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1. 发明授权

US5849272A Ultraviolet absorbing composition 失效
标题翻译：紫外吸收组合物
公开(公告)号：US5849272A
公开(公告)日：1998-12-15
申请号：US806162
申请日：1997-02-25
申请人： Katsuya Baba , Toshihito Yabu , Shoji Nishiyama , Kenzo Ito
发明人： Katsuya Baba , Toshihito Yabu , Shoji Nishiyama , Kenzo Ito
IPC分类号： A61K8/30 , A61K8/00 , A61K8/33 , A61K8/35 , A61K8/37 , A61Q17/04 , A61Q19/00 , C09K3/00 , A61K1/021
CPC分类号： A61K8/35 , A61K8/37 , A61Q17/04 , Y10S514/844 , Y10S514/845 , Y10S514/846
摘要： The ultraviolet absorbing composition in accordance with the present invention comprises the following ingredients (A) and (B): (A) 4-tert-butyl-4'-methoxydibenzoylmethane; and (B) a diester which is liquid at 20.degree. C. and has a structure represented by the following general formula (1): R.sub.1 OOC--(CH.sub.2)n--COOR.sub.2 (1) wherein each of R.sub.1 and R.sub.2 is an alkyl group, an alkenyl group, a hydroxyalkyl group, or a hydroxyalkenyl group each having 1 to 19 carbon atoms, and n is an integer of 0 to 6. In the present invention, crystals of (A) are prevented from depositing by using a diester of (B) togetherwith and an ultraviolet absorbing composition in which (A) can be stably compounded in a high concentration and which exhibits excellent feel of use and safety can be obtained thereby.
摘要翻译：根据本发明的紫外线吸收组合物包含以下成分（A）和（B）：（A）4-叔丁基-4'-甲氧基二苯甲酰甲烷; 和（B）在20℃下为液体并具有由以下通式（1）表示的结构的二酯：R1OOC-（CH2）n-COOR2（1）其中R1和R2各自为烷基，烯基，羟基烷基或羟基烯基，各自具有1至19个碳原子，n为0至6的整数。在本发明中，通过使用（（A）的二酯，可以防止（A）的结晶沉积， B）与其中（A）可以高浓度稳定地配合并且由此可以获得使用和安全性良好的紫外线吸收组合物。

2. 发明授权

US06350459B1 Solubilized cosmetic composition with a pharmaceutical or cosmetic agent, a methacrylate copolymer and a cyclodextrin 失效
标题翻译：用药物或化妆品，甲基丙烯酸酯共聚物和环糊精的溶解化妆品组合物
公开(公告)号：US06350459B1
公开(公告)日：2002-02-26
申请号：US09101189
申请日：1998-07-10
申请人： Kazuaki Suzuki , Wataru Tokue , Kenzo Ito , Shoji Nishiyama
发明人： Kazuaki Suzuki , Wataru Tokue , Kenzo Ito , Shoji Nishiyama
IPC分类号： A61K910
CPC分类号： A61Q19/00 , A61K8/738 , A61K8/8147 , A61K2800/594 , A61Q5/00
摘要： A solubilized cosmetic composition containing an ingredient which is difficult to be dissolved in water, an alkyl-modified carboxyvinyl polymer and a hydroxyalkylated cyclodextrin so as to solubilize the ingredient difficult to be dissolved in water and in particular substantially not containing a surfactant.
摘要翻译：含有难溶于水的成分的溶解化妆品组合物，烷基改性的羧乙烯基聚合物和羟烷基化的环糊精，以溶解难以溶于水的成分，特别是基本上不含有表面活性剂。

3. 发明授权

US5709849A Suppressing stickiness to skin of cosmetic composition 失效
标题翻译：抑制化妆品组合物对皮肤的粘性
公开(公告)号：US5709849A
公开(公告)日：1998-01-20
申请号：US940731
申请日：1992-09-03
申请人： Kenzo Ito , Shoji Nishiyama
发明人： Kenzo Ito , Shoji Nishiyama
IPC分类号： A61K8/30 , A61K8/19 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/44 , A61K8/55 , A61K8/60 , A61K8/96 , A61Q1/00 , A61Q1/02 , A61Q1/12 , A61Q9/00 , A61Q19/00 , A61K7/02 , A61K7/48
CPC分类号： A61K8/553 , A61K8/19 , A61K8/345 , A61K8/365 , A61K8/44 , A61K8/60 , A61Q19/00 , A61Q1/02
摘要： A cosmetic composition containing (i) a water-soluble polyhydric alcohol having two or more hydroxyl groups and/or a lecithin and (ii) a bivalent metal salt of an organic acid.
摘要翻译：一种化妆品组合物，其含有（i）具有两个以上羟基的水溶性多元醇和/或卵磷脂，和（ii）有机酸的二价金属盐。

4. 发明授权

US5658578A Cosmetic composition 失效
标题翻译：化妆品组成
公开(公告)号：US5658578A
公开(公告)日：1997-08-19
申请号：US505666
申请日：1995-07-21
申请人： Haruo Ogawa , Shoji Nishiyama , Kenzo Ito
发明人： Haruo Ogawa , Shoji Nishiyama , Kenzo Ito
IPC分类号： A61K8/30 , A61K8/00 , A61K8/44 , A61K8/55 , A61K8/58 , A61K8/60 , A61K8/96 , A61K8/97 , A61K31/19 , A61K31/675 , A61K36/258 , A61P17/00 , A61P17/02 , A61Q1/00 , A61Q1/04 , A61Q19/00 , A61K7/48
CPC分类号： A61Q19/00 , A61K31/7076 , A61K36/258 , A61K8/0212 , A61K8/44 , A61K8/606 , A61K8/97 , A61Q19/001 , Y10S514/844 , Y10S514/847 , Y10S514/944
摘要： A preparation for external application to the skin which comprises disodium adenosine triphosphate and tranexamic acid for prevention of skin roughening and skin improvement. The preparation further contains ginseng extract.
摘要翻译：外用于皮肤的制剂，其包括三磷酸腺苷二钠和氨甲环酸，用于防止皮肤粗糙化和皮肤改善。制剂还含有人参提取物。

5. 发明授权

US5853705A Anti-aging cosmetic composition 失效
标题翻译：抗衰老化妆品组合物
公开(公告)号：US5853705A
公开(公告)日：1998-12-29
申请号：US823834
申请日：1997-03-25
申请人： Yasukazu Nakayama , Shoji Nishiyama , Yoichi Shimatani , Shigetoyo Sawaki , Katsuhisa Yamada , Kazufumi Naitoh
发明人： Yasukazu Nakayama , Shoji Nishiyama , Yoichi Shimatani , Shigetoyo Sawaki , Katsuhisa Yamada , Kazufumi Naitoh
IPC分类号： A61K8/30 , A61K8/00 , A61K8/02 , A61K8/33 , A61K8/66 , A61K8/96 , A61K8/97 , A61K36/00 , A61K36/899 , A61P17/00 , A61P43/00 , A61Q1/02 , A61Q1/06 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61Q19/10 , C09K3/00 , A61K7/42
CPC分类号： A61Q19/08 , A61K8/0212 , A61K8/66 , A61K8/97 , A61Q19/00 , A61K2800/72 , A61Q1/02 , A61Q1/06 , A61Q17/04 , A61Q19/10 , A61Q5/00 , A61Q5/02 , A61Q5/06
摘要： An anti-aging cosmetic composition in which is blended an enzymolyzed substance obtained by treating by one or more enzymes an alkali extract of a hypoallergenic rice obtained by treating rice in advance with a proteinase and, preferably, a UV protective agent.
摘要翻译：一种抗衰老化妆品组合物，其中将通过一种或多种酶处理获得的酶解物质与通过预先用蛋白酶预处理而获得的低变应原性米的碱提取物，优选紫外线防护剂进行混合。

6. 发明授权

US06306862B1 Triterpene derivatives and pharmaceuticals for treating hepatic disorders 失效
标题翻译：三萜衍生物和治疗肝脏疾病的药物
公开(公告)号：US06306862B1
公开(公告)日：2001-10-23
申请号：US08983127
申请日：1998-06-01
申请人： Kazue Sasaki , Nobuto Minowa , Shoji Nishiyama , Hiroyuki Kuzuhara
发明人： Kazue Sasaki , Nobuto Minowa , Shoji Nishiyama , Hiroyuki Kuzuhara
IPC分类号： A61K31495
CPC分类号： C07J63/008 , C07J71/0005
摘要： A pharmaceutical composition for treating a hepatic disorder, comprising a triterpene derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof is disclosed: wherein R1 represents a hydroxyl group, alkoxy, alkylcarbonyloxy, or aralkyloxy; R2 represents alkyl, —CH2OR5, wherein R5 represents a hydrogen atom, alkyl, aralkyl, or alkylcarbonyl, formyl, —COOR6, wherein R6 represents a hydrogen atom or alkyl, or —CH2N(R7)R8; or R1 and R2 combine with each other to form —O—CR9(R10)—OCH2—, wherein R9 and R10, which may be the same or different, represent a hydrogen atom, alkyl, or aryl; R3 and R4, which may be the same or different, represent a hydrogen atom, a hydroxyl group, alkyl, hydroxyalkyl, formyl, —COOR11, wherein R11 represents a hydrogen atom or alkyl, or —OR12, wherein R12 represents alkyl, aralkyl, C1-6 alkylcarbonyl, arylcarbonyl, alkenyl, alkenylcarbonyl, or arylalkenylcarbonyl which may be optionally substituted; or R3 and R4 combine with each other to form a methylene group; and — — — represents a single or double bond, provided that, when — — — represents a double bond, R4 is absent.
摘要翻译：公开了一种治疗肝病的药物组合物，其包含由式（I）表示的三萜衍生物或其药学上可接受的盐：其中R1表示羟基，烷氧基，烷基羰氧基或芳烷氧基; R 2表示烷基，-CH 2 OR 5，其中R 5表示氢原子，烷基，芳烷基或烷基羰基，甲酰基，-COOR 6，其中R 6表示氢原子或烷基或-CH 2 N（R 7）R 8; 或R 1和R 2彼此结合形成-O-CR 9（R 10）-OCH 2 - ，其中R 9和R 10可以相同或不同，表示氢原子，烷基或芳基; R 3和R 4可以相同或不同，表示氢原子，羟基，烷基，羟基烷基，甲酰基，-COOR11，其中R11表示氢原子或烷基或-OR12，其中R12表示烷基，芳烷基，可以任意取代的C 1-6烷基羰基，芳基羰基，烯基，烯基羰基或芳基烯基羰基; 或R 3和R 4彼此结合形成亚甲基; 和 - - 表示单键或双键，条件是当 - - 表示双键时，R4不存在。

7. 发明授权

US06593364B2 Triterpene derivatives and remedies for liver diseases 失效
标题翻译：三萜衍生物和肝病的补救措施
公开(公告)号：US06593364B2
公开(公告)日：2003-07-15
申请号：US09921983
申请日：2001-08-06
申请人： Kazue Sasaki , Nobuto Minowa , Shoji Nishiyama , Hiroyuki Kuzuhara
发明人： Kazue Sasaki , Nobuto Minowa , Shoji Nishiyama , Hiroyuki Kuzuhara
IPC分类号： A61K31215
CPC分类号： C07J63/008 , C07J63/00 , Y10S514/893 , Y10S514/894
摘要： A triterpene derivative useful for the treatment of hepatic disorders is disclosed. This compound comprises as an active ingredient a triterpene derivative represented by the following formula (I) or a salt thereof: wherein R1 represents a hydroxyl group, arylmethyloxy, lower alkoxy, or lower alkanoyloxy, R2 represents lower alkyl, lower alkenyl, —CH2OR5, formyl, —COOR6, or —CH2N(R7)R8, or R1 and R2 may combine with each other to form —O—C(R9)R10—O—CH2—, R3 and R4, which may be the same or different represent a hydrogen atom, a hydroxyl group, lower alkyl, lower alkenyl, aryl, hydroxymethyl, —N(R11)R12, formyl, —COOR6, or —OR13, or R3 and R4 may combine with each other to form oxo, hydroxyimino, or alkylidene and X represents O, CH2, or NH.
摘要翻译：公开了用于治疗肝脏疾病的三萜衍生物。该化合物包含作为活性成分的下式（I）表示的三萜衍生物或其盐：其中R1表示羟基，芳基甲氧基，低级烷氧基或低级烷酰氧基，R2表示低级烷基，低级烯基，-CH2OR5，甲酰基，-COOR 6或-CH 2 N（R 7）R 8，或R 1和R 2可以彼此结合形成-OC（R 9）R 10 -O-CH 2 - ，R 3和R 4，其可以相同或不同，表示氢原子，羟基，低级烷基，低级烯基，芳基，羟甲基，-N（R 11）R 12，甲酰基，-COOR 6或-OR 13或R 3和R 4可以彼此结合形成氧代，羟基亚氨基或亚烷基， X表示O，CH 2或NH。

8. 发明授权

US5693255A Oil-in-water type emulsion composition 失效
标题翻译：水包油型乳液组合物
公开(公告)号：US5693255A
公开(公告)日：1997-12-02
申请号：US213023
申请日：1994-03-15
申请人： Toru Okamoto , Satoshi Tomomasa , Hiroyuki Kakoki , Shoji Nishiyama , Hideo Nakajima
发明人： Toru Okamoto , Satoshi Tomomasa , Hiroyuki Kakoki , Shoji Nishiyama , Hideo Nakajima
IPC分类号： A61K8/06 , A61K8/34 , A61K8/36 , A61K8/92 , A61K9/107 , A61K47/10 , A61K47/12 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , B01J13/00
CPC分类号： A61Q19/00 , A61K8/06 , A61K8/062 , A61K2800/21 , A61Q17/04 , A61Q19/02 , A61Q5/00 , Y10S514/846 , Y10S514/943 , Y10S514/944 , Y10S516/909 , Y10S516/914 , Y10S516/917 , Y10S516/919 , Y10S516/923
摘要： An oil-in-water type emulsion composition comprising: an amphiphile and a surfactant selected from the substances which can form a gel in an amphiphatic substance-surfactant-water system at a temperature of not lower than ordinary temperatures; oil and water, wherein substantially the total amount of amphiphile and surfactant exist on the boundary surfaces of emulsion particles. The emulsion composition has both the physical properties close to those of an aqueous solution and a creamy feel at the time of use.
摘要翻译：一种水包油型乳剂组合物，其特征在于，包括：两亲物和表面活性剂，其选自可以在不低于常温的温度下在两亲性物质 - 表面活性剂 - 水体系中形成凝胶的物质; 油和水，其中在乳液颗粒的边界表面上基本上存在两亲物和表面活性剂的总量。乳液组合物具有接近水溶液的物理性质和使用时的乳脂感。

9. 发明授权

US5162377A Transparent composition 失效
标题翻译：透明组合物
公开(公告)号：US5162377A
公开(公告)日：1992-11-10
申请号：US366569
申请日：1989-06-15
申请人： Hiroyuki Kakoki , Shoji Nishiyama , Michihiro Yamaguchi , Yoshimaru Kumano
发明人： Hiroyuki Kakoki , Shoji Nishiyama , Michihiro Yamaguchi , Yoshimaru Kumano
IPC分类号： A61K8/06 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/43 , A61K8/55 , A61K8/63 , A61K8/67 , A61K8/86 , A61K8/92 , A61K9/107 , A61Q19/00
CPC分类号： A61K8/06 , A61K8/37 , A61K8/416 , A61K8/42 , A61K8/43 , A61K8/553 , A61K8/63 , A61K8/671 , A61K8/678 , A61K8/86 , A61K8/92 , A61K9/1075 , A61Q19/00 , A61K2800/21 , A61K2800/262 , A61Q5/00 , Y10S514/941 , Y10S514/975
摘要： A transparent composition containing a phospholipid, at least one cationic or nonionic surfactant, an oily component, and water.

10. 发明申请

US20100093871A1 AGENT FOR PREVENTION OR TREATMENT OF IRON OVERLOAD DISORDERS 审中-公开
标题翻译：防止或治疗铁过度病症的代理人
公开(公告)号：US20100093871A1
公开(公告)日：2010-04-15
申请号：US12532361
申请日：2008-03-19
申请人： Hideaki Kagehara , Shoji Nishiyama
发明人： Hideaki Kagehara , Shoji Nishiyama
IPC分类号： A61K31/075 , C07C43/18 , A61P7/00
CPC分类号： C07J53/00 , A61K31/56
摘要： Disclosed is an agent for prevention or treatment of iron overload disorders, comprising 22β-methoxyolean-12-ene-3β,24(4β)-diol or a pharmacologically acceptable salt thereof.
摘要翻译：公开了用于预防或治疗铁超负荷障碍的药物，其包含22-二甲氧基安非炔-12-烯-3和b，24（4'-二） - 二醇或其药理学上可接受的盐。

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