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1. 发明授权

US5780612A Oligonucleotides specific for cytokine signal transducer gp130 mRNA 失效
标题翻译：细胞因子信号转导蛋白gp130 mRNA特异的寡核苷酸
公开(公告)号：US5780612A
公开(公告)日：1998-07-14
申请号：US943834
申请日：1997-10-03
申请人： Kathleen Ann Becherer , Nanibhushan Dattagupta , Yathi M. Naidu
发明人： Kathleen Ann Becherer , Nanibhushan Dattagupta , Yathi M. Naidu
IPC分类号： A61K38/00 , A61K48/00 , C07K14/705 , C12N15/113 , C12N15/00 , C07H21/00 , C12Q1/68
CPC分类号： C12N15/1138 , C07K14/70503 , A61K38/00 , A61K48/00 , C12N2310/315
摘要： The present invention relates to oligonucleotides which are effective inhibitors of disease-associated cellular proliferation. In particular, it relates to the use of oligonulceotides which are substantially complementary to gp130 mRNA sequences. In the form of pharmaceutical compositions, these oligonucleotides are suitable for administration to human subjects for the treatment of abnormal cellular proliferation due to such diseases as cancer, autoimmune disorders and viral infection.
摘要翻译：本发明涉及作为疾病相关细胞增殖的有效抑制剂的寡核苷酸。特别地，它涉及与gp130 mRNA序列基本互补的寡核苷酸的用途。以药物组合物的形式，这些寡核苷酸适合于给予受试者治疗由于诸如癌症，自身免疫病症和病毒感染等疾病引起的异常细胞增殖。

2. 发明授权

US5674995A Oligonucleotides specific for cytokine signal transducer gp130 mRNA 失效
标题翻译：细胞因子信号转导蛋白gp130 mRNA特异的寡核苷酸
公开(公告)号：US5674995A
公开(公告)日：1997-10-07
申请号：US476634
申请日：1995-06-07
申请人： Kathleen Ann Becherer , Nanibhushan Dattagupta , Yathi M. Naidu
发明人： Kathleen Ann Becherer , Nanibhushan Dattagupta , Yathi M. Naidu
IPC分类号： A61K38/00 , A61K48/00 , C07K14/705 , C12N15/113 , C12N15/00 , C07H21/00 , C12Q1/68
CPC分类号： C12N15/1138 , C07K14/70503 , A61K38/00 , A61K48/00 , C12N2310/315
摘要： The present invention relates to oligonucleotides which are effective inhibitors of disease-associated cellular proliferation. In particular, it relates to the use of oligonulceotides which are substantially complementary to gp130 mRNA sequences. In the form of pharmaceutical compositions, these oligonucleotides are suitable for administration to human subjects for the treatment of abnormal cellular proliferation due to such diseases as cancer, autoimmune disorders and viral infection.
摘要翻译：本发明涉及作为疾病相关细胞增殖的有效抑制剂的寡核苷酸。特别地，它涉及与gp130 mRNA序列基本互补的寡核苷酸的用途。以药物组合物的形式，这些寡核苷酸适合于给予受试者治疗由于诸如癌症，自身免疫病症和病毒感染等疾病引起的异常细胞增殖。

3. 发明授权

US5747470A Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA 失效
标题翻译：使用gp130 mRNA的反义寡核苷酸抑制细胞增殖的方法
公开(公告)号：US5747470A
公开(公告)日：1998-05-05
申请号：US484518
申请日：1995-06-07
申请人： Kathleen Becherer , Nanibhushan Dattagupta , Yathi M. Naidu
发明人： Kathleen Becherer , Nanibhushan Dattagupta , Yathi M. Naidu
IPC分类号： A61K38/00 , A61K48/00 , C12N15/113 , A01N43/04
CPC分类号： C12N15/1138 , A61K38/00 , A61K48/00 , C12N2310/315
摘要： The present invention relates to methods of treating disease-associated cellular proliferation using oligonucleotides. In particular, it relates to the use of oligonulceotides which are substantially complementary to gp13O mRNA sequences. In the form of pharmaceutical compositions, these oligonucleotides are suitable for administration to human subjects for the treatment of abnormal cellular proliferation due to such diseases as cancer, autoimmune disorders and viral infection.
摘要翻译：本发明涉及使用寡核苷酸治疗与疾病相关的细胞增殖的方法。特别地，其涉及与gp13O mRNA序列基本互补的寡核苷酸的用途。以药物组合物的形式，这些寡核苷酸适合于给予受试者治疗由于诸如癌症，自身免疫病症和病毒感染等疾病引起的异常细胞增殖。

4. 发明授权

US5945336A Oligonucleotides and methods for inhibiting cellular proliferation 失效
标题翻译：寡核苷酸和抑制细胞增殖的方法
公开(公告)号：US5945336A
公开(公告)日：1999-08-31
申请号：US975570
申请日：1997-11-21
申请人： Steven Joel Brown , Nanibhushan Dattagupta , Yathi M. Naidu
发明人： Steven Joel Brown , Nanibhushan Dattagupta , Yathi M. Naidu
IPC分类号： A61K38/00 , C12N15/113 , C07H21/00 , C12N5/06
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315
摘要： The present invention relates to methods of treating disease-associated cellular proliferation using oligonucleotides. In particular, it relates to the use of oligonulceotides which are substantially complementary to interleukin-6 receptor mRNA sequences. In the form of pharmaceutical compositions, these oligonucleotides are suitable for administration to human subjects for the treatment of abnormal cellular proliferation due to such diseases as cancer, autoimmune disorders and viral infection.
摘要翻译：本发明涉及使用寡核苷酸治疗疾病相关细胞增殖的方法。特别地，它涉及与白细胞介素-6受体mRNA序列基本上互补的寡核苷酸的用途。以药物组合物的形式，这些寡核苷酸适合于给予受试者治疗由于诸如癌症，自身免疫病症和病毒感染等疾病引起的异常细胞增殖。

5. 发明授权

US5716846A Method for inhibiting cellular proliferation using antisense oligonucleotides to interleukin-6 receptor mRNA 失效
标题翻译：使用反义寡核苷酸抑制白细胞介素-6受体mRNA的细胞增殖的方法
公开(公告)号：US5716846A
公开(公告)日：1998-02-10
申请号：US486408
申请日：1995-06-07
申请人： Steven Joel Brown , Nanibhushan Dattagupta , Yathi M. Naidu
发明人： Steven Joel Brown , Nanibhushan Dattagupta , Yathi M. Naidu
IPC分类号： A61K38/00 , C12N15/113 , C12N5/06 , C07H21/00
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315
摘要： The present invention relates to methods of treating disease-associated cellular proliferation using oligonucleotides. In particular, it relates to the use of oligonulceotides which are substantially complementary to interleukin-6 receptor mRNA sequences. In the form of pharmaceutical compositions, these oligonucleotides are suitable for administration to human subjects for the treatment of abnormal cellular proliferation due to such diseases as cancer, autoimmune disorders and viral infection.
摘要翻译：本发明涉及使用寡核苷酸治疗疾病相关细胞增殖的方法。特别地，它涉及与白细胞介素-6受体mRNA序列基本上互补的寡核苷酸的用途。以药物组合物的形式，这些寡核苷酸适合于给予受试者治疗由于诸如癌症，自身免疫病症和病毒感染等疾病引起的异常细胞增殖。

6. 发明申请

US20060073475A1 Compositions and methods for detecting pathogenic bacteria expressing chaperonin proteins 审中-公开
标题翻译：用于检测表达伴侣蛋白的致病菌的组合物和方法
公开(公告)号：US20060073475A1
公开(公告)日：2006-04-06
申请号：US10216488
申请日：2002-08-09
申请人： Nanibhushan Dattagupta , Ketan Shah
发明人： Nanibhushan Dattagupta , Ketan Shah
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689 , C12Q1/6837
摘要： This invention relates generally to compositions and methods for detection of pathogenic bacteria that express extracellular chaperonin proteins. In one embodiment, it relates to Mycobacterium tuberculosis (Mtb) detection and provides for novel probes for a specific and sensitive diagnostic test for Mycobacterium tuberculosis complex (TBC) that hybridize with the groEL-1 gene. Arrays comprising the novel probes immobilized on a support for hybridization analysis and methods for TBC detection using the probes are also provided.
摘要翻译：本发明一般涉及用于检测表达细胞外伴侣蛋白的致病菌的组合物和方法。在一个实施方案中，其涉及结核分枝杆菌（Mtb）检测，并提供用于与groEL-1基因杂交的结核分枝杆菌复合物（TBC）的特异性和灵敏的诊断测试的新型探针。还提供了包含固定在用于杂交分析的载体上的新型探针的阵列和使用探针进行TBC检测的方法。

7. 发明授权

US07009041B1 Oligonucleotides for nucleic acid amplification and for the detection of Mycobacterium tuberculosis 失效
标题翻译：用于核酸扩增和检测结核分枝杆菌的寡核苷酸
公开(公告)号：US07009041B1
公开(公告)日：2006-03-07
申请号：US08480472
申请日：1995-06-06
申请人： Sherrol H. McDonough , Daniel L. Kacian , Nanibhushan Dattagupta , Diane L. McAllister , Philip W. Hammond , Thomas B. Ryder
发明人： Sherrol H. McDonough , Daniel L. Kacian , Nanibhushan Dattagupta , Diane L. McAllister , Philip W. Hammond , Thomas B. Ryder
IPC分类号： C07H21/00 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/689 , C07K14/35
摘要： A method, composition and kit for synthesizing multiple copies of a target nucleic acid sequence autocatalytically under conditions of substantially constant temperature, ionic strength, and pH are provided in which multiple RNA copies of the target sequence autocatalytically generate additional copies using a mixture of blocked and unblocked primers and/or promoter-primers to initiate DNA and RNA synthesis, preferably with reduced non-specific product formation. The invention is useful for generating copies of a nucleic acid target sequence for purposes that include assays to quantitate specific nucleic acid sequences in clinical, environmental, forensic and similar samples, cloning and generating probes.
摘要翻译：提供了一种用于在基本上恒定温度，离子强度和pH条件下自动催化靶核酸序列的多个拷贝的方法，组合物和试剂盒，其中靶序列的多个RNA拷贝自动催化产生另外的拷贝，使用封闭和未封闭的引物和/或启动子 - 引物以引发DNA和RNA合成，优选地减少非特异性产物形成。本发明可用于产生核酸靶序列的拷贝，目的包括在临床，环境，法医学和相似样品中定量特异性核酸序列的测定，克隆和产生探针。

8. 发明授权

US6087133A Isothermal strand displacement nucleic acid amplification 失效
标题翻译：等温链置换核酸扩增
公开(公告)号：US6087133A
公开(公告)日：2000-07-11
申请号：US972799
申请日：1997-11-18
申请人： Nanibhushan Dattagupta , Paul Douglas Stull , Marc Spingola , Daniel Louis Kacian
发明人： Nanibhushan Dattagupta , Paul Douglas Stull , Marc Spingola , Daniel Louis Kacian
IPC分类号： C12N15/09 , C12P19/34 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6844
摘要： Methods for amplifying target nucleic acid sequences using a nucleic acid polymerase lacking 5' exonuclease activity and a set of oligonucleotide primers. Preferably, a primer array is used. The primer array contains two sets of primers. One set contains at least two complementary primers. The other set contains at least two sense primers. Using the described methods amplification can be carried out under essentially constant environmental conditions without the requirement for exonuclease activity or restriction endonuclease activity.
摘要翻译：使用缺少5'核酸外切酶活性的核酸聚合酶和一组寡核苷酸引物扩增靶核酸序列的方法。优选使用引物数组。引物数组包含两组引物。一组含有至少两个互补引物。另一组包含至少两个有义引物。使用所述方法可以在基本恒定的环境条件下进行扩增，而不需要外切核酸酶活性或限制性内切核酸酶活性。

9. 发明授权

US5759519A Method for the intracellular delivery of biomolecules using thiocationic lipids 失效
标题翻译：使用硫代阳离子脂质细胞内转运生物分子的方法
公开(公告)号：US5759519A
公开(公告)日：1998-06-02
申请号：US482430
申请日：1995-06-07
申请人： C. Nagaraja Sridhar , Jasmin R. Patel , Nanibhushan Dattagupta , Aditya Ranjan Das
发明人： C. Nagaraja Sridhar , Jasmin R. Patel , Nanibhushan Dattagupta , Aditya Ranjan Das
IPC分类号： A61K9/127 , A61K47/48 , C07C381/12 , C12N15/88 , A61K49/00 , G01N31/00 , G01N33/48
CPC分类号： C12N15/88 , A61K47/48023 , A61K47/48046 , A61K9/1272 , C07C381/12
摘要： Lipid molecules bearing a cationic charge are described. These cationic lipids are useful in the delivery of biomolecules, such as oligonucleotides, nucleic acids, peptides, diagnostic imaging agents, proteins and drug molecules. In the form of liposomes, they can effectively be used for the intracellular delivery of biomolecules for therapeutic or diagnostic purposes.
摘要翻译：描述了带有阳离子电荷的脂质分子。这些阳离子脂质可用于递送生物分子，如寡核苷酸，核酸，肽，诊断成像剂，蛋白质和药物分子。以脂质体的形式，它们可以有效地用于生物分子的细胞内递送用于治疗或诊断目的。

10. 发明授权

US5587472A Coumarin-labeled nucleoside 5'-triphosphates 失效
标题翻译：香豆素标记核苷5'-三磷酸
公开(公告)号：US5587472A
公开(公告)日：1996-12-24
申请号：US460027
申请日：1995-06-02
申请人： Nanibhushan Dattagupta , Jurgen Kocher
发明人： Nanibhushan Dattagupta , Jurgen Kocher
IPC分类号： C07H21/00 , C07H19/10 , C07H19/20 , C07H21/04
CPC分类号： C07H21/00
摘要： A fluorescent label compound having the formulaA--B.sup.1 --B.sup.2 --B.sup.3 --CwhereinA represents the residue of a natural or synthetic nucleotide or nucleoside or a derivative thereof;B.sup.1 represents a divalent spacer radical or a single bond;B.sup.2 represents a divalent spacer radical;B.sup.3 represents a divalent spacer radical or a single bond; andC represents a coumarin radical having the formula ##STR1## in which R.sup.1 represents hydrogen or cyano;R.sup.2 represents phenyl or thiazolyl bonded in the 2-, 4- or 5-position, wherein the phenyl is unsubstituted or substituted by nitro, cyano, amino, --NH--C.sub.1-4 -alkyl, --(CH.sub.2).sub.1-4 --NH.sub.2, --(CH.sub.2).sub.1-4 --NH--(CH.sub.2).sub.1-3 --CH.sub.3, carboxy, C.sub.1-4 -alkoxycarbonyl, C.sub.1-4 -alkoxycarbonyloxy, hydroxy, C.sub.1-4 -alkylaminocarbonyl, or C.sub.1-4 -alkylcarbonylamino and either further unsubstituted or substituted by C.sub.1-4 -alkyl, fluorine, chlorine or bromine, and where the thiazolyl is unsubstituted or monosubstituted or disubstituted by chlorine, cyano, carboxyl, or C.sub.1-4 -alkoxycarbonyl, or the thiazolyl is fused in the 4- and 5-position with a benzene ring which is either unsubstituted or substituted by carboxyl, amino, or hydroxyl;R.sup.3 represents hydrogen, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxycarbonyl-C.sub.1-4 -alkyl, or phenylsulphonyl, where the C.sub.1-4 -alkyl is unsubstituted or substituted by hydroxyl, amino, carboxyl, or C.sub.1-4 -alkoxycarbonyl, and where the phenylsulphonyl is unsubstituted or monosubstituted or disubstituted by chlorine, bromine, or C.sub.1-4 -alkyl;or where one of the radicals R.sup.2 or R.sup.3 denotes or is substituted by a primary or secondary amino group, hydroxyl, carboxyl, or C.sub.1-4 -alkoxycarbonyl, or can be converted into such a group by hydrolysis or hydrogenation.
摘要翻译：具有式A-B1-B2-B3-C的荧光标记化合物，其中A表示天然或合成的核苷酸或核苷或其衍生物的残基; B1代表二价间隔基团或单键; B2表示二价间隔基; B3表示二价间隔基或单键; 并且C表示具有式“IMAGE”的香豆素基团，其中R 1表示氢或氰基; 氰基，氨基，-NH-C 1-4 - 烷基， - （CH 2）1-4-NH 2，其中苯基未被取代或被硝基，氰基，氨基，， - （CH 2）1-4-NH-（CH 2）1-3 -CH 3，羧基，C 1-4 - 烷氧基羰基，C 1-4 - 烷氧基羰基氧基，羟基，C 1-4 - 烷基氨基羰基或C 1-4 - 烷基羰基氨基进一步未取代或被C 1-4 - 烷基，氟，氯或溴取代，并且其中噻唑基未被取代或被氯，氰基，羧基或C 1-4 - 烷氧基羰基单取代或二取代，或噻唑基稠合在4- 和5-位，其中苯环是未取代的或被羧基，氨基或羟基取代; R 3表示氢，C 1-4 - 烷基，C 1-4 - 烷氧基羰基-C 1-4 - 烷基或苯基磺酰基，其中C 1-4 - 烷基未被取代或被羟基，氨基，羧基或C 1-4 - 烷氧基羰基取代，并且其中苯基磺酰基未被取代或被氯，溴或C 1-4 - 烷基单取代或二取代; 或其中一个基团R 2或R 3表示或被伯或仲氨基，羟基，羧基或C 1-4 - 烷氧基羰基取代，或者可以通过水解或氢化转化为该基团。

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