPC分类号： G01N33/50 , G06F15/18
CPC分类号： C12Q1/6874 , C12Q1/6844 , C12Q1/686 , C12Q1/6869 , G01N21/6428 , G01N2021/6421 , G01N2021/6441 , G01N2201/06113 , G01N2201/12 , G06F19/22 , Y10T436/143333 , C12Q2563/107
摘要： Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.
摘要翻译：计算机实现的方法和执行这种方法的系统用于处理来自分析操作和系统的信号数据，特别是处理来自逐个引入过程的信号数据，以鉴定模板核酸和较大核酸分子的核苷酸序列，例如基因组或片段。

8. 发明授权

US08182993B2 Methods and processes for calling bases in sequence by incorporation methods 有权
标题翻译：通过并入方法顺序调用碱基的方法和方法
公开(公告)号：US08182993B2
公开(公告)日：2012-05-22
申请号：US12134186
申请日：2008-06-05
申请人： Austin B. Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
发明人： Austin B. Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6869 , G06F19/22 , C12Q2563/107
摘要： Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.
摘要翻译：计算机实现的方法和执行这种方法的系统用于处理来自分析操作和系统的信号数据，特别是处理来自逐个引入过程的信号数据，以鉴定模板核酸和较大核酸分子的核苷酸序列，例如基因组或片段。

9. 发明授权

US06671645B2 Method for in-service RAM testing 失效
标题翻译：在线RAM测试方法
公开(公告)号：US06671645B2
公开(公告)日：2003-12-30
申请号：US09968277
申请日：2001-09-28
申请人： Kenneth Mark Maxham
发明人： Kenneth Mark Maxham
IPC分类号： G06F1900
CPC分类号： G06F12/1009 , G06F12/1425
摘要： A method for in-service RAM testing in computer systems and networks having a virtual memory. The method involves identifying a number n of physical memory units pi, i=1 . . . n, in the RAM and a number n−1 of virtual memory units vj, j=1 . . . n−1, in the virtual memory, performing a one-to-one mapping to map the physical memory units pi to virtual memory units vj such that a physical memory unit px is left unmapped, and then testing data in the unmapped physical memory unit px by destructive or non-destructive tests. After the test data from another physical memory unit py is copied to physical memory unit px and a one-to-one re-mapping of physical memory units pi to virtual memory units vj is performed such that physical memory unit py is left unmapped. The data in physical memory unit py is then tested and the steps of copying, one-to-one re-mapping and testing can be repeated until all physical memory units pi are tested. The testing can be performed with the aid of an MMU and it can involve more than one physical memory page at a time.
摘要翻译：一种在具有虚拟存储器的计算机系统和网络中进行在线RAM测试的方法。该方法涉及识别物理存储器单元pi，i = 1的数量n。。。 n，并且虚拟存储器单元vj，j = 1的n-1个数。。。 n-1，在虚拟存储器中，执行一对一映射以将物理存储器单元pi映射到虚拟存储器单元vj，使得物理存储器单元px被未映射，然后在未映射的物理存储器单元中测试数据 px通过破坏性或非破坏性测试。在来自另一物理存储器单元py的测试数据被复制到物理存储器单元px之后，并且执行物理存储器单元pi到虚拟存储器单元vj的一对一重新映射，使得物理存储器单元py被未映射。然后测试物理存储器单元py中的数据，并且可以重复复制，一对一重映射和测试的步骤，直到所有物理存储器单元pi被测试。可以借助MMU执行测试，并且可以一次涉及多个物理内存页面。

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