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1. 发明申请

US20060276433A1 Hydrazone derivative 审中-公开
标题翻译：腙衍生物
公开(公告)号：US20060276433A1
公开(公告)日：2006-12-07
申请号：US10551414
申请日：2004-03-31
申请人： Keiichi Kawagoe , Kayoko Motoki , Takashi Odagiri , Nobuyuki Suzuki , Chun-Jen Chen , Tetsuya Mimura
发明人： Keiichi Kawagoe , Kayoko Motoki , Takashi Odagiri , Nobuyuki Suzuki , Chun-Jen Chen , Tetsuya Mimura
IPC分类号： A61K31/695 , A61K31/537 , A61K31/445 , A61K31/40 , C07D211/56 , C07F7/00 , C07F7/10
CPC分类号： C07D263/58 , A61K31/15 , A61K31/417 , A61K31/421 , A61K31/427 , A61K31/437 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/5377 , C07C251/86 , C07D213/53 , C07D263/32 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D487/12 , C07D513/04
摘要： A compound represented by the following formula (I): wherein R1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof.
摘要翻译：由下式（I）表示的化合物：其中R 1表示氢，可具有取代基的芳基，可具有取代基的饱和或不饱和5-至7-元杂环基等。 R 2表示氢，可具有取代基的芳基，可具有取代基的饱和或不饱和的5至7元杂环基等; R 3表示氢等; Ar表示衍生自芳烃的二价基团等; X表示单键，可具有取代基的具有1〜3个碳原子的直链或支链亚烷基等; G表示卤素，可具有取代基的饱和或不饱和的5或6元环状烃基，可具有取代基的饱和或不饱和5〜7元杂环基等，其盐或其溶剂合物; 以及用于抑制淀粉样蛋白或淀粉样蛋白样蛋白的聚集和/或沉积的试剂，其包含所述化合物，其盐或其溶剂合物。

2. 发明授权

US5919824A Aminophenol derivatives 失效
标题翻译：氨基苯酚衍生物
公开(公告)号：US5919824A
公开(公告)日：1999-07-06
申请号：US894799
申请日：1997-09-12
申请人： Shuichi Yokohama , Keiichi Kawagoe , Yasuyuki Takeda , Yoshihiro Yokomizo , Aki Yokomizo
发明人： Shuichi Yokohama , Keiichi Kawagoe , Yasuyuki Takeda , Yoshihiro Yokomizo , Aki Yokomizo
IPC分类号： C07C275/16 , C07C275/28 , A61K37/44 , C07C59/235
CPC分类号： C07C275/28 , C07C275/16 , Y10S514/925 , Y10S514/927
摘要： Aminophenol derivatives represented by the following formula (1): ##STR1## wherein X is O or S; A is alkylene, R.sup.1 is phenyl, etc., R.sup.2 and R.sup.3 are H or alkyl; R.sup.4 is substituted carbamoylalkyl, etc.; R.sup.5 is substituted amino, etc.; their salts, and optical isomers of the derivatives and salts. Also disclosed are gastrin receptor antagonists, cholecystokinin receptor antagonists, and medicines for digestive diseases. The compounds have strong binding inhibition against gastrin receptor or CCK-A receptor and also they have higher selectivity to either group of CCK-A receptor or gastrin receptor, and therefore, the compounds are useful for preventing and treating gastrointestinal diseases including peptic ulcers as well as central nervous system diseases.
摘要翻译： PCT No.PCT / JP96 / 00611 Sec。 371日期：1997年9月12日 102（e）1997年9月12日PCT PCT 1996年3月12日PCT公布。公开号WO96 / 28416 日期：1996年9月19日由下式（1）表示的苯酚衍生物：其中X为O或S; A是亚烷基，R 1是苯基等，R 2和R 3是H或烷基; R4是取代的氨基甲酰基烷基等; R5是取代氨基等。它们的盐和衍生物和盐的光学异构体。还公开了胃泌素受体拮抗剂，胆囊收缩素受体拮抗剂和用于消化疾病的药物。这些化合物对胃泌素受体或CCK-A受体具有强烈的结合抑制作用，并且对CCK-A受体或胃泌素受体组也具有较高的选择性，因此，该化合物也可用于预防和治疗胃肠疾病，包括消化性溃疡作为中枢神经系统疾病。

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