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1. 发明申请

US20120213742A1 VIRUS GROWING IN HYPOXIC CELL OR VIRUS VECTOR EXPRESSING GENE THEREIN 审中-公开
标题翻译：高血压病毒或病毒载体表达基因的病毒
公开(公告)号：US20120213742A1
公开(公告)日：2012-08-23
申请号：US13404518
申请日：2012-02-24
申请人： Katsuhito TAKAHASHI , Hisako Yamamura , Masahiro Inoue
发明人： Katsuhito TAKAHASHI , Hisako Yamamura , Masahiro Inoue
IPC分类号： A61K35/76 , A61K31/7088
CPC分类号： C07K14/005 , A61K35/76 , A61K48/00 , C12N15/86 , C12N2710/16622 , C12N2710/16632 , C12N2710/16643 , C12N2840/203
摘要： The present invention provides a virus or a viral vector capable of expressing a gene specifically in a cell having replication ability in a hypoxic state such as a cancer stem cell and injuring the cell, and a pharmaceutical composition comprising the same. Specifically, the present invention provides a virus or a viral vector which comprises a gene encoding a fusion protein of an ODD and a protein essentially required for viral proliferation, and a pharmaceutical composition comprising the same.
摘要翻译：本发明提供能够在具有缺氧状态的复制能力的细胞例如癌症干细胞中特异性表达基因的病毒或病毒载体，以及包含该基因的药物组合物。具体地说，本发明提供病毒或病毒载体，其包含编码ODD融合蛋白的基因和病毒增殖基本上必需的蛋白质，以及包含该蛋白质的药物组合物。

2. 发明申请

US20110286972A1 VIRUS GROWING IN HYPOXIC CELL OR VIRUS VECTOR EXPRESSING GENE THEREIN 审中-公开
标题翻译：高血压病毒或病毒载体表达基因的病毒
公开(公告)号：US20110286972A1
公开(公告)日：2011-11-24
申请号：US12863028
申请日：2009-01-13
申请人： Katsuhito Takahashi , Hisako Yamamura , Masahiro Inoue
发明人： Katsuhito Takahashi , Hisako Yamamura , Masahiro Inoue
IPC分类号： A61K48/00 , C12N7/00 , C07H21/00 , A61P9/10 , A61P35/00 , A61P11/00 , A61P9/12 , C12N15/63 , C07K14/005
CPC分类号： C07K14/005 , A61K35/76 , A61K48/00 , C12N15/86 , C12N2710/16622 , C12N2710/16632 , C12N2710/16643 , C12N2840/203
摘要： The present invention provides a virus or a viral vector capable of expressing a gene specifically in a cell having replication ability in a hypoxic state such as a cancer stem cell and injuring the cell, and pharmaceutical composition comprising the same. Specifically, the present invention provides a virus or a viral vector which comprises a gene encoding a fusion protein of an ODD and a protein essentially required for viral proliferation, and a pharmaceutical composition comprising the same.
摘要翻译：本发明提供能够在具有缺氧状态的复制能力的细胞例如癌症干细胞中特异性表达基因的病毒或病毒载体，以及包含该基因的药物组合物。具体地说，本发明提供病毒或病毒载体，其包含编码ODD融合蛋白的基因和病毒增殖基本上必需的蛋白质，以及包含该蛋白质的药物组合物。

3. 发明授权

US08937256B2 Method for manufacturing wiring board for mounting electronic component, wiring board for mounting electronic component, and method for manufacturing wiring board having an electronic component 有权
标题翻译：用于制造电子部件安装用布线板的方法，电子部件安装用布线板以及具有电子部件的布线基板的制造方法
公开(公告)号：US08937256B2
公开(公告)日：2015-01-20
申请号：US13353965
申请日：2012-01-19
申请人： Masahiro Inoue , Hajime Saiki , Atsuhiko Sugimoto
发明人： Masahiro Inoue , Hajime Saiki , Atsuhiko Sugimoto
IPC分类号： H01K1/02 , H05K13/04 , H05K3/34 , H01L23/00
CPC分类号： H05K3/3478 , H01L24/81 , H01L2224/10126 , H01L2224/16225 , H01L2924/14 , H05K3/3436 , H05K3/3484 , H05K2201/10977 , H01L2924/00
摘要： A method for manufacturing a wiring board for mounting an electronic component, a wiring board for mounting an electronic component, and a method for manufacturing an electronic-component-mounted wiring board are provided. A bonding material paste, which can include solder and an electric insulation material made of a resin, can be placed on chip mount terminal pads and heated to fuse the solder and soften the electric insulation material. Subsequently, the solder is solidified to form solder bumps. Further, the electric insulation material is cured on a surface of each of the solder bumps and a surface of a multilayer board around each of the solder bumps to form an electric insulation surface layer. Accordingly, when a chip is mounted to such wiring boards, the electric insulation surface layer minimizes or eliminates the connection between adjacent solder bumps during re-fusing of the solder.
摘要翻译：本发明提供一种电子部件安装用布线基板的制造方法，电子部件的安装用布线基板以及电子元件搭载布线基板的制造方法。可以将包括焊料和由树脂制成的电绝缘材料的接合材料糊料放置在芯片安装端子焊盘上并加热以熔化焊料并软化电绝缘材料。随后，焊料固化形成焊料凸块。此外，电绝缘材料在每个焊料凸块的表面和每个焊料凸块周围的多层板的表面上固化，以形成电绝缘表面层。因此，当芯片安装到这种布线板时，电绝缘表面层在焊料的再熔合期间使相邻焊料凸块之间的连接最小化或消除。

4. 发明授权

US08253313B2 Spark plug and manufacturing method thereof 有权
标题翻译：火花塞及其制造方法
公开(公告)号：US08253313B2
公开(公告)日：2012-08-28
申请号：US13234212
申请日：2011-09-16
申请人： Masahiro Inoue , Hiroyuki Kameda
发明人： Masahiro Inoue , Hiroyuki Kameda
IPC分类号： H01T13/20
CPC分类号： H01T13/32 , H01T21/02
摘要： A spark plug having improved durability having a ground electrode comprised of a ground electrode base member and a noble metal tip. A center axis of the noble metal tip slants in relation to the center axis of the ground electrode base member at angle θ which satisfies a relation 2°≦θ≦25°.
摘要翻译：一种具有改进的耐久性的火花塞，具有由接地电极基体和贵金属电极构成的接地电极。贵金属端头的中心轴相对于接地电极基体的中心轴线以角度θ倾斜; 满足关系2°＆nlE;＆thetas;＆nlE; 25°。

5. 发明申请

US20120164732A1 CANCER TISSUE-DERIVED CELL MASS AND A PROCESS FOR PREPARING SAME 审中-公开
标题翻译：癌组织衍生细胞质量及其制备方法
公开(公告)号：US20120164732A1
公开(公告)日：2012-06-28
申请号：US13254162
申请日：2010-03-01
申请人： Masahiro Inoue , Masayuki Ohue
发明人： Masahiro Inoue , Masayuki Ohue
IPC分类号： C12N5/02 , C12N5/00
CPC分类号： C12N5/0693 , C12N2509/00
摘要： Disclosed is a novel cell mass derived from a cancer tissue, which can reflect the in vivo behavior of a cancer cell correctly. Also disclosed is a process for preparing the cell mass. Specifically disclosed is a cell mass derived from a cancer tissue, which is an separated product that is isolated from a cancer tissue obtained from an individual as a mass containing at least three cancer cells or a cultured product of the separated product and which can retain a proliferation ability in vitro. The cell mass derived from a cancer tissue is produced by, for example, a preparation process comprising the steps of: treating a pulverized product of a cancer tissue removed from a living body with an enzyme; and selecting and collecting a mass containing at least three cancer cells among from an enzymatic treatment product.
摘要翻译：公开了一种衍生自癌组织的新型细胞团，其可以正确反映癌细胞的体内行为。还公开了一种制备细胞块的方法。具体公开了一种衍生自癌组织的细胞块，其是从作为含有至少三种癌细胞的质量的个体获得的癌组织分离的分离产物或分离产物的培养产物，并且可以保留体外增殖能力。衍生自癌组织的细胞块通过例如制备方法制备，所述制备方法包括以下步骤：用酶处理从活体中除去的癌组织的粉碎产物; 以及从酶处理产物中选择和收集含有至少三种癌细胞的物质。

6. 发明申请

US20120104289A1 DROPLET GENERATION AND DETECTION DEVICE, AND DROPLET CONTROL DEVICE 有权
标题翻译：滴液发生和检测装置，以及喷射器控制装置
公开(公告)号：US20120104289A1
公开(公告)日：2012-05-03
申请号：US13283849
申请日：2011-10-28
申请人： Hakaru MIZOGUCHI , Kouji Kakizaki , Osamu Wakabayashi , Masahiro Inoue
发明人： Hakaru MIZOGUCHI , Kouji Kakizaki , Osamu Wakabayashi , Masahiro Inoue
IPC分类号： G01J3/10
CPC分类号： H05G2/006 , H05G2/008
摘要： A droplet generation and detection device may include: a droplet generation unit for outputting a charged droplet; at least one droplet sensor including a magnetic circuit including a coil configured of an electrically conductive material, the magnetic circuit being disposed such that the charged droplet passes around the magnetic circuit, and a current detection unit for detecting current flowing in the coil and outputting a detection signal; and a signal processing circuit for detecting the charged droplet based on the detection signal.
摘要翻译：液滴生成和检测装置可以包括：用于输出带电液滴的液滴产生单元; 至少一个液滴传感器，其包括包括由导电材料构成的线圈的磁路，所述磁路被布置成使得所述带电液滴绕过所述磁路;以及电流检测单元，用于检测在所述线圈中流动的电流并输出检测信号; 以及信号处理电路，用于根据检测信号检测带电液滴。

7. 发明申请

US20120074828A1 SPARK PLUG AND MANUFACTURING METHOD THEREOF 有权
标题翻译： SPARK插头及其制造方法
公开(公告)号：US20120074828A1
公开(公告)日：2012-03-29
申请号：US13234212
申请日：2011-09-16
申请人： Masahiro Inoue , Hiroyuki Kameda
发明人： Masahiro Inoue , Hiroyuki Kameda
IPC分类号： H01T13/20 , H01T21/02
CPC分类号： H01T13/32 , H01T21/02
摘要： A spark plug having improved durability having a ground electrode comprised of a ground electrode base member and a noble metal tip. A center axis of the noble metal tip slants in relation to the center axis of the ground electrode base member at angle θ which satisfies a relation 2°≦θ≦25°.
摘要翻译：一种具有改进的耐久性的火花塞，具有由接地电极基体和贵金属电极构成的接地电极。贵金属端头的中心轴相对于接地电极基体的中心轴线以角度θ倾斜; 满足关系2°＆nlE;＆thetas;＆nlE; 25°。

8. 发明申请

US20110282539A1 CONTROL DEVICE FOR INTERNAL COMBUSTION ENGINE AND MEASURING DEVICE OF MASS FLOW RATE OF NOx RECIRCULATED TO INTAKE PASSAGE WITH BLOWBY GAS 有权
标题翻译：用于内燃机的控制装置和通过气泡进行通气的NOx流量的测量装置
公开(公告)号：US20110282539A1
公开(公告)日：2011-11-17
申请号：US13000046
申请日：2010-01-28
申请人： Masahiro Inoue
发明人： Masahiro Inoue
IPC分类号： G01M15/04
CPC分类号： F01M13/022 , F02D41/0045 , F02D41/0065 , F02D41/144 , F02D41/1454 , F02D41/146 , F02D41/18 , F02D2041/224 , F02D2250/08 , F02D2250/11 , F02D2250/36 , F02M26/23 , F02M35/10393
摘要： A mass flow rate of NOx which is recirculated to an intake passage with a blowby gas is obtained with high precision, and based on the result, a state of an internal combustion engine can be accurately diagnosed. A control device for an internal combustion engine of the present invention measures a NOx concentration in an intake passage downstream from a position where the blowby gas is recirculated, and similarly measures an oxygen concentration in the intake passage downstream from the aforesaid position. Further, the control device measures a mass flow rate of fresh air taken into the intake passage. The control device calculates a mass flow rate of the blowby gas recirculated to the intake passage from the oxygen concentration and the mass flow rate of the fresh air. Next, the control device calculates a mass flow rate of all gases in the intake passage from the mass flow rate of the fresh air and the mass flow rate of the blowby gas. Subsequently, the control device calculates the mass flow rate of NOx in the aforesaid intake passage from the mass flow rate of all the gases and the NOx concentration. The present control device diagnoses the state of the internal combustion engine based on the mass flow rate of NOx thus calculated.
摘要翻译：可以高精度地获得再循环到进气通道的NOx的质量流量，并且根据该结果可以准确地诊断出内燃机的状态。用于本发明的内燃机的控制装置测量从窜气再循环的位置下游的进气通道中的NOx浓度，并且类似地测量在上述位置下游的进气通道中的氧气浓度。此外，控制装置测量进入进气通道的新鲜空气的质量流量。控制装置从氧浓度和新鲜空气的质量流量计算再循环到进气通路的窜气的质量流量。接下来，控制装置从新鲜空气的质量流量和窜气的质量流量计算进气通路中的所有气体的质量流量。随后，控制装置从所有气体的质量流量和NOx浓度计算上述进气通道中的NOx的质量流量。本控制装置基于这样计算的NOx的质量流量来诊断内燃机的状态。

9. 发明申请

US20100206114A1 BALL SCREW WITH BALL SPLINES 审中-公开
标题翻译：球螺丝带球
公开(公告)号：US20100206114A1
公开(公告)日：2010-08-19
申请号：US12734152
申请日：2008-10-23
申请人： Katsura Koyagi , Masahiro Inoue
发明人： Katsura Koyagi , Masahiro Inoue
IPC分类号： F16H25/22
CPC分类号： F16H25/2214 , F16C29/0685 , F16C29/0695 , F16H2025/204 , Y10T74/19749
摘要： A ball screw with ball splines is provided which eliminates a fear that balls within a screw groove override spline grooves.A ball screw with ball splines includes a screw shaft 1 having a screw groove 6 and a plurality of straight line-like spline grooves 7 extending in an axial direction which are formed on an outer circumferential surface thereof, a screw nut 2 through which the screw shaft 1 is inserted and on which a screw balls circulating path is formed which corresponds to the screw groove 6 on the screw shaft 1, a spline nut 3 through which the screw shaft 1 is inserted and on which spline balls circulating paths are formed which correspond to the spline grooves 7 on the screw shaft 1, a plurality of screw balls 4 installed in the screw balls circulating path on the screw nut 2, and a plurality of spline balls 5 installed in the spline balls circulating paths on the spline nut 3. A radial position at a bottom 7a of the spline groove 7 on the screw shaft 1 lies further radially outwards than a radially outermost portion of a ball contact portion of the screw groove 6 where the ball contacts when a maximum load is exerted thereon.
摘要翻译：提供具有滚珠花键的滚珠丝杠，消除了螺旋槽内的滚珠超越花键槽的担心。具有滚珠花键的滚珠丝杠包括螺杆轴1，螺杆轴1具有螺纹槽6和沿其轴向方向延伸的多个直线状花键槽7，螺母轴1在其外圆周表面上形成有螺母2，轴1被插入并形成有与螺杆轴1上的螺纹槽6相对应的螺杆滚珠循环路径，花键螺母3，螺纹轴1穿过该花键螺母3，在其上形成有与其对应的花键球循环路径到螺杆轴1上的花键槽7，安装在螺母2的螺杆滚珠循环路径中的多个螺纹球4和安装在花键螺母3的花键球循环路径中的多个花键球5。螺杆轴1上的花键槽7的底部7a处的径向位置比螺旋槽6的球接触部分的径向最外部部分进一步径向向外，其中当球接触时施加最大载荷。

10. 发明授权

US07774004B2 Reducing paging control traffic in a mobile system by placing router identifications in the uplink pagin request packet 失效
标题翻译：通过将路由器标识放置在上行链路寻呼请求包中来减少移动系统中的寻呼控制流量
公开(公告)号：US07774004B2
公开(公告)日：2010-08-10
申请号：US10870908
申请日：2004-06-21
申请人： Masahiro Inoue , Ichiro Okajima , Narumi Umeda
发明人： Masahiro Inoue , Ichiro Okajima , Narumi Umeda
IPC分类号： H04W68/00 , G06F15/173
CPC分类号： H04W68/00 , H04W64/00 , H04W80/00
摘要： A network system implements paging control in which the control apparatus, upon receiving a packet destined for a mobile terminal, transmits a paging notification packet to a paging area of the mobile terminal, so as to obtain location information of the mobile terminal and to determine a transfer destination of a received packet. The control apparatus is configured to transmit the paging notification packet to a plurality of router devices included in the paging area. Each of the plurality of router devices is configured to transmit a received paging notification packet to a plurality of access points by multicasting. Each of the plurality of access points is configured to transmit a received paging notification packet to the mobile terminal through a link connection by multicasting, when it is judged that an IP address in the paging notification packet is a predetermined IP address.
摘要翻译：网络系统实现寻呼控制，其中控制装置在接收到去往移动终端的分组后，向移动终端的寻呼区域发送寻呼通知分组，以获得移动终端的位置信息，并确定转发目的地址。控制装置被配置为将寻呼通知分组发送到包括在寻呼区域中的多个路由器设备。多个路由器设备中的每一个被配置为通过多播将接收到的寻呼通知分组发送到多个接入点。所述多个接入点中的每一个被配置为当判断为所述寻呼通知分组中的IP地址是预定的IP地址时，通过多播来通过链路连接向所述移动终端发送接收的寻呼通知分组。

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