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1. 发明授权

US4562207A Prostaglandin analogue 失效
标题翻译：前列腺素类似物
公开(公告)号：US4562207A
公开(公告)日：1985-12-31
申请号：US587634
申请日：1984-03-08
申请人： Katsuhiro Imaki , Takashi Muryobayashi , Akiyoshi Kawasaki
发明人： Katsuhiro Imaki , Takashi Muryobayashi , Akiyoshi Kawasaki
IPC分类号： A61K31/557 , A61K31/5575 , A61P1/16 , A61P7/02 , C07C29/09 , C07C35/06 , C07C43/178 , C07C45/67 , C07C51/08 , C07C61/06 , C07C62/38 , C07C67/00 , C07C401/00 , C07C405/00 , C07F9/40 , C08B37/00 , C07C177/00
CPC分类号： C07C255/00 , C07C309/00 , C07C35/06 , C07C405/00 , C07C43/1788 , C07C45/673 , C07C51/08 , C07C61/06 , C07C62/38 , C07F9/4018 , C08B37/0015
摘要： A novel prostaglandin analogue of the formula: ##STR1## [wherein the symbol represents .beta.-configuration, the dotted line ---------- represents .alpha.-configuration, and the double bond between C.sub.13 -C.sub.14 represents transconfiguration] and cyclodextrin clathrates thereof, and non-toxic salts thereof are useful for the treatment and/or prevention of diseases induced by platelet aggregation, such as thrombosis, or induced by cytodamage.
摘要翻译：一种下式的新型前列腺素类似物：其中符号代表β-构型，虚线-----表示α-构型，C13-C14之间的双键表示反式构型]和环糊精包合物并且其无毒盐可用于治疗和/或预防血小板聚集诱发的疾病，例如血栓形成，或由细胞损伤引起。

2. 发明授权

US4503068A Use of prostaglandin analogues to treat cytodamage 失效
标题翻译：使用前列腺素类似物治疗细胞损伤
公开(公告)号：US4503068A
公开(公告)日：1985-03-05
申请号：US497052
申请日：1983-05-23
申请人： Yoshiki Sakai , Katsuhiro Imaki , Takashi Muryobayashi
发明人： Yoshiki Sakai , Katsuhiro Imaki , Takashi Muryobayashi
IPC分类号： A61K31/045 , A61K31/23 , A61K31/275 , A61K31/34 , A61K31/38 , A61K31/40 , A61K31/557 , A61K47/48 , A61P43/00 , C08B37/00 , A61K31/19
CPC分类号： B82Y5/00 , A61K31/34 , A61K31/38 , A61K31/40 , A61K31/557 , A61K47/48969 , C08B37/0015
摘要： The prostaglandin analogues16S-methyl-6-oxo-PGE.sub.1 methyl ester,17S,20-dimethyl-6-oxo-PGE.sub.1 methyl ester,15S-methyl-6-oxo-PGE.sub.1 and non-toxic salts thereof,17S,20-dimethyl-13,14-dihydro-6-oxo-PGE.sub.1 methyl ester,17S,20-dimethyl-6-oxo-PGE.sub.1 alcohol,17S,20-dimethyl-6S-PGI.sub.1 methyl ester,17S,20-dimethyl-trans-.DELTA..sup.2 -6RS-PGI.sub.1 methyl ester,17S,20-dimethyl-6,9.alpha.-nitrilo-PGI.sub.1 methyl ester,2-decarboxy-2-glycoloyl-17S,20-dimethyl-6S-PGI.sub.1,2-decarboxy-2-glycoloyl-15-cyclopentyl-16,17,18,19,20-pentanor-6S-PGI.sub.117S,20-dimethyl-6S-PGI.sub.1 alcohol,15-cyclopentyl-16,17,18,19,20-pentanor-6S-PGI.sub.1 alcohol and15-(3-propylcyclopentyl)-16,17,18,19,20-pentanor-6,9.alpha.-nitrilo-PGI.sub.1 alcohol,and cyclodextrin clathrates thereof are useful in the prevention or treatment of cytodamage.
摘要翻译：前列腺素类似物16S-甲基-6-氧代-PGE1甲酯，17S，20-二甲基-6-氧代-GE-PGE1甲酯，15S-甲基-6-氧代-PGE1及其无毒盐，17S，20-二甲基 -13,14-二氢-6-氧代-GE-PGE1甲酯，17S，20-二甲基-6-氧代-PPE1醇，17S，20-二甲基-6S-PGI1甲酯，17S，20-二甲基 - 反式-TATA 2 -6RS-PGI1甲酯，17S，20-二甲基-6,9α-二硝基-GII1甲酯，2-脱羧-2-乙酰基-17S，20-二甲基-6S-PGI1,2-脱羧-2-乙酰基 - 15-环戊基-16,17,18,19,20-戊酰-6S-PGI1,17S，20-二甲基-6S-PGI1醇，15-环戊基-16,17,18,19,20-戊酰-6S-PGI1 醇和15-（3-丙基环戊基）-16,17,18,19,20-戊醇-6,9α-亚硝基-PGI1醇及其环糊精包合物可用于预防或治疗细胞损伤。

3. 发明授权

US4473587A Prostaglandin E.sub.1 analogues 失效
标题翻译：前列腺素E1类似物
公开(公告)号：US4473587A
公开(公告)日：1984-09-25
申请号：US515909
申请日：1983-07-21
申请人： Takashi Muryobayashi , Katsuhiro Imaki , Yoshiki Sakai
发明人： Takashi Muryobayashi , Katsuhiro Imaki , Yoshiki Sakai
IPC分类号： A61K31/557 , A61K31/5575 , A61P1/16 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/937 , C08B37/00 , C07C177/00 , C07C49/653
CPC分类号： C07D307/937 , C07C405/0025 , C08B37/0015
摘要： Prostaglandin E.sub.1 analogues of the general formula: ##STR1## (wherein R.sup.1 represents a single bond or a straight- or branched-chain alkylene group of from 1 to 5 carbon atom(s), R.sup.2 represents a cycloalkyl group of from 4 to 7 carbon atoms either unsubstituted or substituted by at least one straight- or branched-chain alkyl group of from 1 to 8 carbon(s), and the double bond between C.sub.13 and C.sub.14 is trans) and cyclodextrin clathrate thereof, are useful in the prevention or treatment of cytodamage associated with digestive system disease, especially liver damage.
摘要翻译：前列腺素E1类似物，通式如下：＆lt; IMAGE＆gt;（其中R 1表示单键或1〜5个碳原子的直链或支链亚烷基，R 2表示4〜7个碳原子的环烷基原子是未取代的或被至少一个1至8个碳原子的直链或支链烷基取代，C13和C14之间的双键是反式）和环糊精包合物可用于预防或治疗与消化系统疾病相关的细胞损伤，特别是肝损伤。

4. 发明授权

US4464388A Use of prostaglandin analogues to treat cytodamage 失效
标题翻译：使用前列腺素类似物治疗细胞损伤
公开(公告)号：US4464388A
公开(公告)日：1984-08-07
申请号：US478031
申请日：1983-03-23
申请人： Yoshiki Sakai , Katsuhiro Imaki , Takashi Muryobayashi
发明人： Yoshiki Sakai , Katsuhiro Imaki , Takashi Muryobayashi
IPC分类号： A61K31/34 , A61K31/38 , A61K31/40 , A61K31/557 , A61K31/5575 , A61P1/16 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C08B37/00 , A61K31/215 , A61K31/19
CPC分类号： C08B37/0015 , A61K31/34 , A61K31/38 , A61K31/40 , A61K31/557
摘要： Prostaglandin analogue of the formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atom(s), R.sup.2 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 6 carbon atom(s), the symbols------X--Y--Z-- in formula VB represent one of the groups: ##STR2## wherein in formulae (ii) and (iv), the configuration on C.sub.6 is S- or R-configuration or a mixture thereof and in formulae (iii) and (v) the double bond between C.sub.5 and C.sub.6 is in E- or Z-configuration or a mixture thereof) and n represents an integer of from 3 to 5 non-toxic salts thereof when R.sup.1 represents a hydrogen atom and cyclodextrin clathrates thereof are useful in the prevention or treatment of cytodamage associated with many diseases, especially liver damage.
摘要翻译：具有下式的前列腺素类似物：其中R 1表示氢原子或含有1至12个碳原子的直链或支链烷基，R 2表示氢原子原子或含有1至6个碳原子的直链或支链烷基，式VB中的符号--- XYZ-表示下列组之一：（i）（ii）（iv）其中在式（ii）和（iv）中，C6上的构型是S-或R-构型或其混合物，在式（ⅲ）中，和（v）C 5和C 6之间的双键为E-或Z-构型或其混合物），当R 1表示氢原子时，n表示3至5个无毒盐的整数，并且其环糊精包合物为可用于预防或治疗与许多疾病相关的细胞损伤，特别是肝损伤。

5. 发明授权

US4045468A 16-Cyclobutyl-prostaglandins 失效
标题翻译： 16-环丁基 - 前列腺素
公开(公告)号：US4045468A
公开(公告)日：1977-08-30
申请号：US557437
申请日：1975-03-11
申请人： Masayasu Kurono , Hisao Nakai , Takashi Muryobayashi
发明人： Masayasu Kurono , Hisao Nakai , Takashi Muryobayashi
IPC分类号： A61K31/557 , A61K31/5575 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07D309/12 , C07F9/40 , C07C177/00
CPC分类号： C07D307/935 , C07C405/00 , C07C405/0016 , C07C405/0025 , C07D309/12 , C07F9/4018 , Y10S514/927
摘要： Prostaglandin analogues of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## X represents trans-vinylene or ethylene and Y represents cis-vinylene or ethylene, R represents hydrogen or alkyl of 1 through 12 carbon atoms, R.sup.1, R.sup.2 and R.sup.3 represent hydrogen, or alkyl of 1 through 12 carbon atoms or an aryl group, with the proviso that at least one of the symbols R.sup.1, R.sup.2 and R.sup.3 represents an alkyl or aryl group, are new compounds possessing useful pharmacological properties; they are especially useful for the treatment of gastric ulceration.
摘要翻译：其中A表示下式的组：X表示反式亚乙烯基或亚乙基，Y表示顺式亚乙烯基或亚乙基，R表示氢或1至12个碳原子的烷基，R 1 R 2和R 3表示氢或1〜12个碳原子的烷基或芳基，条件是R1，R2和R3中的至少一个表示烷基或芳基，是具有有用药理特性的新化合物; 它们特别适用于治疗胃溃疡。

6. 发明授权

US4443478A Prostaglandin analogues 失效
标题翻译：前列腺素类似物
公开(公告)号：US4443478A
公开(公告)日：1984-04-17
申请号：US392676
申请日：1982-06-28
申请人： Takashi Muryobayashi , Hajimu Miyake , Takashi Yamato
发明人： Takashi Muryobayashi , Hajimu Miyake , Takashi Yamato
IPC分类号： C07C405/00 , C07C177/00 , A61K31/215
CPC分类号： C07C405/0025 , C07C405/00 , Y10S514/824 , Y10S514/826 , Y10S514/866 , Y10S514/926 , Y10S514/927
摘要： Prostaglandin E.sub.1 analogues of general formula: ##STR1## [wherein R.sup.1 represents a bond or a straight- or branched-chain alkylene group containing from 1 to 5 carbon atom(s), and R.sup.2 represents a hydrogen atom, a straight- or branched-chain alkyl group containing from 1 to 8 carbon atom(s), a cycloalkyl group containing from 4 to 7 carbon atoms in the ring and unsubstituted or substituted by at least one stright- or branched-chain alkyl group containing from 1 to 8 carbon atom(s) or a phenyl or phenoxy group unsubstituted or substituted by at least one halogen atoms, trifluoromethyl group or straight- or branched-chain alkyl group containing from 1 to 4 carbon atom(s), with the proviso that, when R.sup.1 represents a bond, R.sup.2 does not represent a phenoxy group,] possess inhibitory activity or gastric ulceration and cytoprotective activity.
摘要翻译：前列腺素E1类似物，通式为：其中R1表示含有1〜5个碳原子的键或直链或支链亚烷基，R2表示氢原子，直链或支链的亚烷基，含有1至8个碳原子的链烷基，在环中含有4至7个碳原子的环烷基，未被取代或被至少一个含有1至8个碳原子的支链或支链烷基取代或未被取代或被至少一个卤素原子，三氟甲基或含有1至4个碳原子的直链或支链烷基取代的苯基或苯氧基，条件是当R 1表示键，R2不代表苯氧基，]具有抑制活性或胃溃疡和细胞保护活性。

7. 发明授权

US4117119A 15-Cyclobutyl-prostaglandins 失效
标题翻译： 15-CYCLOBUTYL-PROSTAGLANDINS
公开(公告)号：US4117119A
公开(公告)日：1978-09-26
申请号：US794580
申请日：1977-05-06
申请人： Masayasu Kurono , Hisao Nakai , Takashi Muryobayashi
发明人： Masayasu Kurono , Hisao Nakai , Takashi Muryobayashi
IPC分类号： C07C51/353 , C07C51/60 , C07C61/04 , C07C405/00 , C07D307/935 , C07D309/12 , C07F9/40 , C07C177/00 , A61K31/19 , A61K31/215
CPC分类号： C07D307/935 , C07C405/00 , C07C51/353 , C07C51/60 , C07C61/04 , C07D309/12 , C07F9/4018 , Y10S514/899 , Y10S514/925
摘要： Prostaglandin analogues of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## X represents trans-vinylene or ethylene and Y represents cis-vinylene or ethylene, R represents hydrogen or alkyl of 1 through 12 carbon atoms, R.sup.1, R.sup.2 and R.sup.3 represent hydrogen, or alkyl of 1 through 12 carbon atoms or an aryl group, with the proviso that at least one of the symbols R.sup.1, R.sup.2 and R.sup.3 represents an alkyl or aryl group, are new compounds possessing useful pharmacological properties; they are especially useful for the treatment of gastric ulceration.

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