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1. 发明授权

US5474992A Method of treatment with pharmaceutical composition for renal disorder and a dialysis solution for extracorporeal hemodialysis 失效
标题翻译：用于肾脏疾病的药物组合物的治疗方法和用于体外血液透析的透析溶液
公开(公告)号：US5474992A
公开(公告)日：1995-12-12
申请号：US302192
申请日：1994-08-31
申请人： Kazumi Ogata , Takahiro Sakaue , Noriko Saito , Sachiko Matsuura , Rie Nagao , Shinya Ogino
发明人： Kazumi Ogata , Takahiro Sakaue , Noriko Saito , Sachiko Matsuura , Rie Nagao , Shinya Ogino
IPC分类号： A61K31/665 , A61K33/12 , A61M1/16 , A61K31/355 , A61K31/66
CPC分类号： A61K31/665 , A61K33/12 , A61M1/1654
摘要： A pharmaceutical composition for renal disorder and a dialysis solution for extracorporeal hemodialysis which comprise a phosphoric acid diester of the following formula: ##STR1## (wherein R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom or a methyl group) or a pharmacologically acceptable salt thereof.Since the composition of this invention inhibits the formation of free radicals in the body, it can be advantageously used for the prophylaxis and treatment of various renal disorders such as glomerulonephritis, acute renal failure, uremia, adriamycin nephrosis, puromycin nephrosis, gentamicin- and cisplatin-induced disorders of the kidney, renal impairment due to paraquat and other agricultural chemicals, and immune complex nephritis. Moreover, the composition of this invention is also of use as a dialysis solution for extracorporeal hemodialysis with the propylactic/therapeutic effect on dialysis amyloidosis.
摘要翻译：一种用于肾脏疾病的药物组合物和用于体外血液透析的透析溶液，其包含下式的磷酸二酯：其中R 1和R 2相同或不同，各自表示氢原子或甲基）或其药理学上可接受的盐。由于本发明的组合物抑制体内自由基的形成，因此可有利地用于预防和治疗各种肾脏疾病如肾小球性肾炎，急性肾功能衰竭，尿毒症，阿霉素肾病，嘌呤霉素肾病，庆大霉素和顺铂诱发的肾脏疾病，百草枯和其他农药引起的肾损伤和免疫复合性肾炎。此外，本发明的组合物也可用作体外血液透析的透析溶液，具有对透析性淀粉样变性的丙糖/治疗作用。

2. 发明授权

US5650404A Therapeutic composition for pancreatitis 失效
标题翻译：胰腺炎的治疗组合物
公开(公告)号：US5650404A
公开(公告)日：1997-07-22
申请号：US503722
申请日：1995-07-18
申请人： Kazumi Ogata , Takahiro Sakaue , Shinya Ogino , Sachiko Matsuura , Rie Nagao
发明人： Kazumi Ogata , Takahiro Sakaue , Shinya Ogino , Sachiko Matsuura , Rie Nagao
IPC分类号： A61K31/665
CPC分类号： A61K31/665
摘要： This invention provides a therapeutic composition for pancreatitis which comprises a phosphoric diester compound of the following formula or a pharmacologically acceptable salt thereof ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents hydrogen or methyl. The pharmaceutical composition of this invention can be used with advantage in the prevention and treatment of pancreatitis.
摘要翻译：本发明提供了一种胰腺炎治疗组合物，其包含下式的磷酸二酯化合物或其药理学上可接受的盐，其中R 1和R 2相同或不同，各自表示氢或甲基。本发明的药物组合物可有利地用于预防和治疗胰腺炎。

3. 发明授权

US5478815A Liver protectant tocophery-ascorbyl-phosphate 失效
标题翻译：肝保护剂 - 抗坏血酸磷酸酯
公开(公告)号：US5478815A
公开(公告)日：1995-12-26
申请号：US351097
申请日：1994-11-30
申请人： Kazumi Ogata , Takahiro Sakaue , Sachiko Matsuura , Rie Nagao , Shinya Ogino
发明人： Kazumi Ogata , Takahiro Sakaue , Sachiko Matsuura , Rie Nagao , Shinya Ogino
IPC分类号： A61K31/665 , A61K31/355 , A61K31/66
CPC分类号： A61K31/665 , Y10S514/893
摘要： A liver protectant comprising a phosphoric diester compound of the following formula (wherein R.sub.1 and R.sub.2 are the same or different and each represents hydrogen or methyl) or a pharmacologically acceptable salt thereof. ##STR1## The liver protectant composition of this invention effectively inhibits the elevation of GOT and GPT, among other parameters, so that it is useful for the prevention and therapy , of acute liver disorder, chronic liver disorder and fuminant liver disorder. It can also be used in cirrhosis of the liver with success. The liver protectant composition of this invention can be used with advantage in liver damage associated with alcohol intake and hepatic impairment due to acetaminophen and other drugs. Furthermore, the liver protectant composition of this invention is of value in acute intrahepatic cholestasis.
摘要翻译：一种肝保护剂，其包含下式的磷酸二酯化合物（其中R 1和R 2相同或不同，各自表示氢或甲基）或其药理学上可接受的盐。本发明的肝保护剂组合物有效地抑制GOT和GPT的升高等参数，从而可用于预防和治疗急性肝脏疾病，慢性肝脏疾病和fuminant肝脏紊乱。它也可以用于肝硬化，成功。本发明的肝保护剂组合物可有利地用于与对乙酰氨基酚和其他药物引起的酒精摄入和肝脏损伤相关的肝损伤。此外，本发明的肝保护剂组合物在急性肝内胆汁郁积中是有价值的。

4. 发明授权

US5807845A Therapeutic drug for acne vulgaris 失效
标题翻译：治疗寻常痤疮的药物
公开(公告)号：US5807845A
公开(公告)日：1998-09-15
申请号：US903036
申请日：1997-07-29
申请人： Kazumi Ogata , Takahiro Sakaue , Sachiko Matsuura , Masahito Iemura
发明人： Kazumi Ogata , Takahiro Sakaue , Sachiko Matsuura , Masahito Iemura
IPC分类号： A61K31/665
CPC分类号： A61K31/665 , Y10S514/859
摘要： The present invention provides a pharmaceutical composition for the therapy of acne vulgaris which comprises a phosphoric diester compound of the following formula or a pharmacologically acceptable salt thereof ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different and each represents hydrogen or methyl.
摘要翻译：本发明提供用于治疗寻常痤疮的药物组合物，其包含下式的磷酸二酯化合物或其药理学上可接受的盐，其中R 1和R 2可以相同或不同，并且各自表示氢或甲基。

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