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1. 发明申请

US20060183937A1 Alpha-pentafluoroethylacrylic acid derivative and process for producing the same 审中-公开
标题翻译： α-五氟乙基丙烯酸衍生物及其制备方法
公开(公告)号：US20060183937A1
公开(公告)日：2006-08-17
申请号：US10550066
申请日：2004-03-24
申请人： Kenji Tokuhisa , Hideyuki Mimura , Kosuke Kawada , Shoji Arai
发明人： Kenji Tokuhisa , Hideyuki Mimura , Kosuke Kawada , Shoji Arai
IPC分类号： C07C69/62
CPC分类号： C07C57/54 , C07C57/52
摘要： An α-pentafluoroethyl acrylic acid derivative represented by the general formula [I]: [wherein R represents a hydrogen atom, a non-substituted or substituted aromatic ring, or a straight or branched alkyl group having 1 to 20 carbon(s) which may have a cyclic moiety optionally substituted with at least one substituent (halogen atom, hydroxyl group, straight or branched alkoxy group having 1 to 10 carbon(s) which may have a cyclic moiety, non-substituted or substituted aromatic group)].
摘要翻译：由通式[I]表示的α-五氟乙基丙烯酸衍生物：[其中R表示氢原子，未取代或取代的芳环，或具有1至20个碳的直链或支链烷基，其可以具有任选被至少一个取代基（卤素原子，羟基，具有1至10个碳原子的直链或支链烷氧基，可以具有环状部分，未取代或取代的芳族基团）取代的环状部分]。

2. 发明授权

US07019162B2 Process for preparing 2-fluoro-3-oxoalkylcarboxylic acid ester 失效
标题翻译： 2-氟-3-氧代烷基羧酸酯的制备方法
公开(公告)号：US07019162B2
公开(公告)日：2006-03-28
申请号：US10451814
申请日：2001-12-25
申请人： Norihisa Kondo , Hideyuki Mimura , Kazunori Nukui , Kosuke Kawada , Shoji Arai
发明人： Norihisa Kondo , Hideyuki Mimura , Kazunori Nukui , Kosuke Kawada , Shoji Arai
IPC分类号： C07C69/66
CPC分类号： C07C67/58 , C07C67/307 , C07C69/738 , C07C69/716
摘要： A process for producing a 2-fluoro-3-oxoalkylcarboxylic acid ester by fluorinating 3-oxoalkylcarboxylic acid ester with a fluorine gas is provided. The process is characterized in that the concentration of 3-oxoalkylcarboxylic acid ester in the reaction mixture for fluorination is maintained at 3 wt % or higher. Also provided is a process for purifying 2-fluoro-3-oxoalkylcarboxylic acid ester characterized in that 2-fluoro-3-oxoalkylcarboxylic acid ester is produced at high yield and with less impurities by washing fluorinated 3-oxoalkylcarboxylic acid ester with 3 or more times as much water as the amount of reaction mixture. According to the processes of the present invention, not only is the generation of unwanted by-products minimized, but fluorinated 3-oxoalkylcarboxylic acid ester can be purified in an efficient manner. Thus, the present invention permits efficient production of considerably pure 2-fluoro-3-oxoalkylcarboxylic acid ester, a useful intermediate material in the production of various medical and agricultural agents.
摘要翻译：提供了通过用氟气氟化3-氧代烷基羧酸酯来制备2-氟-3-氧代烷基羧酸酯的方法。该方法的特征在于用于氟化的反应混合物中3-氧代烷基羧酸酯的浓度保持在3重量％以上。还提供了一种纯化2-氟-3-氧代烷基羧酸酯的方法，其特征在于2-氟-3-氧代烷基羧酸酯以高产率制备，通过用氟化3-氧代烷基羧酸酯洗涤3次或更多次而得到较少的杂质与反应混合物的量一样多的水。根据本发明的方法，不仅产生不想要的副产物最小化，而且氟化的3-氧代烷基羧酸酯可以以有效的方式被纯化。因此，本发明允许有效地生产相当纯的2-氟-3-氧代烷基羧酸酯，这是生产各种医药和农药的有用的中间体材料。

3. 发明授权

US07220878B2 Method of purifying and separating 2-fluoro-3-oxoalkylcarboxylic acid ester 失效
标题翻译：纯化和分离2-氟-3-氧代烷基羧酸酯的方法
公开(公告)号：US07220878B2
公开(公告)日：2007-05-22
申请号：US10490432
申请日：2001-09-27
申请人： Norihisa Kondo , Hideyuki Mimura , Kosuke Kawada , Shoji Arai
发明人： Norihisa Kondo , Hideyuki Mimura , Kosuke Kawada , Shoji Arai
IPC分类号： C07C69/66
CPC分类号： C07C67/54 , C07C69/716
摘要： The present invention concerns a method for purifying/separating a 2-fluoro-3-oxoalkylcarboxylic acid ester from a reaction mixture resulting from the fluorination of a 3-oxoalkylcarboxylic acid ester. The method involves depleting the reaction mixture of a hydrogen fluoride byproduct; and subsequently, separating the 2-fluoro-3-oxoalkylcarboxylic acid ester by distillation. The 2-fluoro-3-oxoalkylcarboxylic acid ester obtained by the method of the invention is highly pure and is thus suitable for use as an intermediate for the production of pharmacological products or agricultural chemicals.
摘要翻译：本发明涉及从3-氧代烷基羧酸酯氟化得到的反应混合物中纯化/分离2-氟-3-氧代烷基羧酸酯的方法。该方法涉及耗尽氟化氢副产物的反应混合物; 随后通过蒸馏分离2-氟-3-氧代烷基羧酸酯。通过本发明方法获得的2-氟-3-氧代烷基羧酸酯是高纯度的，因此适合用作生产药物产品或农药的中间体。

4. 发明授权

US06894197B2 Process for producing fluorinated alcohol 失效
标题翻译：制备氟化醇的方法
公开(公告)号：US06894197B2
公开(公告)日：2005-05-17
申请号：US10476540
申请日：2002-07-01
申请人： Hideyuki Mimura , Kosuke Kawada , Shoji Arai
发明人： Hideyuki Mimura , Kosuke Kawada , Shoji Arai
IPC分类号： C07C29/124 , C07C31/38 , C07C31/42 , C07C31/44 , C07C205/43 , C07C233/10 , C07C233/28 , C07C233/33 , C07C233/44 , C07C233/55 , C07F9/12 , C07C31/34
CPC分类号： C07C29/124 , C07C31/38
摘要： A method for producing fluorinated alcohols from fluorinated alkyl halides can produce fluorinated alcohols at high product yield and at high selectivity in a single-step reaction. The method eliminates the need to use heavy metals and other toxic compounds that are difficult to handle or process.Specifically, the method produces a fluorinated alcohol represented by the following general formula (2): Rf(A)OH (2) wherein Rf represents a perfluoroalkyl group having 1 to 10 carbon atoms; and A represents a straight-chained or branched saturated hydrocarbon group having 3 to 10 carbon atoms. The method is characterized in that it allows a fluorinated alkyl halide represented by the following general formula (1) to react with an alkali metal salt of 4-hydroxybutyrate in a gamma-butyrolactone solvent: Rf(A)X (1) wherein Rf and A are as defined above; and X represents a halogen atom.
摘要翻译：从氟化烷基卤化物制备氟化醇的方法可以以高产率和在一步反应中以高选择性产生氟化醇。该方法无需使用难处理或加工的重金属和其他有毒化合物。具体地说，该方法产生由以下通式（2）表示的氟化醇：<？in-line-formula description =“In-line formula”end =“lead”？> Rf（A）OH（2）在线公式描述=“In-line Formula”end =“tail”？>其中Rf表示具有1-10个碳原子的全氟烷基; A表示碳原子数3〜10的直链状或支链状的饱和烃基。该方法的特征在于，其允许由以下通式（1）表示的氟化烷基卤在γ-丁内酯溶剂中与4-羟基丁酸的碱金属盐反应：<？在线配方说明=“In 线型公式“end =”lead“？> Rf（A）X（1）<？in-line-formula description =”In-line Formulas“end =”tail“？>其中Rf和A如上所定义; X表示卤素原子。

5. 发明授权

US07470808B2 Method for producing fluorine-containing acrylate 有权
标题翻译：含氟丙烯酸酯的制造方法
公开(公告)号：US07470808B2
公开(公告)日：2008-12-30
申请号：US10550387
申请日：2004-03-24
申请人： Takamasa Fuchikami , Noriko Wakasa , Kenji Tokuhisa , Hideyuki Mimura , Shoji Arai
发明人： Takamasa Fuchikami , Noriko Wakasa , Kenji Tokuhisa , Hideyuki Mimura , Shoji Arai
IPC分类号： C07C69/63 , C07C67/36 , C07C69/66
CPC分类号： C07C67/36 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07C69/653
摘要： A process for producing a fluorine-containing acrylic acid ester represented by CH2═C(Rf)(COOR) characterized in that 1-bromo-1-perfluoroalkylethene represented by CH2═CBr—Rf, or 1,2-dibromo-1-perfluoroalkylethane represented by CH2CBr—CHBr—Rf is allowed to react with an alcohol represented by ROH in the presence of a palladium catalyst, carbon monoxide, and two or more kinds of bases. The fluorine-containing acrylic acid ester is a useful compound having wide applications in materials for pharmaceuticals and functional polymers.
摘要翻译：一种由CH2-C（Rf）（COOR）表示的含氟丙烯酸酯的制备方法，其特征在于由CH2-CBr-Rf表示的1-溴-1-全氟烷基烯或1,2-二溴-1-全氟烷基乙烷由二氯甲烷CH 2 Cl-Rf表示的化合物与钯催化剂，一氧化碳和两种或更多种碱的存在下与ROH表示的醇进行反应。含氟丙烯酸酯是广泛用于药物和功能聚合物的材料的有用化合物。

6. 发明申请

US20060122423A1 Method for producing fluorine-containing acrylate 有权
标题翻译：含氟丙烯酸酯的制造方法
公开(公告)号：US20060122423A1
公开(公告)日：2006-06-08
申请号：US10550387
申请日：2004-03-24
申请人： Takamasa Fuchikami , Noriko Wakasa , Kenji Tokuhisa , Hideyuki Mimura , Shoji Arai
发明人： Takamasa Fuchikami , Noriko Wakasa , Kenji Tokuhisa , Hideyuki Mimura , Shoji Arai
IPC分类号： C07C51/14
CPC分类号： C07C67/36 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07C69/653
摘要： A process for producing a fluorine-containing acrylic acid ester represented by CH2═C(Rf)(COOR) characterized in that 1-bromo-1-perfluoroalkylethene represented by CH2═CBr—Rf, or 1,2-dibromo-1-perfluoroalkylethane represented by CH2CBr—CHBr—Rf is allowed to react with an alcohol represented by ROH in the presence of a palladium catalyst, carbon monoxide, and two or more kinds of bases. The fluorine-containing acrylic acid ester is a useful compound having wide applications in materials for pharmaceuticals and functional polymers.
摘要翻译：一种由CH 2 -C（Rf）（COOR）表示的含氟丙烯酸酯的制备方法，其特征在于由CH 2表示的1-溴-1-全氟烷基乙烯基将由CH 2 CO 2 CBr-CHBr-Rf表示的-CBr-Rf或1,2-二溴-1-全氟烷基乙烷与由ROH表示的醇在钯催化剂存在下反应，一氧化碳和两种或更多种碱。含氟丙烯酸酯是广泛用于药物和功能聚合物的材料的有用化合物。

7. 发明申请

US20060252897A1 Fluorine-containing polymerisable monomer and polymer prepared by using same 有权
标题翻译：含氟可聚合单体和使用它制备的聚合物
公开(公告)号：US20060252897A1
公开(公告)日：2006-11-09
申请号：US11485422
申请日：2006-07-13
申请人： Satoru Miyazawa , Kazuhiko Maeda , Kenji Tokuhisa , Shoji Arai
发明人： Satoru Miyazawa , Kazuhiko Maeda , Kenji Tokuhisa , Shoji Arai
IPC分类号： C08F220/22
CPC分类号： G03F7/0046 , C07C69/65 , C07C69/653 , C07C69/96 , C07C2601/14 , C07C2602/42 , C08F20/22 , C08F20/26 , C08F220/24 , G03F7/0392 , G03F7/0397
摘要： The present invention relates to a polymerizable monomer represented by the general formula (1), wherein R1 is a hydrogen atom, a halogen atom, a hydrocarbon group or a fluorine-containing alkyl group; R2 is a straight-chain or branched alkyl group, a cyclic alkyl group, an aromatic group, or a substituent having at least two of these groups, the R2 being optionally partially fluorinated; R3 is a hydrogen atom, a hydrocarbon group that is optionally branched, a fluorine-containing alkyl group, or a cyclic group having an aromatic or alicyclic structure, the R3 optionally containing a bond of an oxygen atom or carbonyl group; and n is an integer of 1-2.
摘要翻译：本发明涉及由通式（1）表示的可聚合单体，其中R 1是氢原子，卤素原子，烃基或含氟烷基; R 2是直链或支链烷基，环状烷基，芳族基团或具有这些基团中的至少两个的取代基，R 2是任选部分氟化; R 3是氢原子，任选支链的烃基，含氟烷基或具有芳族或脂环结构的环状基团，R 3，任选地含有氧原子或羰基的键; n为1-2的整数。

8. 发明授权

US06784312B2 Fluorine-containing acrylate monomers 有权
标题翻译：含氟丙烯酸酯单体
公开(公告)号：US06784312B2
公开(公告)日：2004-08-31
申请号：US10198044
申请日：2002-07-19
申请人： Satoru Miyazawa , Kazuhiko Maeda , Kenji Tokuhisa , Shoji Arai
发明人： Satoru Miyazawa , Kazuhiko Maeda , Kenji Tokuhisa , Shoji Arai
IPC分类号： C07C6952
CPC分类号： G03F7/0046 , C07C69/65 , C07C69/653 , C07C69/96 , C07C2601/14 , C07C2602/42 , C08F20/22 , C08F20/26 , C08F220/24 , G03F7/0392 , G03F7/0397
摘要： The present invention relates to a polymerizable monomer represented by the general formula (1), wherein R1 is a hydrogen atom, a halogen atom, a hydrocarbon group or a fluorine-containing alkyl group; R2 is a straight-chain or branched alkyl group, a cyclic alkyl group, an aromatic group, or a substituent having at least two of these groups, the R2 being optionally partially fluorinated; R3 is a hydrogen atom, a hydrocarbon group that is optionally branched, a fluorine-containing alkyl group, or a cyclic group having an aromatic or alicyclic structure, the R3 optionally containing a bond of an oxygen atom or carbonyl group; and n is an integer of 1-2.
摘要翻译：本发明涉及由通式（1）表示的可聚合单体，其中R 1是氢原子，卤素原子，烃基或含氟烷基; R 2是直链或支链烷基，环状烷基，芳族基团或具有这些基团中至少两个的取代基，R 2任选地被部分氟化; R 3是氢原子，任选支链的烃基，含氟烷基或具有芳族或脂环结构的环状基团，R 3任选地含有氧原子或羰基的键组; n为1-2的整数。

9. 发明授权

US07094850B2 Fluorine-containing polymerizable monomer and polymer prepared by using same 有权
标题翻译：含氟可聚合单体和通过使用它制备的聚合物
公开(公告)号：US07094850B2
公开(公告)日：2006-08-22
申请号：US10880097
申请日：2004-06-30
申请人： Satoru Miyazawa , Kazuhiko Maeda , Kenji Tokuhisa , Shoji Arai
发明人： Satoru Miyazawa , Kazuhiko Maeda , Kenji Tokuhisa , Shoji Arai
IPC分类号： C08F120/22
CPC分类号： G03F7/0046 , C07C69/65 , C07C69/653 , C07C69/96 , C07C2601/14 , C07C2602/42 , C08F20/22 , C08F20/26 , C08F220/24 , G03F7/0392 , G03F7/0397
摘要： The present invention relates to a polymerizable monomer represented by the general formula (1), wherein R1 is a hydrogen atom, a halogen atom, a hydrocarbon group or a fluorine-containing alkyl group; R2 is a straight-chain or branched alkyl group, a cyclic alkyl group, an aromatic group, or a substituent having at least two of these groups, the R2 being optionally partially fluorinated; R3 is a hydrogen atom, a hydrocarbon group that is optionally branched, a fluorine-containing alkyl group, or a cyclic group having an aromatic or alicyclic structure, the R3 optionally containing a bond of an oxygen atom or carbonyl group; and n is an integer of 1–2.
摘要翻译：本发明涉及由通式（1）表示的可聚合单体，其中R 1是氢原子，卤素原子，烃基或含氟烷基; R 2是直链或支链烷基，环状烷基，芳族基团或具有这些基团中的至少两个的取代基，R 2是任选部分氟化; R 3是氢原子，任选支链的烃基，含氟烷基或具有芳族或脂环结构的环状基团，R 3，任选地含有氧原子或羰基的键; n为1-2的整数。

10. 发明授权

US07759440B2 Fluorine-containing polymerisable monomer and polymer prepared by using same 有权
标题翻译：含氟可聚合单体和使用它制备的聚合物
公开(公告)号：US07759440B2
公开(公告)日：2010-07-20
申请号：US11485422
申请日：2006-07-13
申请人： Satoru Miyazawa , Kazuhiko Maeda , Kenji Tokuhisa , Shoji Arai
发明人： Satoru Miyazawa , Kazuhiko Maeda , Kenji Tokuhisa , Shoji Arai
IPC分类号： C08F120/22
CPC分类号： G03F7/0046 , C07C69/65 , C07C69/653 , C07C69/96 , C07C2601/14 , C07C2602/42 , C08F20/22 , C08F20/26 , C08F220/24 , G03F7/0392 , G03F7/0397
摘要： The present invention relates to a polymerizable monomer represented by the general formula (1), wherein R1 is a hydrogen atom, a halogen atom, a hydrocarbon group or a fluorine-containing alkyl group; R2 is a straight-chain or branched alkyl group, a cyclic alkyl group, an aromatic group, or a substituent having at least two of these groups, the R2 being optionally partially fluorinated; R3 is a hydrogen atom, a hydrocarbon group that is optionally branched, a fluorine-containing alkyl group, or a cyclic group having an aromatic or alicyclic structure, the R3 optionally containing a bond of an oxygen atom or carbonyl group; and n is an integer of 1-2.
摘要翻译：本发明涉及由通式（1）表示的可聚合单体，其中R1是氢原子，卤素原子，烃基或含氟烷基; R2是直链或支链烷基，环状烷基，芳族基团或具有这些基团中至少两个的取代基，R2任选地部分氟化; R3是氢原子，任选支化的烃基，含氟烷基或具有芳族或脂环结构的环状基团，R3任选地含有氧原子或羰基的键; n为1-2的整数。

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