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1. 发明授权

US06413495B1 X-ray intercepting metal complexes of chlorin derivatives 有权
标题翻译：二氢卟酚衍生物的X射线截留金属络合物
公开(公告)号：US06413495B1
公开(公告)日：2002-07-02
申请号：US09743448
申请日：2001-01-10
申请人： Katsuo Aizawa , Shinjiro Sumi , Hirotada Takahashi , Noriaki Aman , Yoshihiko Terayama , Shuichi Gomi
发明人： Katsuo Aizawa , Shinjiro Sumi , Hirotada Takahashi , Noriaki Aman , Yoshihiko Terayama , Shuichi Gomi
IPC分类号： C07D48722
CPC分类号： C07D487/22 , A61K41/0085 , A61K47/546 , A61K49/04 , B82Y5/00
摘要： An X-ray-intercepting gold complex of mono-L-aspartyl (or mono-L-glutamyl) chlorin e6 or a salt thereof is used in the therapy of the tumor, cancer or arteriosclerosis lesions by X-ray irradiation. The complex provides a sharp x-ray image of tumor, solid cancer or lesions of arteriosclerosis. A similar platinum complex may also be utilized.
摘要翻译：将单-L-天冬氨酰基（或单-L-谷氨酰）二氢卟酚e6或其盐的X射线截断金复合物用于通过X射线照射治疗肿瘤，癌症或动脉硬化病变。该复合物提供了肿瘤，实体癌或动脉硬化病变的尖锐x射线图像。也可以使用类似的铂络合物。

2. 发明授权

US5278052A Process for the simultaneous production of benanomicins A and B 失效
标题翻译：同时生产苯那霉素A和B的方法
公开(公告)号：US5278052A
公开(公告)日：1994-01-11
申请号：US715770
申请日：1991-06-14
申请人： Tomio Takeuchi , Takeshi Hara , Masa Hamada , Shinichi Kondo , Masaji Sezaki , Haruo Yamamoto , Shuichi Gomi
发明人： Tomio Takeuchi , Takeshi Hara , Masa Hamada , Shinichi Kondo , Masaji Sezaki , Haruo Yamamoto , Shuichi Gomi
IPC分类号： C07H15/24 , C12P19/56 , C12P19/12
CPC分类号： C12R1/01 , C07H15/24 , C12P19/56 , Y10S435/826
摘要： Benanomicin A and Benanomicin B are fermentatively produced by the cultivation of a new microorganism Actinomadura spadix, designated as MH193-16F4 strain.
摘要翻译：通过培养命名为MH193-16F4菌株的新的微生物Actinomadura spadix发酵生产贝那霉素A和Benanomicin B。

3. 发明授权

US07595182B2 Endoglucanase STCE and cellulase preparation containing the same 有权
标题翻译：内切葡聚糖酶STCE和含有相同的纤维素酶制剂
公开(公告)号：US07595182B2
公开(公告)日：2009-09-29
申请号：US10581717
申请日：2004-10-22
申请人： Jinichiro Koga , Yuko Baba , Akitaka Nakane , Satoshi Hanamura , Tomoko Nishimura , Shuichi Gomi , Hidetoshi Kubota , Toshiaki Kono
发明人： Jinichiro Koga , Yuko Baba , Akitaka Nakane , Satoshi Hanamura , Tomoko Nishimura , Shuichi Gomi , Hidetoshi Kubota , Toshiaki Kono
IPC分类号： C12P21/06 , C12N9/00 , C12N9/24 , C12N1/20 , C12N1/00 , C12N15/00 , C07H21/04
CPC分类号： C12N9/2437 , A23K20/189 , C11D3/38636 , C11D3/38645 , C12Y302/01004 , D06M16/003 , D06M2101/06 , D06M2200/35 , D06M2200/50 , D21H11/20 , D21H25/18
摘要： A novel endoglucanase derived from Staphylotrichum coccosporum, a polynucleotide encoding the endoglucanase, and a cellulase preparation containing the endoglucanase are disclosed. The endoglucanase or cellulase preparation is available for a washing use or fabric processing, such as a color clarification of a cellulose-containing fabric, a reduction of fuzz, an improvement of the touch feel and appearance of the fabric, providing a localized color change to the fabric, or a reduction of stiffness.
摘要翻译：公开了一种衍生自球形葡萄球菌的新型内切葡聚糖酶，一种编码该内切葡聚糖酶的多核苷酸，以及含有内切葡聚糖酶的纤维素酶制剂。内切葡聚糖酶或纤维素酶制剂可用于洗涤用途或织物加工，例如含纤维素织物的颜色澄清，绒毛减少，织物的触感和外观的改善，提供局部颜色变化织物或刚度的降低。

4. 发明授权

US06451800B1 Phenylpiperazine derivatives as integrin &agr;v&bgr;3 antagonists 失效
标题翻译：苯基哌嗪衍生物作为整合素α2β拮抗剂
公开(公告)号：US06451800B1
公开(公告)日：2002-09-17
申请号：US09601176
申请日：2000-07-28
申请人： Keiichi Ajito , Shoichi Murakami , Minoru Ishikawa , Mikio Yamamoto , Dai Kubota , Shuichi Gomi , Mitsugu Hachisu , Kiyoaki Katano
发明人： Keiichi Ajito , Shoichi Murakami , Minoru Ishikawa , Mikio Yamamoto , Dai Kubota , Shuichi Gomi , Mitsugu Hachisu , Kiyoaki Katano
IPC分类号： A61K31497
CPC分类号： C07D239/42 , C07D235/30 , C07D239/14
摘要： An objective of the present invention is to provide compounds having integrin &agr;v&bgr;3 antagonistic activity, GP IIb/IIIa antagonistic activity, and/or human platelet aggregation inhibitory activity, and therapeutic agents for treating integrin &agr;v&bgr;3-mediated diseases and for inhibiting platelet aggregation. The derivatives according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein A represents a five- to seven-membered heterocyclic ring containing two nitrogen atoms or the like; X and Z represent CH or a nitrogen atom; R4 and R5 represent alkyl, halogen or the like; Q represents >C=O, >CH2 or the like; R6 represents H, alkyl, aralkyl or the like; R7 represents H, alkynyl or the like; R8 represents H, substituted amino or the like; R9 represents H or alkyl; m is 0 to 5; n is 0 to 4; p is 2 or 3; and q is 0 or 1.
摘要翻译：本发明的目的是提供具有整合素α2拮抗活性，GP IIb / IIIa拮抗活性和/或人血小板聚集抑制活性的化合物，以及用于治疗整合素α1β介导的疾病和抑制血小板聚集的治疗剂。根据本发明的衍生物是由式（I）表示的化合物或其药学上可接受的盐或溶剂化物：其中A表示含有两个氮原子等的5-至7-元杂环; X和Z表示CH或氮原子; R4和R5代表烷基，卤素等; Q表示> C = O，> CH2等; R6表示H，烷基，芳烷基等; R 7表示H，炔基等; R8表示H，取代的氨基等; R9代表H或烷基; m为0〜5; n为0〜4; p为2或3; q为0或1。

5. 发明授权

US5519122A 16-membered macrolide derivatives and process for producing the same 失效
公开(公告)号：US5519122A
公开(公告)日：1996-05-21
申请号：US359825
申请日：1994-12-20
申请人： Keiichi Ajito , Ken-ichi Kurihara , Akira Shimizu , Shuichi Gomi , Nobue Kikuchi , Minako Araake , Tsuneo Ishizuka , Aiko Miyata , Osamu Hara , Seiji Shibahara
发明人： Keiichi Ajito , Ken-ichi Kurihara , Akira Shimizu , Shuichi Gomi , Nobue Kikuchi , Minako Araake , Tsuneo Ishizuka , Aiko Miyata , Osamu Hara , Seiji Shibahara
IPC分类号： C07H17/08 , B01D53/047
CPC分类号： C07H17/08
摘要： 16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 represents a straight-chain alkyl group having 1 to 3 carbon atoms; R.sup.2 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.3 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.4 represents a straight-chain alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted allyl group; and R.sup.5 represents a substituted or unsubstituted, straight-chain or branched alkyl, alkenyl or aralkyl group having 1 to 10 carbon atoms;and pharmaceutically acceptable salts thereof are disclosed. These compounds show excellent and long-acting antimicrobial activities. A novel process for producing these 16-membered macrolide derivatives is further disclosed.

6. 发明申请

US20070111278A1 Endoglucanase stce and cellulase preparation containing the same 有权
标题翻译：内切葡聚糖酶和含有相同的纤维素酶制剂
公开(公告)号：US20070111278A1
公开(公告)日：2007-05-17
申请号：US10581717
申请日：2004-10-22
申请人： Jinichiro Koga , Yuko Baba , Akitaka Nakane , Satoshi Hanamura , Tomoko Nishimura , Shuichi Gomi , Hidetoshi Kubota , Toshiaki Kono
发明人： Jinichiro Koga , Yuko Baba , Akitaka Nakane , Satoshi Hanamura , Tomoko Nishimura , Shuichi Gomi , Hidetoshi Kubota , Toshiaki Kono
IPC分类号： C07H21/04 , C12P21/06 , C12N9/24 , C12N15/74 , C11D7/42 , C11D3/386
CPC分类号： C12N9/2437 , A23K20/189 , C11D3/38636 , C11D3/38645 , C12Y302/01004 , D06M16/003 , D06M2101/06 , D06M2200/35 , D06M2200/50 , D21H11/20 , D21H25/18
摘要： A novel endoglucanase derived from Staphylotrichum coccosporum, a polynucleotide encoding the endoglucanase, and a cellulase preparation containing the endoglucanase are disclosed. The endoglucanase or cellulase preparation is available for a washing use or fabric processing, such as a color clarification of a cellulose-containing fabric, a reduction of fuzz, an improvement of the touch feel and appearance of the fabric, providing a localized color change to the fabric, or a reduction of stiffness.
摘要翻译：公开了一种衍生自球形葡萄球菌的新型内切葡聚糖酶，一种编码该内切葡聚糖酶的多核苷酸，以及含有内切葡聚糖酶的纤维素酶制剂。内切葡聚糖酶或纤维素酶制剂可用于洗涤用途或织物加工，例如含纤维素织物的颜色澄清，绒毛减少，织物的触感和外观的改善，提供局部颜色变化织物或刚度的降低。

7. 发明授权

US5618795A Dibekacin derivatives and arbekacin derivatives active against resistant bacteria, and the production thereof 失效
标题翻译：对抗性细菌有活性的二比卡星衍生物和阿贝卡星衍生物及其生产
公开(公告)号：US5618795A
公开(公告)日：1997-04-08
申请号：US524644
申请日：1995-09-08
申请人： Shinichi Kondo , Seiji Shibahara , Takayuki Usui , Toshiaki Kudo , Shuichi Gomi , Atsushi Tamura , Yoko Ikeda , Daishiro Ikeda , Tomio Takeuchi
发明人： Shinichi Kondo , Seiji Shibahara , Takayuki Usui , Toshiaki Kudo , Shuichi Gomi , Atsushi Tamura , Yoko Ikeda , Daishiro Ikeda , Tomio Takeuchi
IPC分类号： C07H15/236 , A61K31/70
CPC分类号： C07H15/234
摘要： As new dibekacin derivatives and new arbekacin derivatives are now provided 2"-amino-2"-deoxydibekacin, 2"-amino-5,2"-dideoxydibekacin, 2"-amino-2"-deoxyarbekacin, 2"-amino-5,2"-dideoxyarbekacin, 2"-amino-5,2"-dideoxy-5-epi-fluoroarbekacin and 2"-amino-5,2"-dideoxy-5-epi-aminoarbekacin which all exhibit high antibacterial activity against a wide variety of gram-positive and gram-negative bacteria, including resistant bacteria such as methicillin-resistant Staphylococcus aureus and which are of low toxicity to mammals and are useful as antibacterial agent for treatment of bacterial infections.
摘要翻译：现在提供新的二卡辛衍生物和新的阿贝卡星衍生物2' - 氨基-2' - 脱氧胆碱，2“ - 氨基-5,2” - 脱氧胆酸，2“ - 氨基-2'-脱氧阿糖胞苷，2 “ - 氨基-5,2” - 双脱氧肉豆蔻素，2“ - 氨基-5,2” - 双脱氧-5-表 - 氟代贝卡星和2“ - 氨基-5,2” - 双脱氧-5-表所有这些都表现出对各种革兰氏阳性和革兰氏阴性细菌的高抗菌活性，包括耐甲氧西林金黄色葡萄球菌等抗性细菌，对哺乳动物毒性低，可用作细菌治疗的抗菌剂感染。

8. 发明授权

US06750219B1 &OHgr;-amino-&agr;-hydroxycarboxylic acid derivatives having integrin &agr;&ngr;&bgr;3 antagonistic activity 失效
标题翻译：具有整合素α2β3拮抗活性的ω-氨基-α-羟基羧酸衍生物
公开(公告)号：US06750219B1
公开(公告)日：2004-06-15
申请号：US10048914
申请日：2002-02-05
申请人： Keiichi Ajito , Naokazu Yahata , Minoru Ishikawa , Dai Kubota , Shoichi Murakami , Mikio Yamamoto , Kazuyuki Fujishima , Shuichi Gomi , Shokichi Ouchi
发明人： Keiichi Ajito , Naokazu Yahata , Minoru Ishikawa , Dai Kubota , Shoichi Murakami , Mikio Yamamoto , Kazuyuki Fujishima , Shuichi Gomi , Shokichi Ouchi
IPC分类号： C07D40304
CPC分类号： C07D239/42
摘要： An objective of the present invention is to provide highly water-soluble compounds having integrin &agr;v&bgr;3 antagonistic activity. The compounds according to the present invention are compounds represented by formula (I) and pharmaceutically acceptable salts or solvates thereof: wherein A represents a two nitrogen atom-containing optionally substituted saturated or unsaturated five- to seven-membered heterocyclic group, which is optionally condensed with another carbocyclic ring or heterocyclic ring to form a bicyclic group, or —C(—NR1R2)(═NR3) wherein R1, R2, and R3 represent hydrogen, alkyl or the like; D represents a bond, >NR4, wherein R4 represents hydrogen or optionally substituted alkyl, —O—, or —S—; X and Z represent either CH or N; R7 and R8 represent C1-6 alkyl, halogen, oxygen or the like; Q represents >C═O, >CHR13 or >CHOR13 wherein R13 represents hydrogen or alkyl; R9 represents hydrogen, alkyl or the like; J represents a bond or alkylene having 1 to 3 carbon atoms; R10 and R11 represent hydrogen, alkyl or the like; m is an integer of 0 to 5; n is an integer of 0 to 4; and p and q are an integer of 1 to 3.
摘要翻译：本发明的目的是提供具有整合素α2拮抗活性的高水溶性化合物。根据本发明的化合物是由式（I）表示的化合物及其药学上可接受的盐或溶剂化物：其中A表示两个含有氮原子的任选取代的饱和或不饱和的五至七元杂环基，其任选地稠合与另一个碳环或杂环形成双环基团，或-C（-NR 1 R 2）（= NR 3）（其中R 1，R 2和R 3）代表氢，烷基等; D表示键，NR 4，其中R 4表示氢或任选取代的烷基，-O-或-S-; X和Z表示CH或N; R 7和R 8表示C 1-6烷基，卤素，氧等; Q表示C = O，> CHR 13或CHOR 13，其中R 13表示氢或烷基; R 9表示氢，烷基等; J表示碳原子数1〜3的键或亚烷基。 R 10和R 11代表氢，烷基等; m为0〜5的整数。 n为0〜4的整数。 p和q为1〜3的整数。

9. 发明授权

US5849797A D-.beta.-lysylmethanediamine derivatives and preparation thereof 失效
标题翻译： D-β-赖氨酰基甲二胺衍生物及其制备
公开(公告)号：US5849797A
公开(公告)日：1998-12-15
申请号：US793912
申请日：1997-02-24
申请人： Shinichi Kondo , Yoko Ikeda , Tomio Takeuchi , Rie Shinei , Shuichi Gomi , Seiji Shibahara , Hiroo Hoshino
发明人： Shinichi Kondo , Yoko Ikeda , Tomio Takeuchi , Rie Shinei , Shuichi Gomi , Seiji Shibahara , Hiroo Hoshino
IPC分类号： A61K31/16 , A61P31/12 , A61P31/18 , A61P37/04 , C07C231/02 , C07C231/12 , C07C237/10 , C07C233/05
CPC分类号： C07C237/10
摘要： Now are provided (R)-3,6-diamino-N-(.omega.-aminoalkyl)-hexanamides which are novel compounds having the general formula (I): ##STR1## wherein n stands for 2-5, and which may be for example, (R)-3,6-diamino-N-(2-aminoethyl)hexanamide (n=2) and (R)-3,6-diamino-N-(3-aminopropyl)hexanamide (n=3). Their preparation process is also provided. These novel compounds and acid addition salts thereof have activities inhibitory against Gram-positive bacteria, Gram-negative bacteria and AIDS virus, as well as tumor cells and are chemically stable. These novel compounds and their salts are useful as chemotherapeutic agents for diseases caused by these bacteria or virus and also as antitumor agent.
摘要翻译： PCT No.PCT / JP95 / 01680 Sec。 371日期1997年2月24日 102（e）1997年2月24日PCT PCT 1995年8月24日PCT公布。公开号WO96 / 06069 日期：1996年2月29日提供（R）-3,6-二氨基-N-（ω-氨基烷基） - 己酰胺，它们是具有通式（I）的新化合物：其中n代表2 -5，其可以是例如（R）-3,6-二氨基-N-（2-氨基乙基）己酰胺（n = 2）和（R）-3,6-二氨基-N-（3-氨基丙基）己酰胺（n = 3）。还提供了他们的准备过程。这些新化合物及其酸加成盐具有抑制革兰氏阳性菌，革兰氏阴性菌和艾滋病病毒以及肿瘤细胞的活性，并具有化学稳定性。这些新化合物及其盐可用作由这些细菌或病毒引起的疾病的化学治疗剂，也可用作抗肿瘤剂。

10. 发明授权

US5055453A Benanomicins A and antibiotic compositions 失效
标题翻译： BENANOMICINS A和抗生素组合物
公开(公告)号：US5055453A
公开(公告)日：1991-10-08
申请号：US264888
申请日：1988-10-31
申请人： Tomio Takeuchi , Takeshi Hara , Masa Hamada , Shinichi Kondo , Masaji Sezaki , Haruo Yamamoto , Shuichi Gomi
发明人： Tomio Takeuchi , Takeshi Hara , Masa Hamada , Shinichi Kondo , Masaji Sezaki , Haruo Yamamoto , Shuichi Gomi
IPC分类号： C07H15/24 , C12P19/56
CPC分类号： C12R1/01 , C07H15/24 , C12P19/56 , Y10S435/826
摘要： Two new antibiotics which are now nominated as benanomicin A and benanomicin B, respectively, are fermentatively produced by the cultivation of a new microorganism, designated as MH193-16F4 strain, of Actinomycetes. Benanomicins A and B each show antifungal activity and are useful as a therapeutic antifungal agent. A new compound, dexylosylbenanomicin B is now produced by chemical conversion of benanomicin B, and this semi-synthetic antibiotic also shows antifungal activity and is useful as a therapeutic antifungal agent.

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