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1. 发明授权

US08668933B2 Polyion complex of double-stranded ribonucleic acid 有权
标题翻译：双链核糖核酸的Polyion复合物
公开(公告)号：US08668933B2
公开(公告)日：2014-03-11
申请号：US13259961
申请日：2010-03-31
申请人： Yuichi Hori , Kazunori Kataoka , Toshiro Fujita , Hideki Shimizu , Shinya Kaname , Satoru Matsumoto , Nobuhiro Nishiyama , Kanjiro Miyata , Makoto Oba
发明人： Yuichi Hori , Kazunori Kataoka , Toshiro Fujita , Hideki Shimizu , Shinya Kaname , Satoru Matsumoto , Nobuhiro Nishiyama , Kanjiro Miyata , Makoto Oba
IPC分类号： A61K9/14 , C07H21/02 , C12N15/11
CPC分类号： C12N15/87 , C12N15/111 , C12N2320/32 , Y10T428/2982
摘要： Provided are a delivery system that is useful in delivering a double-stranded ribonucleic acid that functions in gene silencing in glomeruli, particularly in mesangial cells and the like, to the tissue or cells, and the like. A polyion complex in the form of a non-polymeric micelle consisting of a double-stranded ribonucleic acid and a block copolymer represented by the formula (I) or (II) below, which are electrostatically bound together, wherein the polyion complex has an average particle diameter of less than 100 nm as measured by a dynamic light scattering measuring method: wherein each symbol is as defined in the specification.
摘要翻译：提供了一种递送系统，其可用于递送在肾小球，特别是肾小球系膜细胞等中的基因沉默中起作用的组织或细胞等的双链核糖核酸。由双链核糖核酸和由下式（I）或（II）表示的嵌段共聚物组成的非聚合胶束形式的聚离子络合物，其静电结合在一起，其中聚离子络合物具有平均值通过动态光散射测量方法测量的小于100nm的粒径：其中每个符号如说明书中所定义。

2. 发明申请

US20120076836A1 POLYION COMPLEX OF DOUBLE-STRANDED RIBONUCLEIC ACID 有权
标题翻译：双链抗坏血酸的多重复合物
公开(公告)号：US20120076836A1
公开(公告)日：2012-03-29
申请号：US13259961
申请日：2010-03-31
申请人： Yuichi Hori , Kazunori Kataoka , Toshiro Fujita , Hideki Shimizu , Shinya Kaname , Satoru Matsumoto , Nobuhiro Nishiyama , Kanjiro Miyata , Makoto Oba
发明人： Yuichi Hori , Kazunori Kataoka , Toshiro Fujita , Hideki Shimizu , Shinya Kaname , Satoru Matsumoto , Nobuhiro Nishiyama , Kanjiro Miyata , Makoto Oba
IPC分类号： A61K9/14 , C08L71/00 , C07H21/02 , A61K31/80 , A61P13/12 , B82Y5/00
CPC分类号： C12N15/87 , C12N15/111 , C12N2320/32 , Y10T428/2982
摘要： Provided are a delivery system that is useful in delivering a double-stranded ribonucleic acid that functions in gene silencing in glomeruli, particularly in mesangial cells and the like, to the tissue or cells, and the like. A polyion complex in the form of a non-polymeric micelle consisting of a double-stranded ribonucleic acid and a block copolymer represented by the formula (I) or (II) below, which are electrostatically bound together, wherein the polyion complex has an average particle diameter of less than 100 nm as measured by a dynamic light scattering measuring method: wherein each symbol is as defined in the specification.
摘要翻译：提供了一种递送系统，其可用于递送在肾小球，特别是肾小球系膜细胞等中的基因沉默中起作用的组织或细胞等的双链核糖核酸。由双链核糖核酸和由下式（I）或（II）表示的嵌段共聚物组成的非聚合胶束形式的聚离子络合物，其静电结合在一起，其中聚离子络合物具有平均值通过动态光散射测量方法测量的小于100nm的粒径：其中每个符号如说明书中所定义。

3. 发明申请

US20100121043A1 ENVIRONMENT-RESPONDING siRNA CARRIER USING DISULFIDE-CROSS-LINKED POLYMERIC MICELLE 有权
标题翻译：使用非交联聚合物微环境的环境反应siRNA载体
公开(公告)号：US20100121043A1
公开(公告)日：2010-05-13
申请号：US12515464
申请日：2007-11-22
申请人： Kazunori Kataoka , Nobuhiro Nishiyama , Satoru Matsumoto
发明人： Kazunori Kataoka , Nobuhiro Nishiyama , Satoru Matsumoto
IPC分类号： C12N15/113
CPC分类号： A61K47/34 , A61K9/1075 , A61K31/713 , A61K47/42 , A61K47/6907 , A61K48/00 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32
摘要： Disclosed is a siRNA-encapsulating polymeric micelle complex (a polyion complex) having high monodispersibility and structural stability and excellent in the ability of transporting siRNA into a cell. Further disclosed are a nucleic acid delivery device, a nucleic acid delivery kit, a pharmaceutical composition, and a gene therapy agent, each of which uses the complex. The polyion complex is characterized by comprising: a block copolymer composed of a polyethylene glycol moiety and a polycation moiety having a thiol group as a side chain at the terminus; and siRNA.
摘要翻译：公开了具有高的单分散性和结构稳定性以及将siRNA输送到细胞中的能力优异的siRNA包封的聚合物胶束复合物（聚离子络合物）。进一步公开的是核酸递送装置，核酸递送试剂盒，药物组合物和基因治疗剂，其各自使用该复合物。聚阳离子络合物的特征在于包含：由聚乙二醇部分和在末端具有硫醇基作为侧链的聚阳离子部分组成的嵌段共聚物; 和siRNA。

4. 发明授权

US08153110B2 Environment-responding siRNA carrier using disulfide-cross-linked polymeric micelle 有权
标题翻译：使用二硫键交联聚合物胶束的环境反应siRNA载体
公开(公告)号：US08153110B2
公开(公告)日：2012-04-10
申请号：US12515464
申请日：2007-11-22
申请人： Kazunori Kataoka , Nobuhiro Nishiyama , Satoru Matsumoto
发明人： Kazunori Kataoka , Nobuhiro Nishiyama , Satoru Matsumoto
IPC分类号： A61K47/48 , A61K9/14 , C07H21/02
CPC分类号： A61K47/34 , A61K9/1075 , A61K31/713 , A61K47/42 , A61K47/6907 , A61K48/00 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32
摘要： Disclosed is a siRNA-encapsulating polymeric micelle complex (a polyion complex) having high monodispersibility and structural stability and excellent in the ability of transporting siRNA into a cell. Further disclosed are a nucleic acid delivery device, a nucleic acid delivery kit, a pharmaceutical composition, and a gene therapy agent, each of which uses the complex. The polyion complex is characterized by comprising: a block copolymer composed of a polyethylene glycol moiety and a polycation moiety having a thiol group as a side chain at the terminus; and siRNA.
摘要翻译：公开了具有高的单分散性和结构稳定性以及将siRNA输送到细胞中的能力优异的siRNA包封的聚合物胶束复合物（聚离子络合物）。进一步公开的是核酸递送装置，核酸递送试剂盒，药物组合物和基因治疗剂，其各自使用该复合物。聚阳离子络合物的特征在于包含：由聚乙二醇部分和在末端具有硫醇基作为侧链的聚阳离子部分组成的嵌段共聚物; 和siRNA。

5. 发明授权

US09062407B2 Washing machine and control method thereof 有权
标题翻译：洗衣机及其控制方法
公开(公告)号：US09062407B2
公开(公告)日：2015-06-23
申请号：US13088692
申请日：2011-04-18
申请人： Seung Hoon Kim , Sung Mo Lee , Hyun Bae Kim , Satoru Matsumoto , Sung Woo Her
发明人： Seung Hoon Kim , Sung Mo Lee , Hyun Bae Kim , Satoru Matsumoto , Sung Woo Her
IPC分类号： D06F33/02 , D06F35/00 , D06F37/20
CPC分类号： D06F37/203 , D06F35/008 , D06F2204/04 , D06F2204/065 , Y02B40/56
摘要： A washing machine and a control method thereof in which a tub washing course is safely performed using a sensor to measure vibration of a tub. Since whether or not laundry is present in s drum is sensed while performing the tub washing course, consumption of separate time, water, and energy to sense whether or not laundry is present is not required, and operation of the washing machine is controlled by diagnosing malfunction of the sensor. If plural sensors are installed, a micro-computer is connected to the plural sensors in common through a Serial Peripheral Interface (SPI) communication method or an Inter Integrated circuit (I2C) communication method, thereby reducing costs and volume of wire-harness.
摘要翻译：一种洗衣机及其控制方法，其中使用传感器安全地执行洗碗机洗涤过程以测量浴缸的振动。由于不需要在执行桶洗涤过程中是否存在衣物存在的情况下，不需要消耗独立的时间，水和能量来感测是否存在衣物，并且通过诊断来控制洗衣机的操作传感器故障如果安装了多个传感器，则微计算机通过串行外设接口（SPI）通信方式或内部集成电路（I2C）通信方式共同地连接到多个传感器，从而降低了线束的成本和体积。

6. 发明授权

US08608670B2 Guidewire 有权
标题翻译：导丝
公开(公告)号：US08608670B2
公开(公告)日：2013-12-17
申请号：US12977121
申请日：2010-12-23
申请人： Satoru Matsumoto , Masayuki Takahashi
发明人： Satoru Matsumoto , Masayuki Takahashi
IPC分类号： A61B5/00
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09133 , A61M2025/09175
摘要： An object of the present invention is to provide a guidewire having high safety and improved flexibility and rotation followability, and capable of directing a catheter with ease. A guidewire of the present invention has an inner coil that surrounds a distal side portion of a core shaft, and an outer coil that surrounds the inner coil and the distal side portion of the core shaft. The core shaft has a second flat part in flattened shape in substantially contact with an inner peripheral surface of the inner coil. With this configuration, the distal side portion of the guidewire is protected by a double coil structure, while having high torsional stiffness. This leads to improvement in safety and rotation followability, while allowing a catheter to be directed with ease.
摘要翻译：本发明的目的是提供一种具有高安全性和改进的柔性和旋转跟随性的导丝，并且能够容易地引导导管。本发明的导线具有围绕芯轴的前端部的内侧线圈和围绕芯轴的内侧线圈和前端侧部的外侧线圈。芯轴具有与内圈的内周面基本接触的扁平形状的第二扁平部。利用这种构造，导丝的远侧部分被双线圈结构保护，同时具有高的扭转刚度。这导致安全性和旋转跟随性的改善，同时容易地引导导管。

7. 发明授权

US08010363B2 Commercial detection apparatus and video playback apparatus 有权
标题翻译：商业检测装置和视频播放装置
公开(公告)号：US08010363B2
公开(公告)日：2011-08-30
申请号：US11710979
申请日：2007-02-27
申请人： Tatsuo Koga , Yuji Yamamoto , Ryosuke Ohtsuki , Satoru Matsumoto
发明人： Tatsuo Koga , Yuji Yamamoto , Ryosuke Ohtsuki , Satoru Matsumoto
IPC分类号： G10L11/00
CPC分类号： H04N21/812 , H04N21/4394 , H04N21/44008
摘要： An aspect of the invention provides a commercial detection apparatus for detecting commercials that includes a silent detector configured to detect a silent segment based on the strength of the audio signal output in content, and a determination unit configured to determine a sound segment as a commercial if three or more silent segments are detected essentially within a set time span, and if the sound segment is found between two of the three silent segments.
摘要翻译：本发明的一个方面提供了一种用于检测商业广告的商业检测装置，其包括：静音检测器，其被配置为基于内容中输出的音频信号的强度来检测静音段;以及确定单元，被配置为将声音段确定为商业的基本上在设定的时间范围内检测三个或更多个无声段，并且如果在三个静音段中的两个之间找到声音段。

8. 发明授权

US07985915B2 Musical piece matching judging device, musical piece recording device, musical piece matching judging method, musical piece recording method, musical piece matching judging program, and musical piece recording program 失效
标题翻译：音乐片匹配判断装置，乐曲记录装置，音乐片匹配判断方法，音乐作品记录方法，音乐作品匹配判断程序和音乐作品记录程序
公开(公告)号：US07985915B2
公开(公告)日：2011-07-26
申请号：US12029643
申请日：2008-02-12
申请人： Satoru Matsumoto , Yuji Yamamoto , Tatsuo Koga , Ryosuke Ohtsuki
发明人： Satoru Matsumoto , Yuji Yamamoto , Tatsuo Koga , Ryosuke Ohtsuki
IPC分类号： G10H1/00
CPC分类号： G10H1/0058 , G10H2240/141 , G10H2240/325 , G11B27/034 , G11B27/28 , G11B2220/2516
摘要： Characteristic amounts are calculated from each of multiple musical piece contents, and then time points when the characteristic amounts exceed a threshold are detected as cut points. Information on the cut point concerning each of the multiple musical piece contents is stored. Based on the stored information on the cut point, a judgment is made as to whether the multiple musical piece contents match each other.
摘要翻译：从多个乐曲内容中的每一个计算特征量，然后将特征量超过阈值的时间点作为切点检测。存储关于多个乐曲内容中的每一个的切割点的信息。基于存储在切点上的信息，判断多个乐曲内容是否彼此匹配。

9. 外观设计

USD605955S1 Time recorder 有权
标题翻译：时间记录仪
公开(公告)号：USD605955S1
公开(公告)日：2009-12-15
申请号：US29331351
申请日：2009-01-23
申请人： Satoru Matsumoto
设计人： Satoru Matsumoto

10. 发明授权

US07196027B2 Optical glass suffering little change in refractive index by radiation of light 有权
$Optical glass suffering little change in refractive index by radiation of light$
标题翻译：光学玻璃通过光的辐射几乎没有折射率的变化
公开(公告)号：US07196027B2
公开(公告)日：2007-03-27
申请号：US09872842
申请日：2001-06-01
申请人： Akira Masumura , Muneo Nakahara , Satoru Matsumoto , Tatsuya Senoo
发明人： Akira Masumura , Muneo Nakahara , Satoru Matsumoto , Tatsuya Senoo
IPC分类号： C03C3/102 , C03C3/105 , C03C3/108
CPC分类号： G03F7/708 , C03C3/091 , C03C3/102 , C03C3/247 , C03C4/0071 , C03C4/0085 , Y10S501/90
摘要： An optical glass wherein an amount of change in refractive index (Δn: difference in refractive index between a state before radiation and a state after radiation) caused by radiation of laser beam at wavelength of 351 nm having average output power of 0.43 W, pulse repetition rate of 5 kHz and pulse width of 400 ns for one hour is 5 ppm or below is provided. The optical glass comprises a fluorine ingredient and/or a titanium oxide ingredient and/or an arsenic oxide ingredient. The optical glass suffers little change in refractive index by radiation of strong light having wavelengths of 300 nm to 400 nm such as ultraviolet laser.
摘要翻译：一种光学玻璃，其中平均输出功率为0.43W，波长351nm的激光束的辐射引起的折射率变化量（Deltan：辐射前状态下的折射率与辐射后的差异）是脉冲重复提供5kHz的速率和400ns的脉冲宽度为1ppm的时间为5ppm或更低。光学玻璃包含氟成分和/或氧化钛成分和/或氧化砷成分。光学玻璃通过辐射波长为300nm〜400nm的强光，例如紫外线激光器，折射率几乎没有变化。

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