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1. 发明授权

US09329132B2 Method to increase the number of detectable photons during the imaging of a biological marker 有权
标题翻译：在生物标记成像过程中增加可检测光子数量的方法
公开(公告)号：US09329132B2
公开(公告)日：2016-05-03
申请号：US13637551
申请日：2011-03-25
申请人： Kelly Rogers , Spencer Shorte , Joseph Dragavon , Samantha Blazquez
发明人： Kelly Rogers , Spencer Shorte , Joseph Dragavon , Samantha Blazquez
IPC分类号： G01N21/64 , B82Y15/00
CPC分类号： G01N21/6486 , B82Y15/00 , G01N21/6428 , G01N2201/06193
摘要： The present invention relates a method to determine the presence of a photon producing biological marker in a cell, tissue or organism of interest. The method is based on Fluorescence by Unbound Excitation from Luminescence (FUEL) and comprises the steps of a) providing conditions suitable for the biological marker to produce at least one first photon by luminescence; b) providing a FUEL probe pair-upper (FPP-U) disposed in proximity to the cell, tissue or organism, wherein the at least one first photon of step a) excites the FPP-U, which emits at least one second photon. The FPP-U may be selected from the group of quantum dots, carbon nanotubes, fluorescent proteins, diamond nanocrystals and metalloporphyrins. This method is characterized in that said biological marker and said FPP-U are not bound and in that each of the at least one second photon(s) are of a longer wavelength than each of the at least one first photon(s).
摘要翻译：本发明涉及确定感兴趣的细胞，组织或生物体中产生光子的生物标志物的存在的方法。该方法基于通过未发光发光（FUEL）的荧光，并且包括以下步骤：a）提供适于生物标记物的条件以通过发光产生至少一个第一光子; b）提供设置在细胞，组织或生物体附近的FUEL探针对上（FPP-U），其中步骤a）的至少一个第一光子激发FPP-U，其发射至少一个第二光子。 FPP-U可以选自量子点，碳纳米管，荧光蛋白，金刚石纳米晶体和金属卟啉。该方法的特征在于所述生物学标记和所述FPP-U不是结合的，并且所述至少一个第二光子中的每一个具有比所述至少一个第一光子中的每一个更长的波长。

2. 发明申请

US20130115647A1 Method to Increase the Number of Detectable Photons During the Imaging of a Biological Marker 有权
标题翻译：在生物标记成像期间增加可检测光子数量的方法
公开(公告)号：US20130115647A1
公开(公告)日：2013-05-09
申请号：US13637551
申请日：2011-03-25
申请人： Kelly Rogers , Spencer Shorte , Joseph Dragavon , Samantha Blazquez
发明人： Kelly Rogers , Spencer Shorte , Joseph Dragavon , Samantha Blazquez
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , B82Y15/00 , G01N21/6428 , G01N2201/06193
摘要： The present invention relates a method to determine the presence of a photon producing biological marker in a cell, tissue or organism of interest. The method is based on Fluorescence by Unbound Excitation from Luminescence (FUEL) and comprises the steps of a) providing conditions suitable for the biological marker to produce at least one first photon by luminescence; b) providing a FUEL probe pair-upper (FPP-U) disposed in proximity to the cell, tissue or organism, wherein the at least one first photon of step a) excites the FPP-U, which emits at least one second photon. The FPP-U may be selected from the group of quantum dots, carbon nanotubes, fluorescent proteins, diamond nanocrystals and metalloporphyrins. This method is charcterized in that said biological marker and said FPP-U are not bound and in that each of the at least one second photon(s) are of a longer wavelength than each of the at least one first photon(s).
摘要翻译：本发明涉及确定感兴趣的细胞，组织或生物体中产生光子的生物标志物的存在的方法。该方法基于通过未发光发光（FUEL）的荧光，并且包括以下步骤：a）提供适于生物标记物的条件以通过发光产生至少一个第一光子; b）提供设置在细胞，组织或生物体附近的FUEL探针对上（FPP-U），其中步骤a）的至少一个第一光子激发FPP-U，其发射至少一个第二光子。 FPP-U可以选自量子点，碳纳米管，荧光蛋白，金刚石纳米晶体和金属卟啉。该方法的特征在于所述生物标记和所述FPP-U不结合，并且所述至少一个第二光子中的每一个具有比所述至少一个第一光子中的每一个更长的波长。

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