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1. 发明授权

US5861004A Hemostatic puncture closure system including closure locking means and method of use 失效
标题翻译：止血止血系统包括闭锁装置和使用方法
公开(公告)号：US5861004A
公开(公告)日：1999-01-19
申请号：US921270
申请日：1997-08-29
申请人： Kenneth Kensey , John E. Nash , Douglas G. Evans
发明人： Kenneth Kensey , John E. Nash , Douglas G. Evans
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12 , A61B19/00 , F16G11/04 , F16G11/10
CPC分类号： A61B17/0057 , F16G11/108 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/0496 , A61B2090/032 , A61B2090/0811 , A61B90/03 , A61B90/39 , Y10S604/90
摘要： A system for sealing a percutaneous puncture in a blood vessel in a living being and method of use thereof. The system includes a hemostatic closure, a blood vessel locator device for determining the position of the blood vessel via the percutaneous puncture, and a deployment instrument for deploying the closure within the puncture to seal the puncture. The vessel locator includes means for enabling blood from the vessel to flow therethrough so that the position of the vessel can be rapidly determined. Once the vessel has been located the deployment instrument, which includes a tubular carrier storing the closure, is extended into the puncture to deploy the closure. The closure basically comprises a radiopaque rigid anchor for location within the blood vessel, a compressed collagen plug for location within the puncture tract leading to the vessel, and a thin filament connecting the two in a pulley-like arrangement. The deployment instrument also includes a tamper which is used to mechanically deform the plug within the tract. Once the closure is positioned hemostasis occurs rapidly, thereby locking the closure in place.
摘要翻译：一种用于密封生物体内的血管中的经皮穿刺的系统及其使用方法。该系统包括止血闭合件，用于通过经皮穿刺确定血管位置的血管定位器装置，以及用于在穿刺部内展开封闭物以密封穿刺的展开装置。容器定位器包括用于使来自血管的血液流过其中的装置，使得能够快速确定容器的位置。一旦容器已经定位，包括容纳封闭件的管状载体的展开器械延伸到穿刺部分中以展开闭合件。闭合件基本上包括用于定位在血管内的不透射线的刚性锚固件，用于定位在穿过血管的穿刺道内的压缩胶原塞，以及以滑轮状布置连接两者的细丝。部署仪器还包括用于将管塞内的插头机械地变形的篡改。一旦闭合物被定位，止血就快速发生，从而将闭合件锁定就位。

2. 发明授权

US6045569A Hemostatic puncture closure system including closure locking means and methods of use 失效
标题翻译：止血止血系统包括闭锁锁定装置和使用方法
公开(公告)号：US6045569A
公开(公告)日：2000-04-04
申请号：US15190
申请日：1998-01-29
申请人： Kenneth Kensey , John E. Nash , Douglas G. Evans
发明人： Kenneth Kensey , John E. Nash , Douglas G. Evans
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12 , A61B19/00 , F16G11/04 , F16G11/10
CPC分类号： A61B17/0057 , F16G11/108 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/0496 , A61B2090/032 , A61B2090/0811 , A61B90/03 , A61B90/39 , Y10S604/90
摘要： A system for sealing a percutaneous puncture in a blood vessel in a living being and method of use thereof. The system includes a hemostatic closure, a blood vessel locator device for determining the position of the blood vessel via the percutaneous puncture, and a deployment instrument for deploying the closure within the puncture to seal the puncture. The vessel locator includes means for enabling blood from the vessel to flow therethrough so that the position of the vessel can be rapidly determined. Once the vessel has been located the deployment instrument, which includes a tubular carrier storing the closure, is extended into the puncture to deploy the closure. The closure basically comprises a radiopaque rigid anchor for location within the blood vessel, a compressed collagen plug for location within the puncture tract leading to the vessel, and a thin filament connecting the two in a pulley-like arrangement. The deployment instrument also includes a tamper which is used to mechanically deform the plug within the tract. Once the closure is positioned hemostasis occurs rapidly, thereby locking the closure in place.
摘要翻译：一种用于密封生物体内的血管中的经皮穿刺的系统及其使用方法。该系统包括止血闭合件，用于通过经皮穿刺确定血管位置的血管定位器装置，以及用于在穿刺部内展开封闭物以密封穿刺的展开装置。容器定位器包括用于使来自血管的血液流过其中的装置，使得能够快速确定容器的位置。一旦容器已经定位，包括容纳封闭件的管状载体的展开器械延伸到穿刺部分中以展开闭合件。闭合件基本上包括用于定位在血管内的不透射线的刚性锚固件，用于定位在穿过血管的穿刺道内的压缩胶原塞，以及以滑轮状布置连接两者的细丝。部署仪器还包括用于将管塞内的插头机械地变形的篡改。一旦闭合物被定位，止血就快速发生，从而将闭合件锁定就位。

3. 发明授权

US6007563A Method of deploying percutaneous puncture closure 有权
标题翻译：部署经皮穿刺闭合的方法
公开(公告)号：US6007563A
公开(公告)日：1999-12-28
申请号：US168429
申请日：1998-10-07
申请人： John E. Nash , Douglas G. Evans , Kenneth Kensey
发明人： John E. Nash , Douglas G. Evans , Kenneth Kensey
IPC分类号： A61B17/12 , A61B17/00 , A61B17/03 , A61B17/04 , A61B19/00 , A61F2/06 , A61M25/00 , A61M37/00 , F16G11/04 , F16G11/10
CPC分类号： A61B17/0057 , F16G11/108 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/00898 , A61B2017/0496 , A61B2090/032 , A61B2090/0811 , A61B90/03 , A61B90/39 , Y10S604/90
摘要： A system for sealing a percutaneous puncture in a blood vessel in a living being and a method of sealing the puncture. The system includes a hemostatic closure, a blood vessel locator device for determining the position of the blood vessel via the percutaneous puncture, and a deployment instrument for deploying the closure within the puncture to seal the puncture. The vessel locator includes means for enabling blood from the vessel to flow therethrough so that the position of the vessel can be rapidly determined. Once the vessel has been located the deployment instrument, which includes a tubular carrier storing the closure, is extended into the puncture to deploy the closure. The closure basically comprises a radiopaque rigid anchor for location within the blood vessel, a compressed collagen plug for location within the puncture tract leading to the vessel, and a thin filament connecting the two in a pulley-like arrangement. The deployment instrument also includes a tamper which is used to mechanically deform the plug within the tract. Once the closure is positioned hemostasis occurs rapidly, thereby locking the closure in place.
摘要翻译：用于密封生物体内的血管中的经皮穿刺的系统和密封穿刺的方法。该系统包括止血闭合件，用于通过经皮穿刺确定血管位置的血管定位器装置，以及用于在穿刺部内展开封闭物以密封穿刺的展开装置。容器定位器包括用于使来自血管的血液流过其中的装置，使得能够快速确定容器的位置。一旦容器已经定位，包括容纳封闭件的管状载体的展开器械延伸到穿刺部分中以展开闭合件。闭合件基本上包括用于定位在血管内的不透射线的刚性锚固件，用于定位在穿过血管的穿刺道内的压缩胶原塞，以及以滑轮状布置连接两者的细丝。部署仪器还包括用于将管塞内的插头机械地变形的篡改。一旦闭合物被定位，止血就快速发生，从而将闭合件锁定就位。

4. 发明授权

US6090130A Hemostatic puncture closure system including blood vessel locator and method of use 失效
标题翻译：止血性穿刺闭合系统，包括血管定位器和使用方法
公开(公告)号：US6090130A
公开(公告)日：2000-07-18
申请号：US104321
申请日：1998-06-25
申请人： John E. Nash , Douglas G. Evans , Kenneth Kensey
发明人： John E. Nash , Douglas G. Evans , Kenneth Kensey
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12 , A61B19/00 , F16G11/04 , F16G11/10 , A61B17/08
CPC分类号： A61B17/0057 , F16G11/108 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/0496 , A61B2090/032 , A61B2090/0811 , A61B90/03 , A61B90/39 , Y10S604/90
摘要： A system for sealing a percutaneous puncture in a blood vessel in a living being and method of use thereof. The system includes a hemostatic closure, a blood vessel locator device for determining the position of the blood vessel via the percutaneous puncture, and a deployment instrument for deploying the closure within the puncture to seal the puncture. The vessel locator includes means for enabling blood from the vessel to flow therethrough so that the position of the vessel can be rapidly determined. Once the vessel has been located the deployment instrument, which includes a tubular carrier storing the closure, is extended into the puncture to deploy the closure. The closure basically comprises a radiopaque rigid anchor for location within the blood vessel, a compressed collagen plug for location within the puncture tract leading to the vessel, and a thin filament connecting the two in a pulley-like arrangement. The deployment instrument also includes a tamper which is used to mechanically deform the plug within the tract. Once the closure is positioned hemostasis occurs rapidly, thereby locking the closure in place.
摘要翻译：一种用于密封生物体内的血管中的经皮穿刺的系统及其使用方法。该系统包括止血闭合件，用于通过经皮穿刺确定血管位置的血管定位器装置，以及用于在穿刺部内展开封闭物以密封穿刺的展开装置。容器定位器包括用于使来自血管的血液流过其中的装置，使得能够快速确定容器的位置。一旦容器已经定位，包括容纳封闭件的管状载体的展开器械延伸到穿刺部分中以展开闭合件。闭合件基本上包括用于定位在血管内的不透射线的刚性锚固件，用于定位在穿过血管的穿刺道内的压缩胶原塞，以及以滑轮状布置连接两者的细丝。部署仪器还包括用于将管塞内的插头机械地变形的篡改。一旦闭合物被定位，止血就快速发生，从而将闭合件锁定就位。

5. 发明授权

US06261244B1 Viscosity measuring apparatus and method of use 失效
标题翻译：粘度测量装置及其使用方法
公开(公告)号：US06261244B1
公开(公告)日：2001-07-17
申请号：US09383177
申请日：1999-08-25
申请人： Kenneth Kensey , John E. Nash , Harold E. Clupper
发明人： Kenneth Kensey , John E. Nash , Harold E. Clupper
IPC分类号： A61B500
CPC分类号： A61B5/150786 , A61B5/02035 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150755 , A61B5/150992 , A61B5/155 , A61B5/157 , A61B5/6866 , G01N11/04 , G01N11/08 , G06F19/00
摘要： A blood viscosity measuring system and method that monitors the rising head of a column of fluid representing a living being's blood in-vivo to determine the blood viscosity over a range of shears. The system includes a capillary tube, at least a portion of which is located within the vascular system of the being, and a riser tube, having a liquid therein coupled to the capillary tube. A sensor and associated microprocessor are provided to determine the change in the height of the liquid in the riser tube at plural points along the length of the tube from which the viscosity is calculated.
摘要翻译：一种血液粘度测量系统和方法，其在体内监测表示活体血液的一列流体的上升头，以确定剪切范围内的血液粘度。该系统包括毛细管，其毛细管的至少一部分位于血管系统的内部，以及提升管，其中具有联接到毛细管的液体。提供传感器和相关的微处理器以确定沿着管的长度的多个点处的提升管中液体的高度的变化，其中计算粘度。

6. 发明授权

US6019735A Viscosity measuring apparatus and method of use 失效
公开(公告)号：US6019735A
公开(公告)日：2000-02-01
申请号：US919906
申请日：1997-08-28
申请人： Kenneth Kensey , John E. Nash , Harold E. Clupper
发明人： Kenneth Kensey , John E. Nash , Harold E. Clupper
IPC分类号： G01N33/49 , A61B5/145 , A61B5/15 , A61B5/157 , A61B8/12 , A61B10/00 , A61B18/00 , A61B19/00 , G01N11/00 , G01N11/04 , G01N33/15 , G01N33/487 , A61B5/00
CPC分类号： A61B5/150786 , A61B5/02035 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150755 , A61B5/150992 , A61B5/155 , A61B5/157 , A61B5/6866 , G01N11/04 , G01N11/08
摘要： A blood viscosity measuring system and method that monitors the rising head of a column of fluid representing a living being's blood in-vivo to determine the blood viscosity over a range of shears. The system includes a capillary tube, at least a portion of which is located within the vascular system of the being, and a riser tube, having a liquid therein coupled to the capillary tube. A sensor and associated microprocessor are provided to determine the change in the height of the liquid in the riser tube at plural points along the length of the tube from which the viscosity is calculated.

7. 发明授权

US5441517A Hemostatic puncture closure system and method of use 失效
标题翻译：止血穿刺闭合系统及使用方法
公开(公告)号：US5441517A
公开(公告)日：1995-08-15
申请号：US154882
申请日：1993-11-18
申请人： Kenneth Kensey , John E. Nash , Douglas Evans
发明人： Kenneth Kensey , John E. Nash , Douglas Evans
IPC分类号： A61B17/12 , A61B17/00 , A61B17/03 , A61B17/04 , A61B19/00 , A61F2/06 , A61M25/00 , A61M37/00 , F16G11/04 , F16G11/10
CPC分类号： A61B17/0057 , F16G11/108 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/00898 , A61B2017/0496 , A61B2090/032 , A61B2090/0811 , A61B90/03 , A61B90/39 , Y10S604/90
摘要： A system, a closure, and method of use for determining the position of a blood vessel via a percutaneous puncture and for sealing the percutaneous puncture in the blood vessel. The system includes an introducer sheath and associated positioning device, a hemostatic puncture closure, and a deployment instrument. The positioning device enables the introducer sheath to be positioned at a desired position within the vessel. The deployment instrument includes a tubular carrier storing the closure. The carrier has a distally located free end to be extended via an introducer through the puncture and its associated tract. The closure comprises a radiopaque rigid anchor, a compressed collagen plug, and a thin filament connecting the two in a pulley-like arrangement. The carrier ejects the anchor through the introducer and puncture and then draws it against the free end of the introducer. The instrument and introducer are then withdrawn together to pull the anchor against the tissue contiguous with the puncture inside the artery. Further withdrawl draws the plug out of the carrier into the puncture tract, whereupon the plug moves with respect to the anchor into engagement with the outside of artery wall to seal the puncture or incision. A tensioning device limits the force applied to the filament. The carrier also includes a tamper which is used to mechanically deform the plug within the tract. Once positioned hemostasis occurs rapidly, thereby locking the closure in place.
摘要翻译：一种用于通过经皮穿刺确定血管位置并用于密封血管中经皮穿刺的系统，闭合件和方法。该系统包括引导器护套和相关联的定位装置，止血穿刺闭合器和展开装置。定位装置使引导器护套能够定位在容器内的期望位置。展开仪器包括一个储存封闭件的管状载体。载体具有远端定位的自由端，通过穿刺器穿过穿刺器及其相关的管道延伸。闭合件包括不透射线的刚性锚固件，压缩的胶原塞，以及以滑轮状布置连接两者的细丝。托架通过导引器弹出锚固件并穿刺，然后将其拉到导引器的自由端。然后将仪器和引导器一起拉出以将锚固件靠在与动脉内的穿刺相邻的组织上。进一步撤出将塞子从载体中抽出到穿刺管中，于是塞子相对于锚移动，与动脉壁的外侧接合以密封穿刺或切口。张紧装置限制施加到细丝上的力。载体还包括用于使塞子在管道内机械变形的篡改。一旦定位，止血快速发生，从而将闭合件锁定就位。

8. 发明授权

US5282827A Hemostatic puncture closure system and method of use 失效
标题翻译：止血穿刺闭合系统及使用方法
公开(公告)号：US5282827A
公开(公告)日：1994-02-01
申请号：US846322
申请日：1992-03-05
申请人： Kenneth Kensey , John E. Nash , Douglas Evans
发明人： Kenneth Kensey , John E. Nash , Douglas Evans
IPC分类号： A61B17/12 , A61B17/00 , A61B17/03 , A61B17/04 , A61B19/00 , A61F2/06 , A61M25/00 , A61M37/00 , F16G11/04 , F16G11/10
CPC分类号： A61B17/0057 , F16G11/108 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/00898 , A61B2017/0496 , A61B2090/032 , A61B2090/0811 , A61B90/03 , A61B90/39 , Y10S604/90
摘要： A system, a closure, and method of use for determining the position of a blood vessel via a percutaneous puncture and for sealing the percutaneous puncture in the blood vessel. The system includes an introducer sheath and associated positioning device, a hemostatic puncture closure, and a deployment instrument. The positioning device enables the introducer sheath to be positioned at a desired position within the vessel. The deployment instrument includes a tubular carrier storing the closure. The carrier has a distally located free end to be extended via an introducer through the puncture and its associated tract. The closure comprises a radiopaque rigid anchor, a compressed collagen plug, and a thin filament connecting the two in a pulley-like arrangement. The carrier ejects the anchor through the introducer and puncture and then draws it against the free end of the introducer. The instrument and introducer are then withdrawn together to pull the anchor against the tissue contiguous with the puncture inside the artery. Further withdrawl draws the plug out of the carrier into the puncture tract, whereupon the plug moves with respect to the anchor into engagement with the outside of artery wall to seal the puncture or incision. A tensioning device limits the force applied to the filament. The carrier also includes a tamper which is used to mechanically deform the plug within the tract. Once positioned hemostasis occurs rapidly, thereby locking the closure in place.
摘要翻译：一种用于通过经皮穿刺确定血管位置并用于密封血管中经皮穿刺的系统，闭合件和方法。该系统包括引导器护套和相关联的定位装置，止血穿刺闭合器和展开装置。定位装置使引导器护套能够定位在容器内的期望位置。展开仪器包括一个储存封闭件的管状载体。载体具有远端定位的自由端，通过穿刺器穿过穿刺器及其相关的管道延伸。闭合件包括不透射线的刚性锚固件，压缩的胶原塞，以及以滑轮状布置连接两者的细丝。托架通过导引器弹出锚固件并穿刺，然后将其拉到导引器的自由端。然后将仪器和引导器一起拉出以将锚固件靠在与动脉内的穿刺相邻的组织上。进一步撤出将塞子从载体中抽出到穿刺管中，于是塞子相对于锚移动，与动脉壁的外侧接合以密封穿刺或切口。张紧装置限制施加到细丝上的力。载体还包括用于使塞子在管道内机械变形的篡改。一旦定位，止血快速发生，从而将闭合件锁定就位。

9. 发明授权

US06428488B1 Dual riser/dual capillary viscometer for newtonian and non-newtonian fluids 失效
标题翻译：用于牛顿和非牛顿流体的双提升管/双毛细管粘度计
公开(公告)号：US06428488B1
公开(公告)日：2002-08-06
申请号：US09615340
申请日：2000-07-12
申请人： Kenneth Kensey , William N. Hogenauer , John E. Nash , Harold E. Clupper , Sangho Kim , Young Cho , Peter Randolph Hazard Stark , Robert O. Pellizzari , Sergey Kruss
发明人： Kenneth Kensey , William N. Hogenauer , John E. Nash , Harold E. Clupper , Sangho Kim , Young Cho , Peter Randolph Hazard Stark , Robert O. Pellizzari , Sergey Kruss
IPC分类号： A61B500
CPC分类号： A61B5/6866 , A61B5/02035 , A61B5/15003 , A61B5/150992 , G01N11/04 , G01N11/06
摘要： An apparatus and method for measuring the viscosity of Newtonian and non-Newtonian fluids over a range of shear rates, especially low shear rates, by monitoring two rising columns of fluid (Newtonian or non-Newtonian) that pass through respective capillaries having different lengths. Furthermore, a specialized column monitor is provided that uses multiple interrogation sources (e.g., lasers) and a single detector (e.g., a charge-coupled device (CCD) array) to continuously monitor both columns of fluid substantially simultaneously. In particular, the system includes a Y-connector to form two flow paths and wherein each flow path includes a tube that includes a riser tube, a capillary tube of predetermined dimensions and a valve in each for controlling the fluid flow in each path. The specialized column monitor monitors the movement of the fluid columns in each of the riser tubes and an associated microprocessor analyzes these movements, along with the predetermined dimensions of the capillary tubes and riser tubes to determine the viscosity of the fluid.
摘要翻译：一种用于通过监测通过具有不同长度的相应毛细管的两个上升流体（牛顿或非牛顿）来测量牛顿和非牛顿流体在一定范围的剪切速率，特别是低剪切速率下的粘度的装置和方法。此外，提供了使用多个询问源（例如，激光器）和单个检测器（例如，电荷耦合器件（CCD）阵列）的基本上同时连续监测流体两列的专门的列监视器。特别地，该系统包括Y形连接器以形成两个流动路径，并且其中每个流动路径包括管，该管包括提升管，预定尺寸的毛细管和每个用于控制每个路径中的流体流的阀。专门的列监视器监测每个提升管中的流体柱的运动，并且相关联的微处理器分析这些运动以及毛细管和提升管的预定尺寸以确定流体的粘度。

10. 发明授权

US6152888A Viscosity measuring apparatus and method of use 失效
公开(公告)号：US6152888A
公开(公告)日：2000-11-28
申请号：US400501
申请日：1999-09-21
申请人： Kenneth Kensey , John E. Nash , Harold E. Clupper
发明人： Kenneth Kensey , John E. Nash , Harold E. Clupper
IPC分类号： G01N33/49 , A61B5/145 , A61B5/15 , A61B5/157 , A61B8/12 , A61B10/00 , A61B18/00 , A61B19/00 , G01N11/00 , G01N11/04 , G01N33/15 , G01N33/487 , A01B5/00
CPC分类号： A61B5/150786 , A61B5/02035 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150755 , A61B5/150992 , A61B5/155 , A61B5/157 , A61B5/6866 , G01N11/04 , G01N11/08
摘要： A blood viscosity measuring system and method that monitors the rising head of a column of fluid representing a living being's blood in-vivo to determine the blood viscosity over a range of shears. The system includes a capillary tube, at least a portion of which is located within the vascular system of the being, and a riser tube, having a liquid therein coupled to the capillary tube. A sensor and associated microprocessor are provided to determine the change in the height of the liquid in the riser tube at plural points along the length of the tube from which the viscosity is calculated.

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