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1. 发明申请

US20110097678A1 Method of heating and heating apparatus 审中-公开
标题翻译：加热和加热装置的方法
公开(公告)号：US20110097678A1
公开(公告)日：2011-04-28
申请号：US12924808
申请日：2010-10-05
申请人： Keith D. Patch , Linda A. Tempelman , Simon G. Stone , Craig Thompson
发明人： Keith D. Patch , Linda A. Tempelman , Simon G. Stone , Craig Thompson
IPC分类号： F24C15/00
CPC分类号： F23C13/08 , A61F7/12 , A61F2007/126 , A61M5/44 , A61M2205/364 , F23D91/04
摘要： Method of heating and heating apparatus. According to one embodiment, the heating apparatus is designed for warming infusion fluids and includes a pair of catalytic heaters positioned around a cartridge containing the infusion fluid. Each catalytic heater includes a pair of frames jointly defining a cavity. One of the frames per heater is positioned proximate to the cartridge and includes an input port for receiving a liquid solution of methanol. The other frame per heater is positioned distal to the cartridge and includes an input port for receiving oxygen gas and an output port for exhaust gases. A first fluid diffusion medium is positioned within the methanol frame, and a second fluid diffusion medium is positioned within the oxygen frame. Sandwiched between the two diffusion media are a pervaporation membrane facing the first diffusion medium and a porous metal catalyst facing the second diffusion medium. Methanol in liquid form is supplied to the pervaporation membrane, which then transports the methanol in vapor form to the catalyst, where combustion occurs. Heat from the combustion reaction is then conducted through the heater to the cartridge containing the infusion fluid.
摘要翻译：加热和加热装置的方法根据一个实施例，加热装置被设计用于加温输液，并且包括位于围绕包含输注液体的药筒的一对催化加热器。每个催化加热器包括共同限定空腔的一对框架。每个加热器的框架中的一个定位成靠近墨盒，并且包括用于接收甲醇液体溶液的输入端口。每个加热器的另一个框架位于盒的远侧，并且包括用于接收氧气的输入端口和用于废气的输出端口。第一流体扩散介质位于甲醇框架内，第二流体扩散介质位于氧气框架内。在两个扩散介质之间夹有面向第一扩散介质的渗透蒸发膜和面向第二扩散介质的多孔金属催化剂。将液体形式的甲醇供应到渗透蒸发膜，然后将蒸气形式的甲醇输送到发生燃烧的催化剂中。然后将来自燃烧反应的热量通过加热器传导到含有输注流体的药筒。

2. 发明申请

US20120178150A1 SYSTEM FOR FLUID PERFUSION OF BIOLOGICAL MATTER COMPRISING TISSUE 有权
标题翻译：包含组织的生物物质的流体灌注系统
公开(公告)号：US20120178150A1
公开(公告)日：2012-07-12
申请号：US13341565
申请日：2011-12-30
申请人： Linda A. Tempelman , Simon G. Stone
发明人： Linda A. Tempelman , Simon G. Stone
IPC分类号： C12M1/04 , C12M1/38
CPC分类号： A01N1/0226 , A01N1/0247
摘要： System for fluid perfusion of biological matter that includes tissue. According to one embodiment, the system may include a storage container for storing the biological matter, a thermal control device for cooling the contents of the storage container, a gas generator for generating a preserving gas, a fluid conduit coupled to the gas generator and insertable into tissue for delivering the preserving gas to the biological matter, and a process controller for controlling the operation of the gas generator and the thermal control device. The gas generator, in turn, may include an electrochemical oxygen concentrator and/or a water electrolyzer for generating the preserving gas. The system may further include a liquid perfusion system that includes a reservoir of liquid perfusate, a fluid delivery conduit for delivering liquid perfusate from the reservoir to the biological matter, and a fluid draining conduit for draining liquid perfusate from the biological matter.
摘要翻译：包括组织在内的生物物质的流体灌注系统。根据一个实施例，系统可以包括用于存储生物物质的存储容器，用于冷却存储容器的内容物的热控制装置，用于产生保存气体的气体发生器，连接到气体发生器的流体导管和可插入的用于将保存气体输送到生物物质的组织中，以及用于控制气体发生器和热控制装置的操作的过程控制器。气体发生器又可以包括用于产生保存气体的电化学氧浓缩器和/或水电解器。该系统还可以包括液体灌注系统，其包括液体灌注液的储存器，用于将液体灌注液从储存器输送到生物物质的流体输送管道，以及用于从生物物质排出液体灌注液的流体排放导管。

3. 发明授权

US10091985B2 Perfusing an organ with an in situ generated gas 有权
公开(公告)号：US10091985B2
公开(公告)日：2018-10-09
申请号：US12803083
申请日：2010-06-18
申请人： Linda A. Tempelman , Klearchos K. Papas , Simon G. Stone , William Earl Scott, III , Thomas M. Suszynski , Shuichiro Matsumoto , Joana Ferrer Fabrega , Michael D. Rizzari
发明人： Linda A. Tempelman , Klearchos K. Papas , Simon G. Stone , William Earl Scott, III , Thomas M. Suszynski , Shuichiro Matsumoto , Joana Ferrer Fabrega , Michael D. Rizzari
IPC分类号： A01N1/02
摘要： Method and system for organ preservation. According to one aspect, an organ may be preserved by being perfused with an in situ generated preserving gas. The organ may be, for example, a human or porcine pancreas, and perfusion of the pancreas may be anterograde, retrograde, ductal, anterograde/ductal, or retrograde/ductal. The preserving gas used to perfuse the organ may be dissolved in a liquid and then administered to the organ as a gas/liquid solution or may be mixed with one or more other gases and then administered to the organ as a gas/gas mixture. The preserving gas may be, for example, oxygen gas generated in situ using an electrochemical oxygen concentrator. According to another aspect, an organ preservation system may include an electrochemical oxygen concentrator having a water vapor feed, as well as auxiliary equipment to control and measure delivery pressure, flow, temperature and humidity.

4. 发明授权

US09357764B2 System for fluid perfusion of biological matter comprising tissue 有权
标题翻译：包含组织的生物物质的流体灌注系统
公开(公告)号：US09357764B2
公开(公告)日：2016-06-07
申请号：US13341565
申请日：2011-12-30
申请人： Linda A. Tempelman , Simon G. Stone
发明人： Linda A. Tempelman , Simon G. Stone
IPC分类号： A01N1/00 , A01N1/02 , C12M1/36 , C12M1/38 , C12M3/00 , C12M1/00
CPC分类号： A01N1/0226 , A01N1/0247
摘要： System for fluid perfusion of biological matter that includes tissue. According to one embodiment, the system may include a storage container for storing the biological matter, a thermal control device for cooling the contents of the storage container, a gas generator for generating a preserving gas, a fluid conduit coupled to the gas generator and insertable into tissue for delivering the preserving gas to the biological matter, and a process controller for controlling the operation of the gas generator and the thermal control device. The gas generator, in turn, may include an electrochemical oxygen concentrator and/or a water electrolyzer for generating the preserving gas. The system may further include a liquid perfusion system that includes a reservoir of liquid perfusate, a fluid delivery conduit for delivering liquid perfusate from the reservoir to the biological matter, and a fluid draining conduit for draining liquid perfusate from the biological matter.
摘要翻译：包括组织在内的生物物质的流体灌注系统。根据一个实施例，系统可以包括用于存储生物物质的存储容器，用于冷却存储容器的内容物的热控制装置，用于产生保存气体的气体发生器，连接到气体发生器的流体导管和可插入的用于将保存气体输送到生物物质的组织中，以及用于控制气体发生器和热控制装置的操作的过程控制器。气体发生器又可以包括用于产生保存气体的电化学氧浓缩器和/或水电解器。该系统可以进一步包括液体灌注系统，其包括液体灌注液的储存器，用于将液体灌注液从储存器输送到生物物质的流体输送管道，以及用于从生物物质排出液体灌注液的流体排放导管。

5. 发明申请

US20100330547A1 Perfusing an organ with an in situ generated gas 审中-公开
标题翻译：用原位产生的气体灌注器官
公开(公告)号：US20100330547A1
公开(公告)日：2010-12-30
申请号：US12803083
申请日：2010-06-18
申请人： Linda A. Tempelman , Klearchos K. Papas , Simon G. Stone , William Earl Scott, III , Thomas M. Suszynski , Shuichiro Matsumoto , Joana Ferrer Fabrega , Michael D. Rizzari
发明人： Linda A. Tempelman , Klearchos K. Papas , Simon G. Stone , William Earl Scott, III , Thomas M. Suszynski , Shuichiro Matsumoto , Joana Ferrer Fabrega , Michael D. Rizzari
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/0226
摘要： Method and system for organ preservation. According to one aspect, an organ may be preserved by being perfused with an in situ generated preserving gas. The organ may be, for example, a human or porcine pancreas, and perfusion of the pancreas may be anterograde, retrograde, ductal, anterograde/ductal, or retrograde/ductal. The preserving gas used to perfuse the organ may be dissolved in a liquid and then administered to the organ as a gas/liquid solution or may be mixed with one or more other gases and then administered to the organ as a gas/gas mixture. The preserving gas may be, for example, oxygen gas generated in situ using an electrochemical oxygen concentrator. According to another aspect, an organ preservation system may include an electrochemical oxygen concentrator having a water vapor feed, as well as auxiliary equipment to control and measure delivery pressure, flow, temperature and humidity.
摘要翻译：器官保存方法与系统根据一个方面，可以通过用原位产生的保存气体灌注来保存器官。器官可以是例如人或猪胰腺，并且胰腺的灌注可以是前列腺，逆行，导管，前列腺/导管或逆行/导管。用于灌注器官的保存气体可以溶解在液体中，然后作为气体/液体溶液施用于器官，或者可以与一种或多种其它气体混合，然后作为气体/气体混合物施用于器官。保存气体可以是例如使用电化学氧浓缩器原位产生的氧气。根据另一方面，器官保存系统可以包括具有水蒸汽进料的电化学氧浓缩器，以及用于控制和测量输送压力，流量，温度和湿度的辅助设备。

6. 发明申请

US20090045073A1 Electrolysis cell comprising sulfur dioxide-depolarized anode and method of using the same in hydrogen generation 审中-公开
标题翻译：包含二氧化硫去极化阳极的电解槽及其在氢气生成中的使用方法
公开(公告)号：US20090045073A1
公开(公告)日：2009-02-19
申请号：US12221301
申请日：2008-08-01
申请人： Simon G. Stone , Lawrence J. Gestaut
发明人： Simon G. Stone , Lawrence J. Gestaut
IPC分类号： C25B1/02
CPC分类号： C25B1/02 , C25B1/22 , Y02E60/366
摘要： Electrolysis cell and method of using the same in hydrogen generation. According to one embodiment, the electrolysis cell includes a frame having an interior. A proton exchange membrane (PEM) is disposed within the frame to divide the interior into two chambers. An anode in the form of a gas diffusion electrode is disposed within the interior of the frame and is spaced apart from the PEM, the space between the anode and the PEM being filled with an aqueous sulfuric acid. A cathode is disposed within the interior of the frame and is ionically coupled to the PEM. In use, gaseous sulfur dioxide is delivered to the side of the anode facing away from the sulfuric acid solution, and a current is supplied to the electrolysis cell. Consequently, sulfur dioxide is oxidized at the anode, and molecular hydrogen is generated at the cathode.
摘要翻译：电解槽及其在氢气生成中的使用方法。根据一个实施例，电解池包括具有内部的框架。质子交换膜（PEM）设置在框架内以将内部分成两个室。气体扩散电极形式的阳极设置在框架的内部并与PEM间隔开，阳极和PEM之间的空间充满硫酸水溶液。阴极设置在框架的内部并且离子耦合到PEM。在使用中，气态二氧化硫被输送到阳极背离硫酸溶液的一侧，并且电流被提供给电解池。因此，二氧化硫在阳极被氧化，在阴极产生分子氢。

7. 发明授权

US06811905B1 Direct organic fuel cell having a vapor transport member 有权
标题翻译：具有蒸气输送构件的直接有机燃料电池
公开(公告)号：US06811905B1
公开(公告)日：2004-11-02
申请号：US10153065
申请日：2002-05-21
申请人： Cecelia C. Cropley , Simon G. Stone
发明人： Cecelia C. Cropley , Simon G. Stone
IPC分类号： H01M800
CPC分类号： H01M4/8605 , H01M4/90 , H01M4/9016 , H01M4/92 , H01M4/921 , H01M8/0258 , H01M8/0271 , H01M8/0297 , H01M8/04186 , H01M8/1004 , H01M8/1009 , H01M8/241
摘要： A fuel cell and method using the same. The fuel cell comprises a membrane electrode assembly, the membrane electrode assembly comprising a proton exchange membrane having a front face and a rear face. An anode is coupled to the front face of the proton exchange membrane, and a cathode is coupled to the rear face of the proton exchange membrane. A vapor diffusion chamber is positioned in the front of the anode, and a vapor transport member is positioned in front of the vapor diffusion chamber. The vapor transport member is substantially impermeable to an organic fuel/water mixture in a liquid phase but is permeable to the organic fuel/water mixture in a vapor phase. In operation, a liquid fuel mixture delivered to the vapor transport member evaporates from the vapor transport member and is delivered to the anode in vapor form.
摘要翻译：燃料电池及其使用方法。燃料电池包括膜电极组件，膜电极组件包括具有前表面和后表面的质子交换膜。阳极耦合到质子交换膜的前表面，并且阴极耦合到质子交换膜的后表面。蒸汽扩散室位于阳极的前部，蒸气传输构件位于蒸气扩散室的前面。蒸汽输送构件对于液相中的有机燃料/水混合物是基本上不可渗透的，但是在气相中可渗透有机燃料/水混合物。在操作中，输送到蒸汽输送构件的液体燃料混合物从蒸汽输送构件蒸发并以蒸气形式输送到阳极。

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