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1. 发明授权

US07785274B2 Guide wire 有权
标题翻译：导丝
公开(公告)号：US07785274B2
公开(公告)日：2010-08-31
申请号：US11013384
申请日：2004-12-17
申请人： Katsuro Mishima , Yutaka Itou , Hiraku Murayama , Hideo Satou
发明人： Katsuro Mishima , Yutaka Itou , Hiraku Murayama , Hideo Satou
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61M2025/09091 , A61M2025/09133 , A61M2025/0915
摘要： A guide wire includes a wire body having a first wire disposed at a distal end thereof and a second wire joined to a proximal end of the first wire. The first wire and the second wire are preferably joined to each other by welding, providing a layer joint therebetween. The joint is of a curved shape, particularly a convex curved shape that is convex toward the proximal end of the wire body. In the joint, at least one component (e.g., Ti) of the material of the first wire decreases toward the proximal end and at least one component (e.g., Fe) of the material of the second wire decreases toward the distal end. When a tensile test is conducted on a region of the wire body including the joint, the region of the wire body has, in a tensile load and elongation diagram, an elastic section extending substantially straight upwardly to the right, a yield section extending substantially horizontally or upwardly to the right from the elastic section, and a substantially straight section extending upwardly to the right from the yield section. This region of the wire body possesses characteristics such that the region is fracturable near a terminal end of the straight section at a fracture position on other than the joint.
摘要翻译：引导线包括具有设置在其远端处的第一线的线主体和连接到第一线的近端的第二线。第一线和第二线优选通过焊接彼此连接，在它们之间提供层接合。接头是弯曲形状，特别是凸起的弯曲形状，其朝向线体的近端凸出。在接头中，第一线材料的至少一个部件（例如Ti）朝向近端减小，并且第二线材料的至少一个部件（例如，Fe）朝向远端减小。当在包括接头的线体的区域上进行拉伸试验时，线体的区域在拉伸载荷和延伸率图中具有基本向上向右延伸的弹性部分，基本上水平地延伸的屈服部分或从弹性部分向上或向右的右侧，以及从屈服部分向右向上延伸的基本上直的部分。线体的该区域具有这样的特性，使得该区域在除了接头之外的断裂位置处在直线部分的终端附近是可断裂的。

2. 发明申请

US20120310218A1 GUIDE WIRE 审中-公开
标题翻译：指导线
公开(公告)号：US20120310218A1
公开(公告)日：2012-12-06
申请号：US13585319
申请日：2012-08-14
申请人： Katsuro Mishima , Yutaka Itou , Hiraku Murayama , Hideo Satou
发明人： Katsuro Mishima , Yutaka Itou , Hiraku Murayama , Hideo Satou
IPC分类号： A61M25/01
CPC分类号： A61M25/09 , A61M2025/09091 , A61M2025/09133 , A61M2025/0915
摘要： A guide wire includes a wire body having a first wire disposed at a distal end and a second wire joined to a proximal end of the first wire at a joint by welding. The joint is curved. In the joint, at least one component (e.g., Ti) of the material of the first wire decreases toward the proximal end and at least one component (e.g., Fe) of the material of the second wire decreases toward the distal end. When a tensile test is conducted on a region of the wire body including the joint, the region of the wire body has, in a tensile load and elongation diagram, an elastic section extending substantially straight upwardly to the right, a yield section extending substantially horizontally or upwardly to the right from the elastic section, and a substantially straight section extending upwardly to the right from the yield section.
摘要翻译：引导线包括具有设置在远端的第一线的线主体和通过焊接在接头处连接到第一线的近端的第二线。关节弯曲。在接头中，第一线材料的至少一个部件（例如Ti）朝向近端减小，并且第二线材料的至少一个部件（例如，Fe）朝向远端减小。当在包括接头的线体的区域上进行拉伸试验时，线体的区域在拉伸载荷和延伸率图中具有基本向上向右延伸的弹性部分，基本上水平地延伸的屈服部分或从弹性部分向上或向右的右侧，以及从屈服部分向右向上延伸的基本上直的部分。

3. 发明授权

US09033004B2 Guide wire 有权
标题翻译：导丝
公开(公告)号：US09033004B2
公开(公告)日：2015-05-19
申请号：US13477616
申请日：2012-05-22
申请人： Katsuro Mishima , Yutaka Itou , Hiraku Murayama , Hideo Satou
发明人： Katsuro Mishima , Yutaka Itou , Hiraku Murayama , Hideo Satou
IPC分类号： B21F15/02 , A61B5/00 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/09091 , A61M2025/09133 , A61M2025/0915
摘要： A guide wire includes a wire body having a first wire disposed at a distal end and a second wire joined to a proximal end of the first wire at a joint by welding. The joint is curved. In the joint, at least one component (e.g., Ti) of the material of the first wire decreases toward the proximal end and at least one component (e.g., Fe) of the material of the second wire decreases toward the distal end. When a tensile test is conducted on a region of the wire body including the joint, the region of the wire body has, in a tensile load and elongation diagram, an elastic section extending substantially straight upwardly to the right, a yield section extending substantially horizontally or upwardly to the right from the elastic section, and a substantially straight section extending upwardly to the right from the yield section.
摘要翻译：引导线包括具有设置在远端的第一线的线主体和通过焊接在接头处连接到第一线的近端的第二线。关节弯曲。在接头中，第一线材料的至少一个部件（例如Ti）朝向近端减小，并且第二线材料的至少一个部件（例如，Fe）朝向远端减小。当在包括接头的线体的区域上进行拉伸试验时，线体的区域在拉伸载荷和延伸率图中具有基本向上向右延伸的弹性部分，基本上水平地延伸的屈服部分或从弹性部分向上或向右的右侧，以及从屈服部分向右向上延伸的基本上直的部分。

4. 发明授权

US08313445B2 Guide wire 有权
标题翻译：导丝
公开(公告)号：US08313445B2
公开(公告)日：2012-11-20
申请号：US12842458
申请日：2010-07-23
申请人： Katsuro Mishima , Yutaka Itou , Hiraku Murayama , Hideo Satou
发明人： Katsuro Mishima , Yutaka Itou , Hiraku Murayama , Hideo Satou
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61M2025/09091 , A61M2025/09133 , A61M2025/0915
摘要： A guide wire includes a wire body having a first wire disposed at a distal end and a second wire joined to a proximal end of the first wire at a joint by welding. The joint is curved. In the joint, at least one component (e.g., Ti) of the material of the first wire decreases toward the proximal end and at least one component (e.g., Fe) of the material of the second wire decreases toward the distal end. When a tensile test is conducted on a region of the wire body including the joint, the region of the wire body has, in a tensile load and elongation diagram, an elastic section extending substantially straight upwardly to the right, a yield section extending substantially horizontally or upwardly to the right from the elastic section, and a substantially straight section extending upwardly to the right from the yield section.
摘要翻译：引导线包括具有设置在远端的第一线的线主体和通过焊接在接头处连接到第一线的近端的第二线。关节弯曲。在接头中，第一线材料的至少一个部件（例如Ti）朝向近端减小，并且第二线材料的至少一个部件（例如，Fe）朝向远端减小。当在包括接头的线体的区域上进行拉伸试验时，线体的区域在拉伸载荷和延伸率图中具有基本向上向右延伸的弹性部分，基本上水平地延伸的屈服部分或从弹性部分向上或向右的右侧，以及从屈服部分向右向上延伸的基本上直的部分。

5. 发明申请

US20050152731A1 Guide wire 有权
标题翻译：导丝
公开(公告)号：US20050152731A1
公开(公告)日：2005-07-14
申请号：US11013384
申请日：2004-12-17
申请人： Katsuro Mishima , Yutaka Itou , Hiraku Murayama , Hideo Satou
发明人： Katsuro Mishima , Yutaka Itou , Hiraku Murayama , Hideo Satou
IPC分类号： A61M25/01 , A61M25/09 , B41J2/25
CPC分类号： A61M25/09 , A61M2025/09091 , A61M2025/09133 , A61M2025/0915
摘要： A guide wire includes a wire body having a first wire disposed at a distal end thereof and a second wire joined to a proximal end of the first wire. The first wire and the second wire are preferably joined to each other by welding, providing a layer joint therebetween. The joint is of a curved shape, particularly a convex curved shape that is convex toward the proximal end of the wire body. In the joint, at least one component (e.g., Ti) of the material of the first wire decreases toward the proximal end and at least one component (e.g., Fe) of the material of the second wire decreases toward the distal end. When a tensile test is conducted on a region of the wire body including the joint, the region of the wire body has, in a tensile load and elongation diagram, an elastic section extending substantially straight upwardly to the right, a yield section extending substantially horizontally or upwardly to the right from the elastic section, and a substantially straight section extending upwardly to the right from the yield section. This region of the wire body possesses characteristics such that the region is fracturable near a terminal end of the straight section at a fracture position on other than the joint.
摘要翻译：引导线包括具有设置在其远端处的第一线的线体和连接到第一线的近端的第二线。第一线和第二线优选通过焊接彼此连接，在它们之间提供层接合。接头是弯曲形状，特别是凸起的弯曲形状，其朝向线体的近端凸出。在接头中，第一线材料的至少一个部件（例如Ti）朝向近端减小，并且第二线材料的至少一个部件（例如，Fe）朝向远端减小。当在包括接头的线体的区域上进行拉伸试验时，线体的区域在拉伸载荷和延伸率图中具有基本向上向右延伸的弹性部分，基本上水平地延伸的屈服部分或从弹性部分向上或向右的右侧，以及从屈服部分向右向上延伸的基本上直的部分。线体的该区域具有这样的特性，使得该区域在除了接头之外的断裂位置处在直线部分的终端附近是可断裂的。

6. 发明授权

US07632237B2 Guide wire and method of manufacturing the guide wire 有权
标题翻译：导丝及制造导丝的方法
公开(公告)号：US07632237B2
公开(公告)日：2009-12-15
申请号：US10802869
申请日：2004-03-18
申请人： Hiraku Murayama , Katsuro Mishima
发明人： Hiraku Murayama , Katsuro Mishima
IPC分类号： A61M25/00 , A61M5/178
CPC分类号： A61M25/09 , A61M2025/09075 , A61M2025/09108 , Y10T29/5187
摘要： A guide wire includes a distal end side portion formed of a first metallic material, a proximal end side portion formed of a second metallic material higher in rigidity than the first metallic material, and an intermediate portion provided between the distal end side portion and the proximal end side portion and formed of a mixture of the first metallic material and the second metallic material. The intermediate portion includes a gradient physical property portion in which the content of the second metallic material increases from the distal end side toward the proximal end side.
摘要翻译：导丝包括由第一金属材料形成的前端侧部分，刚性高于第一金属材料的第二金属材料形成的近端侧部分和设置在前端侧部分和近端部分之间的中间部分并且由第一金属材料和第二金属材料的混合物形成。中间部分包括梯度物理性质部分，其中第二金属材料的含量从远端侧朝向近端侧增加。

7. 发明授权

US07575559B2 Guide wire 有权
标题翻译：导丝
公开(公告)号：US07575559B2
公开(公告)日：2009-08-18
申请号：US10809901
申请日：2004-03-26
申请人： Hiraku Murayama , Katsuro Mishima
发明人： Hiraku Murayama , Katsuro Mishima
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61M2025/09108 , A61M2025/09133
摘要： A guide wire includes a distal end portion and a main body portion, wherein the main body portion includes a center layer formed of a first material, a surface layer formed of a second material, and an intermediate layer formed of a mixture of the first material and the second material.
摘要翻译：导丝包括前端部分和主体部分，其中主体部分包括由第一材料形成的中心层，由第二材料形成的表面层和由第一材料的混合物形成的中间层和第二种材料。

8. 发明申请

US20050027214A1 Guide wire 有权
标题翻译：导丝
公开(公告)号：US20050027214A1
公开(公告)日：2005-02-03
申请号：US10809901
申请日：2004-03-26
申请人： Hiraku Murayama , Katsuro Mishima
发明人： Hiraku Murayama , Katsuro Mishima
IPC分类号： A61M25/01 , A61B5/00 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/09108 , A61M2025/09133
摘要： A guide wire includes a distal end portion and a main body portion, wherein the main body portion includes a center layer formed of a first material, a surface layer formed of a second material, and an intermediate layer formed of a mixture of the first material and the second material.
摘要翻译：导丝包括前端部分和主体部分，其中主体部分包括由第一材料形成的中心层，由第二材料形成的表面层和由第一材料的混合物形成的中间层和第二种材料。

9. 发明申请

US20070265552A1 Guide wire 有权
公开(公告)号：US20070265552A1
公开(公告)日：2007-11-15
申请号：US11878140
申请日：2007-07-20
申请人： Hiraku Murayama , Akihiko Umeno , Jun Iwami , Yutaka Itou , Youki Aimi
发明人： Hiraku Murayama , Akihiko Umeno , Jun Iwami , Yutaka Itou , Youki Aimi
IPC分类号： A61M25/09
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09108
摘要： A method of making a guide wire involves butting a connection end face at a proximal end of a first wire against a connection end face at a distal end of a second wire while applying voltage and a pressing force to weld together the first and second wires at a welded portion. The welded portion forms a projection that projects outwardly in an outer peripheral direction relative to portions of the first and second wire adjacent the projection. The outer dimension of the projection at the welded portion is adjusted so that upon completing adjusting the outer dimension of the projection the projection still projects outwardly in the outer peripheral direction relative to the portions of the first and second wire adjacent the projection.

10. 发明申请

US20070232957A1 Guide wire 审中-公开
标题翻译：导丝
公开(公告)号：US20070232957A1
公开(公告)日：2007-10-04
申请号：US11797328
申请日：2007-05-02
申请人： Hiraku Murayama , Akihiko Umeno , Jun Iwami , Yutaka Itou , Youki Aimi
发明人： Hiraku Murayama , Akihiko Umeno , Jun Iwami , Yutaka Itou , Youki Aimi
IPC分类号： A61M25/01
CPC分类号： A61M25/09033 , A61M25/09 , A61M2025/09083 , A61M2025/0915 , B21F15/08
摘要： A guide wire includes a first wire disposed on the distal side, and a second wire disposed on the proximal side and made from a material having an elastic modulus larger than that of the first wire. The first wire and the second wire are joined to each other by welding. The second wire has, in the vicinity of the welded portion, a small cross-sectional area portion having a cross-sectional area smaller than that of a proximal end portion of the first wire. The outer diameter of the small cross-sectional area portion is gradually reduced in the direction toward the distal end. The first wire may be made from a superelastic alloy, whereas the second wire may be made from a stainless steel. The first wire and the second wire may be welded to each other by a butt resistance welding process. Since the change in rigidity of the guide wire becomes smooth in the longitudinal direction, the operationality and kink resistance of the guide wire are improved.
摘要翻译：引导线包括设置在远侧的第一线，以及设置在近侧的由具有大于第一线的弹性模量的材料制成的第二线。第一线和第二线通过焊接彼此接合。第二线在焊接部附近具有截面积小于第一线的基端部的截面积的小截面积部。小横截面积部分的外径在朝向远端的方向上逐渐减小。第一线可以由超弹性合金制成，而第二线可以由不锈钢制成。第一线和第二线可以通过对接电阻焊接方法彼此焊接。由于导丝的刚性的变化在长度方向上变得平滑，所以导丝的操作性和抗扭结性提高。

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