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1. 发明授权

US07745121B2 Polymorphism in the macrophage migration inhibitory factor (MIF) gene as marker for prostate cancer 失效
标题翻译：巨噬细胞迁移抑制因子（MIF）基因多态性作为前列腺癌的标志物
公开(公告)号：US07745121B2
公开(公告)日：2010-06-29
申请号：US11438370
申请日：2006-05-23
申请人： Katherine Siegler , Kenneth Iczkowski , Richard Bucala , Pedro L. Vera
发明人： Katherine Siegler , Kenneth Iczkowski , Richard Bucala , Pedro L. Vera
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The present invention relates to the risk assessment, detection, diagnosis, or prognosis of prostate cancer. More specifically, this invention relates to the detection of certain polymorphism in the promoter region of the MIF gene to determine the risk, detect, diagnose, or prognosticate prostate cancer. Applicants have discovered that the presence of a −173C and/or −749 (CATT)7 or more repeat predispose an individual to prostate cancer.
摘要翻译：本发明涉及前列腺癌的风险评估，检测，诊断或预后。更具体地，本发明涉及检测MIF基因启动子区域中某些多态性以确定前列腺癌的风险，检测，诊断或预后。申请人已经发现，-173C和/或-749（CATT）7或更多重复的存在使个体前列腺癌易患。

2. 发明申请

US20090035301A1 METHODS FOR DIAGNOSING AND TREATING BLADDER CANCER 审中-公开
标题翻译：用于诊断和治疗乳腺癌的方法
公开(公告)号：US20090035301A1
公开(公告)日：2009-02-05
申请号：US12183687
申请日：2008-07-31
申请人： Katherine Meyer Siegler , Pedro L. Vera
发明人： Katherine Meyer Siegler , Pedro L. Vera
IPC分类号： A61K39/395 , A61P35/00 , A61K31/715 , A61K31/7088
CPC分类号： G01N33/57407 , C07K14/52 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2333/52
摘要： The present invention relates to the diagnosis and treatment of bladder cancer. More specifically, this invention uses the levels of macrophage migration inhibitory factor (MIF) produced by the bladder epithelia (urothelia) as a marker for bladder cancer. Moreover, the present invention also provides a method for attenuating bladder carcinoma by inhibiting of macrophage MIF.
摘要翻译：本发明涉及膀胱癌的诊断和治疗。更具体地说，本发明使用由膀胱上皮细胞（urothelia）产生的巨噬细胞迁移抑制因子（MIF）作为膀胱癌的标志物。此外，本发明还提供了通过抑制巨噬细胞MIF来减轻膀胱癌的方法。

3. 发明授权

US07897349B2 Macrophage migration inhibitory factor (MIF) as marker for urological inflammatory disease 有权
标题翻译：巨噬细胞迁移抑制因子（MIF）作为泌尿系炎症性疾病的标志物
公开(公告)号：US07897349B2
公开(公告)日：2011-03-01
申请号：US11024405
申请日：2004-12-30
申请人： Katherine Meyer Siegler , Pedro L. Vera
发明人： Katherine Meyer Siegler , Pedro L. Vera
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2800/348
摘要： The present invention relates to the association between detecting and quantifying the presence of macrophage migration inhibitory factor (MIF) in urine, bladder and prostate tissues for the purpose of diagnosis and prognosis of urological inflammatory. In addition, methods to inactivate MIF activity by use of antibodies or specific MIF inhibitors can be used to treat these diseases. For instance, such diseases as chronic pelvic pain syndrome, non-bacterial prostatitis, and interstitial cystitis may be mediated by MIF release. Periodic assays for MIF could be conducted for a patient to determine if the patient's MIF urine levels are high or increasing. In addition, intravesical MIF antibodies or other MIF-specific inhibitors would reduce or ameliorate these pelvic diseases.
摘要翻译：本发明涉及检测和量化尿液，膀胱和前列腺组织中巨噬细胞迁移抑制因子（MIF）的存在与泌尿系炎症诊断和预后的关系。此外，可以使用通过使用抗体或特异性MIF抑制剂来灭活MIF活性的方法来治疗这些疾病。例如，诸如慢性盆腔疼痛综合征，非细菌性前列腺炎和间质性膀胱炎等疾病可能由MIF释放介导。可以为患者进行MIF的定期测定以确定患者的MIF尿液水平是高还是增加。此外，膀胱内MIF抗体或其他MIF特异性抑制剂可降低或改善这些盆腔疾病。

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