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1. 发明授权

US06916939B2 Process for the preparation of cyclic esters and method for purification of the same 有权
标题翻译：环酯的制备方法及其纯化方法
公开(公告)号：US06916939B2
公开(公告)日：2005-07-12
申请号：US10344461
申请日：2001-08-08
申请人： Kazuyuki Yamane , Yukichika Kawakami , Hajime Hoshi , Kazuhiko Sunagawa
发明人： Kazuyuki Yamane , Yukichika Kawakami , Hajime Hoshi , Kazuhiko Sunagawa
IPC分类号： C07D319/12
CPC分类号： C08J3/28 , C07D319/12 , C08J11/24 , C08J2300/14 , C08J2367/04 , Y02W30/706
摘要： The present invention provides a process for production of a cyclic ester by depolymerization of an aliphatic polyester. In the process, a mixture containing the aliphatic polyester and a specific polyalkylene glycol ether, which has a boiling point of 230-450° C. and a molecular weight of 150-450, is heated under normal or reduced pressure to a temperature at which depolymerization of the aliphatic polyester takes place. Then, a substantially homogeneous solution phase, consisting of the melt phase of the aliphatic polyester and the liquid phase of the polyalkylene glycol ether, is formed. Heating of the solution phase is continued to form the cyclic ester by depolymerization and distil out the cyclic ester together with the polyalkylene glycol ether, and then the cyclic ester is recovered from the distillate. The present invention also provides a process for purification of a crude cyclic ester by use of the specific polyalkylene glycol ether described above.
摘要翻译：本发明提供了通过脂肪族聚酯的解聚制备环状酯的方法。在该方法中，将含有脂族聚酯和特定的聚亚烷基二醇醚的混合物在沸点为230-450℃，分子量为150-450的条件下，在正常或减压下加热至发生脂肪族聚酯的解聚。然后，形成由脂肪族聚酯的熔融相和聚亚烷基二醇醚的液相组成的基本均匀的溶液相。溶液相的加热继续通过解聚形成环酯，并与聚亚烷基二醇醚一起蒸馏出环状酯，然后从馏出物中回收环状酯。本发明还提供了通过使用上述特定的聚亚烷基二醇醚来纯化粗环酯的方法。

2. 发明授权

US5279719A Method for chlorination of methylated aromatic compounds 失效
标题翻译：甲基化芳香族化合物氯化方法
公开(公告)号：US5279719A
公开(公告)日：1994-01-18
申请号：US970305
申请日：1992-11-02
申请人： Kazuhiko Sunagawa , Hajime Hoshi , Tsumoru Watanabe
发明人： Kazuhiko Sunagawa , Hajime Hoshi , Tsumoru Watanabe
IPC分类号： C07C17/12 , C07C17/14 , C07C25/02 , C07C25/125 , C07C25/22 , C07C17/00
CPC分类号： C07C17/12 , C07C17/14 , C07C25/125
摘要： A process for chlorination of methylated aromatic compounds in a titanium tetrachloride is disclosed. The ring chlorination is first carried out by reacting said methylated aromatic compounds with chlorine gas under reduced light conditions, and then the side chain chlorination is carried out by reacting the resulting mixture with chlorine gas under light irradiation conditions. The process ensures continuous chlorination of aromatic rings and side chains of methylated aromatic compounds at a high yield without using any catalysts or perilous solvents such as carbon tetrachloride.
摘要翻译：公开了一种在四氯化钛中氯化甲基化芳族化合物的方法。环氯化首先通过使所述甲基化芳香族化合物与降低光照条件下的氯气反应进行，然后通过在光照射条件下使所得混合物与氯气反应来进行侧链氯化。该方法确保甲基化芳族化合物的芳香环和侧链在不使用任何催化剂或危险溶剂如四氯化碳的情况下以高产率连续氯化。

3. 发明授权

US5646291A Process for the manufacture of 2-phenyl-4,5-oxazoledione 4-phenylhydrazone derivatives 失效
标题翻译： 2-苯基-4,5-恶唑二酮4-苯腙衍生物的制备方法
公开(公告)号：US5646291A
公开(公告)日：1997-07-08
申请号：US431573
申请日：1995-05-01
申请人： Hajime Hoshi , Kazuhiko Sunagawa , Takeo Watanabe
发明人： Hajime Hoshi , Kazuhiko Sunagawa , Takeo Watanabe
IPC分类号： C09B26/02 , C07D263/18
CPC分类号： C09B26/02
摘要： A process for manufacturing derivatives of 2-phenyl-4,5-oxazoledione 4-phenylhyrazone is disclosed. The process comprises reacting a derivative of a benezenediazonium salt, a hippuric acid derivative, and acetic anhydride in the presence of a neutralizing agent to effect the cyclization reaction for the formation of the oxazolone ring and the succeeding diazo-coupling reaction. The process does not require the conventional separate, independent step for the preparation of a solution of a hippuric acid derivative and acetic anhydride, thus eliminating the quick heating and quenching procedures and further avoiding the loss of the hippuric acid derivative due to decomposition of the oxazolone derivative. There is thus obtained a high yield of the desired product in a short period of time.
摘要翻译：公开了一种制备2-苯基-4,5-恶唑二酮4-苯基腙的衍生物的方法。该方法包括在中和剂存在下使衍生重氮盐，马尿酸衍生物和乙酸酐的衍生物进行反应，以进行恶唑酮环的形成和后续的重氮偶合反应的环化反应。该方法不需要用于制备马尿酸衍生物和乙酸酐的常规独立的独立步骤，因此消除了快速加热和淬灭程序，并进一步避免了由于恶唑酮分解导致的马尿酸衍生物的损失衍生物。因此在短时间内获得了高产率的所需产物。

4. 发明授权

US07166750B1 Process for the preparation of 5-[(4-chlorophenyl)methyl]-2,2-dimethylcyclopentanone 有权
标题翻译：制备5 - [（4-氯苯基）甲基] -2,2-二甲基环戊酮的方法
公开(公告)号：US07166750B1
公开(公告)日：2007-01-23
申请号：US10332471
申请日：2000-08-11
申请人： Kazuhiko Sunagawa , Hajime Hoshi , Shigeru Mizusawa , Nobuyuki Kusano , Satoru Kumazawa
发明人： Kazuhiko Sunagawa , Hajime Hoshi , Shigeru Mizusawa , Nobuyuki Kusano , Satoru Kumazawa
IPC分类号： C07C45/00 , C07C261/00 , C07C69/74
CPC分类号： C07C67/333 , C07C45/676 , C07C49/697 , C07C67/343 , C07C2601/08 , C07C69/757
摘要： 5-[(4-chlorophenyl)methyl]-2,2-dimethylcyclopentanone is produced by reacting 1-[(4-chlorophenyl)methyl]-3-methyl-2-oxocyclopentanecarboxylic acid methyl ester or 1-[(4-chlorophenyl)methyl]-3-methyl-2-oxocyclopentanecarboxylic acid ethyl ester with sodium hydride and methyl halide, then hydrolyzing the obtained 1-[(4-chlorophenyl)methyl]-3,3-dimethyl-2-oxocyclopentanecarboxylic acid methyl ester or 1-[(4-chlorophenyl)methyl]-3,3-dimethyl-2-oxocyclopentanecarboxylic acid ethyl ester. The process provides 5-[(4-chlorophenyl)methyl]-2,2-dimethylcyclopentanone, an important intermediate of an agricultural or horticultural fungicide, e.g., Metconazole.
摘要翻译： 5 - [（4-氯苯基）甲基] -2,2-二甲基环戊酮通过使1 - [（4-氯苯基）甲基] -3-甲基-2-氧代环戊烷甲酸甲酯或1 - [（4-氯苯基）甲基] -3-甲基-2-氧代环戊烷甲酸乙酯与氢化钠和甲基卤反应，然后水解所得的1 - [（4-氯苯基）甲基] -3,3-二甲基-2-氧代环戊烷甲酸甲酯或1- [（4-氯苯基）甲基] -3,3-二甲基-2-氧代环戊烷甲酸乙酯。该方法提供了5 - [（4-氯苯基）甲基] -2,2-二甲基环戊酮，农业或园艺杀真菌剂如甲基康唑的重要中间体。

5. 发明授权

US08722907B2 Production process of glycolide 有权
标题翻译：乙交酯的生产过程
公开(公告)号：US08722907B2
公开(公告)日：2014-05-13
申请号：US13142012
申请日：2009-12-09
申请人： Shigeru Suzuki , Kazuyuki Yamane , Toshihiko Ono , Kazuhiko Sunagawa
发明人： Shigeru Suzuki , Kazuyuki Yamane , Toshihiko Ono , Kazuhiko Sunagawa
IPC分类号： C07D319/00
CPC分类号： C07D319/12
摘要： The invention provides a production process of glycolide comprising the respective steps of: Step 1 of heating a mixture containing a glycolic acid oligomer and a high boiling polar organic under normal or reduced pressure to reflux the mixture and at that time, conducting a total reflux operation in a reflux time within a range of 0.1 to 20 hours under conditions that substantially the whole amount of a distillate distilled out of a reflux system containing the mixture is refluxed into the reflux system; Step 2 of heating the mixture after the total reflux operation or a mixture obtained by adding the high boiling polar organic solvent to a glycolic acid oligomer component recovered from the mixture after the total reflux operation to conduct depolymerization; and Step 3 of collecting glycolide from a co-distillate.
摘要翻译：本发明提供了一种乙交酯的制备方法，其包括以下各步骤：步骤1，在正常或减压下加热含有乙醇酸低聚物和高沸点极性有机物的混合物以回流混合物，并且此时进行总的回流操作在从含有该混合物的回流系统蒸馏出的基本上全部量的馏出物回流至回流系统的条件下，在0.1至20小时的范围内的回流时间内，在全部回流操作之后加热混合物的步骤2或通过在完全回流操作后从混合物中回收的乙醇酸低聚物组分加入高沸点极性有机溶剂而获得的混合物进行解聚; 和从共馏出物收集乙交酯的步骤3。

6. 发明申请

US20110263875A1 Production Process of Glycolide 有权
标题翻译：乙交酯的生产工艺
公开(公告)号：US20110263875A1
公开(公告)日：2011-10-27
申请号：US13142012
申请日：2009-12-09
申请人： Shigeru Suzuki , Kazuyuki Yamane , Toshihiko Ono , Kazuhiko Sunagawa
发明人： Shigeru Suzuki , Kazuyuki Yamane , Toshihiko Ono , Kazuhiko Sunagawa
IPC分类号： C07D319/12
CPC分类号： C07D319/12
摘要： The invention provides a production process of glycolide comprising the respective steps of: Step 1 of heating a mixture containing a glycolic acid oligomer and a high boiling polar organic under normal or reduced pressure to reflux the mixture and at that time, conducting a total reflux operation in a reflux time within a range of 0.1 to 20 hours under conditions that substantially the whole amount of a distillate distilled out of a reflux system containing the mixture is refluxed into the reflux system; Step 2 of heating the mixture after the total reflux operation or a mixture obtained by adding the high boiling polar organic solvent to a glycolic acid oligomer component recovered from the mixture after the total reflux operation to conduct depolymerization; and Step 3 of collecting glycolide from a co-distillate.
摘要翻译：本发明提供了一种乙交酯的制备方法，其包括以下各步骤：步骤1，在正常或减压下加热含有乙醇酸低聚物和高沸点极性有机物的混合物以回流混合物，并且此时进行总的回流操作在从含有该混合物的回流系统蒸馏出的基本上全部量的馏出物回流至回流系统的条件下，在0.1至20小时的范围内的回流时间内，在全部回流操作之后加热混合物的步骤2或通过在完全回流操作后从混合物中回收的乙醇酸低聚物组分加入高沸点极性有机溶剂而获得的混合物进行解聚; 和从共馏出物收集乙交酯的步骤3。

7. 发明授权

US09278966B2 Method for manufacturing oxetane compound, method for manufacturing azolylmethylcyclopentanol compound, and intermediate compound 有权
标题翻译：制备氧杂环丁烷化合物的方法，制备唑基甲基环戊醇化合物的方法和中间体化合物
公开(公告)号：US09278966B2
公开(公告)日：2016-03-08
申请号：US14124114
申请日：2012-06-06
申请人： Kazuhiko Sunagawa , Toru Yamazaki , Emiko Obata
发明人： Kazuhiko Sunagawa , Toru Yamazaki , Emiko Obata
IPC分类号： C07D401/00 , C07D277/22 , C07D277/30 , C07D249/08 , C07D305/00 , C07D407/00 , C07D493/00 , C07D417/14 , C07D333/28 , C07C309/66 , C07C309/73 , C07D401/08 , C07D405/06 , C07D409/06 , C07D409/08 , C07D417/06 , C07D417/08 , C07D277/20 , C07D277/32 , C07D213/61 , C07D305/14 , C07D405/14
CPC分类号： C07D417/14 , C07C309/66 , C07C309/73 , C07C2601/08 , C07D213/61 , C07D249/08 , C07D277/20 , C07D277/32 , C07D305/14 , C07D333/28 , C07D401/08 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/08 , C07D417/06 , C07D417/08
摘要： In order to produce an intermediate from which a cyclic alcohol compound can be stereoselectively obtained, a method for producing an oxetane compound according to the present invention includes the step of reacting, with a cyanide salt, a compound represented by Formula (I): wherein R1 is selected from a hydrogen atom and an alkyl group optionally having a substituent; X1 is selected from a halogen atom and —OSO2R3 where R3 is selected from an alkyl group optionally having a substituent, a phenyl group, and a naphthyl group; and a ring Z1 represents a cyclic hydrocarbon optionally having a substituent, to obtain a compound represented by Formula (II):
摘要翻译：为了制备可以立体选择性地获得环状醇化合物的中间体，根据本发明的氧杂环丁烷化合物的制备方法包括使氰化物盐与式（I）表示的化合物反应的步骤：其中 R1选自氢原子和任选具有取代基的烷基; X1选自卤素原子和-OSO 2 R 3，其中R 3选自任选具有取代基的烷基，苯基和萘基; 并且环Z1表示任选具有取代基的环状烃，以获得由式（II）表示的化合物：

8. 发明申请

US20060106264A1 Method for producing p-dichlorobenzene 有权
标题翻译：对二氯苯的制备方法
公开(公告)号：US20060106264A1
公开(公告)日：2006-05-18
申请号：US10526557
申请日：2003-09-03
申请人： Takashi Wakasugi , Tsugio Nonaka , Tadashi Miyakawa , Takanobu Hanabusa , Kazuhiko Sunagawa , Shigeru Mizusawa
发明人： Takashi Wakasugi , Tsugio Nonaka , Tadashi Miyakawa , Takanobu Hanabusa , Kazuhiko Sunagawa , Shigeru Mizusawa
IPC分类号： C07C17/06
CPC分类号： C07C17/12 , C07C25/08
摘要： In a process for preparing p-dichlorobenzene by nuclear chlorination of benzene and/or chlorobenzene as the starting material with chlorine molecules, chlorination is carried out using aluminum chloride in an amount of 0.1-3 millimols per mol of the starting material and phenothiazines such as 10H-phenothiazine-10-carboxylic acid phenyl ester in an amount of 0.1-0.9 mols per mol of aluminum chloride so as to be a chlorination degree in a range of 1.2-2.5, by which p-dichlorobenzene can be obtained in a high para-selectivity and a short reaction time.
摘要翻译：在通过用氯分子的苯和/或氯苯作为起始原料的核氯化制备对二氯苯的方法中，使用氯化铝使用0.1-3毫摩尔/摩尔原料和吩噻嗪，例如 10 H-吩噻嗪-10-羧酸苯酯，其用量为0.1-0.9摩尔/摩尔氯化铝，氯化度在1.2-2.5范围内，可以以高的比例获得对二氯苯对位选择性和反应时间短。

9. 发明授权

US06200933B1 6-(Nonsubstituted or substituted) phenoxy picolinic acids, process of preparing the same, and agricultural/horticultural germicides containing the same 失效
标题翻译： 6-（非取代或取代的）苯氧基吡啶甲酸，其制备方法，以及含有相同的农业/园艺杀菌剂
公开(公告)号：US06200933B1
公开(公告)日：2001-03-13
申请号：US09331734
申请日：1999-08-09
申请人： Hisashi Kanno , Yoichi Kanda , Kazuhiko Sunagawa , Takayoshi Eizuka
发明人： Hisashi Kanno , Yoichi Kanda , Kazuhiko Sunagawa , Takayoshi Eizuka
IPC分类号： A01N4340
CPC分类号： C07D213/79 , A01N43/40
摘要： An agricultural or horticultural fungicide containing 6-(unsubstituted or substituted) phenoxy picolinic acid represented by the general formula (I), as an effective ingredient. wherein R is a halogen atom, a C1 to C4 alkyl group, a C1 to C4 haloalkyl group, a C1 to C4 alkoxy group, a C1 to C4 haloalkoxy group, a C1 to C4 alkylthio group, a C1 to C4 alkylamino group, a di(C1 to C4 alkyl)amino group or a C7 to C8 aralkyl(C1 to C4 alkyl)amino group; n2 is an integer of 0 to 3; Y is a C1 to C4 alkyl group, a C1 to C4 haloalkyl group, a C1 to C4 alkoxy group, a C1 to C4 haloalkoxy group, a C1 to C4 alkylthio group, a C1 to C4 haloalkylthio group or a halogen atom; and m is an integer of 0 to 5, and when m and n2 are not less than 2, Rs and Ys may be the same or different, respectively. The compound is useful as an effective ingredient of agricultural or horticultural fungicides.
摘要翻译：一种含有由通式（I）表示的6-（未取代或取代的）苯氧基吡啶甲酸作为有效成分的农业或园艺杀真菌剂，其中R为卤素原子，C1至C4烷基，C1至C4卤代烷基， C1〜C4烷氧基，C1〜C4卤代烷氧基，C1〜C4烷硫基，C1〜C4烷基氨基，二（C1〜C4烷基）氨基或C7〜C8芳烷基（C1〜C4烷基）氨基; n2为0〜3的整数，Y为C1〜C4烷基，C1〜C4卤代烷基，C1〜C4烷氧基，C1〜C4卤代烷氧基，C1〜C4烷硫基， C1〜C4卤代烷硫基或卤素原子; andm为0〜5的整数，当m和n2不小于2时，Rs和Y可以相同或不同。化合物可用作农业或园艺杀真菌剂的有效成分。

10. 发明申请

US20090038382A1 PROBE AND CANTILEVER 审中-公开
标题翻译：探测器和CANTILEVER
公开(公告)号：US20090038382A1
公开(公告)日：2009-02-12
申请号：US12089349
申请日：2006-10-06
申请人： Kouji Koyama , Toshiro Kotaki , Kazuhiko Sunagawa
发明人： Kouji Koyama , Toshiro Kotaki , Kazuhiko Sunagawa
IPC分类号： G12B21/02
CPC分类号： G01Q60/38 , G01Q70/10
摘要： [Object of the Invention] To provide a probe 1 for use in a cantilever 2 of an scanning probe microscope (SPM) manufacturable in a simple manufacturing process and usable while allowing full use of the properties of single-crystalline material and a cantilever 2 using that probe.[Solution] A probe 1 disposed at the tip of beam part 2a of a cantilever 2 used for an SPM, wherein the probe 1 comprises a needle-like part 1a having a length of not less than 10 μm or and a flat plate part 1b having a face contacting a beam part of the cantilever, the needle-like part 1a and the flat plate part 1b are integrally formed with a single-crystalline material, and at least one side face of the flat plate part 1b contains a flat surface 1c in order to indicate the crystal orientation of the single-crystalline material.
摘要翻译：本发明的目的在于提供一种用于可在简单的制造工艺中制造的扫描探针显微镜（SPM）的悬臂2中的探针1，并且可以充分利用单晶材料和悬臂梁2的性质使用那个探头。 [解决方案]设置在用于SPM的悬臂2的梁部2a的前端的探针1，其中探针1包括长度不小于10um的针状部分1a和平板部分1b 具有与悬臂的梁部接触的面，针状部1a和平板部1b与单晶材料一体形成，平板部1b的至少一个侧面包含平坦面1c 以表示单晶材料的晶体取向。

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