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1. 发明授权

US10041876B2 Photoacoustic measurement apparatus 有权
公开(公告)号：US10041876B2
公开(公告)日：2018-08-07
申请号：US13003503
申请日：2009-07-09
申请人： Hiroshi Nishihara , Kazuhiko Fukutani , Takao Nakajima
发明人： Hiroshi Nishihara , Kazuhiko Fukutani , Takao Nakajima
IPC分类号： A61B5/05 , G01N21/17 , A61B5/00 , A61B5/145
摘要： A measurement apparatus capable of measuring a position and a size of an absorber with high accuracy, which includes: a light source unit for emitting a pulse beam; an illumination optical unit for leading the pulse beam emitted by the light source unit to an inside of an inspection object; and an acoustic signal detection unit for detecting a photoacoustic signal generated by the pulse beam in which the illumination optical unit includes a first and second illumination optical units that are arranged so that the inspection object is irradiated with the pulse beam from both sides thereof opposingly; and the acoustic signal detection unit is provided so that a detection surface of the acoustic signal detection unit is positioned on the same side as that of one of irradiation surfaces of the inspection object which the first and second illumination optical units irradiate with the pulse beam.

2. 发明授权

US08540637B2 Biological information acquisition apparatus and biological information acquisition method 有权
标题翻译：生物信息采集仪和生物信息采集方法
公开(公告)号：US08540637B2
公开(公告)日：2013-09-24
申请号：US13140816
申请日：2009-12-16
申请人： Toshinobu Tokita , Kazuhiko Fukutani , Takao Nakajima , Katsumi Nakagawa
发明人： Toshinobu Tokita , Kazuhiko Fukutani , Takao Nakajima , Katsumi Nakagawa
IPC分类号： A61B8/00
CPC分类号： A61B5/0095 , A61B5/0091 , A61B5/4312 , A61B8/0825 , A61B8/5207
摘要： When a subject is pressed by a plate and an acoustic wave is received by a probe via the plate, the acoustic wave is refracted because of the difference between a sound velocity in the subject and a sound velocity in the plate. When the refraction is not considered, a reduction in resolution occurs. Weights for signals or virtual wavefronts corresponding to the signals to be added to one another are determined using a thickness of the plate, the sound velocity in the plate, the sound velocity in the subject, positions of image elements (pixels or voxels) for image information, and arrival times of the acoustic wave from an object that is a sound source. The signals or the virtual wavefronts corresponding to the signals are added to one another, thereby acquiring the image information.
摘要翻译：当受试者被板按压并且通过探针经由板接收声波时，由于被检体中的声速和板中的声速之间的差异，声波被折射。当不考虑折射时，会发生分辨率降低。使用板的厚度，板中的声速，被摄体中的声速，图像的像素（像素或体素）的位置来确定对应于要添加到彼此的信号的信号或虚拟波前的权重信息和来自作为声源的物体的声波的到达时间。对应于信号的信号或虚拟波前相互添加，从而获取图像信息。

3. 发明授权

US08300224B2 Photoacoustic apparatus, and probe for receiving photoacoustic waves 有权
标题翻译：光声设备和用于接收光声波的探头
公开(公告)号：US08300224B2
公开(公告)日：2012-10-30
申请号：US13367894
申请日：2012-02-07
申请人： Takao Nakajima , Kazuhiko Fukutani , Yasufumi Asao , Ryuichi Nanaumi
发明人： Takao Nakajima , Kazuhiko Fukutani , Yasufumi Asao , Ryuichi Nanaumi
IPC分类号： G01N21/00
CPC分类号： G01N21/1702 , A61B5/0059 , A61B5/0095 , A61B8/4281 , G01N2021/1706
摘要： A photoacoustic apparatus obtains information on a specimen by receiving photoacoustic waves which are generated from the specimen resulting from light irradiated to the specimen. The apparatus includes a light source for irradiating light to the specimen, an acoustic wave receiver for receiving the photoacoustic waves, and a light reflection member for causing the light, which is radiated out of the specimen by optical diffusion thereof after having entered an interior of the specimen from the light source, to reenter the interior of the specimen, wherein the light reflection member allows elastic waves to pass therethrough. As a result, a photoacoustic apparatus and a probe are provided which can confine scattered light from the specimen into the specimen, and which can reliably prevent photoacoustic waves from being generated from a receiving element region of the probe by the scattered light.
摘要翻译：光声设备通过接收由照射到样本的光产生的样本产生的光声来获得关于样本的信息。该装置包括用于向样本照射光的光源，用于接收光声波的声波接收器，以及光反射构件，其用于使得通过其进入其内部的光学扩散而从样本中辐射出的光来自光源的样本，重新进入样本的内部，其中光反射构件允许弹性波通过。结果，提供了一种光声装置和探针，其可以将来自样本的散射光限制在样本中，并且可以可靠地防止通过散射光从探测器的接收元件区域产生光声波。

4. 发明授权

US09131851B2 Biological information imaging apparatus and method for analyzing biological information 有权
标题翻译：生物信息成像装置及生物信息分析方法
公开(公告)号：US09131851B2
公开(公告)日：2015-09-15
申请号：US12365237
申请日：2009-02-04
申请人： Kazuhiko Fukutani , Takao Nakajima , Yasufumi Asao
发明人： Kazuhiko Fukutani , Takao Nakajima , Yasufumi Asao
IPC分类号： A61B5/00 , G01N29/24 , A61B8/08
CPC分类号： A61B5/0095 , A61B5/0091 , A61B5/4312 , A61B5/4887 , A61B5/489 , A61B8/0825 , A61B8/4416 , A61B8/5223 , G01N29/2418
摘要： There are provided a biological information imaging apparatus that can measure ultrasound generated from an optical absorber in a deep part of a subject living body with high sensitivity, and a method for analyzing biological information using the biological information imaging apparatus. The biological information imaging apparatus that detects ultrasound and images biological information, includes: a light source that irradiates the subject with light for generating ultrasound from an optical absorber existing in the subject; an ultrasound transmission unit that transmits focused ultrasound to a specific region where the optical absorber exists; and an ultrasound detection unit that detects an ultrasound synthesized signal due to interaction between ultrasound generated from the optical absorber that absorbs the light and the focused ultrasound transmitted to the specific region.
摘要翻译：本发明提供一种生物信息成像装置，其能够高灵敏度地测量本体体内深部的光吸收体产生的超声波，以及使用该生物体信息成像装置分析生物信息的方法。检测超声波和图像生物信息的生物信息成像装置包括：从存在于被检体内的光吸收体照射被检体的光用于产生超声的光源; 超声波发送单元，其将聚焦超声波发送到存在光吸收体的特定区域; 以及超声波检测单元，其检测由吸收光的光吸收体产生的超声波与发送到特定区域的聚焦超声波之间的相互作用引起的超声合成信号。

5. 发明授权

US08396534B2 Intravital-information imaging apparatus 有权
标题翻译：动脉内信息成像装置
公开(公告)号：US08396534B2
公开(公告)日：2013-03-12
申请号：US12130331
申请日：2008-05-30
申请人： Kazuhiko Fukutani , Takao Nakajima , Kenichi Nagae , Yasuhiro Someda , Yasufumi Asao
发明人： Kazuhiko Fukutani , Takao Nakajima , Kenichi Nagae , Yasuhiro Someda , Yasufumi Asao
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0095 , A61B8/08 , G01N21/1702
摘要： An intravital-information imaging apparatus includes light sources for irradiating a living body with light, and acoustic-wave detectors that detect acoustic waves generated from a light absorber having absorbed part of energy of the light from the light sources, the light absorber existing in the living body. Furthermore, the intravital-information imaging apparatus includes signal processors that calculate information representing a distribution of optical characteristic values of the living body using sound pressures of the acoustic waves generated from the light absorber.
摘要翻译：活体信息成像装置包括用于对生物体照射光的光源，以及声波检测器，其检测由吸收了来自光源的光的能量的光吸收体产生的声波，存在于活体。此外，活体内信息成像装置包括使用从光吸收体产生的声波的声压来计算表示生物体的光学特性值的分布的信息的信号处理器。

6. 发明授权

US08260403B2 Photoacoustic imaging apparatus and photoacoustic imaging method 有权
标题翻译：光声成像装置和光声成像方法
公开(公告)号：US08260403B2
公开(公告)日：2012-09-04
申请号：US12816556
申请日：2010-06-16
申请人： Kazuhiko Fukutani , Takao Nakajima
发明人： Kazuhiko Fukutani , Takao Nakajima
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0073 , A61B5/0095 , G01N21/1702
摘要： A photoacoustic wave detector detects a photoacoustic wave generated inside a specimen by light irradiated thereto. A signal processing device: forms first volume data from a first signal, the first signal being the detection signal acquired from the detector or a signal obtained by adjusting an amplitude of the detection signal; forms second volume data from a second signal, the second signal being a signal obtained by changing a phase of the first signal; forms third volume data from the first and second volume data; and generates and outputs image data representing information on an interior of the specimen from the third volume data.
摘要翻译：光声波检测器通过照射到其上的光检测检测体内的光声波。信号处理装置：从第一信号形成第一体积数据，第一信号是从检测器获取的检测信号或通过调整检测信号的幅度而获得的信号; 从第二信号形成第二音量数据，第二信号是通过改变第一信号的相位而获得的信号; 从第一和第二卷数据形成第三卷数据; 并从第三体积数据生成并输出表示样本内部的信息的图像数据。

7. 发明申请

US20110178385A1 PHOTOACOUSTIC MEASURING APPARATUS WITH MOVABLE DETECTOR ARRAY 审中-公开
标题翻译：具有可移动探测器阵列的光电测量设备
公开(公告)号：US20110178385A1
公开(公告)日：2011-07-21
申请号：US13121899
申请日：2009-10-01
申请人： Kazuhiko Fukutani , Takao Nakajima
发明人： Kazuhiko Fukutani , Takao Nakajima
IPC分类号： A61B6/00
CPC分类号： G01S15/8945 , A61B5/0059 , A61B5/0095 , A61B8/4281 , A61B8/4494 , A61B8/54 , G01N21/1702 , G01N29/2418 , G01N29/265 , G01N2291/106 , G01S15/8925 , G01S15/8997
摘要： A measuring apparatus includes an acoustic transducer with a plurality of elements, each element detecting an acoustic wave generated from a sample and converting the wave into an electric signal; a movement control unit which moves the acoustic transducer from a first position to a second position; and a processing unit which generates image data on the basis of the electric signal. The acoustic transducer has a gap in the arrangement of the elements. The acoustic transducer detects an acoustic wave at the first position, is moved by the movement control unit such that the position of the gap at the first position corresponds to the position of the element at the second position, and then detects an acoustic wave at the second position. The processing unit generates image data on the basis of electric signals obtained at the first and second positions.
摘要翻译：测量装置包括具有多个元件的声换能器，每个元件检测从样本产生的声波并将波转换成电信号; 移动控制单元，其将所述声换能器从第一位置移动到第二位置; 以及处理单元，其基于电信号生成图像数据。声换能器在元件的布置上具有间隙。声换能器检测在第一位置处的声波，由移动控制单元移动，使得在第一位置处的间隙的位置对应于元件在第二位置处的位置，然后检测在该声波处的声波第二名处理单元基于在第一和第二位置处获得的电信号来生成图像数据。

8. 发明申请

US20110112391A1 PHOTOACOUSTIC MEASUREMENT APPARATUS 审中-公开
标题翻译：光电测量设备
公开(公告)号：US20110112391A1
公开(公告)日：2011-05-12
申请号：US13003503
申请日：2009-07-09
申请人： Hiroshi Nishihara , Kazuhiko Fukutani , Takao Nakajima
发明人： Hiroshi Nishihara , Kazuhiko Fukutani , Takao Nakajima
IPC分类号： A61B5/05
CPC分类号： G01N21/1702 , A61B5/0059 , A61B5/0091 , A61B5/0095 , A61B5/14546 , A61B5/4312 , G01N2021/1706
摘要： A measurement apparatus capable of measuring a position and a size of an absorber with high accuracy, which includes: a light source unit for emitting a pulse beam; an illumination optical unit for leading the pulse beam emitted by the light source unit to an inside of an inspection object; and an acoustic signal detection unit for detecting a photoacoustic signal generated by the pulse beam in which the illumination optical unit includes a first and second illumination optical units that are arranged so that the inspection object is irradiated with the pulse beam from both sides thereof opposingly; and the acoustic signal detection unit is provided so that a detection surface of the acoustic signal detection unit is positioned on the same side as that of one of irradiation surfaces of the inspection object which the first and second illumination optical units irradiate with the pulse beam.
摘要翻译：一种测量装置，其能够高精度地测量吸收体的位置和尺寸，该测量装置包括：用于发射脉冲光束的光源单元; 照明光学单元，用于将由光源单元发射的脉冲光束引导到检查对象的内部; 以及声学信号检测单元，用于检测由脉冲束产生的光声信号，其中照明光学单元包括第一和第二照明光学单元，其布置成使得检查对象从其两侧的脉冲光束相对照射; 提供声信号检测单元，使得声信号检测单元的检测表面位于与第一和第二照明光学单元用脉冲光束照射的检查对象的照射面中的一个的相同侧。

9. 发明申请

US20100331707A1 BIOLOGICAL INFORMATION IMAGING APPARATUS, BIOLOGICAL INFORMATION ANALYZING METHOD, AND BIOLOGICAL INFORMATION IMAGING METHOD 有权
标题翻译：生物信息成像装置，生物信息分析方法和生物信息成像方法
公开(公告)号：US20100331707A1
公开(公告)日：2010-12-30
申请号：US12876336
申请日：2010-09-07
申请人： Kazuhiko Fukutani , Takao Nakajima , Yasufumi Asao , Toru Den
发明人： Kazuhiko Fukutani , Takao Nakajima , Yasufumi Asao , Toru Den
IPC分类号： A61B6/00 , G01N21/00
CPC分类号： A61B5/0073 , A61B5/0035 , A61B5/0095
摘要： A biological information imaging apparatus includes: a light source; an acoustic wave detector that detects an acoustic wave generated from a light absorption material in a living body that has absorbed a part of energy of light irradiated from the light source to the living body, and converts it into a first electric signal; a photodetector that detects optical intensity of a portion of the light irradiated from the light source to the living body and propagating in the living body, and converts it into a second electric signal; and a calculation unit that calculates optical property distribution information on the living body by making use of an analytical result of one of the first electric signal and the second electric signal for analysis of the other electric signal.
摘要翻译：生物信息成像装置包括：光源; 声波检测器，其检测从吸收从光源照射到生物体的光的一部分能量的生物体中的光吸收材料产生的声波，并将其转换为第一电信号; 光检测器，其检测从光源照射到生物体并在生物体中传播的光的一部分的光强度，并将其转换为第二电信号; 以及计算单元，其通过利用第一电信号和第二电信号中的一个的分析结果来计算其他电信号的分析结果来计算生物体的光学性质分布信息。

10. 发明申请

US20100331662A1 PHOTOACOUSTIC IMAGING APPARATUS AND PHOTOACOUSTIC IMAGING METHOD 有权
标题翻译：摄影成像设备和摄影成像方法
公开(公告)号：US20100331662A1
公开(公告)日：2010-12-30
申请号：US12816556
申请日：2010-06-16
申请人： Kazuhiko Fukutani , Takao Nakajima
发明人： Kazuhiko Fukutani , Takao Nakajima
IPC分类号： A61B5/05
CPC分类号： A61B5/0059 , A61B5/0073 , A61B5/0095 , G01N21/1702
摘要： A photoacoustic wave detector detects a photoacoustic wave generated inside a specimen by light irradiated thereto. A signal processing device: forms first volume data from a first signal, the first signal being the detection signal acquired from the detector or a signal obtained by adjusting an amplitude of the detection signal; forms second volume data from a second signal, the second signal being a signal obtained by changing a phase of the first signal; forms third volume data from the first and second volume data; and generates and outputs image data representing information on an interior of the specimen from the third volume data.
摘要翻译：光声波检测器通过照射到其上的光检测检测体内的光声波。信号处理装置：从第一信号形成第一体积数据，第一信号是从检测器获取的检测信号或通过调整检测信号的幅度而获得的信号; 从第二信号形成第二音量数据，第二信号是通过改变第一信号的相位而获得的信号; 从第一和第二卷数据形成第三卷数据; 并从第三体积数据生成并输出表示样本内部的信息的图像数据。

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