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1. 发明申请

US20060189632A1 Pyrazolo[1,5-A] pyrimidine derivatives 失效
公开(公告)号：US20060189632A1
公开(公告)日：2006-08-24
申请号：US10547080
申请日：2004-03-01
申请人： Kenichiro Kataoka , Naotaka Suzuki , Tomomi Kosugi , Minoru Imai , Hiroaki Makino , Mika Takakuwa , Gen Unoki , Aiko Fujino , Yasuhiro Oue , Yuko Yamakoshi , Satoshi Sugiura , Robert Mitchell , James Simpson , John Harris , Joelle Le
发明人： Kenichiro Kataoka , Naotaka Suzuki , Tomomi Kosugi , Minoru Imai , Hiroaki Makino , Mika Takakuwa , Gen Unoki , Aiko Fujino , Yasuhiro Oue , Yuko Yamakoshi , Satoshi Sugiura , Robert Mitchell , James Simpson , John Harris , Joelle Le
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04
摘要： The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent kinase inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for a protein kinase mediated disorder in which kinase is implicated, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth.

2. 发明申请

US20070191344A1 Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases 有权
标题翻译：药物活性的4,6-二取代氨基嘧啶衍生物作为蛋白激酶的调节剂
公开(公告)号：US20070191344A1
公开(公告)日：2007-08-16
申请号：US10572043
申请日：2004-09-15
申请人： Axel Choidas , Alexander Backes , Matt Cotten , Ola Engkvist , Beatrice Felber , Achim Freisleben , Klaus Godl , Zoltan Greff , Peter Habenberger , Doris Hafenbradl , Christian Hartung , Thomas Herget , Edmund Hoppe , Bert Klebl , Andrea Missio , Gerhard Muller , Wilfried Schwab , Birgit Zech , Jose Bravo , John Harris , Joelle Le , Jackie Macritchie , Vladimir Savic , Brad Sherborne , Don Simpson
发明人： Axel Choidas , Alexander Backes , Matt Cotten , Ola Engkvist , Beatrice Felber , Achim Freisleben , Klaus Godl , Zoltan Greff , Peter Habenberger , Doris Hafenbradl , Christian Hartung , Thomas Herget , Edmund Hoppe , Bert Klebl , Andrea Missio , Gerhard Muller , Wilfried Schwab , Birgit Zech , Jose Bravo , John Harris , Joelle Le , Jackie Macritchie , Vladimir Savic , Brad Sherborne , Don Simpson
IPC分类号： A61K31/55 , A61K31/506 , C07D403/02
CPC分类号： C04B35/632 , C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.
摘要翻译：本发明涉及4,6-二取代的氨基嘧啶衍生物和/或其药学上可接受的盐，这些衍生物作为药物活性剂的用途，特别是用于预防和/或治疗感染性疾病，包括机会性疾病，朊病毒疾病，免疫学疾病，自身免疫疾病，双相和临床疾病，心血管疾病，细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性疾病和中风，以及含有所述4,6-二取代氨基嘧啶衍生物和 /或其药学上可接受的盐。此外，本发明涉及所述4,6-二取代氨基嘧啶衍生物作为蛋白激酶的抑制剂和包含至少一种固定化形式的所述4,6-二取代氨基嘧啶衍生物的介质和使用所述培养基用于富集，纯化和/或消除与固定的4,6-二取代氨基嘧啶衍生物结合的核苷酸结合蛋白。

3. 发明授权

US08084457B2 Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases 有权
标题翻译：药物活性的4,6-二取代氨基嘧啶衍生物作为蛋白激酶的调节剂
公开(公告)号：US08084457B2
公开(公告)日：2011-12-27
申请号：US10572043
申请日：2004-09-15
申请人： Axel Choidas , Alexander Backes , Matt Cotten , Ola Engkvist , Beatrice Felber , Achim Freisleben , Klaus Godl , Zoltán Greff , Peter Habenberger , Doris Hafenbradl , Christian Hartung , Thomas Herget , Edmund Hoppe , Bert Klebl , Andrea Missio , Gerhard Müller , Wilfried Schwab , Birgit Zech , Jose Bravo , John Harris , Joelle Le , Jackie Macritchie , Vladimir Savic , Brad Sherborne , Don Simpson
发明人： Axel Choidas , Alexander Backes , Matt Cotten , Ola Engkvist , Beatrice Felber , Achim Freisleben , Klaus Godl , Zoltán Greff , Peter Habenberger , Doris Hafenbradl , Christian Hartung , Thomas Herget , Edmund Hoppe , Bert Klebl , Andrea Missio , Gerhard Müller , Wilfried Schwab , Birgit Zech , Jose Bravo , John Harris , Joelle Le , Jackie Macritchie , Vladimir Savic , Brad Sherborne , Don Simpson
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04 , C07D239/00 , C07D239/02
CPC分类号： C04B35/632 , C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.
摘要翻译：本发明涉及4,6-二取代的氨基嘧啶衍生物和/或其药学上可接受的盐，这些衍生物作为药物活性剂的用途，特别是用于预防和/或治疗感染性疾病，包括机会性疾病，朊病毒疾病，免疫学疾病，自身免疫疾病，双相和临床疾病，心血管疾病，细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性疾病和中风，以及含有所述4,6-二取代氨基嘧啶衍生物和 /或其药学上可接受的盐。此外，本发明涉及所述4,6-二取代氨基嘧啶衍生物作为蛋白激酶的抑制剂和包含至少一种固定化形式的所述4,6-二取代氨基嘧啶衍生物的介质和使用所述培养基用于富集，纯化和/或消除与固定的4,6-二取代氨基嘧啶衍生物结合的核苷酸结合蛋白。

4. 发明授权

US08978056B2 Video loading control 有权
标题翻译：视频加载控制
公开(公告)号：US08978056B2
公开(公告)日：2015-03-10
申请号：US13314324
申请日：2011-12-08
申请人： Nandakishore Albal , John Harris
发明人： Nandakishore Albal , John Harris
IPC分类号： H04N7/173 , H04N7/16 , H04N17/00 , H04N7/14
CPC分类号： H04N21/4331 , H04L65/1083 , H04L65/80 , H04N21/6373 , H04W28/18 , H04W36/023 , H04W76/19
摘要： The specification and drawings present a new method, apparatus and software related product (e.g., a computer readable memory) for controlling loading (e.g., pre-filling) of video data to a user equipment by a wireless network (e.g., from internet) while the video is played by the user equipment using an additional pre-filling based on predicted degradation of connectivity of the user equipment with the wireless network to avoid interruption or deterioration of playing the video and/or to reduce video data loading cost.
摘要翻译：说明书和附图提出了一种用于通过无线网络（例如，从互联网）控制向用户设备加载（例如，预填充）视频数据的新方法，装置和软件相关产品（例如，计算机可读存储器），而视频由用户设备使用基于用户设备与无线网络的连接性的预测劣化的附加预填充来播放，以避免播放视频的中断或恶化和/或减少视频数据加载成本。

5. 发明申请

US20130088731A1 PROCESSING IMAGE DATA STRIPS 有权
标题翻译：处理图像数据条
公开(公告)号：US20130088731A1
公开(公告)日：2013-04-11
申请号：US13611134
申请日：2012-09-12
申请人： Bradley R. Larson , John Harris , Mary T. Prenn
发明人： Bradley R. Larson , John Harris , Mary T. Prenn
IPC分类号： H04N1/60
CPC分类号： G06K15/12 , G06K15/1857 , G06K15/1865 , G06K15/1894 , H04N1/506 , H04N1/648
摘要： An apparatus and methods for processing image data in multi-row strips to generate print data for colorizers of a printer.
摘要翻译：一种用于处理多行条带中的图像数据以产生打印机着色器的打印数据的装置和方法。

6. 发明申请

US20130057571A1 Display Orientation Control 审中-公开
标题翻译：显示方向控制
公开(公告)号：US20130057571A1
公开(公告)日：2013-03-07
申请号：US13224618
申请日：2011-09-02
申请人： John Harris
发明人： John Harris
IPC分类号： G09G5/00
CPC分类号： G06F1/1613 , G06F2200/1614 , G09G5/38 , G09G2320/0261 , G09G2340/0492 , G09G2354/00
摘要： In accordance with the exemplary embodiments of the invention there is at least a method, apparatus, and computer program code to perform the operations of, determining whether there is a corresponding change of a position of a user of the portable electronic device with respect to the display, and in response to the determining indicating that there is not a corresponding change of the position of the user with respect to the display, maintaining a display orientation of information on the display.
摘要翻译：根据本发明的示例性实施例，存在至少一种方法，装置和计算机程序代码，用于执行以下操作：确定便携式电子设备的用户的位置是否相对于并且响应于确定指示用户相对于显示器的位置没有相应的改变，保持显示器上的信息的显示取向。

7. 发明授权

US07813995B2 System and method for estimating a spread value 有权
标题翻译：用于估计传播价值的系统和方法
公开(公告)号：US07813995B2
公开(公告)日：2010-10-12
申请号：US10804631
申请日：2004-03-19
申请人： Michael J. Burns , John Harris
发明人： Michael J. Burns , John Harris
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04 , G06Q30/06 , G06Q40/00 , G06Q40/025 , G06Q40/06
摘要： An estimated spread value is computed that represents a price at which a trader might have been able to buy or sell a spread given the current market conditions of the legs. In particular, when an event occurs in one of the legs, price information is gathered from each of the other legs based on the spread definition, in addition to the defined event, and is used in estimating the value of a spread. According to one feature, the computations may be triggered by any predefined event. According to another feature, the computation may be programmed by a user to tailor the estimation process according to the type of spread being traded. The estimated spread value may be used to analyze spreads, it may be fed to other trading related software tools, or it may be used in charting.
摘要翻译：计算出估计的差价值，其代表交易者可能已经能够在现有的腿的市场状况下购买或出售差价的价格。特别地，当在一条腿中发生事件时，除了所定义的事件之外，还基于扩展定义从每个其他腿收集价格信息，并且用于估计扩展的值。根据一个特征，计算可以由任何预定义的事件来触发。根据另一特征，计算可以由用户编程，以根据所交易的传播类型来定制估计过程。估计的差价值可用于分析利差，可以将其提供给其他与交易相关的软件工具，也可以用于图表中。

8. 发明申请

US20080021341A1 Methods and Systems for Facilitating Clinical Trials 审中-公开
标题翻译：促进临床试验的方法和系统
公开(公告)号：US20080021341A1
公开(公告)日：2008-01-24
申请号：US11766756
申请日：2007-06-21
申请人： John Harris , Kent Leyde
发明人： John Harris , Kent Leyde
IPC分类号： A61B5/0476
CPC分类号： A61N1/37229 , A61B5/0031 , A61B5/0476 , A61B5/4094 , A61B2560/0214 , A61N1/36064
摘要： The present invention provides methods and systems for improving clinical trials of experimental therapies. The present invention uses minimally invasive, leadless implantable devices that facilitate long term monitoring of a physiological signal (e.g., neural signals) from a patient population which may provide an indication of the effect of the experimental therapy on the patient population. In preferred embodiments, neural signals are sampled from the patients in the patient population with an externally powered, leadless implanted device and are transmitted to an external device for further processing.
摘要翻译：本发明提供用于改善实验疗法的临床试验的方法和系统。本发明使用促进长期监测来自患者群体的生理信号（例如，神经信号）的微创无引导植入式装置，其可以提供实验治疗对患者群体的影响的指示。在优选实施例中，使用外部供电的无引线植入装置从患者群体中的患者采集神经信号，并将其传输到外部装置以进行进一步处理。

9. 发明申请

US20070288134A1 SYSTEM AND METHOD FOR DEMONSTRATING FUNCTIONALITY OF ON-BOARD DIAGNOSTICS FOR VEHICLES 有权
标题翻译：用于演示车辆诊断诊断功能的系统和方法
公开(公告)号：US20070288134A1
公开(公告)日：2007-12-13
申请号：US11423628
申请日：2006-06-12
申请人： John Rollinger , Paul Pietrzyk , John Smiley , Duncan Borthwick , Gregory Sapick , Marian Chupa , John Harris , Robert Grant
发明人： John Rollinger , Paul Pietrzyk , John Smiley , Duncan Borthwick , Gregory Sapick , Marian Chupa , John Harris , Robert Grant
IPC分类号： G01M17/00 , G06F19/00
CPC分类号： F02D41/222 , F01N11/007 , F01N2560/025 , F02D41/0235
摘要： A system and method for demonstrating or testing operation of on-board diagnostics in a vehicle include imitating performance degradation of a vehicle hardware component and/or associated vehicle system by dynamically modifying at least one control system parameter value associated with the hardware component in response to a request to demonstrate operation of a selected diagnostic function or a specified performance degradation. Embodiments modify at least one control system parameter value associated with the input/output signal of a sensor/actuator to imitate a specified performance degradation. The diagnostics independently monitor operation of various vehicle control systems and operate to detect the degraded performance without knowledge of, or distinguishing between, whether the performance degradation was caused by an actual hardware component, or by the requested modification to the control system parameter value(s) associated with a particular hardware component.
摘要翻译：用于演示或测试车辆中车载诊断操作的系统和方法包括通过动态地修改与硬件组件相关联的至少一个控制系统参数值来模仿车辆硬件组件和/或相关联的车辆系统的性能下降，以响应于显示所选诊断功能的运行或指定的性能下降的请求。实施例修改与传感器/致动器的输入/输出信号相关联的至少一个控制系统参数值，以模拟规定的性能下降。诊断独立地监视各种车辆控制系统的操作，并且操作以在不知道或区分性能劣化是由实际硬件部件引起的情况下，还是通过对控制系统参数值（s）的所请求的修改来检测降级的性能）与特定硬件组件相关联。

10. 发明申请

US20070142056A1 Wireless communication system capacity control facilitation method and apparatus 有权
标题翻译：无线通信系统容量控制简化方法和装置
公开(公告)号：US20070142056A1
公开(公告)日：2007-06-21
申请号：US11311646
申请日：2005-12-19
申请人： John Harris
发明人： John Harris
IPC分类号： H04Q7/20
CPC分类号： H04W28/24
摘要： System capacity control in a wireless communication system can be facilitated with respect to a mobile to mobile communication. Such facilitation can comprise adjusting (103) a quality of service for at least one leg of that mobile to mobile communication. More particularly, this facilitation can comprise obtaining information (101) regarding at least one of power requirements as correspond to each leg of the mobile to mobile communication, a number of mobile stations as comprise communication targets in the mobile to mobile communication and that do not share a same sector using a shared channel, and/or expected battery life for at least one mobile station as comprises the mobile to mobile communication. These teachings can then provide for relatively degrading quality of service on a leg of the mobile to mobile communication as corresponds to at least one of relatively low mobile station power requirements, a leg comprising a reverse speaker leg and corresponding target legs are relatively few in number, and/or a leg comprising a reverse speaker leg and the corresponding mobile station has a relatively low expected battery life.
摘要翻译：无线通信系统中的系统容量控制可以相对于移动通信到移动通信而言是便利的。这种促进可以包括调整（103）移动通信的至少一条腿的服务质量。更具体地，这种促进可以包括获得关于与移动到移动通信的每条腿相对应的功率需求中的至少一个的信息（101），多个移动站包括移动到移动通信中的通信目标，并且不使用共享信道共享相同的扇区，和/或至少一个移动站的预期电池寿命包括移动到移动通信。这些教导可以提供对移动通信的一条腿上的相对降级的服务质量，对应于相对低的移动台功率需求中的至少一个，包括反向扬声器支腿和相应的目标支路的腿数量相对较少，和/或包括反向扬声器支腿的支腿和相应的移动台具有相对低的预期电池寿命。

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