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1. 发明申请

US20140155451A1 Aniline Type Compounds 有权
标题翻译：苯胺类化合物
公开(公告)号：US20140155451A1
公开(公告)日：2014-06-05
申请号：US14236362
申请日：2012-08-10
申请人： Karsten Koerber , Prashant Deshmukh , Florian Kaiser , Michael Rack , Timo Frasetto , Gemma Veitch , Markus Kordes , Marco Naujok
发明人： Karsten Koerber , Prashant Deshmukh , Florian Kaiser , Michael Rack , Timo Frasetto , Gemma Veitch , Markus Kordes , Marco Naujok
IPC分类号： A01N43/50 , A01N41/12
CPC分类号： A01N43/56 , A01N37/28 , A01N41/12 , A01N43/50 , A01N43/80 , C07B2200/13 , C07C381/10 , C07D401/04 , C07D401/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to compounds of the formula (I) wherein R1 and R2 independently of one another are hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C10-cycloalkyl, C3-C10-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl or together represent an aliphatic chain, or the like; R3 is halogen, cyano, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C2-C8-alkenyl, C2-C8-haloalkenyl, C1-C8-alkoxy, phenyl, or the like; R4 is hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl, phenyl, or the like; t is 0 or 1; p is 0, 1, 2, 3 or 4. The present invention also relates to a process for preparing a compound of the formula (I) which comprises reacting a compound of the formula II with a compound of the formulae III or IV: where t, p, R1 R3, R3 and R4 are as defined in any of claims 1 to 6 and where A− is an equivalent of an anion having a pKB of at least 10 (determined under standard conditions in water).
摘要翻译：本发明涉及式（I）化合物，其中R 1和R 2彼此独立地是氢，C 1 -C 10 - 烷基，C 1 -C 10 - 卤代烷基，C 3 -C 10 - 环烷基，C 3 -C 10 - 卤代环烷基，C 2 -C 10 烯基，C 2 -C 10 - 卤代链烯基或一起代表脂族链等; R3是卤素，氰基，C1-C8-烷基，C1-C8-卤代烷基，C3-C8-环烷基，C3-C8-卤代环烷基，C2-C8-烯基，C2-C8-卤代烯基，C1-C8-烷氧基，苯基，或类似物; R4是氢，C1-C10-烷基，C1-C10-卤代烷基，C3-C8-环烷基，C3-C8-卤代环烷基，C2-C10-烯基，C2-C10-卤代烯基，苯基等; t为0或1; 本发明还涉及制备式（I）化合物的方法，其包括使式II化合物与式III或IV化合物反应：其中 t，p，R 1，R 3，R 3和R 4如权利要求1至6中任一项所定义，其中A-是pKB为至少10（在水中标准条件下测定）的阴离子的当量。

2. 发明授权

US09006485B2 Aniline type compounds 有权
标题翻译：苯胺型化合物
公开(公告)号：US09006485B2
公开(公告)日：2015-04-14
申请号：US14236362
申请日：2012-08-10
申请人： Karsten Koerber , Prashant Deshmukh , Florian Kaiser , Michael Rack , Timo Frasetto , Gemma Veitch , Markus Kordes , Marco Naujok
发明人： Karsten Koerber , Prashant Deshmukh , Florian Kaiser , Michael Rack , Timo Frasetto , Gemma Veitch , Markus Kordes , Marco Naujok
IPC分类号： C07C313/00 , A01N41/12 , A01N43/50 , A01N43/56 , A01N43/80 , C07D401/04 , C07C381/10 , C07D401/14 , C07D413/14 , C07D409/14 , A01N37/28
CPC分类号： A01N43/56 , A01N37/28 , A01N41/12 , A01N43/50 , A01N43/80 , C07B2200/13 , C07C381/10 , C07D401/04 , C07D401/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to compounds of the formula (I) wherein R1 and R2 independently of one another are hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C10-cycloalkyl, C3-C10-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl or together represent an aliphatic chain, or the like; R3 is halogen, cyano, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C2-C8-alkenyl, C2-C8-haloalkenyl, C1-C8-alkoxy, phenyl, or the like; R4 is hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl, phenyl, or the like; t is 0 or 1; p is 0, 1, 2, 3 or 4. The present invention also relates to a process for preparing a compound of the formula (I) which comprises reacting a compound of the formula II with a compound of the formulae III or IV: where t, p, R1 R3, R3 and R4 are as defined in any of claims 1 to 6 and where A− is an equivalent of an anion having a pKB of at least 10 (determined under standard conditions in water).
摘要翻译：本发明涉及式（I）化合物，其中R 1和R 2彼此独立地是氢，C 1 -C 10 - 烷基，C 1 -C 10 - 卤代烷基，C 3 -C 10 - 环烷基，C 3 -C 10 - 卤代环烷基，C 2 -C 10 烯基，C 2 -C 10 - 卤代链烯基或一起代表脂族链等; R3是卤素，氰基，C1-C8-烷基，C1-C8-卤代烷基，C3-C8-环烷基，C3-C8-卤代环烷基，C2-C8-烯基，C2-C8-卤代烯基，C1-C8-烷氧基，苯基，或类似物; R4是氢，C1-C10-烷基，C1-C10-卤代烷基，C3-C8-环烷基，C3-C8-卤代环烷基，C2-C10-烯基，C2-C10-卤代烯基，苯基等; t为0或1; 本发明还涉及制备式（I）化合物的方法，其包括使式II化合物与式III或IV化合物反应：其中 t，p，R 1，R 3，R 3和R 4如权利要求1至6中任一项所定义，其中A-是pKB为至少10（在水中标准条件下测定）的阴离子的当量。

3. 发明授权

US08921567B2 Process for preparing N-substituted 1H-pyrazole-5-carbonylchloride compounds 有权
标题翻译：制备N-取代的1H-吡唑-5-碳酰氯化合物的方法
公开(公告)号：US08921567B2
公开(公告)日：2014-12-30
申请号：US14235556
申请日：2012-08-10
申请人： Karsten Körber , Prashant Deshmukh , Florian Kaiser , Michael Rack , Timo Frassetto , Gemma Veitch , Markus Kordes
发明人： Karsten Körber , Prashant Deshmukh , Florian Kaiser , Michael Rack , Timo Frassetto , Gemma Veitch , Markus Kordes
IPC分类号： C07D401/04
CPC分类号： C07D401/04
摘要： The present invention relates to a process for preparing an N-substituted 1H-pyrazole-5-carbonylchloride compound of the formula (I) in which R1 is hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-fluoroalkyl, C3-C8-cycloalkyl, C3-C8-fluorocycloalkyl, C2-C6-alkenyl, C2-C6-fluoroalkenyl, C1-C6-alkoxy, C1-C6-fluoroalkoxy, C1-C4-fluoroalkoxy-C1-C4-alkyl, phenyl and the like; each R2 is independently selected from halogen, C1-C6-alkyl, C1-C6-fluoroalkyl, C3-C8-cycloalkyl, C3-C8-fluorocycloalkyl, C2-C6-alkenyl, C2-C6-fluoroalkenyl, C1-C6-alkoxy, phenyl and the like; r is 0, 1, 2, 3 or 4; comprising the steps of i) deprotonating a compound of the formula (II) in which the variables R1, R2 and r are each as defined above, with a base selected from lithium-organic base having a carbon or nitrogen bound lithium or with a magnesium-organic base having a carbon bound magnesium; and ii) subjecting the product obtained in step (i) to a chlorocarbonylation by reacting it with a reagent selected from the group consisting of phosgene or a phosgene equivalent, to obtain a compound of formula (I).
摘要翻译：本发明涉及制备式（I）的N-取代的1H-吡唑-5-碳酰氯化合物的方法，其中R1是氢，卤素，氰基，C1-C6-烷基，C1-C6-氟烷基，C3 C 1-8 - 环烷基，C 3 -C 8 - 氟代环烷基，C 2 -C 6 - 烯基，C 2 -C 6 - 氟烯基，C 1 -C 6 - 烷氧基，C 1 -C 6 - 氟烷氧基，C 1 -C 4 - 氟烷氧基-C 1 -C 4烷基，苯基和喜欢; 每个R 2独立地选自卤素，C 1 -C 6 - 烷基，C 1 -C 6 - 氟代烷基，C 3 -C 8 - 环烷基，C 3 -C 8 - 氟代环烷基，C 2 -C 6 - 烯基，C 2 -C 6 - 氟烯基，C 1 -C 6烷氧基，苯基等; r为0,1,2,3或4; 包括以下步骤：i）将其中变量R1，R2和r各自如上定义的式（II）化合物与选自具有碳或氮键合的锂的锂基或与镁结合的碱的碱具有碳结合镁的无机碱; 和ii）通过使步骤（i）中获得的产物与选自光气或光气当量的试剂反应来进行氯羰化反应，得到式（I）化合物。

4. 发明申请

US20140163234A1 Process for preparing N-substituted 1H-pyrazole-5-carbonylchloride compounds 有权
公开(公告)号：US20140163234A1
公开(公告)日：2014-06-12
申请号：US14235556
申请日：2012-08-10
申请人： Karsten Körber , Prashant Deshmukh , Florian Kaiser , Michael Rack , Timo Frassetto , Gemma Veitch , Markus Kordes
发明人： Karsten Körber , Prashant Deshmukh , Florian Kaiser , Michael Rack , Timo Frassetto , Gemma Veitch , Markus Kordes
IPC分类号： C07D401/04
CPC分类号： C07D401/04
摘要： The present invention relates to a process for preparing an N-substituted 1H-pyrazole-5-carbonylchloride compound of the formula (I) in which R1 is hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-fluoroalkyl, C3-C8-cycloalkyl, C3-C8-fluorocycloalkyl, C2-C6-alkenyl, C2-C6-fluoroalkenyl, C1-C6-alkoxy, C1-C6-fluoroalkoxy, C1-C4-fluoroalkoxy-C1-C4-alkyl, phenyl and the like; each R2 is independently selected from halogen, C1-C6-alkyl, C1-C6-fluoroalkyl, C3-C8-cycloalkyl, C3-C8-fluorocycloalkyl, C2-C6-alkenyl, C2-C6-fluoroalkenyl, C1-C6-alkoxy, phenyl and the like; r is 0, 1, 2, 3 or 4; comprising the steps of i) deprotonating a compound of the formula (II) in which the variables R1, R2 and r are each as defined above, with a base selected from lithium-organic base having a carbon or nitrogen bound lithium or with a magnesium-organic base having a carbon bound magnesium; and ii) subjecting the product obtained in step (i) to a chlorocarbonylation by reacting it with a reagent selected from the group consisting of phosgene or a phosgene equivalent, to obtain a compound of formula (I).

5. 发明授权

US09006447B2 Method for preparing substituted isoxazoline compounds and their precursors 4-chloro, 4-bromo- or 4-iodobenzaldehyde oximes 有权
标题翻译：取代异恶唑啉化合物及其前体4-氯，4-溴 - 或4-碘苯甲醛肟的制备方法
公开(公告)号：US09006447B2
公开(公告)日：2015-04-14
申请号：US13883149
申请日：2011-10-31
申请人： Karsten Koerber , Markus Kordes , Michael Rack , Wolfgang Von Deyn , Florian Kaiser
发明人： Karsten Koerber , Markus Kordes , Michael Rack , Wolfgang Von Deyn , Florian Kaiser
IPC分类号： C07D261/04 , C07D413/12 , C07C249/12 , C07C251/48
CPC分类号： C07D261/04 , C07C249/12 , C07D413/12 , C07C251/48
摘要： The present invention relates to a method for preparing 4-chloro-, 4-bromo- or 4-iodobenzaldehyde oximes and phenyl-substituted isoxazoline compounds prepared from these oximes.
摘要翻译：本发明涉及由这些肟制备的4-氯代，4-溴代或4-碘苯甲醛肟和苯基取代的异恶唑啉化合物的方法。

6. 发明申请

US20130225826A1 Method for preparing substituted isoxazoline compounds and their precursors 4-chloro, 4-bromo- or 4-iodobenzaldehyde oximes 有权
公开(公告)号：US20130225826A1
公开(公告)日：2013-08-29
申请号：US13883149
申请日：2011-10-31
申请人： Karsten Koerber , Markus Kordes , Michael Rack , Wolfgang Von Deyn , Florian Kaiser
发明人： Karsten Koerber , Markus Kordes , Michael Rack , Wolfgang Von Deyn , Florian Kaiser
IPC分类号： C07D261/04 , C07D413/12
CPC分类号： C07D261/04 , C07C249/12 , C07D413/12 , C07C251/48
摘要： The present invention relates to a method for preparing 4-chloro-, 4-bromo- or 4-iodobenzaldehyde oximes and phenyl-substituted isoxazoline compounds prepared from these oximes.

7. 发明授权

US09732051B2 Isothiazoline compounds for combating invertebrate pests 有权
公开(公告)号：US09732051B2
公开(公告)日：2017-08-15
申请号：US14366161
申请日：2012-12-21
申请人： Pascal Bindschaedler , Wolfgang Von Deyn , Karsten Koerber , Florian Kaiser , Michael Rack , Deborah L. Culbertson , Paul Neese , Franz Josef Braun
发明人： Pascal Bindschaedler , Wolfgang Von Deyn , Karsten Koerber , Florian Kaiser , Michael Rack , Deborah L. Culbertson , Paul Neese , Franz Josef Braun
IPC分类号： C07D275/02 , C07D417/04 , C07D275/03 , A01N43/80
CPC分类号： C07D275/02 , A01N43/80 , C07D275/03 , C07D417/04
摘要： The present invention relates to isothiazoline compounds of formula I wherein the variables are as defined in the claims or the description, which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes, and to a method for producing them. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

8. 发明授权

US08853410B2 Process for preparing substituted isoxazoline compounds and their precursors 有权
标题翻译：取代异恶唑啉化合物及其前体的制备方法
公开(公告)号：US08853410B2
公开(公告)日：2014-10-07
申请号：US13266265
申请日：2010-04-29
申请人： Michael Rack , Karsten Koerber , Florian Kaiser
发明人： Michael Rack , Karsten Koerber , Florian Kaiser
IPC分类号： C07D413/12 , C07D413/04
CPC分类号： C07D413/04
摘要： The present invention relates to a new method of preparing halogenated styrene compounds of formula (VIII) which are precursors in the process of synthesis of substituted isoxazoline compounds of formula (I) wherein R1 to R5, R8 and R9 are described as in the description. The present invention relates further to the synthesis of compounds of formula (I) starting from acetophenones. The desired styrenes of formula are prepared from the appropriate substituted acetophenone. Asides bromo anilines react with formoxime. Obtained oximes undergo a cycloaddition with the styrenes and give isoxazolines. Compounds of formula (I) can then be prepared in a palladium catalyzed carbonylative amination reaction of the isoxazolines.
摘要翻译：本发明涉及一种制备式（Ⅷ）卤代苯乙烯化合物的新方法，它是在合成式（I）的取代的异恶唑啉化合物的方法中的前体，其中R1至R5，R8和R9如说明书所述。本发明还涉及从苯乙酮开始合成式（I）化合物。所需的配方苯乙烯由合适的取代苯乙酮制备。溴代苯胺与甲肟反应。获得的肟与苯乙烯进行环加成并得到异恶唑啉。然后可以在异恶唑啉的钯催化的羰基化胺化反应中制备式（I）化合物。

9. 发明申请

US20120059171A1 Process for Preparing Substituted Isoxazoline Compounds and Their Precursors 有权
标题翻译：制备取代的异恶唑啉化合物及其前体的方法
公开(公告)号：US20120059171A1
公开(公告)日：2012-03-08
申请号：US13266265
申请日：2010-04-29
申请人： Michael Rack , Karsten Koerber , Florian Kaiser
发明人： Michael Rack , Karsten Koerber , Florian Kaiser
IPC分类号： C07D413/12
CPC分类号： C07D413/04
摘要： The present invention relates to a new method of preparing halogenated styrene compounds of formula (VIII) which are precursors in the process of synthesis of substituted isoxazoline compounds of formula (I) wherein R1 to R5, R8 and R9 are described as in the description.The present invention relates further to the synthesis of compounds of formula (I) starting from acetophenones. The desired styrenes of formula are prepared from the appropriate substituted acetophenone. Asides bromo anilines react with formoxime. Obtained oximes undergo a cycloaddition with the styrenes and give isoxazolines. Compounds of formula (I) can then be prepared in a palladium catalyzed carbonylative amination reaction of the isoxazolines.
摘要翻译：本发明涉及一种制备式（Ⅷ）卤代苯乙烯化合物的新方法，它是在合成式（I）的取代的异恶唑啉化合物的方法中的前体，其中R1至R5，R8和R9如说明书所述。本发明还涉及从苯乙酮开始合成式（I）化合物。所需的配方苯乙烯由合适的取代苯乙酮制备。溴代苯胺与甲肟反应。获得的肟与苯乙烯进行环加成并得到异恶唑啉。然后可以在异恶唑啉的钯催化的羰基化胺化反应中制备式（I）化合物。

10. 发明申请

US20140364466A1 Isothiazoline compounds for combating invertebrate pests 有权
标题翻译：用于防治无脊椎动物害虫的异噻唑啉化合物
公开(公告)号：US20140364466A1
公开(公告)日：2014-12-11
申请号：US14366161
申请日：2012-12-21
申请人： Pascal Bindschaedler , Wolfgang Von Deyn , Karsten Koerber , Florian Kaiser , Michael Rack , Deborah L. Culbertson , Paul Neese , Franz Josef Braun
发明人： Pascal Bindschaedler , Wolfgang Von Deyn , Karsten Koerber , Florian Kaiser , Michael Rack , Deborah L. Culbertson , Paul Neese , Franz Josef Braun
IPC分类号： C07D275/02 , A01N43/80
CPC分类号： C07D275/02 , A01N43/80 , C07D275/03 , C07D417/04
摘要： The present invention relates to isothiazoline compounds of formula I wherein the variables are as defined in the claims or the description, which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes, and to a method for producing them. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.
摘要翻译：本发明涉及式I的异噻唑啉化合物，其中变量如权利要求或描述中所定义，其可用于防治或控制无脊椎害虫，特别是节肢动物害虫和线虫，以及其制备方法。本发明还涉及通过使用这些化合物和植物繁殖材料以及包含所述化合物的农业和兽用组合物来控制无脊椎害虫的方法。

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