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1. 发明授权

US10321894B2 Specimen information acquisition apparatus 有权
公开(公告)号：US10321894B2
公开(公告)日：2019-06-18
申请号：US14119411
申请日：2012-05-11
申请人： Katsuya Oikawa , Makoto Yamakawa , Tsuyoshi Shiina
发明人： Katsuya Oikawa , Makoto Yamakawa , Tsuyoshi Shiina
IPC分类号： A61B8/08 , A61B8/00 , G01S7/52
摘要： The present invention relates to formation of an image indicating viscoelastic characteristics in a specimen by a simple method.Stepwise pressurization in which, after pressure is instantaneously increased to a certain pressure value, the certain pressure value is kept for a certain time period is performed to measure the variation with time of strain distribution in the specimen and to calculate a stress from strain distribution at a saturation measurement time when the effect of the viscosity of a viscoelasticity measurement reference layer is saturated, thereby evaluating the modulus of elasticity and the coefficient of viscosity of a body tissue.

2. 发明申请

US20140221833A1 SUBJECT INFORMATION ACQUISITION APPARATUS 有权
标题翻译：主体信息获取装置
公开(公告)号：US20140221833A1
公开(公告)日：2014-08-07
申请号：US14110125
申请日：2012-04-05
申请人： Katsuya Oikawa , Kenichi Nagae , Makoto Yamakawa , Tsuyoshi Shiina
发明人： Katsuya Oikawa , Kenichi Nagae , Makoto Yamakawa , Tsuyoshi Shiina
IPC分类号： A61B8/08
CPC分类号： A61B8/485 , A61B8/085 , A61B8/0858 , A61B8/4483 , A61B8/5223 , A61B8/585 , G01S7/52042
摘要： Viscoelastic characteristics in a subject are imaged by a simple method.A viscoelasticity measurement reference layer whose elastic modulus and viscosity coefficient are known is included between an ultrasonic wave transmitting/receiving probe and the subject and distributions of elastic modulus and viscosity coefficient inside the subject are calculated from a change over time of strain generated in the viscoelasticity measurement reference layer and the subject according to a pressure applied to the subject which changes over time and known elastic modulus and viscosity coefficient of the viscoelasticity measurement reference layer.
摘要翻译：受试者的粘弹性特征通过简单的方法成像。弹性模量和粘度系数已知的粘弹性测量参考层包括在超声波发射/接收探头和被摄体之间，并且由粘弹性产生的应变随时间变化计算被测物内的弹性模量和粘度系数的分布测量参考层和受试者根据随时间变化的受试者的压力和粘弹性测量参考层的已知弹性模量和粘度系数。

3. 发明申请

US20140206995A1 SPECIMEN INFORMATION ACQUISITION APPARATUS 审中-公开
标题翻译：样本信息获取装置
公开(公告)号：US20140206995A1
公开(公告)日：2014-07-24
申请号：US14119411
申请日：2012-05-11
申请人： Katsuya Oikawa , Makoto Yamakawa , Tsuyoshi Shiina
发明人： Katsuya Oikawa , Makoto Yamakawa , Tsuyoshi Shiina
IPC分类号： A61B8/08 , A61B8/00
CPC分类号： A61B8/485 , A61B8/0825 , A61B8/0858 , A61B8/403 , A61B8/4227 , A61B8/429 , A61B8/5223 , A61B8/54 , G01S7/52042
摘要： The present invention relates to formation of an image indicating viscoelastic characteristics in a specimen by a simple method.Stepwise pressurization in which, after pressure is instantaneously increased to a certain pressure value, the certain pressure value is kept for a certain time period is performed to measure the variation with time of strain distribution in the specimen and to calculate a stress from strain distribution at a saturation measurement time when the effect of the viscosity of a viscoelasticity measurement reference layer is saturated, thereby evaluating the modulus of elasticity and the coefficient of viscosity of a body tissue.
摘要翻译：本发明涉及通过简单的方法形成指示样品中的粘弹性特征的图像。逐步加压，其中压力瞬时增加到一定压力值后，一定压力值保持一定时间，以测量样品中应变分布随时间的变化，并计算应变分布的应力当粘弹性测量参考层的粘度的影响饱和时的饱和度测量时间，从而评估身体组织的弹性模量和粘度系数。

4. 发明授权

US09655589B2 Subject information acquisition apparatus 有权
公开(公告)号：US09655589B2
公开(公告)日：2017-05-23
申请号：US14110125
申请日：2012-04-05
申请人： Katsuya Oikawa , Kenichi Nagae , Makoto Yamakawa , Tsuyoshi Shiina
发明人： Katsuya Oikawa , Kenichi Nagae , Makoto Yamakawa , Tsuyoshi Shiina
IPC分类号： A61B8/00 , A61B8/08 , G01S7/52
CPC分类号： A61B8/485 , A61B8/085 , A61B8/0858 , A61B8/4483 , A61B8/5223 , A61B8/585 , G01S7/52042
摘要： Viscoelastic characteristics in a subject are imaged by a simple method.A viscoelasticity measurement reference layer whose elastic modulus and viscosity coefficient are known is included between an ultrasonic wave transmitting/receiving probe and the subject and distributions of elastic modulus and viscosity coefficient inside the subject are calculated from a change over time of strain generated in the viscoelasticity measurement reference layer and the subject according to a pressure applied to the subject which changes over time and known elastic modulus and viscosity coefficient of the viscoelasticity measurement reference layer.

5. 发明授权

US08747318B2 Ultrasonic measurement apparatus 有权
标题翻译：超声波测量仪器
公开(公告)号：US08747318B2
公开(公告)日：2014-06-10
申请号：US12433006
申请日：2009-04-30
申请人： Tsuyoshi Shiina , Yasuhiro Someda , Kenichi Nagae , Katsuya Oikawa
发明人： Tsuyoshi Shiina , Yasuhiro Someda , Kenichi Nagae , Katsuya Oikawa
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B8/4477 , A61B8/485 , G01S7/52042 , G01S7/5209 , G01S15/8913 , G01S15/8993
摘要： A sample moves, either naturally (as in the case of the heart) or by application of force, and its movement is measured. A processing unit calculates first displacement related information concerning a first direction of the object to be measured (the sample) by using data in either one of an increase period and a decrease period of the force applied to the objected to be measured, from data received by a first ultrasonic probe. In addition, the processing unit calculates second displacement related information concerning a second direction of the object to be measured by using data in the same period as that used to calculate the first displacement related information, from data received by a second ultrasonic probe.
摘要翻译：样本自然地移动（如在心脏的情况下）或通过施加力，并且测量其运动。处理单元通过使用从接收到的被接收的被测对象的力的增加期间和减少期间中的任一个中的数据来计算关于待测量对象的第一方向（样本）的第一位移相关信息通过第一超声波探头。此外，处理单元从与第二超声波探头接收的数据相对应地使用与用于计算第一位移相关信息的数据相同的周期内的数据，计算与被测量物体的第二方向有关的第二位移关联信息。

6. 发明授权

US08382670B2 Ultrasonic diagnosis system and distortion distribution display method 有权
标题翻译：超声诊断系统和失真分布显示方法
公开(公告)号：US08382670B2
公开(公告)日：2013-02-26
申请号：US12956959
申请日：2010-11-30
申请人： Tsuyoshi Shiina , Makoto Yamakawa , Naotaka Nitta
发明人： Tsuyoshi Shiina , Makoto Yamakawa , Naotaka Nitta
IPC分类号： A61B8/00 , A61B8/14
CPC分类号： A61B8/485 , A61B5/0048 , A61B8/08 , A61B8/0825 , A61B8/488 , G01S7/52042 , G01S15/10 , G01S15/88 , G01S15/8906
摘要： An ultrasonic diagnosis system and strain distribution display method utilizing an ultrasonic probe for performing transmission/reception of ultrasonic signals to/from a subject, a storage arrangement for storing the properties of signals detected with the ultrasonic probe, a correlation computer for calculating a correlation coefficient between the properties with and without pressure applied to the subject, and a phase difference between the received signals with and without application of pressure, based upon the properties stored in the storage arrangement with and without pressure applied to the subject, a computer for calculating a displacement of each measurement point, and a strain distribution of tissue of the subject due to application of pressure, based upon the correlation coefficient and phase difference calculated by the correlation computer, and a display for displaying the strain distribution.
摘要翻译：超声波诊断系统和应变分布显示方法，利用超声波探头对被检体进行超声波信号的发送接收，存储由超声波探头检测的信号的特性的存储装置，计算相关系数的相关计算机在施加到受试者的压力和不施加压力的属性之间以及在施加和不施加压力的情况下的接收信号之间的相位差，基于在施加和不施加压力的情况下存储在存储装置中的性质，用于计算基于相关计算机计算出的相关系数和相位差，以及用于显示应变分布的显示器，由于施加压力而使每个测量点的位移以及受试者的组织的应变分布。

7. 发明申请

US20100081935A1 Ultrasonic diagnostic apparatus 审中-公开
标题翻译：超声波诊断仪
公开(公告)号：US20100081935A1
公开(公告)日：2010-04-01
申请号：US12310477
申请日：2007-08-31
申请人： Takeshi Matsumura , Tsuyoshi Shiina , Makoto Yamakawa
发明人： Takeshi Matsumura , Tsuyoshi Shiina , Makoto Yamakawa
IPC分类号： A61B8/14
CPC分类号： A61B8/08 , A61B5/0053 , A61B5/6843 , A61B8/12 , A61B8/13 , A61B8/485
摘要： An ultrasonic diagnostic apparatus for collecting correct strain information irrespective of the depth of an object.The ultrasonic diagnostic apparatus comprises an ultrasonic probe for transmitting/receiving ultrasonic waves to/from an object, pressing means for pressing biological tissues of the object, transmission means for transmitting ultrasonic waves to the biological tissues via the ultrasonic probe, reception means for receiving the reflected echo signals generated from the object via the ultrasonic probe, strain information calculating means for calculating the strain distribution of the biological tissues on the basis of the data on a pair of frames at different acquisition times received by the reception means, strain image construction means for constructing the strain image according to the strain distribution determined by the strain information calculating means, and display means for displaying the strain image.The ultrasonic diagnostic apparatus further comprises strain distribution correcting means for correcting strain distribution by using a strain distribution correcting function defined under the press condition of the press by the pressing means.Therefore, corrected strain information can be collected irrespective of the depth of the object.
摘要翻译：一种超声波诊断装置，用于收集正确的应变信息，而不管对象的深度。超声波诊断装置包括：用于从物体发送超声波的超声波探头，用于按压物体的生物体组织的按压装置，经由超声波探头向超声波生物体传送超声波的发送装置;接收装置，通过超声波探头从物体产生的反射回波信号，应变信息计算装置，用于根据由接收装置接收的不同获取时间的一对帧上的数据计算生物组织的应变分布;应变图像构造装置用于根据由应变信息计算装置确定的应变分布来构造应变图像;以及显示装置，用于显示应变图像。超声波诊断装置还包括：应变分布校正装置，用于通过使用在按压装置的按压状态下限定的应变分布校正函数来校正应变分布。因此，可以收集校正的应变信息，而不管对象的深度。

8. 发明授权

US08734351B2 Method of displaying elastic image and diagnostic ultrasound system 有权
标题翻译：显示弹性图像和诊断超声系统的方法
公开(公告)号：US08734351B2
公开(公告)日：2014-05-27
申请号：US11573221
申请日：2005-08-04
申请人： Koji Waki , Tsuyoshi Shiina , Makoto Yamakawa , Masaru Maeda
发明人： Koji Waki , Tsuyoshi Shiina , Makoto Yamakawa , Masaru Maeda
IPC分类号： A61B8/00 , A61B8/08 , G01S7/52
CPC分类号： A61B8/485 , A61B8/08 , A61B8/463 , A61B8/469 , A61B8/5223 , G01S7/52036 , G01S7/52042 , G01S7/52071 , G01S7/52074
摘要： A method of displaying an elastic image according to the present invention includes the steps of measuring ultrasound cross-section data of a cross-section region of a subject while applying compression to the subject 1 (2, 3, 4), determining distortion of tissue in the cross-section region on the basis of the ultrasound cross-section data, generating an elastic image of the cross-section region on the basis of the distortion, displaying the elastic image on a display device (7), setting a plurality of ROIs on the elastic image displayed on the display device, converting the distortion of each ROI into an index value (12), and displays the index value on the display device (8). In this way, the method enables quantitative evaluation of the hardness of body tissue of a region to be diagnosed.
摘要翻译：根据本发明的显示弹性图像的方法包括以下步骤：在对被检体1（2,3,4）施加压缩的同时测量被检体的横截面区域的超声横截面数据，确定组织的变形在所述横截面区域中，根据所述超声波截面数据，根据所述失真产生所述截面区域的弹性图像，将所述弹性图像显示在显示装置（7）上，将多个在显示装置上显示的弹性图像上的ROI，将每个ROI的失真转换为索引值（12），并将该索引值显示在显示装置（8）上。以这种方式，能够定量评价要诊断的区域的身体组织的硬度。

9. 发明申请

US20060052696A1 Ultrasonic diagnosis system and strain distribution display method 有权
标题翻译：超声诊断系统和应变分布显示方法
公开(公告)号：US20060052696A1
公开(公告)日：2006-03-09
申请号：US10522807
申请日：2003-07-31
申请人： Tsuyoshi Shiina , Makoto Yamakawa , Naotaka Nitta
发明人： Tsuyoshi Shiina , Makoto Yamakawa , Naotaka Nitta
IPC分类号： A61B8/00
CPC分类号： A61B8/485 , A61B5/0048 , A61B8/08 , A61B8/0825 , A61B8/488 , G01S7/52042 , G01S15/10 , G01S15/88 , G01S15/8906
摘要： An ultrasonic diagnosis system and strain distribution display method utilizing an ultrasonic probe for performing transmission/reception of ultrasonic signals to/from a subject, a storage arrangement for storing the properties of signals detected with the ultrasonic probe, a correlation computer for calculating a correlation coefficient between the properties with and without pressure applied to the subject, and a phase difference between the received signals with and without application of pressure, based upon the properties stored in the storage arrangement with and without pressure applied to the subject, a computer for calculating a displacement of each measurement point, and a strain distribution of tissue of the subject due to application of pressure, based upon the correlation coefficient and phase difference calculated by the correlation computer, and a display for displaying the strain distribution.
摘要翻译：超声波诊断系统和应变分布显示方法，利用超声波探头对被检体进行超声波信号的发送接收，存储由超声波探头检测的信号的特性的存储装置，计算相关系数的相关计算机在施加到受试者的压力和不施加压力的属性之间以及在施加和不施加压力的情况下的接收信号之间的相位差，基于在施加和不施加压力的情况下存储在存储装置中的性质，用于计算基于相关计算机计算出的相关系数和相位差，以及用于显示应变分布的显示器，由于施加压力而使每个测量点的位移以及受试者的组织的应变分布。

10. 发明授权

US08041415B2 Ultrasonic diagnosis system and strain distribution display method 有权
标题翻译：超声诊断系统和应变分布显示方法
公开(公告)号：US08041415B2
公开(公告)日：2011-10-18
申请号：US10522807
申请日：2003-07-31
申请人： Tsuyoshi Shiina , Makoto Yamakawa , Naotaka Nitta
发明人： Tsuyoshi Shiina , Makoto Yamakawa , Naotaka Nitta
IPC分类号： A61B8/00
CPC分类号： A61B8/485 , A61B5/0048 , A61B8/08 , A61B8/0825 , A61B8/488 , G01S7/52042 , G01S15/10 , G01S15/88 , G01S15/8906
摘要： An ultrasonic diagnosis system and strain distribution display method utilizing an ultrasonic probe for performing transmission/reception of ultrasonic signals to/from a subject, a storage arrangement for storing the properties of signals detected with the ultrasonic probe, a correlation computer for calculating a correlation coefficient between the properties with and without pressure applied to the subject, and a phase difference between the received signals with and without application of pressure, based upon the properties stored in the storage arrangement with and without pressure applied to the subject, a computer for calculating a displacement of each measurement point, and a strain distribution of tissue of the subject due to application of pressure, based upon the correlation coefficient and phase difference calculated by the correlation computer, and a display for displaying the strain distribution.
摘要翻译：超声波诊断系统和应变分布显示方法，利用超声波探头对被检体进行超声波信号的发送接收，存储由超声波探头检测的信号的特性的存储装置，计算相关系数的相关计算机在施加到受试者的压力和不施加压力的属性之间以及在施加和不施加压力的情况下的接收信号之间的相位差，基于在施加和不施加压力的情况下存储在存储装置中的性质，用于计算基于相关计算机计算出的相关系数和相位差，以及用于显示应变分布的显示器，由于施加压力而使每个测量点的位移以及受试者的组织的应变分布。

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