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1. 发明授权

US06316776B1 Charged particle beam apparatus and method for operating the same 有权
标题翻译：带电粒子束装置及其操作方法
公开(公告)号：US06316776B1
公开(公告)日：2001-11-13
申请号：US09388437
申请日：1999-09-02
申请人： Kazuo Hiramoto , Hiroshi Akiyama , Koji Matsuda , Tetsuro Norimine , Masahiro Tadokoro
发明人： Kazuo Hiramoto , Hiroshi Akiyama , Koji Matsuda , Tetsuro Norimine , Masahiro Tadokoro
IPC分类号： H05H900
CPC分类号： A61N5/1042 , A61N5/1049 , A61N2005/1087 , A61N2005/1095
摘要： A method of irradiation with a charged particle beam and an irradiation apparatus wherein the charged particle beam supplied from an accelerator and extracted from the irradiation apparatus. The irradiation apparatus includes an electromagnet for scanning with the charged particle beam. The method includes the steps of stopping the extraction of the charged particle beam from the irradiation apparatus, changing an irradiation point of the charged particle beam by controlling the electromagnet under a condition when the extraction is stopped, and resuming the extraction of the charged particle beam from the irradiation apparatus after changing the irradiation point.
摘要翻译：一种带电粒子束照射的方法和照射装置，其中从加速器提供并从照射装置中提取的带电粒子束。照射装置包括用于用带电粒子束扫描的电磁体。该方法包括以下步骤：停止从照射装置提取带电粒子束，通过在提取停止的条件下控制电磁体来改变带电粒子束的照射点，并恢复提取带电粒子束改变照射点后从照射装置。

2. 发明授权

US06218675B1 Charged particle beam irradiation apparatus 有权
标题翻译：带电粒子束照射装置
公开(公告)号：US06218675B1
公开(公告)日：2001-04-17
申请号：US09136308
申请日：1998-08-19
申请人： Hiroshi Akiyama , Kazuo Hiramoto , Koji Matsuda , Tetsuro Norimine
发明人： Hiroshi Akiyama , Kazuo Hiramoto , Koji Matsuda , Tetsuro Norimine
IPC分类号： H01J3714
CPC分类号： H01J37/147 , A61N5/1043 , A61N2005/1087 , G21K5/04
摘要： A charged particle beam irradiation apparatus for irradiating a target with a charged particle beam emitted from an accelerator includes a plurality of scanning electromagnets, and a quadrupole electromagnet is used between two of the plurality of the scanning electromagnets.
摘要翻译：用于从加速器发射的带电粒子束照射靶的带电粒子束照射装置包括多个扫描电磁体，并且在多个扫描电磁体中的两个之间使用四极电磁体。

3. 发明授权

US07247869B2 Particle therapy system 有权
标题翻译：粒子治疗系统
公开(公告)号：US07247869B2
公开(公告)日：2007-07-24
申请号：US10971004
申请日：2004-10-25
申请人： Masahiro Tadokoro , Shunji Kakiuchi , Hiroshi Akiyama , Mamoru Katane , Koji Matsuda
发明人： Masahiro Tadokoro , Shunji Kakiuchi , Hiroshi Akiyama , Mamoru Katane , Koji Matsuda
IPC分类号： G01J1/00
CPC分类号： A61N5/1048 , A61N5/1075 , A61N2005/1074 , A61N2005/1087 , A61N2005/1095 , G21K5/04
摘要： A particle therapy system capable of measuring energy of a charged particle beam even during irradiation of the charged particle beam is provided. A beam delivery (irradiation) system comprises a block collimator constituted by a pair of collimator members, and an energy detector mounted to one of the collimator members to be disposed on the upstream side thereof. When the pair of collimator members are moved in directions away from each other, a beam passage is formed between them. The energy detector constitutes an energy measuring device together with a signal processing unit. A part of the ion beam having reached the interior of the irradiation nozzle is irradiated to a patient through the beam passage. When a part of the remaining ion beam enters the energy detector, electric charges generate in the energy detector. The signal processing unit determines energy of the ion beam based on a position within the energy detector at which electric charges have generated in maximum amount.
摘要翻译：提供了即使在带电粒子束的照射期间也能够测量带电粒子束的能量的粒子治疗系统。射束（照射）系统包括由一对准直器构件构成的块准直器，以及安装在准备器件中的一个待设置在其上游侧的能量检测器。当一对准直器构件沿彼此远离的方向移动时，在它们之间形成梁通道。能量检测器与信号处理单元一起构成能量测量装置。已经到达照射喷嘴内部的离子束的一部分通过束通道照射到患者身上。当剩余离子束的一部分进入能量检测器时，在能量检测器中产生电荷。信号处理单元基于能量检测器内以最大量产生电荷的位置来确定离子束的能量。

4. 发明申请

US20050087700A1 Particle therapy system 有权
公开(公告)号：US20050087700A1
公开(公告)日：2005-04-28
申请号：US10971004
申请日：2004-10-25
申请人： Masahiro Tadokoro , Shunji Kakiuchi , Hiroshi Akiyama , Mamoru Katane , Koji Matsuda
发明人： Masahiro Tadokoro , Shunji Kakiuchi , Hiroshi Akiyama , Mamoru Katane , Koji Matsuda
IPC分类号： G21K1/02 , A61N5/10 , G21K5/04 , H05H7/10 , H05H13/04 , B01D59/44 , H01J37/08 , H01J49/00
CPC分类号： A61N5/1048 , A61N5/1075 , A61N2005/1074 , A61N2005/1087 , A61N2005/1095 , G21K5/04
摘要： A particle therapy system capable of measuring energy of a charged particle beam even during irradiation of the charged particle beam is provided. A beam delivery (irradiation) system comprises a block collimator constituted by a pair of collimator members, and an energy detector mounted to one of the collimator members to be disposed on the upstream side thereof. When the pair of collimator members are moved in directions away from each other, a beam passage is formed between them. The energy detector constitutes an energy measuring device together with a signal processing unit. A part of the ion beam having reached the interior of the irradiation nozzle is irradiated to a patient through the beam passage. When a part of the remaining ion beam enters the energy detector, electric charges generate in the energy detector. The signal processing unit determines energy of the ion beam based on a position within the energy detector at which electric charges have generated in maximum amount.

5. 发明授权

US07825388B2 Charged particle beam irradiation system and charged particle beam extraction method 有权
标题翻译：带电粒子束照射系统和带电粒子束提取方法
公开(公告)号：US07825388B2
公开(公告)日：2010-11-02
申请号：US11678300
申请日：2007-02-23
申请人： Hideaki Nihongi , Koji Matsuda , Kazuo Hiramoto , Hiroshi Akiyama
发明人： Hideaki Nihongi , Koji Matsuda , Kazuo Hiramoto , Hiroshi Akiyama
IPC分类号： H05H9/00
CPC分类号： G21K1/10 , A61N5/1048 , A61N5/1065 , A61N2005/1087 , A61N2005/1095 , A61N2005/1096 , H05H7/10
摘要： A charged particle beam irradiation system and a charged particle beam extraction method which can prevent erroneous irradiation of a charged particle beam in the direction of advance of the charged particle beam. The system and method are featured in stopping supply of an ion beam to one or more of a plurality of angle zones in each of which a target dose is attained, the angle zones being formed by dividing an RMW in a rotating direction thereof, and in allowing the supply of the ion beam to one or more other angle zones in each of which a target dose is not yet attained. The invention can easily adjust beam doses at various positions in an affected part of the patient body in the direction of advance of the ion beam, and can greatly reduce the probability of erroneous irradiation that the beam dose becomes excessive or deficient at the various positions within the affected part of the patient body in the direction of advance of the ion beam.
摘要翻译：带电粒子束照射系统和带电粒子束提取方法，其可以防止带电粒子束沿着带电粒子束的前进方向的错误照射。该系统和方法的特征在于停止向多个角区域中的一个或多个角度区域供应目标剂量，其中角度区域通过沿其旋转方向分割RMW而形成，并且在允许将离子束供应到一个或多个其他角度区域，其中每个角度区域中尚未获得目标剂量。本发明可以容易地在离子束前进方向上调整患者身体的受影响部位的各个位置处的光束剂量，并且可以大大降低光束剂量在各种位置内过度或不足的错误照射的可能性患者身体的受影响部分在离子束前进方向。

6. 发明授权

US07394082B2 Ion beam delivery equipment and an ion beam delivery method 有权
标题翻译：离子束输送设备和离子束输送方法
公开(公告)号：US07394082B2
公开(公告)日：2008-07-01
申请号：US11414204
申请日：2006-05-01
申请人： Hisataka Fujimaki , Koji Matsuda , Hiroshi Akiyama , Masaki Yanagisawa , Alfred R. Smith , Kazuo Hiramoto
发明人： Hisataka Fujimaki , Koji Matsuda , Hiroshi Akiyama , Masaki Yanagisawa , Alfred R. Smith , Kazuo Hiramoto
IPC分类号： A61N5/00
CPC分类号： A61N5/1048 , A61N2005/1087 , A61N2005/1095 , G21K1/10 , G21K5/04
摘要： The invention is intended to confirm whether the SOBP (spread-out Bragg peak) width is a desired value in real time during beam irradiation, and to improve safety in treatment. Ion beam delivery equipment comprises a beam generator including a synchrotron, an RMW (range modulation wheel) device for forming an SOBP width of an ion beam extracted from the beam generator, a beam delivery nozzle including a reference dose monitor and a main dose monitor which are installed respectively upstream and downstream of the RMW device in the direction of travel of the ion beam, and an SOBP width computing unit for computing the SOBP width of the ion beam, which is formed by the RMW device, based on values detected by both the reference dose monitor and the main dose monitor.
摘要翻译：本发明旨在确认在光束照射期间SOBP（展开布拉格峰）宽度是否是实时的期望值，并且提高了处理中的安全性。离子束输送设备包括一个光束发生器，它包括同步加速器，用于形成从光束发生器提取的离子束的SOBP宽度的RMW（范围调制轮）装置，包括参考剂量监测器和主剂量监测器分别安装在RMW装置的上游和下游沿着离子束行进的方向;以及SOBP宽度计算单元，用于根据由两个检测到的值计算由RMW装置形成的离子束的SOBP宽度参考剂量监测仪和主剂量监测仪。

7. 发明申请

US20080067405A1 CHARGED PARTICLE BEAM IRRADIATION SYSTEM AND CHARGED PARTICLE BEAM EXTRACTION METHOD 有权
标题翻译：充电颗粒光束辐射系统和充电颗粒光束提取方法
公开(公告)号：US20080067405A1
公开(公告)日：2008-03-20
申请号：US11678300
申请日：2007-02-23
申请人： Hideaki Nihongi , Koji Matsuda , Kazuo Hiramoto , Hiroshi Akiyama
发明人： Hideaki Nihongi , Koji Matsuda , Kazuo Hiramoto , Hiroshi Akiyama
IPC分类号： G01K1/08
CPC分类号： G21K1/10 , A61N5/1048 , A61N5/1065 , A61N2005/1087 , A61N2005/1095 , A61N2005/1096 , H05H7/10
摘要： A charged particle beam irradiation system and a charged particle beam extraction method which can prevent erroneous irradiation of a charged particle beam in the direction of advance of the charged particle beam. The system and method are featured in stopping supply of an ion beam to one or more of a plurality of angle zones in each of which a target dose is attained, the angle zones being formed by dividing an RMW in a rotating direction thereof, and in allowing the supply of the ion beam to one or more other angle zones in each of which a target dose is not yet attained. The invention can easily adjust beam doses at various positions in an affected part of the patient body in the direction of advance of the ion beam, and can greatly reduce the probability of erroneous irradiation that the beam dose becomes excessive or deficient at the various positions within the affected part of the patient body in the direction of advance of the ion beam.
摘要翻译：带电粒子束照射系统和带电粒子束提取方法，其可以防止带电粒子束沿着带电粒子束的前进方向的错误照射。该系统和方法的特征在于停止向多个角区域中的一个或多个角度区域供应目标剂量，其中角度区域通过沿其旋转方向分割RMW而形成，并且在允许将离子束供应到一个或多个其他角度区域，其中每个角度区域中尚未获得目标剂量。本发明可以容易地在离子束前进方向上调整患者身体的受影响部位的各个位置处的光束剂量，并且可以大大降低光束剂量在各种位置内过度或不足的错误照射的可能性患者身体的受影响部分在离子束前进方向。

8. 发明授权

US06433349B1 Charged-particle beam irradiation method and system 有权
公开(公告)号：US06433349B1
公开(公告)日：2002-08-13
申请号：US09850140
申请日：2001-05-08
申请人： Hiroshi Akiyama , Kazuo Hiramoto , Koji Matsuda
发明人： Hiroshi Akiyama , Kazuo Hiramoto , Koji Matsuda
IPC分类号： H05H1304
摘要： A charged-particle beam irradiation system for an affected part in which while a charged-particle beam ejected from an accelerator is scanned by an electromagnet onto the affected part, each layer of the affected part resulting from division of the affected part into a plurality of layers in a direction of progression of said charged-particle beam is irradiated with the charged-particle beam. The system includes a changer for changing an energy of said charged-particle beam in accordance with a layer of the plurality of layers to be irradiated with the charged-particle beam and an intensity controller for controlling an intensity of the charged-particle beam.

9. 发明授权

US6087672A Charged particle beam irradiation system and irradiation method thereof 失效
标题翻译：带电粒子束照射系统及其照射方法
公开(公告)号：US6087672A
公开(公告)日：2000-07-11
申请号：US106905
申请日：1998-06-30
申请人： Koji Matsuda , Hiroshi Akiyama , Kazuo Hiramoto
发明人： Koji Matsuda , Hiroshi Akiyama , Kazuo Hiramoto
IPC分类号： A61N5/10 , G21K1/04 , G21K5/04 , G21K1/00 , H01J1/52
CPC分类号： A61N5/1042 , G21K1/04 , G21K1/046 , A61N2005/1087 , A61N2005/1095
摘要： A charged particle beam irradiation system includes a beam spreading device, a ridge filter, a range shifter, a collimator, and a bolus. Further, on a supporting plate in the ridge filter, a plurality of ridge components are arranged, and shielding elements are attached at the top parts of a part of the plurality of the ridge components.
摘要翻译：带电粒子束照射系统包括光束扩展装置，脊滤波器，范围移位器，准直器和推注。此外，在脊形过滤器的支撑板上，布置有多个脊部件，并且屏蔽元件安装在多个脊部件的一部分的顶部。

10. 发明授权

US5986274A Charged particle irradiation apparatus and an operating method thereof 失效
标题翻译：带电粒子照射装置及其操作方法
公开(公告)号：US5986274A
公开(公告)日：1999-11-16
申请号：US18317
申请日：1998-02-03
申请人： Hiroshi Akiyama , Kazuo Hiramoto , Koji Matsuda , Tetsuo Norimine
发明人： Hiroshi Akiyama , Kazuo Hiramoto , Koji Matsuda , Tetsuo Norimine
IPC分类号： G21K1/093 , A61N5/10 , G21K5/04 , G21K5/10 , H01J37/21 , A61N5/00 , H01J33/00
CPC分类号： A61N5/10 , G21K5/10 , A61N2005/1087 , A61N5/1048
摘要： A charged particle irradiation apparatus, which is capable of decreasing a lateral dose falloff at boundaries of irradiation field of charged particle beam, and reducing the size of the charged particle irradiation apparatus, is provided by controlling magnetic fields of quadrupole electromagnets 1-5 and deflection electromagnets 6-8 so that center of the charged particle beam passes always center of a scatterer irrespective of direction and intensity of a magnetic field generated by scanning electromagnets 50, 60.
摘要翻译：通过控制四极电磁铁1-5的磁场和偏转来提供带电粒子照射装置，其能够减少带电粒子束的照射场的边界处的横向剂量衰减并且减小带电粒子照射装置的尺寸电磁体6-8，使得带电粒子束的中心总是通过扫描电磁体50,60产生的磁场的方向和强度通过散射体的中心。

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