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1. 发明申请

US20090057210A1 IN-LINE FILTRATION SYSTEMS 审中-公开
标题翻译：在线过滤系统
公开(公告)号：US20090057210A1
公开(公告)日：2009-03-05
申请号：US12193198
申请日：2008-08-18
申请人： Kenneth Charles Barrett , Scott Boyette , Caibin Xiao , Zhaoyang Wan
发明人： Kenneth Charles Barrett , Scott Boyette , Caibin Xiao , Zhaoyang Wan
IPC分类号： B01D61/58 , B01D35/22 , B01D35/157 , C02F1/00 , B01D35/30 , B01D36/00
CPC分类号： B01D61/18 , B01D65/08 , B01D2315/08 , B01D2315/10 , B01D2321/2083 , C02F1/44 , C02F2303/16
摘要： A filtration system is disclosed that uses a combination of dead end filtration across opposing membranes with a sample take-off in the middle and cross-flow to prevent cake formation on these opposing filters. In one embodiment is a system that uses opposing filters with a central collection chamber that flips flow back and forth between the sides at a frequency that minimizes filter cake formation. In another embodiment, a combination flip-flip, cross flow system is disclosed. An additional embodiment discloses an actuator valve driven sampling system, in which valves collect the cross flow/counter flow filter cake samples as they are liberated from a filter surface and a quick through filter fluid pulse loosens the sample cake from the filter material. The invention increases effective operation time, allows for continuous filtration operation without interruption, and provides filtered samples that accurately represent the concentration of macromolecular species in industrial systems.
摘要翻译：公开了一种过滤系统，其使用在相对的膜上的死端过滤的组合以及在中间的样品取出和交叉流动以防止在这些相对的过滤器上形成饼状物。在一个实施例中是一种系统，其使用具有中心收集室的相对的过滤器，所述中央收集室翻转以使滤饼形成最小化的频率在侧面之间来回流动。在另一个实施例中，公开了一种组合式翻盖式横流系统。另外的实施例公开了一种致动器阀驱动的采样系统，其中阀门从过滤器表面释放时收集交叉流/逆流滤饼样品，并且快速通过的过滤器流体脉冲使样品滤饼从过滤材料松开。本发明增加了有效的操作时间，允许不间断的连续过滤操作，并提供了准确表示工业系统中大分子物质浓度的过滤样品。

2. 发明申请

US20070146715A1 SENSOR SYSTEMS FOR QUANTIFICATION OF PHYSICAL PARAMETERS, CHEMICAL AND BIOCHEMICAL VOLATILE AND NONVOLATILE COMPOUNDS IN FLUIDS 审中-公开
标题翻译：用于定量流体中物理参数，化学和生物化学挥发性和非挥发性化合物的传感器系统
公开(公告)号：US20070146715A1
公开(公告)日：2007-06-28
申请号：US11668061
申请日：2007-01-29
申请人： Radislav Potyrailo , Scott Boyette , Caibin Xiao , William Morris , Andrew Leach , Ronald Wroczynski
发明人： Radislav Potyrailo , Scott Boyette , Caibin Xiao , William Morris , Andrew Leach , Ronald Wroczynski
IPC分类号： G01N21/00
CPC分类号： G01N21/5907 , G01N35/00069
摘要： system and method employing a substrate for supporting a highly reproducible sensor array for producing a prerecorded standard response for quantitative analysis of physical, chemical and biochemical parameters are provided. The system includes a substrate for supporting a highly reproducible sensor array, a light source for directing light onto the sensor spot, at least one optical pickup for detecting light transmitted through or reflected from a sensor spot, the transmitted or reflected light being indicative of a concentration of a compound, and an analog-to-digital converter for quantifying an intensity of the detected light.
摘要翻译：提供了使用用于支持高度可重现的传感器阵列的基板的系统和方法，用于产生用于物理，化学和生物化学参数的定量分析的预先记录的标准响应。该系统包括用于支持高度可重现的传感器阵列的基板，用于将光引导到传感器光点上的光源，用于检测透射通过传感器点或从传感器点反射的光的至少一个光学拾取器，所发射或反射的光指示化合物的浓度，以及用于量化检测到的光的强度的模拟 - 数字转换器。

3. 发明申请

US20050157304A1 Handheld device with a disposable element for chemical analysis of multiple analytes 有权
标题翻译：具有一次性元件的手持式设备，用于多种分析物的化学分析
公开(公告)号：US20050157304A1
公开(公告)日：2005-07-21
申请号：US10760438
申请日：2004-01-20
申请人： Caibin Xiao , Scott Boyette , Radislav Potyrailo
发明人： Caibin Xiao , Scott Boyette , Radislav Potyrailo
IPC分类号： G01N21/25 , G01N21/27 , G01N21/31 , G01N21/55 , G01N21/77 , G01N21/86 , G01N33/543 , G01N21/47
CPC分类号： G01N21/7703 , G01N21/253 , G01N21/272 , G01N21/274 , G01N21/314 , G01N21/552 , G01N21/8483 , G01N2021/7783 , G01N2021/8488 , G01N2201/0221 , G01N2201/0245 , G01N2201/0461 , G01N2201/122
摘要： A portable system and method for measuring the concentration of multiple chemical or biological substances where an onsite analysis of such substances is needed. The new and original handheld sensor system uses a disposable optical test element and a spectroscopic detector that measures the test element response to specific analytes through a change in light absorbance, luminescence, and other forms of light-based response. In this way, reflection light intensities indicative of the test element response can be used to measure the concentration of the target analytes. The sensor system is also capable of being interfaced to an information processing unit or computer so that analytical data can be manipulated or stored electronically.
摘要翻译：用于测量需要对这些物质进行现场分析的多种化学或生物物质的浓度的便携式系统和方法。新的和原始的手持传感器系统使用一次性光学测试元件和光谱检测器，其通过光吸收，发光和其他形式的基于光的响应的变化来测量测试元件对特定分析物的响应。以这种方式，可以使用指示测试元件响应的反射光强度来测量目标分析物的浓度。传感器系统还能够连接到信息处理单元或计算机，从而可以电子地操纵或存储分析数据。

4. 发明申请

US20070092975A1 Methods and systems for delivery of fluidic samples to sensor arrays 有权
标题翻译：将流体样品传送到传感器阵列的方法和系统
公开(公告)号：US20070092975A1
公开(公告)日：2007-04-26
申请号：US11507689
申请日：2006-08-22
申请人： Radislav Potyrailo , Prashant Shrikhande , Scott Boyette , Caibin Xiao , Andrew Leach
发明人： Radislav Potyrailo , Prashant Shrikhande , Scott Boyette , Caibin Xiao , Andrew Leach
IPC分类号： G01N21/77
CPC分类号： G01N21/78 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L2200/0605 , B01L2200/0642 , B01L2300/0806 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2400/0406 , B01L2400/0427 , B01L2400/0448 , G01N21/80 , G01N35/00069 , G01N2021/7766 , G01N2021/7773 , G01N2021/7783 , G01N2021/7786 , G01N2021/7793 , Y10T436/144444 , Y10T436/25 , Y10T436/2575
摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.
摘要翻译：公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。提供输送装置以将计量的样品流体传送到传感器阵列。提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。该方法结合了多变量优化算法来分析多个传感器响应。这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。然后可以使用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

5. 发明申请

US20070092407A1 Optical sensor array system and method for parallel processing of chemical and biochemical information 有权
标题翻译：光学传感器阵列系统和化学和生化信息并行处理方法
公开(公告)号：US20070092407A1
公开(公告)日：2007-04-26
申请号：US11259643
申请日：2005-10-26
申请人： Caibin Xiao , Radislav Potyrailo , William Morris , Scott Boyette , LiJie Yu , Theodore Cecconie , Andrew Leach , Prashant Shrikhande
发明人： Caibin Xiao , Radislav Potyrailo , William Morris , Scott Boyette , LiJie Yu , Theodore Cecconie , Andrew Leach , Prashant Shrikhande
IPC分类号： G01N21/29 , G01N21/41
CPC分类号： G01N21/78 , B01L3/50273 , B01L3/502746 , B01L2200/0621 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/088 , G01N21/253 , G01N21/80 , G01N31/22 , Y10T137/7036
摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.
摘要翻译：公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。该方法结合了多变量优化算法来分析多个传感器响应。这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

6. 发明申请

US20050105583A1 Deposition sensor based on differential heat flux measurement 有权
标题翻译：基于差热通量测量的沉积传感器
公开(公告)号：US20050105583A1
公开(公告)日：2005-05-19
申请号：US10717154
申请日：2003-11-19
申请人： Caibin Xiao , David Little , Scott Boyette
发明人： Caibin Xiao , David Little , Scott Boyette
IPC分类号： G01N17/00 , G01N25/18 , G01K17/00
CPC分类号： G01N17/008 , G01N25/18
摘要： An apparatus and method for the monitoring and measurement of chemical and/or biological deposition in heat exchangers and other fluid processing vessels. The new and original sensing system includes at least two hollow fluid vessels conductively mounted across a constant heat transfer path. Thin film heat flux sensors are attached to a heat transfer surface of the vessels in order to measure changes in differential heat flux that occur when deposition begins to accumulate in the vessel. In this way, it is shown that differential heat flux measurements can be used to detect and measure the early onset of chemical and/or biological deposition.
摘要翻译：用于监测和测量热交换器和其它流体处理容器中的化学和/或生物沉积的装置和方法。新的和原始的感测系统包括至少两个导电地安装在恒定传热路径上的中空流体容器。薄膜热通量传感器连接到容器的传热表面，以便测量当沉积开始在容器中积聚时发生的差热通量的变化。以这种方式，可以看出差示热通量测量可用于检测和测量化学和/或生物沉积的早期发生。

7. 发明申请

US20050111000A1 Sensor systems and methods for quantification of physical parameters, chemical and biochemical volatile and nonvolatile compounds in fluids 失效
标题翻译：用于定量流体物理参数，化学和生物化学挥发性和非挥发性化合物的传感器系统和方法
公开(公告)号：US20050111000A1
公开(公告)日：2005-05-26
申请号：US10723534
申请日：2003-11-24
申请人： Radislav Potyrailo , William Morris , Scott Boyette , Marc Wisnudel , Andrew Leach , Mary Stanley
发明人： Radislav Potyrailo , William Morris , Scott Boyette , Marc Wisnudel , Andrew Leach , Mary Stanley
IPC分类号： G01N21/59 , G01N35/00 , G01N21/00
CPC分类号： G01N21/5907 , G01N35/00069
摘要： A system and method employing optical disc drives for quantitative analysis of physical, chemical and biochemical parameters are provided. The system including a disc drive for supporting and rotating an optical disc including at least one sensor spot; a light source for directing light onto the sensor spot; at least one optical pickup for detecting light transmitted from the sensor spot, the transmitted light being indicative of a concentration of a compound; and an analog-to-digital converter for quantifying an intensity of the transmitted light. The method comprising the steps of preparing the optical disc with a plurality of sensor spots, the sensor spots being responsive to a compound; exposing the optical disc to a fluid; measuring intensity of transmitted light from at least one of the plurality of sensor spots; and correlating the measured intensity of transmitted light to an amount of compound exposed to the optical disc.
摘要翻译：提供了一种使用光盘驱动器进行物理，化学和生物化学参数定量分析的系统和方法。该系统包括用于支撑和旋转包括至少一个传感器点的光盘的盘驱动器; 用于将光引导到传感器点上的光源; 至少一个用于检测从传感器光点传输的光的光学拾取器，所述透射光指示化合物的浓度; 以及用于量化透射光强度的模拟 - 数字转换器。该方法包括以下步骤：准备具有多个传感器点的光盘，所述传感器点响应于化合物; 将光盘暴露于流体; 测量来自所述多个传感器光点中的至少一个的透射光的强度; 并将测得的透射光强度与暴露于光盘的化合物的量相关联。

8. 发明申请

US20050112358A1 Methods for deposition of sensor regions onto optical storage media substrates and resulting devices 失效
标题翻译：将传感器区域沉积到光学存储介质基板和所得到的装置上的方法
公开(公告)号：US20050112358A1
公开(公告)日：2005-05-26
申请号：US10723536
申请日：2003-11-24
申请人： Radislav Potyrailo , Marc Wisnudel , Scott Boyette , Andrew Leach , Kasiraman Krishnan
发明人： Radislav Potyrailo , Marc Wisnudel , Scott Boyette , Andrew Leach , Kasiraman Krishnan
IPC分类号： G01N33/543 , G01N33/58 , B32B27/30 , B32B3/26
CPC分类号： B82Y5/00 , B82Y10/00 , B82Y30/00 , G01N33/54366 , G01N33/54393 , Y10T428/249994 , Y10T428/31935
摘要： Methods for applying sensor materials to optical storage media substrates are disclosed. After exposure to a sample of interest, the resulting sensors may be read in optical storage media drives for quantitative analysis of physical, chemical and biological parameters of the sample.
摘要翻译：公开了将传感器材料应用于光学存储介质基板的方法。在暴露于感兴趣的样品之后，所得到的传感器可以在光学存储介质驱动器中读取，用于定量分析样品的物理，化学和生物学参数。

9. 发明授权

US08158405B2 Process for concentrating and processing fluid samples 有权
标题翻译：浓缩和处理流体样品的方法
公开(公告)号：US08158405B2
公开(公告)日：2012-04-17
申请号：US12215768
申请日：2008-06-30
申请人： Scott Boyette , Rong Xu , Jing Luo , Weiqing Xu , Jing Chen , Weimin Xiao , Tong Chen
发明人： Scott Boyette , Rong Xu , Jing Luo , Weiqing Xu , Jing Chen , Weimin Xiao , Tong Chen
IPC分类号： C12N1/06
CPC分类号： C12Q1/24
摘要： A method of treating a liquid sample having microbiological target species therein to concentrate the species and collect lysate is disclosed. The liquid sample comprises non-target microbiological particles, inorganic particles, and microbiological target species. The liquid is passed through a prefilter medium to allow the target species to pass through as filtrate and retain non-target microbiological products and inorganic particles thereon. The filtrate is contacted with a main filtration medium adapted to retain the target species thereon as retentate. The retentate is lysed to form a lysate containing target material that was enveloped within the microbiological target species. The microbiological species may comprise cell containing or viral material. Target materials comprise intracellular nucleic acids, or in the case of viral sampling, nucleic acids encased within the protein sheath or coating of the virus.
摘要翻译：公开了一种处理其中具有微生物靶物种的液体样品以浓缩物种并收集裂解物的方法。液体样品包括非目标微生物颗粒，无机颗粒和微生物目标物种。使液体通过预过滤介质，使目标物质作为滤液通过，并在其上保留非目标微生物产物和无机颗粒。将滤液与适于将其上保留目标物质的主过滤介质接触，作为保留物。将渗余物溶解以形成包含在微生物目标物种内的目标物质的裂解物。微生物物种可以包含含细胞或病毒物质。目标材料包含细胞内核酸，或者在病毒取样的情况下，包含在病毒的蛋白质鞘或涂层内的核酸。

10. 发明申请

US20090326211A1 Process for concentrating and processing fluid samples 有权
标题翻译：浓缩和处理流体样品的方法
公开(公告)号：US20090326211A1
公开(公告)日：2009-12-31
申请号：US12215768
申请日：2008-06-30
申请人： Scott Boyette , Rong Xu , Jing Luo , Weiqing Xu , Jing Chen , Weimin Xiao , Tong Chen
发明人： Scott Boyette , Rong Xu , Jing Luo , Weiqing Xu , Jing Chen , Weimin Xiao , Tong Chen
IPC分类号： C07H1/06 , C12N1/06
CPC分类号： C12Q1/24
摘要： A method of treating a liquid sample having microbiological target species therein to concentrate the species and collect lysate is disclosed. The liquid sample comprises non-target microbiological particles, inorganic particles, and microbiological target species. The liquid is passed through a prefilter medium to allow the target species to pass through as filtrate and retain non-target microbiological products and inorganic particles thereon. The filtrate is contacted with a main filtration medium adapted to retain the target species thereon as retentate. The retentate is lysed to form a lysate containing target material that was enveloped within the microbiological target species. The microbiological species may comprise cell containing or viral material. Target materials comprise intracellular nucleic acids, or in the case of viral sampling, nucleic acids encased within the protein sheath or coating of the virus.
摘要翻译：公开了一种处理其中具有微生物靶物种的液体样品以浓缩物种并收集裂解物的方法。液体样品包括非目标微生物颗粒，无机颗粒和微生物目标物种。使液体通过预过滤介质，使目标物质作为滤液通过，并在其上保留非目标微生物产物和无机颗粒。将滤液与适于将其上保留目标物质的主过滤介质接触，作为保留物。将渗余物溶解以形成包含在微生物目标物种内的目标物质的裂解物。微生物物种可以包含含细胞或病毒物质。目标材料包含细胞内核酸，或者在病毒取样的情况下，包含在病毒的蛋白质鞘或涂层内的核酸。

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