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1. 发明申请

US20090012168A1 ADIPONECTION INDUCERS OR SECRETAGOGUES 审中-公开
标题翻译： ADIPONECTION感应器或秘密
公开(公告)号：US20090012168A1
公开(公告)日：2009-01-08
申请号：US11770121
申请日：2007-06-28
申请人： Katsumi MAEZONO , Naoyuki FUKUCHI , Nozomu ISHIDA , Akira MITSUI , Kenji TAKEHANA
发明人： Katsumi MAEZONO , Naoyuki FUKUCHI , Nozomu ISHIDA , Akira MITSUI , Kenji TAKEHANA
IPC分类号： A61K31/198 , A61P3/04 , A61P9/12
CPC分类号： A61K31/198 , A23L33/175 , A61K31/519 , A61K45/06
摘要： The present invention discloses an adiponectin inducer or secretagogue which comprises an amino acid(s) selected from the group consisting of leucine, isoleucine, valine, methionine, cystein, alanine and a mixture(s) thereof, and a therapeutic agent of hypoadiponectinemia, hyperlipemia, hypertension or vascular disorders or an anti-inflammatory agent, which comprises the adiponectin inducer or secretagogue.
摘要翻译：本发明公开了一种脂联素诱导剂或促分泌素，其包含选自亮氨酸，异亮氨酸，缬氨酸，甲硫氨酸，半胱氨酸，丙氨酸及其混合物的氨基酸，以及低脂联素血症，高脂血症，高血压或血管疾病或抗炎剂，其包含脂联素诱导剂或促分泌素。

2. 发明申请

US20100063151A1 ACYLAMIDE COMPOUNDS HAVING SECRETAGOGUE OR INDUCER ACTIVITY OF ADIPONECTIN 审中-公开
标题翻译：具有ADIPONECTIN的秘密活性或诱导活性的酰亚胺化合物
公开(公告)号：US20100063151A1
公开(公告)日：2010-03-11
申请号：US12621142
申请日：2009-11-18
申请人： Katsumi MAEZONO , Toshihiko YOSHIMURA , Nozomu ISHIDA , Naoyuki FUKUCHI , Toshihiro HATANAKA , Osamu IKEHARA , Yayoi KAWATO , Hideyuki TANAKA
发明人： Katsumi MAEZONO , Toshihiko YOSHIMURA , Nozomu ISHIDA , Naoyuki FUKUCHI , Toshihiro HATANAKA , Osamu IKEHARA , Yayoi KAWATO , Hideyuki TANAKA
IPC分类号： A61K31/164 , A61P3/10 , A61P3/04
CPC分类号： C07C233/47 , A23L33/10 , C07C323/59
摘要： The present invention provides acylamide compounds, prodrugs thereof, or pharmaceutically acceptable salts thereof; and an adiponectin inducer or secretagogue, and therapeutic methods by administering the same.
摘要翻译：本发明提供酰酰胺化合物，其前药或其药学上可接受的盐; 和脂联素诱导剂或促分泌素，以及通过施用它们的治疗方法。

3. 发明申请

US20090259061A1 PPAR ACTIVITY REGULATORS 失效
标题翻译： PPAR活性调节剂
公开(公告)号：US20090259061A1
公开(公告)日：2009-10-15
申请号：US12398378
申请日：2009-03-05
申请人： Akiko OONUKI , Toshihiko YOSHIMURA , Katsumi MAEZONO , Yayoi KAWATO , Hideyuki TANAKA , Naoyuki FUKUCHI , Nozomu ISHIDA
发明人： Akiko OONUKI , Toshihiko YOSHIMURA , Katsumi MAEZONO , Yayoi KAWATO , Hideyuki TANAKA , Naoyuki FUKUCHI , Nozomu ISHIDA
IPC分类号： C11C3/00
CPC分类号： C07C233/47 , C07C233/49 , C07C233/52 , C07C2601/14
摘要： The object of the present invention is to provide PPAR (peroxisome proliferator-activated receptor) activity regulators, which can be widely used for improving insulin resistance and preventing/treating various diseases such as diabetes, metabolic syndromes, hyperlipemia, high-blood pressure, vascular disorders, inflammation, hepatitis, fatty liver, liver fibrosis, NASH (non-alcoholic steatohepatitis) and obesity.The present invention provides PPAR activity regulators which comprise an acylamide compound having the specific structure, prodrugs thereof, or pharmaceutically acceptable salts thereof.
摘要翻译：本发明的目的是提供PPAR（过氧化物酶体增殖物激活受体）活性调节剂，其可广泛用于改善胰岛素抵抗和预防/治疗各种疾病如糖尿病，代谢综合征，高脂血症，高血压，血管疾病，炎症，肝炎，脂肪肝，肝纤维化，NASH（非酒精性脂肪性肝炎）和肥胖症。本发明提供了包含具有特定结构的酰基酰胺化合物，其前药或其药学上可接受的盐的PPAR活性调节剂。

4. 发明申请

US20120060702A1 APPARATUS FOR UNBINDING A MASS OF MUTUALLY STICKED NOODLES 有权
标题翻译：装置用于不包含大量的马铃薯块状物
公开(公告)号：US20120060702A1
公开(公告)日：2012-03-15
申请号：US13230279
申请日：2011-09-12
申请人： Yoshiaki NAGAYAMA , Nozomu ISHIDA
发明人： Yoshiaki NAGAYAMA , Nozomu ISHIDA
IPC分类号： A23N4/04
CPC分类号： F26B1/00 , A21C15/00 , F26B2210/06
摘要： Within a housing, a rotating shaft extends horizontally, and curved unbinding rods are secured to the rotating shaft at diagonally opposed positions to extend in radial directions. Within the housing, an inner wall surface is arranged along a circular arc whose center is aligned with an axis of the rotating shaft and whose diameter is slightly larger than a diameter of a circle drawn by rotating tips of the unbinding rods. A portion of the inner wall surface is formed as an unbinding surface having a circular arc cross sectional shape facing the unbinding rods with a small clearance. A mass of noodles for one meal charged into the housing from the inlet is sent in the counter-clockwise direction by the unbinding rods rotated at a high speed and is hit by the unbinding rods repeatedly to perform an effective unbinding function.
摘要翻译：在壳体内，旋转轴水平延伸，并且弯曲的解锁杆在对角相对位置处固定到旋转轴，以沿径向方向延伸。在壳体内，内壁表面沿着圆弧布置，其中心与旋转轴的轴线对准，并且其直径略大于通过解开杆的旋转尖端拉出的圆的直径。内壁表面的一部分形成为具有与具有小间隙的解开杆相对的圆弧形横截面形状的非绑定表面。从入口装入外壳的一顿饭的面条通过高速旋转的解束杆以逆时针方向被发送，并且被解绑杆重复地击打以执行有效的解除绑定功能。

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