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1. 发明申请

US20100105721A1 IMIDAZO[1,2-a]PYRIDINE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS 有权
标题翻译：咪唑并[1,2-a]吡啶衍生物：制备和药物应用
公开(公告)号：US20100105721A1
公开(公告)日：2010-04-29
申请号：US12651052
申请日：2009-12-31
申请人： Ken C. Lee , Eric T. Sun , Haishan Wang
发明人： Ken C. Lee , Eric T. Sun , Haishan Wang
IPC分类号： A61K31/437 , A61P25/00 , A61P37/00 , A61P17/00 , A61P9/00 , A61P35/00
CPC分类号： C07D471/04 , A61K31/44 , C07D491/02 , C07D498/02 , Y02A50/409 , Y02A50/411
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).
摘要翻译：本发明涉及作为组蛋白脱乙酰酶抑制剂的异羟肟酸酯化合物。更具体地，本发明涉及含咪唑并[1,2-a]吡啶的化合物及其制备方法。这些化合物可用作治疗增殖性疾病的药物以及涉及与组蛋白脱乙酰酶活性（HDAC）的酶有关或与之有关的其它疾病。

2. 发明授权

US07666880B2 Imidazo[1,2-A]pyridine derivatives: preparation and pharmaceutical applications 有权
标题翻译：咪唑并[1,2-A]吡啶衍生物：制备和药物应用
公开(公告)号：US07666880B2
公开(公告)日：2010-02-23
申请号：US11857807
申请日：2007-09-19
申请人： Ken C. Lee , Eric T. Sun , Haishan Wang
发明人： Ken C. Lee , Eric T. Sun , Haishan Wang
IPC分类号： A01N43/42 , A61K31/44 , C07D491/02 , C07D498/02
CPC分类号： C07D471/04 , A61K31/44 , C07D491/02 , C07D498/02 , Y02A50/409 , Y02A50/411
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).
摘要翻译：本发明涉及作为组蛋白脱乙酰酶抑制剂的异羟肟酸酯化合物。更具体地，本发明涉及含咪唑并[1,2-a]吡啶的化合物及其制备方法。这些化合物可用作治疗增殖性疾病的药物以及涉及与组蛋白脱乙酰酶活性（HDAC）的酶有关或与之有关的其它疾病。

3. 发明授权

US08143282B2 Heterocyclic compounds 有权
标题翻译：杂环化合物
公开(公告)号：US08143282B2
公开(公告)日：2012-03-27
申请号：US12065989
申请日：2006-08-01
申请人： Dizhong Chen , Weiping Deng , Ken C. Lee , Pek L. Lye , Eric T. Sun , Haishan Wang , Niefang Yu
发明人： Dizhong Chen , Weiping Deng , Ken C. Lee , Pek L. Lye , Eric T. Sun , Haishan Wang , Niefang Yu
IPC分类号： C07D401/04 , C07D235/14 , A61K31/4184 , A61K31/454 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： C07D235/08 , C07D235/06 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/16 , C07D235/24 , C07D401/04 , C07D403/04
摘要： The present invention relates to compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.
摘要翻译：本发明涉及作为组蛋白脱乙酰酶抑制剂的化合物。更具体地说，本发明涉及杂环化合物及其制备方法。这些化合物可用作治疗增殖性疾病以及涉及与组蛋白脱乙酰酶（HDAC）活性的酶有关或伴随其它疾病的其它疾病的药物。

4. 发明申请

US20090048300A1 Heterocyclic Compounds 有权
标题翻译：杂环化合物
公开(公告)号：US20090048300A1
公开(公告)日：2009-02-19
申请号：US12065989
申请日：2006-08-01
申请人： Dizhong Chen , Weiping Deng , Ken C. Lee , Pek L. Lye , Eric T. Sun , Haishan Wang , Niefang Yu
发明人： Dizhong Chen , Weiping Deng , Ken C. Lee , Pek L. Lye , Eric T. Sun , Haishan Wang , Niefang Yu
IPC分类号： C07D401/04 , C07D235/14 , A61K31/4184 , A61K31/454 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： C07D235/08 , C07D235/06 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/16 , C07D235/24 , C07D401/04 , C07D403/04
摘要： The present invention relates to compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.
摘要翻译：本发明涉及作为组蛋白脱乙酰酶抑制剂的化合物。更具体地说，本发明涉及杂环化合物及其制备方法。这些化合物可用作治疗增殖性疾病以及涉及与组蛋白脱乙酰酶（HDAC）活性的酶有关或伴随其它疾病的其它疾病的药物。

5. 发明授权

US08648092B2 Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applications 有权
公开(公告)号：US08648092B2
公开(公告)日：2014-02-11
申请号：US12651052
申请日：2009-12-31
申请人： Ken Chi Lik Lee , Eric T. Sun , Haishan Wang
发明人： Ken Chi Lik Lee , Eric T. Sun , Haishan Wang
IPC分类号： A61K31/44 , C07D471/04
CPC分类号： C07D471/04 , A61K31/44 , C07D491/02 , C07D498/02 , Y02A50/409 , Y02A50/411
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).

6. 发明授权

US07199121B2 Protein tyrosine phosphatase inhibitor 失效
标题翻译：蛋白酪氨酸磷酸酶抑制剂
公开(公告)号：US07199121B2
公开(公告)日：2007-04-03
申请号：US10363914
申请日：2001-09-07
申请人： Catherine J. Pallen , Haishan Wang , Kah Leong Lim , Su Ling Yeo , Yue Wang , Yin Hwee Tan
发明人： Catherine J. Pallen , Haishan Wang , Kah Leong Lim , Su Ling Yeo , Yue Wang , Yin Hwee Tan
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00 , A61P31/10
CPC分类号： C07D487/04 , A61K31/53 , C12P17/182 , C12R1/465
摘要： Use of a compound of formula (I): wherein each R, which are the same or different, is H or C1–C6 alkyl, and X completes a ring which is a substituted triazine having one of the following formulae (II) to (IV): wherein R′ is H or C1–C6 alkyl; or an enol tautomer of a compound of formula (I) in which any of the groups R or R′ is hydrogen; in the manufacture of a medicament for use as a protein tyrosine phosphatase (PTP) inhibitor. Formula (I) embraces 2-methylfervenulone, which can be produced by fermentation of a novel microbial strain. Fermentation of the said strain also produces novel precursors to 2-methylfervenulone having utility as prodrugs.
摘要翻译：式（I）化合物的用途：

7. 发明授权

US06389160B1 Hybrid wavelet and JPEG system and method for compression of color images 有权
标题翻译：混合小波和JPEG系统和彩色图像压缩方法
公开(公告)号：US06389160B1
公开(公告)日：2002-05-14
申请号：US09289458
申请日：1999-04-09
申请人： Charles K. Chui , Haishan Wang
发明人： Charles K. Chui , Haishan Wang
IPC分类号： G06K900
CPC分类号： G06T9/007
摘要： A data encoder and method encodes color image data. The image data include Y, U and V data. A data image quality level is selected, which corresponds to a compression ratio. The Y data is encoded using a wavelet or wavelet-like compression method in accordance with the selected data image quality level. When the compression ratio is less than a threshold value, indicating a low compression ratio, the U and V data are compressed using a JPEG compression method. Otherwise the U and V data are compressed using the wavelet or wavelet-like compression method. The encoded image data includes an indication of which compression method was used to encode the U and V data. When encoded image data is decoded by a data decoder, the decoder determines which compression method was used to encode the U and V data, and then decodes the encoded image data accordingly.
摘要翻译：数据编码器和方法对彩色图像数据进行编码。图像数据包括Y，U和V数据。选择对应于压缩比的数据图像质量等级。根据选择的数据图像质量水平，使用小波或小波样压缩方法对Y数据进行编码。当压缩比小于阈值时，表示低压缩比，使用JPEG压缩方法压缩U和V数据。否则，使用小波或小波压缩方法压缩U和V数据。编码图像数据包括用于对U和V数据进行编码的压缩方法的指示。当编码图像数据被数据解码器解码时，解码器确定使用哪种压缩方法对U和V数据进行编码，然后相应地解码编码图像数据。

8. 发明申请

US20080085896A1 IMIDAZO[1,2-A]PYRIDINE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS 有权
标题翻译：咪唑并[1,2-A]吡啶衍生物：制备和药物应用
公开(公告)号：US20080085896A1
公开(公告)日：2008-04-10
申请号：US11857807
申请日：2007-09-19
申请人： Ken Lee , Eric Sun , Haishan Wang
发明人： Ken Lee , Eric Sun , Haishan Wang
IPC分类号： A61K31/5377 , A61K31/4355 , A61P25/28 , A61P37/00 , C07D413/14 , C07D471/04 , C07D401/14 , A61P35/00 , A61K31/497
CPC分类号： C07D471/04 , A61K31/44 , C07D491/02 , C07D498/02 , Y02A50/409 , Y02A50/411
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).
摘要翻译：本发明涉及作为组蛋白脱乙酰酶抑制剂的异羟肟酸酯化合物。更具体地，本发明涉及含咪唑并[1,2-a]吡啶的化合物及其制备方法。这些化合物可用作治疗增殖性疾病的药物以及涉及与组蛋白脱乙酰酶活性（HDAC）的酶有关或与之有关的其它疾病。

9. 发明授权

US06904176B1 System and method for tiled multiresolution encoding/decoding and communication with lossless selective regions of interest via data reuse 有权
标题翻译：用于平铺多分辨率编码/解码和通过数据重用与无损选择性感兴趣区域进行通信的系统和方法
公开(公告)号：US06904176B1
公开(公告)日：2005-06-07
申请号：US09999760
申请日：2001-10-31
申请人： Charles K. Chui , Haishan Wang
发明人： Charles K. Chui , Haishan Wang
IPC分类号： G06K9/32 , G06K9/36 , H04N7/26
CPC分类号： H04N19/40 , H04N19/103 , H04N19/17 , H04N19/587 , H04N19/63
摘要： A method and apparatus for processing an image is described. In one embodiment, the method comprises: receiving a portion of an encoded version of a downsized image and one or more encoded residual images, decoding the portion of the encoded version of the downsized image to create a decoded portion of the downsized image, decoding a portion of at least one or more encoded residual images, enlarging the decoded portion of the portion of the downsized image, and combining the enlarged and decoded portion of the downsized image with a first decoded residual image to create a new image.
摘要翻译：描述用于处理图像的方法和装置。在一个实施例中，该方法包括：接收缩小尺寸图像的编码版本的一部分和一个或多个编码残差图像，对经缩小尺寸图像的编码版本的部分进行解码，以创建缩小图像的解码部分，解码至少一个或多个编码残差图像的部分，放大缩小图像的部分的解码部分，以及将缩小尺寸图像的放大和解码部分与第一解码剩余图像组合以创建新图像。

10. 发明授权

US08270469B2 Encoding video at multiple resolution levels 失效
标题翻译：以多个分辨率级别编码视频
公开(公告)号：US08270469B2
公开(公告)日：2012-09-18
申请号：US11639780
申请日：2006-12-15
申请人： Charles K. Chui , Haishan Wang
发明人： Charles K. Chui , Haishan Wang
IPC分类号： H04N7/12
CPC分类号： H04N19/59 , H04N19/107 , H04N19/159 , H04N19/169 , H04N19/172 , H04N19/176 , H04N19/30 , H04N19/31 , H04N19/40 , H04N19/46 , H04N19/61 , H04N19/70
摘要： A method and related system of encoding or re-encoding video is disclosed. In the method, video data comprising a sequence of frames is received. For a respective frame in the sequence of frames, a multi-level frame is generated comprising the respective frame and a plurality of copies of the respective frame. Each copy has an associated video resolution level that is a member of a predefined range of video resolution levels, ranging from a highest video resolution level to a lowest video resolution level. The multi-level frame is encoded.
摘要翻译：公开了编码或重新编码视频的方法和相关系统。在该方法中，接收包括帧序列的视频数据。对于帧序列中的相应帧，生成包括相应帧和相应帧的多个副本的多级帧。每个副本具有相关联的视频分辨率级别，其是预定范围的视频分辨率级别的成员，范围从最高视频分辨率级别到最低视频分辨率级别。多级帧被编码。

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