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1. 发明申请

US20090221475A9 Treatment of lung disorders 审中-公开
标题翻译：治疗肺部疾病
公开(公告)号：US20090221475A9
公开(公告)日：2009-09-03
申请号：US10396855
申请日：2003-03-25
申请人： Kazunori Murakami , Perenlei Enkhbaatar , Lillian Traber , Donald Prough , David Herndon , Daniel Traber
发明人： Kazunori Murakami , Perenlei Enkhbaatar , Lillian Traber , Donald Prough , David Herndon , Daniel Traber
IPC分类号： A61K38/48
CPC分类号： A61K9/0078 , A61K38/57
摘要： The invention features methods of treating a subject having a lung disorder such as lung inflammation and injury, by administering antithrombin III by inhalation.
摘要翻译：本发明的特征在于通过吸入施用抗凝血酶III来治疗患有肺部疾病如肺部炎症和损伤的受试者的方法。

2. 发明申请

US20070232873A1 NONINVASIVE, ACCURATE GLUCOSE MONITORING WITH OCT BY USING TISSUE WARMING AND TEMPERATURE CONTROL 审中-公开
标题翻译：使用组织加温和温度控制对OCT进行精确的葡萄糖监测
公开(公告)号：US20070232873A1
公开(公告)日：2007-10-04
申请号：US11685677
申请日：2007-03-13
申请人： Rinat Esenaliev , Donald Prough
发明人： Rinat Esenaliev , Donald Prough
IPC分类号： A61B5/00
CPC分类号： A61B5/0066 , A61B5/0053 , A61B5/0073 , A61B5/14532
摘要： A new OCT system and method are disclosed, where the system includes a probe equipped with a heating element and a high heat conductive member to warm a tissue site to be scanned to an elevated and/or to maintain the elevated tissue temperature with a temperature variation of less than or equal to 1° C. to improve an accuracy and reliability of an OCT glucose concentration value other long measurement durations. The new OCT system and method can also be equipped with pressure components to reduce a pressure exerted on the tissue site to a minimal constant pressure.
摘要翻译：公开了一种新的OCT系统和方法，其中系统包括配备有加热元件和高导热构件的探针，以将待扫描的组织部位加热到升高和/或维持升高的组织温度与温度变化小于或等于1℃，以提高其他长测量持续时间的OCT葡萄糖浓度值的精度和可靠性。新的OCT系统和方法还可以配备压力组件以将施加在组织部位上的压力降低到最小的恒定压力。

3. 发明申请

US20070255141A1 Noninvasive glucose sensing methods and systems 有权
标题翻译：无创葡萄糖感测方法和系统
公开(公告)号：US20070255141A1
公开(公告)日：2007-11-01
申请号：US11656336
申请日：2007-01-22
申请人： Rinat Esenaliev , Donald Prough
发明人： Rinat Esenaliev , Donald Prough
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/0095 , A61B5/1075
摘要： New methods and systems for noninvasive glucose monitoring and sensing with electromagnetic waves or ultrasound are disclosed. The methods are based on absolute or relative measurement of tissue dimensions (or changes in the dimensions) including, but not limited to: thickness, length, width, diameter, curvature, roughness as well as time of flight of ultrasound and optical pulses and optical thickness, which change with changing blood glucose concentrations. By measuring noninvasively absolute or relative changes in at least one dimension of at least one tissue or tissue layer or absolute or relative changes in time of flight of ultrasound or optical pulses, one can monitor blood glucose concentration noninvasively.
摘要翻译：公开了用于用电磁波或超声波进行无创葡萄糖监测和感测的新方法和系统。这些方法基于组织尺寸（或尺寸变化）的绝对或相对测量，包括但不限于：超声和光脉冲的光学厚度，长度，宽度，直径，曲率，粗糙度以及飞行时间和光学厚度随着血糖浓度的变化而变化。通过测量至少一个组织或组织层的至少一个维度中的非侵入性绝对或相对变化或超声或光脉冲的飞行时间的绝对或相对变化，可以非侵入性地监测血糖浓度。

4. 发明申请

US20090311323A1 Autologous somatic cells from peripheral blood and uses thereof 审中-公开
标题翻译：来自外周血的自体体细胞及其用途
公开(公告)号：US20090311323A1
公开(公告)日：2009-12-17
申请号：US11919527
申请日：2006-04-28
申请人： Joaquin Cortiella , Joan E. Nichols , Jean A. Niles , Eric Lee , Donald Prough
发明人： Joaquin Cortiella , Joan E. Nichols , Jean A. Niles , Eric Lee , Donald Prough
IPC分类号： A61K35/12 , C12N5/08 , A61K38/20 , A61K9/14
CPC分类号： C12N5/0623 , C12N2502/08 , C12N2506/11
摘要： The present invention is directed to developing treatment for spinal cord injury, traumatic brain injury and neural disease using autologous somatic stem cells isolated from peripheral blood. The method identified in the present invention will generate functional neural cells/tissues in order to replace the diseased or damaged neural cells/tissues. In doing so, the cells will not only reverse the motor as well as cognitive dysfunction but will also stabilize the injury site, reduce inflammation and scaring, and halt progressive loss of functional tissue. Further, this method also holds a great promise since it is non-invasive, autologous and can be used acutely.
摘要翻译：本发明涉及使用从外周血分离的自体体细胞干细胞来开发脊髓损伤，创伤性脑损伤和神经疾病的治疗。在本发明中鉴定的方法将产生功能性神经细胞/组织，以便替代患病或受损的神经细胞/组织。在这样做时，细胞不仅会逆转运动以及认知功能障碍，而且还会稳定受伤部位，减少炎症和惊吓，并停止功能组织的进行性损失。此外，这种方法也是非常有希望的，因为它是非侵入性的，自体的，可以被急性使用。

5. 发明申请

US20070232872A1 CONTINUOUS NONINVASIVE GLUCOSE MONITORING IN DIABETIC, NON-DIABETIC, AND CRITICALLY ILL PATIENTS WITH OCT 审中-公开
标题翻译：在糖尿病，非糖尿病和临床相关患者中连续使用无创性葡萄糖监测
公开(公告)号：US20070232872A1
公开(公告)日：2007-10-04
申请号：US11685574
申请日：2007-03-13
申请人： Donald Prough , Rinat Esenaliev , Massoud Motamedi
发明人： Donald Prough , Rinat Esenaliev , Massoud Motamedi
IPC分类号： A61B5/00
CPC分类号： A61B5/0066 , A61B5/14532 , A61B5/412
摘要： New optical coherence tomography (OCT) techniques are disclosed which are designed to improve OCT glucose concentration measure accuracy and are capable of being performed on a continuous basis. New multi-wavelength optical coherence tomography (OCT) techniques are also disclosed and designed to reduce artifacts do to water. New optical coherence tomography (OCT) techniques are also disclosed for determining local profusion rates, local analyte transport rates and tissue analyte transport rates as a measure of tissue health, disease progression and state and tissue transplantation effectiveness.
摘要翻译：公开了新的光学相干断层扫描（OCT）技术，其被设计用于提高OCT葡萄糖浓度测量精度并且能够连续地执行。还公开并设计了新的多波长光学相干断层扫描（OCT）技术以减少对水的伪影。还公开了新的光学相干断层扫描（OCT）技术，用于确定局部渗透率，局部分析物传输速率和组织分析物传输速率，作为组织健康，疾病进展和状态和组织移植有效性的量度。

6. 发明申请

US20060195021A1 Noninvasive blood analysis by optical probing of the veins under the tongue 有权
公开(公告)号：US20060195021A1
公开(公告)日：2006-08-31
申请号：US10554149
申请日：2004-04-26
申请人： Rinat Esenal , Donald Prough
发明人： Rinat Esenal , Donald Prough
IPC分类号： A61B5/00
CPC分类号： A61B5/0068 , A61B5/0066 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/682
摘要： A method for analysis of blood components or parameters is disclosed where a probe having an excitation outlet and a response inlet is placed in proximity to or in contact with a tissue of an underside of a patient's tongue over a big vein in the tongue so that an excitation signal exits the outlet, produces a response which enters the inlet for detection and analysis.

7. 发明授权

US06751490B2 Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit 有权
标题翻译：连续光声监测血红蛋白浓度和血细胞比容
公开(公告)号：US06751490B2
公开(公告)日：2004-06-15
申请号：US09796992
申请日：2001-03-01
申请人： Rinat Esenaliev , Massoud Motamedi , Donald Prough
发明人： Rinat Esenaliev , Massoud Motamedi , Donald Prough
IPC分类号： A61B500
CPC分类号： A61B5/14535 , A61B5/0095 , A61B5/1455
摘要： An optoacoustic apparatus is disclosed which includes a radiation source of pulsed optical radiation and a probe having a front face to be placed in contact with a tissue site of an animal body. The probe further includes an optical fiber terminating at the surface of the front face of the probe and connected to a pulsed laser. The front face of the probe also has mounted therein or thereon a piezoelectric transducer for detecting an acoustic response to the radiation pulses connected to a processing unit which converts the transducer signal into a measure of hemoglobin concentration and/or hematocrit of blood.
摘要翻译：公开了一种光声装置，其包括脉冲光辐射的辐射源和具有与动物体的组织部位接触的前表面的探针。探头还包括终端于探头正面的表面并连接到脉冲激光的光纤。探针的前表面也安装在其中或其上安装有用于检测连接到处理单元的辐射脉冲的声响应的压电换能器，其将换能器信号转换成血红蛋白浓度和/或血细胞比容的测量。

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