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1. 发明授权

US06440458B1 Sustained release preparations 有权
公开(公告)号：US06440458B1
公开(公告)日：2002-08-27
申请号：US09403787
申请日：1999-11-05
申请人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
发明人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
IPC分类号： A61K922
CPC分类号： A61K31/453 , A61K9/141 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/4858 , A61K31/407 , A61K31/436
摘要： Providing an oral formulation of a macrolide compound where the dissolution of the macrolide compound is under sustained release; and a sustained-release formulation containing a composition in solid solution, where the macrolide compound is present at an amorphous state in a solid base.

2. 发明授权

US08551522B2 Sustained-release formulation 有权
标题翻译：持续释放制剂
公开(公告)号：US08551522B2
公开(公告)日：2013-10-08
申请号：US12265108
申请日：2008-11-05
申请人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
发明人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
IPC分类号： A61K9/00 , A61K9/14 , A61K9/66 , C12N11/00
CPC分类号： A61K31/453 , A61K9/141 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/4858 , A61K31/407 , A61K31/436
摘要： A sustained-release formulation is provided comprising a solid dispersion composition comprising a tricyclic compound or a pharmaceutically acceptable salt thereof in a mixture comprising a water-soluble polymer and a water-insoluble polymer, and an excipient.
摘要翻译：提供了包含在包含水溶性聚合物和水不溶性聚合物和赋形剂的混合物中的包含三环化合物或其药学上可接受的盐的固体分散体组合物的缓释制剂。

3. 发明授权

US06884433B2 Sustained release formulation containing tacrolimus 有权
标题翻译：含有他克莫司的缓释制剂
公开(公告)号：US06884433B2
公开(公告)日：2005-04-26
申请号：US10412281
申请日：2003-04-14
申请人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
发明人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
IPC分类号： C07H15/04 , A61K20060101 , A61K9/10 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/48 , A61K9/52 , A61K31/40 , A61K31/405 , A61K31/407 , A61K31/4353 , A61K31/436 , A61K31/453 , A61K31/706 , A61K47/04 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/40 , A61P31/00 , A61P37/06 , C07D498/18 , G01N33/15 , A61K9/00 , A61K31/44
CPC分类号： A61K31/453 , A61K9/141 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/4858 , A61K31/407 , A61K31/436
摘要： Sustained release formulation containing tacrolimus or its hydrate is provided. The time (T63.2%) required for 63.2% of the maximum amount of tacrolimus or its hydrate to be dissolved is 0.7 to 15 hours. The time is measured in accordance to the Japanes Pharmacopocia, the 13-th edition, Dissolution Test, No. 2 (Puddles method, 50 rpm) using an aqueous 0.005% hydroxypropyl cellulose solution. This aqueous test solution is adjusted to pH 4.5, accordingly. The formulation further comprises a solid base which is a water-soluble or water-insoluble polymer. The formulation is in the form of a powder, fine powder, granule, tablet or capsule. The formulation is administered to a patient once a day for preventing organ or tissue rejection by transplantation or autoimmune disease. In addition, a solid dispersion composition is provided. The solid dispersion comprises tacrolimus or its hydrate in a mixture containing water-soluble or water-insoluble polymer and an excipient.
摘要翻译：提供含他克莫司或其水合物的缓释制剂。最高量的他克莫司或其水合物溶解63.2％所需的时间（T63.2％）为0.7〜15小时。该时间根据Japanes Pharmacopocia，第13版，溶出度试验，2号（Puddles法，50rpm），使用0.005％羟丙基纤维素水溶液测量。相应地将该水性测试溶液调节至pH 4.5。该制剂还包含固体碱，其为水溶性或水不溶性聚合物。制剂为粉末，细粉，颗粒，片剂或胶囊的形式。该制剂每天一次施用于患者，以通过移植或自身免疫疾病预防器官或组织排斥反应。此外，提供了固体分散体组合物。固体分散体包含他克莫司或其水合物，其含有水溶性或水不溶性聚合物和赋形剂的混合物。

4. 发明申请

US20050169993A1 Sustained-release formulation 审中-公开
标题翻译：持续释放制剂
公开(公告)号：US20050169993A1
公开(公告)日：2005-08-04
申请号：US11059439
申请日：2005-02-17
申请人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
发明人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
IPC分类号： C07H15/04 , A61K20060101 , A61K9/10 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/48 , A61K9/52 , A61K31/40 , A61K31/405 , A61K31/407 , A61K31/4353 , A61K31/436 , A61K31/453 , A61K31/706 , A61K47/04 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/40 , A61P31/00 , A61P37/06 , C07D498/18 , G01N33/15 , A61K31/4745
CPC分类号： A61K31/453 , A61K9/141 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/4858 , A61K31/407 , A61K31/436
摘要： A sustained-release formulation is provided comprising a solid dispersion composition comprising a tricyclic compound or a pharmaceutically acceptable salt thereof in a mixture comprising a water-soluble polymer and a water-insoluble polymer, and an excipient.
摘要翻译：提供了包含在包含水溶性聚合物和水不溶性聚合物和赋形剂的混合物中的包含三环化合物或其药学上可接受的盐的固体分散体组合物的缓释制剂。

5. 发明授权

US06576259B2 Sustained release formulations containing tacrolimus 有权
标题翻译：含有他克莫司的缓释制剂
公开(公告)号：US06576259B2
公开(公告)日：2003-06-10
申请号：US09978025
申请日：2001-10-17
申请人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
发明人： Kazunari Yamashita , Eiji Hashimoto , Yukihiro Nomura , Fumio Shimojo , Shigeki Tamura , Takeo Hirose , Satoshi Ueda , Takashi Saitoh , Rinta Ibuki , Toshio Ideno
IPC分类号： A61K900
CPC分类号： A61K31/453 , A61K9/141 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/4858 , A61K31/407 , A61K31/436
摘要： Sustained release formulation containing tacrolimus or its hydrate is provided. The time (T63.2%) required for 63.2% of the maximum amount of tacrolimus or its hydrate to be dissolved is 0.7 to 15 hours. The time is measured in accordance to the Japanese Pharmacopoeia, the 13-th edition, Dissolution Test, No. 2 (Puddle method, 50 rpm) using an aqueous 0.005% hydroxypropyl cellulose solution. This aqueous test solution is adjusted to pH 4.5, accordingly. The formulation further comprise a solid base which is a water-soluble polymer and/or wax. The formulation is in the form of a powder, fine powder, granule, tablet or capsule. Furthermore, the formulation is administered to a patient once a day for preventing organ or tissue rejection by transplantation or autoimmune diseases.
摘要翻译：提供含他克莫司或其水合物的缓释制剂。最高量的他克莫司或其水合物溶解63.2％所需的时间（T63.2％）为0.7〜15小时。时间根据日本药典，第13版，溶出度试验，第2号（Puddle法，50rpm），使用0.005％羟丙基纤维素水溶液测量。相应地将该水性测试溶液调节至pH 4.5。制剂还包含固体碱，其为水溶性聚合物和/或蜡。制剂为粉末，细粉，颗粒，片剂或胶囊的形式。此外，该制剂每天一次施用于患者，以通过移植或自身免疫疾病预防器官或组织排斥反应。

6. 发明授权

US4677959A Air intake side secondary air supply system for an internal combustion engine 失效
标题翻译：用于内燃机的进气侧二次空气供应系统
公开(公告)号：US4677959A
公开(公告)日：1987-07-07
申请号：US865394
申请日：1986-05-21
申请人： Norio Suzuki , Akira Watabe , Kazunari Yamashita
发明人： Norio Suzuki , Akira Watabe , Kazunari Yamashita
IPC分类号： F02D35/00 , F02D41/14 , F02M23/04 , F02M23/08
CPC分类号： F02D41/149 , F02D35/003 , F02M23/04 , F02M23/08 , Y02T10/146
摘要： Air intake side secondary air supply system for an internal combustion engine includes first and second secondary air supply passages leading to an intake manifold in which an open/close valve and an air control valve are respectively provided for a proportional control and an integral control of secondary air. In order to improve a driveability of the engine during a transition period from a feedback control mode to an open loop control mode, pressure control device for controlling a supply of first and second control pressures respectively for opening and closing the air control valve is constructed to rapidly supply the second control pressure when a state of engine operation in which the feedback control mode is to be stopped is detected.
摘要翻译：用于内燃机的进气侧二次空气供应系统包括通向进气歧管的第一和第二二次空气供应通道，其中分别设有开/关阀和空气控制阀用于比例控制和二次侧积分控制空气。为了提高在从反馈控制模式到开环控制模式的过渡期间发动机的驾驶性能，分别用于控制用于打开和关闭空气控制阀的第一和第二控制压力的供给的压力控制装置被构造成当检测到反馈控制模式要停止的发动机运转状态时，迅速地提供第二控制压力。

7. 发明授权

US4796589A Air-fuel ratio feedback control method for internal combustion engines 失效
标题翻译：内燃机空燃比反馈控制方法
公开(公告)号：US4796589A
公开(公告)日：1989-01-10
申请号：US148486
申请日：1988-01-26
申请人： Sachito Fujimoto , Kazunari Yamashita
发明人： Sachito Fujimoto , Kazunari Yamashita
IPC分类号： F02D41/00 , F02D41/14 , F02M23/08 , F02B3/00
CPC分类号： F02D41/1491
摘要： A method of effecting feedback control of the air-fuel ratio of an air-fuel mixture being supplied to an internal combustion engine, to bring the air-fuel ratio to desired values by correcting a fuel quantity to be supplied to the engine by means of a correction coefficient which varies in response to output from an exhaust gas concentration sensor, when the engine is operating in an air-fuel ratio feedback control region. An average value of values of the correction coefficient obtained is calculated while the engine is operating in the feedback control region. The calculated average value is corrected in dependence on a temperature of the engine and the feedback control is initiated by using the corrected average value as an initial value of the correction coefficient when the engine has shifted into the feedback control region from the another region. The calculated average value is corrected to such a value as to make the air-fuel ratio leaner as the engine temperature is lower.
摘要翻译：一种对供给到内燃机的空气燃料混合物的空燃比的反馈控制的方法，通过将供给发动机的燃料量修正为期望值，借助于当发动机在空燃比反馈控制区域中运行时，响应于排气浓度传感器的输出而变化的校正系数。在发动机在反馈控制区域中操作时，计算所获得的校正系数的值的平均值。计算出的平均值根据发动机的温度进行校正，并且当发动机从另一区域转移到反馈控制区域时，通过使用校正的平均值作为校正系数的初始值来启动反馈控制。计算出的平均值被校正为使得随着发动机温度较低而使空燃比变稀的值。

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