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1. 发明申请

US20080306073A1 Antitumor Effect Potentiator, Antitumor Preparation, and Method for Treating Cancer 审中-公开
标题翻译：抗肿瘤效应增强剂，抗肿瘤制剂和治疗癌症的方法
公开(公告)号：US20080306073A1
公开(公告)日：2008-12-11
申请号：US11629185
申请日：2005-06-02
申请人： Katsuhisa Koizumi , Junji Uchida , Teiji Takechi , Mamoru Nukatsuka
发明人： Katsuhisa Koizumi , Junji Uchida , Teiji Takechi , Mamoru Nukatsuka
IPC分类号： A61K31/53 , C07F15/00 , A61P35/00
CPC分类号： A61K45/06 , A61K31/132 , A61K31/44 , A61K31/506 , A61K31/53 , A61K33/24 , A61K2300/00
摘要： An antitumor effect fortifier comprising as an active ingredient an effective amount of platinum (II) cis-oxalato(1R,2R-diaminocyclohexane) so as to enhance the antitumor activity of antitumor agent containing a therapeutically effective amount of tegafur, an amount, effective for the enhancement of antitumor effect, of gimeracil and an amount, effective for the suppression of side effects, of oteracil potassium; and a relevant antitumor agent. Further, there is provided a method of therapy for cancer, characterized in that an amount, effective for the enhancement of antitumor effect, of platinum (II) cis-oxalato(1R,2R-diaminocyclohexane) is concomitantly administered to a mammal. Still further, there is provided an antitumor agent consisting of a pharmaceutical preparation form composed of at least two separate preparations containing efficacious ingredients consisting of tegafur, gimeracil, oteracil potassium and platinum (II) cis-oxalato(1R,2R-diaminocyclohexane) each alone or in an arbitrary combination, or a pharmaceutical preparation form constituted of a single preparation containing all the efficacious ingredients. Still further, there is provided a relevant kit.
摘要翻译：一种抗肿瘤作用增强剂，其包含有效量的顺式草甘膦（II）顺式草甘膦（1R，2R-二氨基环己烷）作为活性成分，以增强含有治疗有效量的替加氟的抗肿瘤剂的抗肿瘤活性，吉非他赛的抗肿瘤作用的提高和对抑制副作用有效量的奥替卡尔钾; 和相关的抗肿瘤剂。此外，提供了一种癌症治疗方法，其特征在于向哺乳动物伴随施用有效提高抗肿瘤作用的量的铂（II）顺式草酸（1R，2R-二氨基环己烷）的量。另外，提供了由药物制剂形式组成的抗肿瘤药物，该药物制剂形式由至少两个单独的制剂组成，所述制剂含有由替加氟，吉美西尔，邻苯二甲酸钾和顺式草酸二（1R），顺式 - 草酸（1R，2R-二氨基环己烷）组成的有效成分或任意组合，或由含有所有有效成分的单一制剂构成的药物制剂形式。此外，还提供了相关工具包。

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