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1. 发明授权

US07224395B2 Camera having a shutter to cut reverse-incident light from the eyepiece lens 失效
标题翻译：相机具有用于从目镜透镜切割反向入射光的快门
公开(公告)号：US07224395B2
公开(公告)日：2007-05-29
申请号：US10084585
申请日：2002-02-26
申请人： Koji Kato , Ryuji Hirata , Takayuki Kijima , Keiichi Mori , Hideaki Yoshida , Junzo Sakurai , Toshiyuki Noguchi , Keiji Kunishige
发明人： Koji Kato , Ryuji Hirata , Takayuki Kijima , Keiichi Mori , Hideaki Yoshida , Junzo Sakurai , Toshiyuki Noguchi , Keiji Kunishige
IPC分类号： H04N5/225 , G03B3/00
CPC分类号： H04N5/2254 , H04N5/238
摘要： A camera comprises a beam splitter configured to divide an incident light from a subject through a photographing lens, an eyepiece lens configured to observe the incident light divided by the beam splitter with a viewfinder, a relay lens provided between the beam splitter and the eyepiece lens, and a shutter provided in a vicinity of the relay lens and configured to cut a reverse-incident light from the eyepiece lens.
摘要翻译：相机包括分束器，其被配置为通过拍摄镜头分割来自被摄体的入射光，目镜透镜被配置为用取景器观察由分束器分开的入射光;设置在分束器和目镜之间的中继透镜以及设置在所述中继透镜附近并被配置为切割来自所述目镜的反向入射光的快门。

2. 发明授权

US07557841B2 Imaging apparatus that detects pixel defect of an imaging element and imaging method 有权
标题翻译：检测成像元件的像素缺陷的成像装置和成像方法
公开(公告)号：US07557841B2
公开(公告)日：2009-07-07
申请号：US11585523
申请日：2006-10-24
申请人： Hitoshi Hashimoto , Keiichi Mori , Takayuki Kijima , Hideaki Yoshida
发明人： Hitoshi Hashimoto , Keiichi Mori , Takayuki Kijima , Hideaki Yoshida
IPC分类号： G09G5/00 , H04N9/64
CPC分类号： H04N5/3675
摘要： An imaging apparatus comprises an imaging element, an imaging optical system configured to input an image of an object to the imaging element, a non-volatile memory part for storing defect data concerning the imaging element, and includes a first memory area storing initial defect data concerning the imaging element, and a second memory area different from the first memory area, a defect detection part for detecting defect data concerning the imaging element, and a control part for controlling reading and writing of the defect data on the imaging element from and to the non-volatile memory part, the control part writing, to the second memory area, defect data detected by the defect detection part.
摘要翻译：一种成像装置，包括成像元件，被配置为将成像元件的图像输入到成像元件的成像光学系统，用于存储关于成像元件的缺陷数据的非易失性存储器部分，并且包括存储初始缺陷数据的第一存储区域关于成像元件以及与第一存储区域不同的第二存储区域，用于检测关于成像元件的缺陷数据的缺陷检测部分，以及用于控制成像元件上的缺陷数据的读取和写入的控制部件，非易失性存储器部分，控制部分向第二存储区域写入由缺陷检测部分检测到的缺陷数据。

3. 发明申请

US20070035643A1 Imaging apparatus 有权
标题翻译：成像设备
公开(公告)号：US20070035643A1
公开(公告)日：2007-02-15
申请号：US11585523
申请日：2006-10-24
申请人： Hitoshi Hashimoto , Keiichi Mori , Takayuki Kijima , Hideaki Yoshida
发明人： Hitoshi Hashimoto , Keiichi Mori , Takayuki Kijima , Hideaki Yoshida
IPC分类号： H04N9/64
CPC分类号： H04N5/3675
摘要： An imaging apparatus comprises an imaging element, an imaging optical system configured to input an image of an object to the imaging element, a non-volatile memory part for storing defect data concerning the imaging element, and includes a first memory area storing initial defect data concerning the imaging element, and a second memory area different from the first memory area, a defect detection part for detecting defect data concerning the imaging element, and a control part for controlling reading and writing of the defect data on the imaging element from and to the non-volatile memory part, the control part writing, to the second memory area, defect data detected by the defect detection part.
摘要翻译：一种成像装置，包括成像元件，被配置为将成像元件的图像输入到成像元件的成像光学系统，用于存储关于成像元件的缺陷数据的非易失性存储器部分，并且包括存储初始缺陷数据的第一存储区域关于成像元件以及与第一存储区域不同的第二存储区域，用于检测关于成像元件的缺陷数据的缺陷检测部分，以及用于控制成像元件上的缺陷数据的读取和写入的控制部件，非易失性存储器部分，控制部分向第二存储区域写入由缺陷检测部分检测到的缺陷数据。

4. 发明申请

US20060256206A1 Image pickup device capable of adjusting the overflow level of the sensor based on the read out mode 审中-公开
公开(公告)号：US20060256206A1
公开(公告)日：2006-11-16
申请号：US11491712
申请日：2006-07-24
申请人： Keiichi Mori , Hideaki Yoshida
发明人： Keiichi Mori , Hideaki Yoshida
IPC分类号： H04N5/228
CPC分类号： H04N5/343 , H01L27/14812 , H01L27/14868 , H01L27/14887 , H04N5/3592 , H04N5/3728
摘要： The driving device of a solid-state imaging device comprises a driving unit for driving the solid-state imaging device in either an addition driving mode in which a plurality of pixels are added and read as a single pixel or a non-addition driving mode, and a substrate bias voltage supply for applying a bias voltage to the substrate of the solid-state imaging device according to the driving mode. The substrate bias voltage is set according to the number of pixels added in the addition driving mode so that the overflow level of the charge accumulating portion may be lower in the addition driving mode than in the normal driving mode. This suppresses the input of excess charges to the horizontal transfer path even in the addition driving mode, thereby preventing the generation of horizontal streak noise.

5. 发明授权

US07088390B2 Imaging apparatus in which exposure control is performed to suppress changes in sensitivity due to changes in gradation mode 有权
标题翻译：执行曝光控制以抑制由于灰度模式的变化引起的灵敏度变化的成像装置
公开(公告)号：US07088390B2
公开(公告)日：2006-08-08
申请号：US09883833
申请日：2001-06-18
申请人： Keiichi Mori , Hideaki Yoshida
发明人： Keiichi Mori , Hideaki Yoshida
IPC分类号： H04N5/202
CPC分类号： H04N1/407 , H04N5/202 , H04N5/2352
摘要： A digital camera which can change gradation properties comprises a CCD image pickup element 105 for photographing a subject, an exposure control mechanism 103 for controlling an exposure on the image pickup element 105, a digital processing circuit 108 including a gradation converting circuit for being capable of generating image signals having different gradation properties (gamma properties) based on the output signal from the image pickup element 105, and a system controller 112 including a selecting circuit for selecting one of the different gradation properties, which is used in the gradation converting circuit. In the digital camera, to suppress the change of a sensitivity (output level) due to the a change of the gradation property, the exposure control mechanism 103 changes a control target value to control the exposure in accordance with the selected gamma value so that the output level is maintained at constant in the average exposure.
摘要翻译：可以改变灰度特性的数码相机包括用于拍摄对象的CCD图像拾取元件105，用于控制图像拾取元件105上的曝光的曝光控制机构103，包括灰度转换电路的数字处理电路108，基于来自图像拾取元件105的输出信号产生具有不同灰度特性（伽马特性）的图像信号;以及系统控制器112，其包括用于在灰度转换电路中使用的不同灰度特性之一的选择电路。在数字照相机中，为了抑制由于灰度特性的变化引起的灵敏度（输出电平）的改变，曝光控制机构103根据所选择的伽马值改变控制目标值以控制曝光，使得平均曝光量的输出水平保持恒定。

6. 发明授权

US07365783B2 Image pickup apparatus which stores initial defect data concerning image pickup device and data on later developed defects 有权
标题翻译：存储关于图像拾取装置的初始缺陷数据和稍后发展的缺陷的数据的图像拾取装置
公开(公告)号：US07365783B2
公开(公告)日：2008-04-29
申请号：US10098081
申请日：2002-03-14
申请人： Hitoshi Hashimoto , Keiichi Mori , Takayuki Kijima , Hideaki Yoshida
发明人： Hitoshi Hashimoto , Keiichi Mori , Takayuki Kijima , Hideaki Yoshida
IPC分类号： H04N9/64 , H04N5/217
CPC分类号： H04N5/3675
摘要： An imaging apparatus comprises an imaging element, an imaging optical system configured to input an image of an object to the imaging element, a non-volatile memory part for storing defect data concerning the imaging element, and includes a first memory area storing initial defect data concerning the imaging element, and a second memory area different from the first memory area, a defect detection part for detecting defect data concerning the imaging element, and a control part for controlling reading and writing of the defect data on the imaging element from and to the non-volatile memory part, the control part writing, to the second memory area, defect data detected by the defect detection part.
摘要翻译：一种成像装置，包括成像元件，被配置为将成像元件的图像输入到成像元件的成像光学系统，用于存储关于成像元件的缺陷数据的非易失性存储器部分，并且包括存储初始缺陷数据的第一存储区域关于成像元件以及与第一存储区域不同的第二存储区域，用于检测关于成像元件的缺陷数据的缺陷检测部分，以及用于控制成像元件上的缺陷数据的读取和写入的控制部件，非易失性存储器部分，控制部分向第二存储区域写入由缺陷检测部分检测到的缺陷数据。

7. 发明授权

US07102680B2 Image pickup device capable of adjusting the overflow level of the sensor based on the read out mode 有权
标题翻译：能够根据读出模式调整传感器的溢出水平的摄像装置
公开(公告)号：US07102680B2
公开(公告)日：2006-09-05
申请号：US09803391
申请日：2001-03-09
申请人： Keiichi Mori , Hideaki Yoshida
发明人： Keiichi Mori , Hideaki Yoshida
IPC分类号： H04N3/14
CPC分类号： H04N5/343 , H01L27/14812 , H01L27/14868 , H01L27/14887 , H04N5/3592 , H04N5/3728
摘要： The driving device of a solid-state imaging device comprises a driving unit for driving the solid-state imaging device in either an addition driving mode in which a plurality of pixels are added and read as a single pixel or a non-addition driving mode, and a substrate bias voltage supply for applying a bias voltage to the substrate of the solid-state imaging device according to the driving mode. The substrate bias voltage is set according to the number of pixels added in the addition driving mode so that the overflow level of the charge accumulating portion may be lower in the addition driving mode than in the normal driving mode. This suppresses the input of excess charges to the horizontal transfer path even in the addition driving mode, thereby preventing the generation of horizontal streak noise.
摘要翻译：固态成像装置的驱动装置包括：驱动单元，用于以附加驱动模式驱动固态成像装置，其中多个像素被添加并读取为单个像素或非加法驱动模式，以及基板偏置电压源，用于根据驱动模式向固态成像器件的衬底施加偏置电压。根据在相加驱动模式中添加的像素数量来设置衬底偏置电压，使得在相加驱动模式下电荷累积部分的溢出电平可能低于正常驱动模式。这即使在相加驱动模式下也能够抑制对水平传送路径的过剩电荷的输入，从而防止产生水平条纹噪声。

8. 发明申请

US20060146164A1 Imaging apparatus in which exposure control is performed to suppress changes in sensitivity due to changes in gradation mode 审中-公开
标题翻译：执行曝光控制以抑制由于灰度模式的变化引起的灵敏度变化的成像装置
公开(公告)号：US20060146164A1
公开(公告)日：2006-07-06
申请号：US11366713
申请日：2006-03-02
申请人： Keiichi Mori , Hideaki Yoshida
发明人： Keiichi Mori , Hideaki Yoshida
IPC分类号： H04N5/335
CPC分类号： H04N1/407 , H04N5/202 , H04N5/2352
摘要： A digital camera that can change gradation properties is provided which includes a CCD image pickup element for photographing a subject, an exposure control mechanism for controlling an exposure on the image pickup element, a digital processing circuit including a gradation converting circuit for generating image signals having different gradation properties (gamma properties) based on the output signal from the image pickup element, and a system controller including a selecting circuit for selecting one of the different gradation properties, which is used in the gradation converting circuit. In the digital camera, to suppress change of sensitivity (output level) due to a change of the gradation property, the exposure control mechanism changes a control target value to control the exposure in accordance with the selected gamma value so that the output level is maintained at a constant in the average exposure.
摘要翻译：提供了可以改变灰度特性的数码相机，其包括用于拍摄对象的CCD图像拾取元件，用于控制图像拾取元件上的曝光的曝光控制机构，数字处理电路，包括用于产生具有基于来自图像拾取元件的输出信号的不同的灰度特性（伽马特性），以及包括用于在灰度转换电路中使用的不同灰度特性之一的选择电路的系统控制器。在数字照相机中，为了抑制由于灰度特性变化引起的灵敏度变化（输出电平），曝光控制机构根据所选择的伽马值改变控制目标值以控制曝光，从而保持输出电平平均曝光不变。

9. 发明授权

US08716451B2 Stabilized human IgG2 and IgG3 antibodies 有权
标题翻译：稳定的人IgG2和IgG3抗体
公开(公告)号：US08716451B2
公开(公告)日：2014-05-06
申请号：US11794950
申请日：2006-01-12
申请人： Nobuaki Takahashi , Hideaki Yoshida
发明人： Nobuaki Takahashi , Hideaki Yoshida
IPC分类号： C07K16/00 , C12N15/00
CPC分类号： C07K16/00 , C07K16/2878 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/94
摘要： It is intended to provide highly stable variants of human antibody IgG2 and IgG3 subclasses. The present invention provides an IgG heavy chain comprising the constant region of a human IgG2 heavy chain having at least a substitution of Y for F at the 300th position, L for V at the 309th position, or A for T at the 339th position designated by the EU index of Kabat et al. and an IgG heavy chain comprising the constant region of a human IgG3 heavy chain having at least a substitution of K for N at the 392nd position or V for M at the 397th position designated by the EU index of Kabat et al. The present invention also provides monoclonal antibodies comprising these heavy chains.
摘要翻译：旨在提供人抗体IgG2和IgG3亚类的高度稳定的变体。本发明提供一种IgG重链，其包含人IgG2重链的恒定区，其在第300位具有至少取代F的F，在第309位具有至少取代F的L，在第309位具有至少取代F的第三十九位，欧盟指数Kabat等和IgG重链，其包含人类IgG3重链的恒定区，在Kabat等人的EU指数指定的第397位具有至少在第392位具有K取代为N或V代表M。本发明还提供了包含这些重链的单克隆抗体。

10. 发明申请

US20130053547A1 AGONIST ANTIBODY TO HUMAN THROMBOPOIETIN RECEPTOR 审中-公开
标题翻译：人类抗抑郁药受体的激素抗体
公开(公告)号：US20130053547A1
公开(公告)日：2013-02-28
申请号：US13543183
申请日：2012-07-06
申请人： Masayuki KAI , Kazuhiro Motoki , Shiro Kataoka , Hideaki Yoshida , Tetsuya Hagiwara
发明人： Masayuki KAI , Kazuhiro Motoki , Shiro Kataoka , Hideaki Yoshida , Tetsuya Hagiwara
IPC分类号： C07K16/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/524 , C07K14/715 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/72 , C07K2317/74 , Y10S424/801 , Y10S424/809
摘要： This invention provides an agonist antibody to a human thrombopoietin receptor (human c-Mpl), and pharmaceutical compositions comprising the same for use in treatment of thrombocytopenia. The disclosed agonist antibody comprises (1) antibody constant regions comprising heavy and light chain constant regions, each of which may optionally contain domain substitutions, or may contain deletions, substitutions, additions, or insertions of amino acid residues, and (2) antibody variable regions capable of binding to and activating a human thrombopoietin receptor. The-agonist antibody further induces colony formation at a concentration of 10,000 ng/ml or lower, and has a maximal activity at least 50% higher than that of PEG-rHuMGDF and an 50% effective concentration (EC50) of 100 nM or less.
摘要翻译：本发明提供了对人类血小板生成素受体（人c-Mpl）的激动剂抗体，以及包含其用于治疗血小板减少症的药物组合物。所公开的激动剂抗体包含（1）包含重链和轻链恒定区的抗体恒定区，每个区可任选地含有结构域取代，或可含有氨基酸残基的缺失，替换，添加或插入，和（2）抗体可变能够结合并激活人血小板生成素受体的区域。激动剂抗体进一步诱导浓度为10,000ng / ml或更低的集落形成，并且具有比PEG-rHuMGDF高至少50％的最大活性和100nM或更低的50％有效浓度（EC 50）。

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