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1. 发明授权

US07045343B2 Sterilization indicator test packs 有权
公开(公告)号：US07045343B2
公开(公告)日：2006-05-16
申请号：US10372993
申请日：2003-02-24
申请人： Kelvin J. Witcher , William E. Foltz , Sailaja Chandrapati , Thomas T. Rosenlund , Robert A. Asmus , Ronald G. Lulich
发明人： Kelvin J. Witcher , William E. Foltz , Sailaja Chandrapati , Thomas T. Rosenlund , Robert A. Asmus , Ronald G. Lulich
IPC分类号： C12M1/34
CPC分类号： C12Q1/22 , A61L2/28 , G01N31/226
摘要： Sterilization indicator test packs for testing the effectiveness of a sterilization procedure are provided. Both non-challenge and challenge-type test packs are disclosed. The non-challenge test packs include generally comprise a tray for holding a sterilization indicator the tray containing an elevated rim surface defining the perimeter of the tray and a recessed trough for receiving a sterilization indicator. The rim surface includes a plurality of spaced-apart grooves along its length extending through the rim to the recessed trough; a sterilization indicator within the recessed trough of the tray; and a lid that forms a plurality of channels with the grooves in the tray such that sterilant can enter the tray through the channels and contact the sterilization indicator.The challenge-type test packs generally include a tray for holding a sterilization indicator, the tray comprising a substantially planar surface, a recessed trough for receiving a sterilization indicator, and a recessed groove of a defined length and cross-sectional area extending through the recessed trough and penetrating the edge of the tray; a sterilization indicator within the recessed trough of the tray; and a lid forming a substantially sterilant-impermeable seal with the planar surface of the tray and forming a lumen path with the recessed groove in the tray.

2. 发明授权

US08980622B2 Biological sterilization indicator and method of using same 有权
标题翻译：生物灭菌指标及其使用方法
公开(公告)号：US08980622B2
公开(公告)日：2015-03-17
申请号：US13384886
申请日：2010-07-06
申请人： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati
发明人： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati
IPC分类号： C12M1/34 , A61L2/28 , C12Q1/22
CPC分类号： C12Q1/22 , A61L2/28
摘要： A biological sterilization indicator (BI) and a method of using same for assaying the lethality of a sterilization process. The BI can include a housing, which can include a first portion, and a second portion, which can be movable with respect to the first portion between a first and second position. The BI can further include a frangible container comprising a liquid. The BI can further include a spore reservoir and a projection positioned in the housing. The projection can be configured to fracture the container when the second portion of the housing is moved from the first position to the second position. The method can include maintaining a minimal cross-sectional area of space around the container when the second portion of the housing is in the first position, and fracturing the container in response to moving the second portion between the first and second positions.
摘要翻译：生物灭菌指示剂（BI）及其用于测定灭菌过程的致死性的方法。 BI可以包括可以包括第一部分的壳体和可以在第一和第二位置之间相对于第一部分移动的第二部分。 BI可进一步包括包含液体的易碎容器。 BI还可以包括孢子贮存器和位于壳体中的突起。当壳体的第二部分从第一位置移动到第二位置时，突起可被构造成使容器破裂。该方法可以包括当壳体的第二部分处于第一位置时保持围绕容器的最小的空间横截面面积，并响应于在第一和第二位置之间移动第二部分而破裂容器。

3. 发明授权

US08647574B2 Sample preparation container and method 有权
标题翻译：样品制备容器和方法
公开(公告)号：US08647574B2
公开(公告)日：2014-02-11
申请号：US12743252
申请日：2008-11-19
申请人： Kurt J. Halverson , Stephen C. P. Joseph , Raj Rajagopal , David J. Velasquez , Cynthia D. Zook , Sailaja Chandrapati , Daniel E. Siltberg , Paul J. Cobian , Theresa J. Gerten
发明人： Kurt J. Halverson , Stephen C. P. Joseph , Raj Rajagopal , David J. Velasquez , Cynthia D. Zook , Sailaja Chandrapati , Daniel E. Siltberg , Paul J. Cobian , Theresa J. Gerten
IPC分类号： G01N15/06
CPC分类号： G01N1/38 , G01N1/4077 , G01N2001/4088
摘要： A system and method for preparing and collecting samples for analyte testing. The system can include a sample preparation system and a sample collection system coupled to the sample preparation system. The sample preparation system can include at least one of a deformable self-supporting receptacle comprising a reservoir and a freestanding receptacle comprising a reservoir. The reservoir can be adapted to contain a liquid composition. The sample collection system can be positioned in fluid communication with a reservoir of the sample preparation system, and can be adapted to capture an analyte of interest. The method can include providing a fluid path defined at least partially by the sample preparation system and the sample collection system, positioning the liquid composition in a reservoir of the sample preparation system, and moving at least a portion of the liquid composition in the fluid path to the sample collection system.
摘要翻译：用于制备和收集样品用于分析物测试的系统和方法。该系统可以包括与样品制备系统耦合的样品制备系统和样品收集系统。样品制备系统可以包括可变形的自支撑容器中的至少一个，其包括储存器和包括储存器的独立容器。储存器可以适于容纳液体组合物。样品收集系统可以定位成与样品制备系统的储存器流体连通，并且可以适于捕获感兴趣的分析物。该方法可以包括提供至少部分地由样品制备系统和样品收集系统限定的流体路径，将液体组合物定位在样品制备系统的储存器中，并且将至少一部分液体组合物移动到流体路径到采样系统。

4. 发明申请

US20110182770A1 BIOLOGICAL STERILIZATION INDICATOR, SYSTEM, AND METHODS OF USING SAME 有权
标题翻译：生物灭菌指示剂，系统和使用方法
公开(公告)号：US20110182770A1
公开(公告)日：2011-07-28
申请号：US13063945
申请日：2009-10-12
申请人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
发明人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
IPC分类号： A61L2/18
CPC分类号： A61L2/28 , C12Q1/22
摘要： A biological sterilization indicator, system, and methods of determining the effectiveness of a sterilization process. The biological sterilization indicator can include a locus of spores, a reservoir containing a liquid, and a sterilant path positioned to provide fluid communication between ambience and the locus of spores. The reservoir can have a closed state in which the reservoir is not in fluid communication with the locus of spores and an open state in which the reservoir is in fluid communication with the locus of spores. The biological sterilization indicator system can include the biological sterilization indicator and a detection device adapted to be coupled to the biological sterilization indicator. In some embodiments, the method can include assaying the spores for a detectable change in a characteristic, and detecting substantially all of the detectable change.
摘要翻译：一种生物灭菌指标，系统和确定灭菌过程有效性的方法。生物灭菌指示剂可以包括孢子的位点，含有液体的储存器和定位成在气氛和孢子的位置之间提供流体连通的消毒剂通道。储存器可以具有闭合状态，其中储存器不与孢子的轨迹流体连通，并且储存器与孢子的轨迹流体连通的打开状态。生物灭菌指示器系统可以包括生物灭菌指示器和适于联接到生物灭菌指示器的检测装置。在一些实施方案中，该方法可以包括测定孢子以获得特征的可检测变化，并且检测基本上所有可检测的变化。

5. 发明申请

US20130224849A1 BIOLOGICAL STERILIZATION INDICATOR 有权
标题翻译：生物灭菌指标
公开(公告)号：US20130224849A1
公开(公告)日：2013-08-29
申请号：US13881741
申请日：2011-10-28
申请人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Jeffrey D. Smith , RuthAnn R. Duda , Brian J. Engel
发明人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Jeffrey D. Smith , RuthAnn R. Duda , Brian J. Engel
IPC分类号： C12Q1/22
CPC分类号： C12M37/06 , C12M23/32 , C12M25/06 , C12Q1/04 , C12Q1/22 , G01N21/6486
摘要： A biological sterilization indicator (BI). The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a substrate positioned in the housing between the first chamber and the second chamber. The substrate can be positioned in fluid communication with the first chamber and the second chamber, and the substrate can be further positioned such that the substrate is not in direct contact with the source of biological activity.
摘要翻译：生物灭菌指示剂（BI）。 BI可以包括壳体和位于壳体中的容器。容器可以容纳液体，容器的至少一部分可以是易碎的。 BI还可以包括第一室和第二室。第二室可以包括至少一种生物活性来源。 BI还可以包括位于第一室和第二室之间的壳体中的衬底。衬底可以定位成与第一腔室和第二腔室流体连通，并且衬底可以进一步定位成使得衬底不与生物活性源直接接触。

6. 发明申请

US20130217107A1 BIOLOGICAL STERILIZATION INDICATOR SYSTEM AND METHOD 有权
标题翻译：生物灭菌指标体系及方法
公开(公告)号：US20130217107A1
公开(公告)日：2013-08-22
申请号：US13821647
申请日：2011-10-28
申请人： Jeffrey C. Pederson , Sailaja Chandrapati , Bryan S. Behun , Barry W. Robole , Leroy J. Longworth , Kaileen Chen
发明人： Jeffrey C. Pederson , Sailaja Chandrapati , Bryan S. Behun , Barry W. Robole , Leroy J. Longworth , Kaileen Chen
IPC分类号： C12Q1/22
CPC分类号： C12Q1/22 , A61L2/28
摘要： A biological sterilization indicator (BI) system and method. The system can include a BI and a reading apparatus comprising a well. The BI can include a housing, which can include a first portion, and a second portion movable between a first “unactivated” position and a second “activated” position. The reading apparatus can detect at least one of (i) when the well is empty; (ii) when the biological sterilization indicator is positioned in the well with the second portion of the housing in the first position, and (iii) when the biological sterilization indicator is positioned in the well with the second portion of the housing in the second position. The method can include detecting at least one of the above conditions, which can be used to detect an activation status of the biological sterilization indicator.
摘要翻译：一种生物灭菌指标（BI）系统及方法。该系统可以包括BI和包括井的读取装置。 BI可以包括壳体，其可以包括第一部分，以及可在第一“未激活”位置和第二“激活”位置之间移动的第二部分。读取装置可以检测（i）当井是空的时候的至少一个; （ii）当所述生物灭菌指示器位于所述井中时，所述壳体的第二部分位于所述第一位置，以及（iii）当所述生物灭菌指示器位于所述井中时，所述壳体的第二部分处于所述第二位置。该方法可以包括检测可用于检测生物灭菌指示剂的活化状态的上述条件中的至少一个。

7. 发明申请

US20130210069A1 BIOLOGICAL STERILIZATION INDICATOR SYSTEM AND METHOD 有权
标题翻译：生物灭菌指标体系及方法
公开(公告)号：US20130210069A1
公开(公告)日：2013-08-15
申请号：US13881065
申请日：2011-10-28
申请人： Jeffrey C. Pederson , Sailaja Chandrapati , Bryan S. Behun , Barry W. Robole , Leroy J. Longworth
发明人： Jeffrey C. Pederson , Sailaja Chandrapati , Bryan S. Behun , Barry W. Robole , Leroy J. Longworth
IPC分类号： C12Q1/02
CPC分类号： C12Q1/025 , A61L2/28 , C12Q1/22
摘要： A biological sterilization indicator (BI) system and method. The system can include a BI and a reading apparatus comprising a well. The BI can include a housing, which can include a first portion, and a second portion movable between a first “unactivated” position and a second “activated” position. The BI can further include a frangible container containing a liquid and dimensioned to be positioned in the housing. The reading apparatus can be configured to detect activation of the biological sterilization indicator, for example, by detecting that the second portion is in the second position, and/or by detecting that the liquid from the frangible container is present in a specific chamber of the biological sterilization indicator. The method can include positioning the BI in the well of the reading apparatus and detecting activation, for example, by detecting one or more of the above conditions.
摘要翻译：一种生物灭菌指标（BI）系统及方法。该系统可以包括BI和包括井的读取装置。 BI可以包括壳体，其可以包括第一部分，以及可在第一“未激活”位置和第二“激活”位置之间移动的第二部分。 BI还可以包括容纳液体并且尺寸设置在壳体中的易碎容器。读取装置可以被配置为检测生物灭菌指示器的激活，例如通过检测第二部分处于第二位置，和/或通过检测来自易碎容器的液体存在于生物灭菌指标。该方法可以包括将BI定位在读取装置的阱中并检测激活，例如通过检测上述一个或多个条件。

8. 发明申请

US20120149094A1 Biological Sterilization Indicator and Method of Using Same 有权
标题翻译：生物灭菌指标及其使用方法
公开(公告)号：US20120149094A1
公开(公告)日：2012-06-14
申请号：US13384886
申请日：2010-07-06
申请人： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati
发明人： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati
IPC分类号： C12M1/34 , C12M1/40
CPC分类号： C12Q1/22 , A61L2/28
摘要： A biological sterilization indicator (BI) and a method of using same for assaying the lethality of a sterilization process. The BI can include a housing, which can include a first portion, and a second portion, which can be movable with respect to the first portion between a first and second position. The BI can further include a frangible container comprising a liquid. The BI can further include a spore reservoir and a projection positioned in the housing. The projection can be configured to fracture the container when the second portion of the housing is moved from the first position to the second position. The method can include maintaining a minimal cross-sectional area of space around the container when the second portion of the housing is in the first position, and fracturing the container in response to moving the second portion between the first and second positions.
摘要翻译：生物灭菌指示剂（BI）及其用于测定灭菌过程的致死性的方法。 BI可以包括可以包括第一部分的壳体和可以在第一和第二位置之间相对于第一部分移动的第二部分。 BI可进一步包括包含液体的易碎容器。 BI还可以包括孢子贮存器和位于壳体中的突起。当壳体的第二部分从第一位置移动到第二位置时，突出部可以构造成使容器破裂。该方法可以包括当壳体的第二部分处于第一位置时保持围绕容器的最小的空间横截面面积，并且响应于在第一和第二位置之间移动第二部分来压裂容器。

9. 发明申请

US20100248215A1 SAMPLE PREPARATION CONTAINER AND METHOD 有权
标题翻译：样品制备容器和方法
公开(公告)号：US20100248215A1
公开(公告)日：2010-09-30
申请号：US12743449
申请日：2008-11-19
申请人： Kurt J. Halverson , Stephen C.P. Joseph , Raj Rajagopal , Matthew D. Reier , David J. Velasquez , Cynthia D. Zook , Sailaja Chandrapati
发明人： Kurt J. Halverson , Stephen C.P. Joseph , Raj Rajagopal , Matthew D. Reier , David J. Velasquez , Cynthia D. Zook , Sailaja Chandrapati
IPC分类号： C12M1/34 , C12N1/00 , C12N7/00 , G01N33/53 , C12Q1/70 , C12Q1/02 , G01N27/26 , C12Q1/68
CPC分类号： G01N1/38
摘要： A system and method for preparing and delivering samples for analyte testing. The system can include a sample preparation system and a sample delivery system coupled to the sample preparation system. The sample preparation system can include a deformable self-supporting receptacle comprising a reservoir adapted to contain a liquid composition comprising a source and a diluent. The sample delivery system can include a valve positioned in fluid communication with the reservoir and adapted to control the removal of a sample from the sample preparation system. The method can include applying pressure to the deformable self-supporting receptacle to remove a sample from the sample preparation system via the sample delivery system.
摘要翻译：用于制备和递送样品以进行分析物测试的系统和方法。该系统可以包括与样品制备系统耦合的样品制备系统和样品递送系统。样品制备系统可以包括可变形的自支撑容器，其包括适于容纳包含源和稀释剂的液体组合物的储存器。样品输送系统可以包括定位成与储存器流体连通的阀，并适于控制样品从样品制备系统中的去除。该方法可以包括向可变形的自支撑容器施加压力，以经由样品输送系统从样品制备系统移除样品。

10. 发明授权

US09410180B2 Biological sterilization indicator system and method 有权
标题翻译：生物灭菌指标体系及方法
公开(公告)号：US09410180B2
公开(公告)日：2016-08-09
申请号：US13821647
申请日：2011-10-28
申请人： Jeffrey C. Pederson , Sailaja Chandrapati , Bryan S. Behun , Barry W. Robole , Leroy J. Longworth , Kaileen Chen
发明人： Jeffrey C. Pederson , Sailaja Chandrapati , Bryan S. Behun , Barry W. Robole , Leroy J. Longworth , Kaileen Chen
IPC分类号： C12Q1/00 , C12M1/00 , C12Q1/22 , A61L2/28
CPC分类号： C12Q1/22 , A61L2/28
摘要： A biological sterilization indicator (BI) system and method. The system can include a BI and a reading apparatus comprising a well. The BI can include a housing, which can include a first portion, and a second portion movable between a first “unactivated” position and a second “activated” position. The reading apparatus can detect at least one of (i) when the well is empty; (ii) when the biological sterilization indicator is positioned in the well with the second portion of the housing in the first position, and (iii) when the biological sterilization indicator is positioned in the well with the second portion of the housing in the second position. The method can include detecting at least one of the above conditions, which can be used to detect an activation status of the biological sterilization indicator.
摘要翻译：一种生物灭菌指标（BI）系统及方法。该系统可以包括BI和包括井的读取装置。 BI可以包括壳体，其可以包括第一部分，以及可在第一“未激活”位置和第二“激活”位置之间移动的第二部分。读取装置可以检测（i）当井是空的时候的至少一个; （ii）当生物灭菌指示器位于井中时，壳体的第二部分处于第一位置，以及（iii）当生物灭菌指示器位于井中时，壳体的第二部分位于第二位置。该方法可以包括检测可用于检测生物灭菌指示剂的活化状态的上述条件中的至少一个。

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