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1. 发明申请

US20090048436A1 Methods of synthesizing chemically cleavable phosphoramidite linkers 审中-公开
标题翻译：化学可裂解亚磷酰胺接头的合成方法
公开(公告)号：US20090048436A1
公开(公告)日：2009-02-19
申请号：US11893614
申请日：2007-08-15
申请人： Keith Anderson , Michael Jensen , Ronald W. Davis , Charles K. Brush , Kaizhang He
发明人： Keith Anderson , Michael Jensen , Ronald W. Davis , Charles K. Brush , Kaizhang He
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： The present invention provides a method of synthesizing phosphoramidite linkers that are useful for the production of synthesizing two or more oligonucleotides in tandem. The inventive linker has the following desirable properties: (i) enhanced stability to alkali conditions versus the linkers previously published, (ii) cleaves to produce 5′ and 3′ ends that are fully biologically compatible, (iii) cleaves completely under conditions that are already used in cleavage/deprotection processes so it is fully compatible with conditions that are common in laboratories and does not require additives that necessitate further purification after cleavage, (iv) integrates easily onto commercially available synthesizers because it is compatible with standard coupling chemistry, and (v) is compatible with DNA, RNA, forward, reverse, and LNA, synthesis chemistries. In addition, the inventive linkers may be coupled to a solid support. Thus, the inventive linkers provide a significant advancement in the state of the art.
摘要翻译：本发明提供了一种合成亚磷酰胺接头的方法，其可用于串联合成两种或多种寡核苷酸。本发明的接头具有以下所需的性质：（i）与先前公开的接头相比，提高了对碱性条件的稳定性，（ii）切割产生完全生物相容的5'和3'末端，（iii）在条件下完全切割已经用于裂解/去保护过程，因此它与实验室常见的条件完全相容，并且不需要在裂解后需要进一步纯化的添加剂，（iv）容易地与市售合成仪整合，因为它与标准偶联化学相容，并且（v）与DNA，RNA，正向，反向和LNA的合成化学物质相容。此外，本发明的接头可以连接到固体支持物。因此，本发明的接头提供了现有技术的显着进步。

2. 发明申请

US20090047712A1 Chemically cleavable phosphoramidite linkers 审中-公开
标题翻译：化学上可裂解的亚磷酰胺接头
公开(公告)号：US20090047712A1
公开(公告)日：2009-02-19
申请号：US11893596
申请日：2007-08-15
申请人： Keith Anderson , Michael Jensen , Ronald W. Davis
发明人： Keith Anderson , Michael Jensen , Ronald W. Davis
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C07H19/00 , C12P19/34
CPC分类号： C07H21/00 , C07H19/00 , C07H21/02 , C07H21/04 , C12P19/34
摘要： The present invention provides phosphoramidite linkers that are useful for the production of synthesizing two or more oligonucleotides in tandem. The inventive linkers have the following desirable properties: (i) enhanced stability to alkali conditions versus the linkers previously published, (ii) cleave to produce 5′ and 3′ ends that are fully biologically compatible, (iii) cleave completely under conditions that are already used in cleavage/deprotection processes so they are fully compatible with conditions that are common in laboratories and do not require additives that necessitate further purification after cleavage, (iv) integrate easily onto commercially available synthesizers because they are compatible with standard coupling chemistry, and (v) are compatible with DNA, RNA, forward, reverse, and synthesis chemistries. In addition, the inventive linkers may be coupled to a solid support. Thus, the inventive linkers provide a significant advancement in the state of the art.
摘要翻译：本发明提供了可用于串联合成两种或多种寡核苷酸的亚磷酰胺接头。本发明的接头具有以下所需的性质：（i）与先前公布的接头相比，提高了对碱性条件的稳定性，（ii）切割产生完全生物相容的5'和3'末端，（iii）在条件下完全切割已经用于裂解/去保护过程，因此它们与实验室常见的条件完全相容，并且不需要在裂解后需要进一步纯化的添加剂，（iv）容易地与市售的合成仪结合，因为它们与标准偶联化学相容，（v）与DNA，RNA，正向，反向和合成化学物质相容。此外，本发明的接头可以连接到固体支持物。因此，本发明的接头提供了现有技术的显着进步。

3. 发明授权

US11077236B2 Powered lavage handle and associated use therefore 有权
公开(公告)号：US11077236B2
公开(公告)日：2021-08-03
申请号：US14890528
申请日：2015-11-09
申请人： Daniel Glenn Doerr , Roland Strelitzki , Mohammed Ali Barakat , Keith Anderson , Gary Wayne Haberland , John A. Farnella , Kenneth M. Roger
发明人： Daniel Glenn Doerr , Roland Strelitzki , Mohammed Ali Barakat , Keith Anderson , Gary Wayne Haberland , John A. Farnella , Kenneth M. Roger
IPC分类号： A61M1/00 , A61M3/02
摘要： A lavage handle for facilitating at least one of an irrigation function and a suctioning function at a target zone preferably includes a portable body, a power-operated fluid-displacing mechanism in communication with said body wherein said fluid-displacing mechanism has one of a first operating mode for inducing outward irrigation of fluid towards the target zone and a second operating mode for inducing inward suction of fluid from the target zone. An actuation mechanism is located at said body and operable communicated with said fluid-displacing mechanism such that said fluid-displacing mechanism is selectively operated in at least one of said first operating mode and said second operating mode. The actuation mechanism may include an irrigation-inducing mechanism and/or a suction-inducing mechanism.

4. 发明申请

US20140073495A1 Cable Attachment For Exercise Machine 审中-公开
标题翻译：运动机电缆附件
公开(公告)号：US20140073495A1
公开(公告)日：2014-03-13
申请号：US13845016
申请日：2013-03-17
申请人： Keith Anderson , Karl Anderson
发明人： Keith Anderson , Karl Anderson
IPC分类号： A63B21/00 , F16G11/00
CPC分类号： F16G11/00 , A63B21/151 , A63B21/4035 , A63B21/4043 , F16G11/046 , F16G11/14 , Y10T24/3913 , Y10T24/3916
摘要： A cable attachment that permits the strap of an exercise machine to be replaced independently of the machine's handle without the need for sewing machines or special tools such as crimping devices comprises a body having three juncture points arranged in a generally triangular relationship, the first point being near its top to accommodate the body's attachment to the cable of the exercise machine, the other two juncture points lying below the first point and separated from each other by the center section of the body. The two lower junction points are configured to securely accommodate a removably-coupled handle-coupling strap, and are the locations to which the straps can be secured, preferably with a suitable knot. The two lower juncture points are configured to resist lateral slippage of the straps in order to laterally stabilize the load against which the user is working, and to accommodate knots having excellent holding strength.
摘要翻译：允许独立于机器手柄替换锻炼机的皮带的电缆附件，而不需要缝纫机或诸如压接装置的专用工具包括具有以大致三角关系布置的三个接合点的主体，第一点为靠近其顶部以适应身体与运动机的电缆的连接，另外两个接合点位于第一点下方并且通过身体的中心部分彼此分离。两个下连接点构造成可靠地容纳可拆卸地联接的手柄耦合带，并且是带可以固定的位置，优选地具有合适的结。两个下部接合点构造成抵抗带子的横向滑动，以横向稳定使用者正在加工的负载，并适应具有优良保持强度的结。

5. 发明申请

US20100264832A1 Improvements in or Relating to Lighting Control Systems 有权
标题翻译：照明控制系统的改进或相关
公开(公告)号：US20100264832A1
公开(公告)日：2010-10-21
申请号：US12738750
申请日：2008-04-22
申请人： Geoffrey Howard Gillet Archenhold , Keith Anderson
发明人： Geoffrey Howard Gillet Archenhold , Keith Anderson
IPC分类号： H05B37/02
CPC分类号： H05B33/0866
摘要： A system for controlling solid state lighting comprises a source (1) to supply any one of a range of AC or DC voltages to a plurality of light strings (3, 4, 5). The source (1) includes a power factor correction circuit 14 for controlling the power factor to the system and a separate transformer (15, 16, 17) for each light string (3, 4, 5). The current that can pass through each LED string (3, 4 and 5) is independently limited by each corresponding LED driver circuit (6, 19 and 20). The current through each LED string (3, 4 and 5) can be modified according to a feedback monitor system (18, 21 and 22) that measures parameters such as LED characteristics, forward current, temperature, and LED output intensity/colour. Each LED string (3, 4 and 5) has an independent sensor (7, 23 and 24) that monitors the voltage across each switching device in the corresponding LED driver circuits (6, 19 and 20) and utilises a control unit (8, 25 and 26) to control the voltages supplied by each corresponding transformer (15, 16 and 17) through control signals (2, 27 and 28) in response to the monitored switching device voltages.
摘要翻译：一种用于控制固态照明的系统，包括：向多个灯串（3,4,5）提供AC或DC电压范围中的任何一个的源（1）。源（1）包括用于控制系统的功率因数的功率因数校正电路14和用于每个灯串（3,4,5）的单独的变压器（15,16,17）。可以通过每个LED串（3,4和5）的电流由每个相应的LED驱动电路（6,19和20）独立地限制。可以根据测量诸如LED特性，正向电流，温度和LED输出强度/颜色等参数的反馈监视系统（18,21和22）来修改通过每个LED串（3,4和5）的电流。每个LED串（3,4和5）具有独立的传感器（7,23和24），用于监控相应的LED驱动电路（6,19和20）中每个开关装置的电压，并利用控制单元（8， 25和26），以响应于所监视的开关器件电压来控制由每个相应的变压器（15,16和17）提供的电压通过控制信号（2,27和28）。

6. 外观设计

USD603637S1 Rack for exercise equipment 有权
标题翻译：机架运动器材
公开(公告)号：USD603637S1
公开(公告)日：2009-11-10
申请号：US29281169
申请日：2007-06-15
申请人： Keith Anderson , Karl Anderson , Thomas W. Grace
设计人： Keith Anderson , Karl Anderson , Thomas W. Grace

7. 发明申请

US20070134688A1 CALCULATED INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER-RELATED GENES 审中-公开
标题翻译：雌激素受体（ER）和ER相关基因的基因表达的计算指数
公开(公告)号：US20070134688A1
公开(公告)日：2007-06-14
申请号：US11530785
申请日：2006-09-11
申请人： W. Fraser Symmans , Christos Hatzis , Keith Anderson , Lajos Pusztai
发明人： W. Fraser Symmans , Christos Hatzis , Keith Anderson , Lajos Pusztai
IPC分类号： C12Q1/68 , G01N33/574 , A61K31/56
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/6842 , G01N33/743 , G01N2333/723 , G01N2800/52 , G16B20/00 , G16B25/00
摘要： The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention may be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent or class of agents such as hormonal or endocrine treatment.
摘要翻译：本发明提供了在对给定治疗剂有反应的肿瘤中表达的基因的鉴定和组合，并且其组合表达可用作与对该治疗剂的反应性相关的指标。本发明的一个或多个基因可以用作标记物（或替代标记物），以鉴定可能被该试剂或一类试剂例如激素或内分泌治疗成功治疗的肿瘤。

8. 发明申请

US20070119862A1 UNIT DOSE FLEXIBLE CONTAINER 审中-公开
标题翻译：单位软管灵活容器
公开(公告)号：US20070119862A1
公开(公告)日：2007-05-31
申请号：US11562248
申请日：2006-11-21
申请人： Larry Backes , Keith Anderson
发明人： Larry Backes , Keith Anderson
IPC分类号： B65D35/22 , B65D35/00 , B65D47/10
CPC分类号： B65D75/30 , B65D1/095 , B65D75/58 , B65D75/5855 , B65D75/5866 , B65D81/3266
摘要： A pliable single use liquid container and dispensing device for delivery of a precise amount of orally administered liquids across a broad range of viscosities is provide with the container being formed of generally opposed pliable sheets, a first seal joining the first and second pliable sheets and partially defining a liquid-containing chamber, a second seal joining the first and second pliable sheets and partially defining a pressure relieving chamber adjacent to the liquid-containing chamber, a boundary seal joining the first and second pliable sheets between the liquid-containing chamber and the pressure relieving chamber, a precisely measured single dose volume of fluent liquid disposed within the liquid-containing chamber, the boundary seal being lighter than the first and second seals so that upon application of pressure to the liquid in the liquid-containing chamber the fluid transfer region seal opens to permit the liquid to flow from the liquid-containing chamber into the pressure relieving chamber, a sealed outlet adapted for fluid communication with the pressure relieving chamber for flow of the liquid from the pressure relieving chamber out of the liquid container and sized based on the viscosity of the liquid and the geometry of the dispensing device, the outlet seal adapted to open upon application of fluid pressure from liquid in the pressure relieving chamber for dispensing the liquid from the liquid container and prevent spilling and splashing of the liquid prior to delivery, control the delivery rate of the liquid to the recipient, and provide tactile force flow rate information feedback to the administrator.
摘要翻译：提供一种用于在宽范围的粘度下递送精确量的口服液体的柔韧的一次性液体容器和分配装置，容器由大致相对的柔韧片形成，第一密封接合第一和第二柔韧片，限定液体容纳室，第二密封件，其接合所述第一和第二柔性片材并且部分地限定邻近所述液体容纳室的减压室;边界密封件，将所述第一和第二柔性片材在所述液体容纳室和压力释放室，设置在液体容纳室内的精确测量的单剂量体积的流体液体，边界密封件比第一和第二密封件轻，使得当对液体容纳室中的液体施加压力时，流体转移区域密封件打开以允许液体从含液室流入pr 基部释放室，密封出口，适于与压力释放室流体连通，用于使液体从压力释放室流出液体容器，并基于液体的粘度和分配装置的几何尺寸来定尺寸，出口密封件适于在压力释放室中的液体施加流体压力时打开，用于从液体容器分配液体，并防止在输送之前液体溢出和飞溅，控制液体向接收器的传送速率，并提供触觉强制流量信息反馈给管理员。

9. 发明授权

US11420240B1 Pipe cleaning tool 有权
公开(公告)号：US11420240B1
公开(公告)日：2022-08-23
申请号：US17238274
申请日：2021-04-23
申请人： Keith Anderson
发明人： Keith Anderson
IPC分类号： B08B9/04 , F16L55/40 , F16L55/30 , B08B9/043 , F16L101/12
摘要： A pipe and hose cleaning tool is provided. The pipe and hose cleaning tool is especially useful in cleaning industrial pipes and hoses used in pouring, for example, concrete at construction sites. The pipe and hose cleaning tool has a durable and somewhat rigid rope, a handle and a cleaning assembly.

10. 发明授权

US09220619B2 Stent delivery system 有权
标题翻译：支架输送系统
公开(公告)号：US09220619B2
公开(公告)日：2015-12-29
申请号：US13240765
申请日：2011-09-22
申请人： Tim Ramos , Gerald Grabowski , Keith Anderson
发明人： Tim Ramos , Gerald Grabowski , Keith Anderson
IPC分类号： A61F2/06 , A61F2/966 , A61F2/95
CPC分类号： A61F2/966 , A61F2002/9517
摘要： A stent delivery system including a stent disposed between an inner member and a deployment sheath is disclosed. Additionally, the stent delivery system includes a handle that may be coupled to the inner member and to the deployment sheath. The handle may include an actuation member coupled to the gear rack assembly so that actuation of the actuation member shifts the longitudinal position of the gear rack assembly and the deployment sheath. The gear rack assembly may include an engagement mechanism that may be configured to engage the inner member so that proximal retraction of the gear rack assembly results in proximal retraction of the inner shaft.
摘要翻译：公开了一种支架输送系统，其包括设置在内部构件和展开护套之间的支架。此外，支架输送系统包括可以联接到内部构件和部署护套的手柄。手柄可以包括联接到齿条组件的致动构件，使得致动构件的致动使齿条组件和展开护套的纵向位置移动。齿条组件可以包括接合机构，该接合机构可被配置为接合内部构件，使得齿轮架组件的近侧收缩导致内部轴的近侧缩回。

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