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1. 发明申请

US20110151567A1 Recombinant Microorganism 有权
标题翻译：重组微生物
公开(公告)号：US20110151567A1
公开(公告)日：2011-06-23
申请号：US12530135
申请日：2008-04-08
申请人： Shenghao Liu , Keiji Endo , Katsutoshi Ara
发明人： Shenghao Liu , Keiji Endo , Katsutoshi Ara
IPC分类号： C12N15/87 , C12N1/21 , C12N9/50 , C12N9/42
CPC分类号： C12P21/02
摘要： A recombinant microorganism having improved productivity for a protein or a polypeptide, and a method for producing a protein or a polypeptide using the recombinant microorganism, are provided. A recombinant microorganism obtained by transfecting a gene for encoding a desired protein or polypeptide into a microorganism strain which is obtained by genetically constructing to overexpress secY gene of Bacillus subtilis or a gene corresponding to the secY gene, and deleting or inactivating one or more genes selected from sporulation-associated genes and genes corresponding to the sporulation-associated genes from the genome.
摘要翻译：提供了具有提高的蛋白质或多肽的生产力的重组微生物，以及使用该重组微生物生产蛋白质或多肽的方法。将通过将所需蛋白质或多肽编码的基因转染到通过遗传构建以过表达枯草芽孢杆菌的secY基因或相应于所述secY基因的基因而获得的微生物菌株获得的重组微生物，以及删除或灭活所选择的一种或多种基因来自与来自基因组的孢子形成相关基因相对应的孢子形成相关基因和基因。

2. 发明申请

US20100255534A1 Recombinant Microorganism 有权
标题翻译：重组微生物
公开(公告)号：US20100255534A1
公开(公告)日：2010-10-07
申请号：US12528039
申请日：2007-12-27
申请人： Keiji Endo , Katsutoshi Ara
发明人： Keiji Endo , Katsutoshi Ara
IPC分类号： C12P21/00 , C12N1/21
CPC分类号： C12N15/75 , C07K14/32 , C12P21/02
摘要： Provision of a recombinant microorganism which has increased productivity of a protein or polypeptide of interest and a method for producing a protein or polypeptide of interest using the recombinant microorganism. The recombinant microorganism is produced by transferring a gene encoding a protein or polypeptide of interest to a microorganism strain, wherein the microorganism strain is prepared by: introducing a transcription initiation regulatory region that functions in the microorganism or both the transcription initiation regulatory region and a ribosome-binding site that functions in the microorganism into the upstream of a Bacillus subtilis prsA gene or a gene corresponding thereto in the genome of a parental microorganism, or introducing a gene fragment prepared by ligating a transcription initiation regulatory region that functions in the microorganism or both the transcription initiation regulatory region and a ribosome-binding site that functions in the microorganism to the upstream of the Bacillus subtilis prsA gene or a gene corresponding thereto into the genome of a parental microorganism; and deleting or inactivating one or more genes selected from an abrB gene, a dltA gene, a dltB gene, a dltC gene, a dltD gene, a dltE gene, and a gene (genes) corresponding thereto.
摘要翻译：提供具有增加的目的蛋白质或多肽的生产力的重组微生物以及使用重组微生物产生感兴趣的蛋白质或多肽的方法。通过将编码目的蛋白质或多肽的基因转移到微生物菌株来产生重组微生物，其中微生物菌株通过以下方式制备：引入在微生物中起作用的转录起始调节区或转录起始调节区和核糖体在微生物中起作用的枯草芽孢杆菌prsA基因或与亲本微生物基因组相对应的基因的上游的引入位点，或引入通过连接在微生物中起作用的转录起始调节区或两者兼有的基因片段转录起始调节区和在微生物中起作用的枯草芽孢杆菌prsA基因上游的核糖体结合位点或与之相对应的基因转化为亲本微生物的基因组; 以及删除或失活一个或多个选自abrB基因，dltA基因，dltB基因，dltC基因，dltD基因，dltE基因和与其相对应的基因（基因）的基因。

3. 发明授权

US08389264B2 Recombinant microorganism that expresses a secY gene with deletion of sporulation-associated genes and method of producing thereof 有权
标题翻译：表达具有孢子形成相关基因缺失的secY基因的重组微生物及其制备方法
公开(公告)号：US08389264B2
公开(公告)日：2013-03-05
申请号：US12530135
申请日：2008-04-08
申请人： Shenghao Liu , Keiji Endo , Katsutoshi Ara
发明人： Shenghao Liu , Keiji Endo , Katsutoshi Ara
IPC分类号： C12N1/21
CPC分类号： C12P21/02
摘要： A recombinant microorganism having improved productivity for a protein or a polypeptide, and a method for producing a protein or a polypeptide using the recombinant microorganism, are provided.A recombinant microorganism obtained by transfecting a gene for encoding a desired protein or polypeptide into a microorganism strain which is obtained by genetically constructing to overexpress secY gene of Bacillus subtilis or a gene corresponding to the secY gene, and deleting or inactivating one or more genes selected from sporulation-associated genes and genes corresponding to the sporulation-associated genes from the genome.
摘要翻译：提供了具有提高的蛋白质或多肽的生产力的重组微生物，以及使用该重组微生物生产蛋白质或多肽的方法。将通过将所需蛋白质或多肽编码的基因转染到通过遗传构建以过表达枯草芽孢杆菌的secY基因或相应于所述secY基因的基因而获得的微生物菌株获得的重组微生物，以及删除或灭活所选择的一种或多种基因来自与来自基因组的孢子形成相关基因相对应的孢子形成相关基因和基因。

4. 发明授权

US08293516B2 Recombinant microorganism 有权
标题翻译：重组微生物
公开(公告)号：US08293516B2
公开(公告)日：2012-10-23
申请号：US12528039
申请日：2007-12-27
申请人： Keiji Endo , Katsutoshi Ara
发明人： Keiji Endo , Katsutoshi Ara
IPC分类号： C12N1/20 , C12P21/06
CPC分类号： C12N15/75 , C07K14/32 , C12P21/02
摘要： A recombinant microorganism is provided that has increased productivity of a protein or polypeptide of interest. A method for producing a protein of interest using the microorganism is also provided. The microorganism is prepared by inserting, in its genome, a transcription initiation regulatory region or both a transcription initiation regulatory region and a ribosome-binding site, upstream of a Bacillus subtilis prsA gene and by deleting or inactivating one or more of the abrB gene, dltA gene, dltB gene, dltC gene, dltD gene, dltE gene, or a gene (genes) corresponding thereto.
摘要翻译：提供了具有增加的感兴趣的蛋白质或多肽的生产力的重组微生物。还提供了使用该微生物生产感兴趣的蛋白质的方法。通过在其基因组中插入转录起始调节区或在枯草芽孢杆菌prsA基因的上游插入转录起始调节区和核糖体结合位点，以及通过缺失或失活一个或多个abrB基因， dltA基因，dltB基因，dltC基因，dltD基因，dltE基因或与其对应的基因（基因）。

5. 发明申请

US20090221055A1 Novel Bacillus Subtilis Mutant Strain 有权
标题翻译：新型枯草芽孢杆菌突变株
公开(公告)号：US20090221055A1
公开(公告)日：2009-09-03
申请号：US12083539
申请日：2006-09-25
申请人： Ryosuke Kadoya , Keiji Endo , Masatoshi Tohata , Katsutoshi Ara , Naotake Ogasawara
发明人： Ryosuke Kadoya , Keiji Endo , Masatoshi Tohata , Katsutoshi Ara , Naotake Ogasawara
IPC分类号： C12N1/21
CPC分类号： C12N15/75 , C12N9/2417 , C12N9/54 , C12P21/02
摘要： Novel Bacillus subtilis mutant strains having good productivity of various enzymes are provided through extensive analysis of strains that are derived from Bacillus subtilis via gene disruption. The Bacillus subtilis mutant strains according to the present invention have genomic structures prepared by deletion of regions listed in the columns for deficient regions. Each of these Bacillus subtilis mutant strains exerts significantly improved secretory productivity of a protein when a gene encoding such a secretory target protein is introduced so that it can be expressed, compared with a case in which the same gene is introduced into a wild-type strain.
摘要翻译：通过对通过基因破坏衍生自枯草芽孢杆菌的菌株的广泛分析，提供具有各种酶的良好生产力的新型枯草芽孢杆菌突变菌株。根据本发明的枯草芽孢杆菌突变菌株具有通过缺失缺陷区列中列出的区域而制备的基因组结构。当与将相同基因导入野生型菌株的情况相比，当引入编码这种分泌型靶蛋白的基因以使其能够被表达时，这些枯草芽孢杆菌突变菌株中的每一种都能显着提高蛋白质的分泌生产力。

6. 发明申请

US20090029417A1 Recombinant Microorganism 有权
标题翻译：重组微生物
公开(公告)号：US20090029417A1
公开(公告)日：2009-01-29
申请号：US12279271
申请日：2007-02-15
申请人： Keiji Endo , Shenghao Liu , Katsutoshi Ara
发明人： Keiji Endo , Shenghao Liu , Katsutoshi Ara
IPC分类号： C12P21/00 , C12N1/21
CPC分类号： C12N9/2437
摘要： The object of the invention is to provide a microorganism which enhances productivity of cellulase and is useful for industrial production of cellulase, and to provide a method for producing cellulase by use of the microorganism. The present invention provides a recombinant microorganism produced by transferring a gene encoding cellulase to a parental microorganism which has been genetically modified so as to overexpress a Bacillus subtilis secY gene or a gene corresponding thereto.
摘要翻译：本发明的目的是提供一种提高纤维素酶生产率并可用于纤维素酶的工业生产的微生物，并提供使用微生物生产纤维素酶的方法。本发明提供了一种通过将编码纤维素酶的基因转移到已被遗传修饰以使其过表达枯草芽孢杆菌SecY基因或相应基因的亲本微生物而产生的重组微生物。

7. 发明授权

US08460893B2 Recombinant microorganism expressing a secY gene and method of use thereof 有权
标题翻译：表达SecY基因的重组微生物及其使用方法
公开(公告)号：US08460893B2
公开(公告)日：2013-06-11
申请号：US12279271
申请日：2007-02-15
申请人： Keiji Endo , Shenghao Liu , Katsutoshi Ara
发明人： Keiji Endo , Shenghao Liu , Katsutoshi Ara
IPC分类号： C12Q1/34 , C12N1/21 , C12P21/00 , C12N15/00 , C12N9/42
CPC分类号： C12N9/2437
摘要： The object of the invention is to provide a microorganism which enhances productivity of cellulase and is useful for industrial production of cellulase, and to provide a method for producing cellulase by use of the microorganism. The present invention provides a recombinant microorganism produced by transferring a gene encoding cellulase to a parental microorganism which has been genetically modified so as to overexpress a Bacillus subtilis secY gene or a gene corresponding thereto.
摘要翻译：本发明的目的是提供一种提高纤维素酶生产率并可用于纤维素酶的工业生产的微生物，并提供使用微生物生产纤维素酶的方法。本发明提供了一种通过将编码纤维素酶的基因转移到已被遗传修饰以使其过表达枯草芽孢杆菌SecY基因或相应基因的亲本微生物而产生的重组微生物。

8. 发明授权

US07981659B2 Bacillus subtilis mutant strain 有权
标题翻译：枯草芽孢杆菌突变菌株
公开(公告)号：US07981659B2
公开(公告)日：2011-07-19
申请号：US12083539
申请日：2006-09-25
申请人： Ryosuke Kadoya , Keiji Endo , Masatoshi Tohata , Katsutoshi Ara , Naotake Ogasawara
发明人： Ryosuke Kadoya , Keiji Endo , Masatoshi Tohata , Katsutoshi Ara , Naotake Ogasawara
IPC分类号： C12N1/20
CPC分类号： C12N15/75 , C12N9/2417 , C12N9/54 , C12P21/02
摘要： Novel Bacillus subtilis mutant strains having good productivity of various enzymes are provided through extensive analysis of strains that are derived from Bacillus subtilis via gene disruption. The Bacillus subtilis mutant strains according to the present invention have genomic structures prepared by deletion of regions listed in the columns for deficient regions. Each of these Bacillus subtilis mutant strains exerts significantly improved secretory productivity of a protein when a gene encoding such a secretory target protein is introduced so that it can be expressed, compared with a case in which the same gene is introduced into a wild-type strain.
摘要翻译：通过对通过基因破坏衍生自枯草芽孢杆菌的菌株的广泛分析，提供具有各种酶的良好生产力的新型枯草芽孢杆菌突变菌株。根据本发明的枯草芽孢杆菌突变菌株具有通过缺失缺陷区列中列出的区域而制备的基因组结构。当与将相同基因导入野生型菌株的情况相比，当引入编码这种分泌型靶蛋白的基因以使其能够被表达时，这些枯草芽孢杆菌突变菌株中的每一种都能显着提高蛋白质的分泌生产力。

9. 发明申请

US20100323896A1 USE OF SULFONANILIDES AS HERBICIDE 审中-公开
标题翻译：使用磺酰亚胺作为除草剂
公开(公告)号：US20100323896A1
公开(公告)日：2010-12-23
申请号：US12868032
申请日：2010-08-25
申请人： Koichi Araki , Yoshitaka Sato , Takuya Gomibuchi , Keiji Endo , Shinichi Shirakura , Shin Nakamura , Christopher Rosinger , Dieter Feucht
发明人： Koichi Araki , Yoshitaka Sato , Takuya Gomibuchi , Keiji Endo , Shinichi Shirakura , Shin Nakamura , Christopher Rosinger , Dieter Feucht
IPC分类号： A01N43/66 , C07D239/52 , C07D251/16 , A01N43/54 , A01P13/00
CPC分类号： C07D251/20 , A01N43/54 , A01N43/66 , C07D239/52
摘要： Herbicidal compositions comprising containing sulfonanilides of the formula (I) wherein R1 represents hydrogen, fluorine, chlorine, C1-4 alkyl, C1-4 alkoxy, C3-6 cycloalkyl-C1-4 alkyloxy or C1-4 haloalkoxy, R2 represents hydrogen, fluorine or chlorine, R3 represents hydrogen or fluorine, R4 represents hydrogen or C1-4 alkyl which may be optionally C1-4 alkoxy-substituted, C3-6 alkenyl or C3-6 alkynyl, R5 represents hydrogen, R6 represents hydroxy, fluorine or chlorine, or R5 and R6 may form, together with the carbon to which they are bonded, C═O, and X represents CH or N, provided that the following cases are excluded: (i) R1 represents hydrogen, fluorine or chlorine, R2 represents hydrogen, R3 represents hydrogen, R4 represents hydrogen, R5 represents hydrogen, and R6 represents hydroxy, (ii) R1 represents hydrogen, fluorine or chlorine, R2 represents hydrogen, R3 represents hydrogen, R4 represents hydrogen, and R5 and R6 form C═O together with the carbon to which they are bonded, (iii) R1 represents C1-4 alkyl, R2 represents hydrogen, R3 represents hydrogen, R4 represents hydrogen, R5 represents hydrogen, R6 represents hydroxy, and X represents CH, or (iv) R1 represents C1-4 alkyl, R2 represents hydrogen, R3 represents hydrogen, R4 represents hydrogen, R5 and R6 form C═O together with the carbon to which they are bonded, and X represents CH, and new compounds being embraced by the formula (I).
摘要翻译：包含含有式（I）的磺酰苯胺的除草组合物，其中R 1表示氢，氟，氯，C 1-4烷基，C 1-4烷氧基，C 3-6环烷基-C 1-4烷氧基或C 1-4卤代烷氧基，R 2表示氢，氟或氯，R 3表示氢或氟，R 4表示氢或可以任选被C 1-4烷氧基取代的C 1-4烷基，C 3-6烯基或C 3-6炔基，R 5表示氢，R 6表示羟基，氟或氯，或者R 5和R 6可以与它们所键合的碳一起形成C = O，X表示CH或N，条件是排除以下情况：（i）R 1表示氢，氟或氯，R 2表示氢，R3表示氢，R4表示氢，R5表示氢，R6表示羟基，（ii）R1表示氢，氟或氯，R2表示氢，R3表示氢，R4表示氢，R5和R6表示C = O 与它们结合的碳，（iii）R 1表示C 1-4烷基，R 2表示氢，R 3表示氢，R 4表示氢，R 5表示氢，R 6表示羟基，X表示CH，或（ⅳ）R 1表示C 1-4烷基， R3表示氢，R4表示氢，R5和R6与它们所键合的碳一起形成C = O，X表示CH，并且新化合物被式（I）所包围。

10. 发明授权

US07855165B2 Herbicide composition for paddy field 失效
标题翻译：稻田除草剂组成
公开(公告)号：US07855165B2
公开(公告)日：2010-12-21
申请号：US11622514
申请日：2007-01-12
申请人： Keiji Endo , Shinichi Shirakura , Shin Nakamura , Natsuko Minegishi
发明人： Keiji Endo , Shinichi Shirakura , Shin Nakamura , Natsuko Minegishi
IPC分类号： A01N43/64 , A01N43/60
CPC分类号： A01N43/54 , A01N43/66 , A01N25/32 , A01N37/18 , A01N37/22 , A01N39/02 , A01N43/08 , A01N43/12 , A01N43/56 , A01N43/78 , A01N43/80 , A01N43/86 , A01N43/90 , A01N47/30 , A01N47/36 , A01N47/38 , A01N57/14 , A01N2300/00
摘要： A herbicide composition for paddy field characterized by containing (a) a herbicidal difluoromethanesulfonamide derivative represented by the formula (I) and (b) at least one herbicidal compound selected from the group consisting of pretilachlor, butachlor, alachlor, metolachlor, acetochlor, clomeprop, bromobutide, benfuresate, indanofan, pyrazolate, benzofenap, pyrazoxyfen, pyraclonil, oxaziclomefone, bensulfuron-methyl, azimsulfuron, imazosulfuron, pyrazosulfuron-ethyl, cyclosulfamuron, ethoxysulfuron, halosulfuron-methyl, orthosulfamuron, cinosulfuron, metsulfuron-methyl, penoxsulam, thiobencarb, pyributycarb, molinate, dimethametryn, simetryn, cafenstrole, quinclorac, anilofos, mefenacet, fentrazamide, pentoxazone, oxadiargyl, oxadiazon, benzobicyclon, mesotrione, AVH301 (code no.), cyhalofop-butyl, metamifop, bispyribac-sodium, pyriftalid, pyrimisulfan, pyrimenobac-methyl, chlormethoxynil, oxyfluorfen, dithiopyr, MCPA, MCPB, 2,4-D, dymron, cumyluron, quinoclamine and clomazone, and/or (c) one or more compounds selected from the group consisting of safeners dymron, isoxadifen(-ethyl), flurazole, fenchlorazole-ethyl, fenclorim, cloquintocet-mexyl, oxabetrinil, fluxofenim, mefenpyr-diethyl, furilazole, R-29148 (code no.), benoxacor, dichlormid and dicyclonone as effective components.
摘要翻译：一种用于稻田的除草剂组合物，其特征在于含有（a）由式（I）和（b）表示的除草二氟甲磺酰胺衍生物，至少一种选自草酰草胺，丁草胺，甲草胺，异丙甲草胺，乙草胺，氯米普，溴替丁，苯呋酮，吡唑啉，吡嘧磺隆，苯唑芬酮，吡嘧磺隆，吡嘧磺隆，恶唑磺隆，吡嘧磺隆，吡嘧磺隆，咪唑磺隆，吡嘧磺隆，环磺胺嘧啶，乙氧基磺隆，卤代磺隆，邻氨基磺隆，茉莉酸，二甲基苯甲酸，西妥昔单抗，喹诺酮，芬太拉唑，依诺沙星，恶草精，恶二酮，苯并环己酮，甲基磺草酮，AVH301（编号），cyhalofop-butyl，metamifop，bispyribac-sodium，pyriftalid，，氯氟乙氧基，氧氟芬，二硫代吡啶，MCPA，MCPB，2,4-D，胞嘧啶，异戊肾上腺素，喹诺酮和克罗莫他， d /或（c）一种或多种选自安息剂dymron，异恶草酮（ - 乙基），氟尿嘧啶，芬氯唑，芬舍洛芬，氯喹毒素，奥沙利坦，氟吡芬，咪芬吡啶二乙基，呋喃唑，R-29148 （代号），benoxacor，dichlormid和dicyclonone作为有效成分。

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