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1. 发明申请

US20100297108A1 METHOD OF PROVIDING PATIENT SPECIFIC IMMUNE RESPONSE IN AMYLOIDOSES AND PROTEIN AGGREGATION DISORDERS 有权
标题翻译：提供AMYLOIDIDES和蛋白质聚集障碍患者特异性免疫应答的方法
公开(公告)号：US20100297108A1
公开(公告)日：2010-11-25
申请号：US12733437
申请日：2008-09-01
申请人： Karsten Henco , Roger Nitsch , Jan Grimm , Anja Zeller , Marcel Maier
发明人： Karsten Henco , Roger Nitsch , Jan Grimm , Anja Zeller , Marcel Maier
IPC分类号： A61K39/395 , A61K39/00 , G01N33/53 , C12P21/06 , C12N5/0781 , G01N33/566 , C07K14/00
CPC分类号： A61K39/0007 , A61K31/7088 , A61K39/39 , A61K2039/53 , A61K2039/545 , A61K2039/55511 , A61K2039/55561 , A61K2039/57 , A61K2039/575 , C12N15/117 , G01N33/6896 , G01N2333/4709 , Y02A50/41
摘要： A novel treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed against pathological protein aggregates or neo-epitopes present on pathogenic forms of said protein or protein complex. Furthermore, therapeutic methods are also described, wherein ex vivo stimulated antigen-selected peripheral blood lymphocytes are regrafted into the cognate donor.
摘要翻译：通过增强或维持针对主要针对存在于所述蛋白质或蛋白质复合物的致病形式的病理蛋白聚集体或新表位的抗体应答来提供对阿尔茨海默氏病和涉及蛋白质错误折叠或聚集的其它病症的新颖治疗。此外，还描述了将离体刺激的抗原选择的外周血淋巴细胞移植到同源供体中的治疗方法。

2. 发明授权

US09370531B2 Method of providing patient specific immune response in amyloidoses and protein aggregation disorders 有权
标题翻译：在淀粉样变性和蛋白质聚集障碍中提供患者特异性免疫应答的方法
公开(公告)号：US09370531B2
公开(公告)日：2016-06-21
申请号：US12733437
申请日：2008-09-01
申请人： Karsten Henco , Roger Nitsch , Jan Grimm , Anja Zeller , Marcel Maier
发明人： Karsten Henco , Roger Nitsch , Jan Grimm , Anja Zeller , Marcel Maier
IPC分类号： A61K45/00 , A61K39/00 , C12N15/117 , A61K31/7088 , A61K39/39
CPC分类号： A61K39/0007 , A61K31/7088 , A61K39/39 , A61K2039/53 , A61K2039/545 , A61K2039/55511 , A61K2039/55561 , A61K2039/57 , A61K2039/575 , C12N15/117 , G01N33/6896 , G01N2333/4709 , Y02A50/41
摘要： A treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed against pathological protein aggregates or neo-epitopes present on pathogenic forms of said protein or protein complex. Furthermore, therapeutic methods are also described, wherein ex vivo stimulated antigen-selected peripheral blood lymphocytes are regrafted into the cognate donor.
摘要翻译：通过增强或维持针对主要针对存在于所述蛋白质或蛋白质复合物的致病形式的病理蛋白聚集体或新表位的抗体应答来提供治疗阿尔茨海默氏病和其它涉及蛋白质错误折叠或聚集的疾病。此外，还描述了将离体刺激的抗原选择的外周血淋巴细胞移植到同源供体中的治疗方法。

3. 发明授权

US09439998B2 Compositions and methods for disinfecting materials 有权
标题翻译：消毒材料的组成和方法
公开(公告)号：US09439998B2
公开(公告)日：2016-09-13
申请号：US13393520
申请日：2010-09-01
申请人： Karsten Henco , Thomas Freier , Rivelino Montenegro
发明人： Karsten Henco , Thomas Freier , Rivelino Montenegro
IPC分类号： A01N43/16 , C08B37/08 , A61P17/02 , A61K31/722 , A61L15/28 , A61L26/00
CPC分类号： A61L26/0023 , A61L15/28 , A61L26/0066 , A61L2300/232 , A61L2300/404 , C08L5/08
摘要： The present invention relates to methods for disinfecting or decontaminating a material or for preventing an infection or contamination of a material. The invention further relates to compositions which are suitable for disinfecting a material or for preventing an infection or contamination of a material and to uses of such compositions. The invention further relates to a medical use of chitosan and to a pharmaceutical composition comprising the chitosan. The invention further relates to a method of treating a microbial infection and to an aqueous solution comprising chitosan. The invention moreover relates to a chitosan or a pharmaceutical composition comprising a chitosan for an epithelial cell growth stimulating treatment of a patient's tissue and to a method of stimulating the growth of epithelial cells. The invention also relates to a tissue dressing material.
摘要翻译：本发明涉及消毒或净化材料或防止材料的感染或污染的方法。本发明还涉及适用于消毒材料或防止材料的感染或污染以及这些组合物的用途的组合物。本发明还涉及壳聚糖和包含壳聚糖的药物组合物的医学用途。本发明还涉及一种治疗微生物感染的方法和包含壳聚糖的水溶液。本发明还涉及壳聚糖或包含用于上皮细胞生长刺激治疗患者组织的壳聚糖和刺激上皮细胞生长的方法的药物组合物。本发明还涉及组织敷料材料。

4. 发明授权

US07534576B2 Method and a device for the evaluation of biopolymer fitness 失效
标题翻译：用于评估生物聚合物适应性的方法和装置
公开(公告)号：US07534576B2
公开(公告)日：2009-05-19
申请号：US11730931
申请日：2007-04-04
申请人： Rudolf Rigler , Manfred Eigen , Karsten Henco , Ulo Mets , Jerker Widengren , Michael Stuke , Michael Brinkmeyer , Wolfgang Simm , Olaf Lehman
发明人： Rudolf Rigler , Manfred Eigen , Karsten Henco , Ulo Mets , Jerker Widengren , Michael Stuke , Michael Brinkmeyer , Wolfgang Simm , Olaf Lehman
IPC分类号： G01N33/569
CPC分类号： G01N21/6452 , C12Q1/04 , C12Q1/6827 , G01N21/64 , G01N21/6402 , G01N21/6408 , G01N21/6428 , G01N21/6458 , G02B21/24 , Y10S435/808 , Y10S436/805 , Y10T436/11 , C12Q2565/107 , C12Q2561/113 , C12Q2535/131
摘要： A Method for identifying one or a small number of molecules, especially in a dilution of ≦1 μM, using laser excited FCS with measuring times ≦500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably ≦10−14 l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined.The device which can be preferably used for performing the method according to the invention is a per se known system of microscope optics for laser focusing for fluorescence excitation in a small measuring compartment of a very diluted solution and for imaging the emitted light in the subsequent measurement through confocal imaging wherein at least one system of optics with high numerical aperture of preferably ≧1.2 N.A. is employed, the light quantity is limited by a confocally arranged pinhole aperture in the object plane behind the microscope objective, and the measuring compartment is positioned at a distance of between 0 and 1000 μm from the observation objective.
摘要翻译：使用测量时间<= 500ms的激光激发FCS和要分析的分子的短扩散路径来识别一个或少数分子，特别是稀释度为<=1μM的分子的方法，其中测量在通过确定由待分析的分子的发光测量确定的材料特异性参数，优选<=10-14μl的小体积单位。可以优选用于执行根据本发明的方法的装置是本身已知的用于在非常稀释的溶液的小测量室中进行荧光激发的激光聚焦的显微镜光学系统，并且用于在后续测量中对发射的光进行成像通过共焦成像，其中使用具有优选> = 1.2NA的高数值孔径的至少一个光学系统，光量受到在显微镜物镜后面的物平面中的共同排列的针孔的限制，并且测量室位于与观察目标之间的距离为0至1000μm。

5. 发明授权

US5795747A Process for manufacturing new biopolymers 失效
标题翻译：生产新生物聚合物的方法
公开(公告)号：US5795747A
公开(公告)日：1998-08-18
申请号：US507190
申请日：1995-06-26
申请人： Karsten Henco , Manfred Eigen
发明人： Karsten Henco , Manfred Eigen
IPC分类号： C12N15/10 , C12Q1/68 , C12P19/34
CPC分类号： C12N15/1079 , C12N15/1058 , C12Q1/6811
摘要： The process of generating new biopolymers with improved characteristics, assisted by polymerases, is characterized in that at least one cycle of the steps described below, will be performed in a series of parallel preparations which are to be compared. Sequences of nucleic acids or, a mixture of similar sequences of nucleic acids in the distribution of mutants of a quasi-species, are subjected, in the region of the error threshold, to limited mutagenesis. These mixtures are replicated under simultaneous conditions and/or in succession. The mixtures of the so product nucleic acids are compartmentalized by segregation, and thereafter selected by a selection system which reflects the characteristics of interest of the nucleic acid sequence itself or, indirectly, via its translation product.
摘要翻译：通过聚合酶辅助产生具有改进特征的新生物聚合物的方法的特征在于下述步骤的至少一个循环将在一系列待比较的平行制剂中进行。序列的核酸或类似核酸序列的混合物在拟种突变体的分布中，在误差阈值区域受到有限的诱变。这些混合物在同时条件下和/或连续复制。这样的产物核酸的混合物通过分离进行分隔，然后通过反映核酸序列本身的感兴趣特征的选择系统或通过其翻译产物间接选择。

6. 发明授权

US07015017B2 Process and agent for instabilizing viral quasi-species-distributions avoiding resistance phenomena 失效
公开(公告)号：US07015017B2
公开(公告)日：2006-03-21
申请号：US10032897
申请日：2001-10-25
申请人： Manfred Eigen , Andreas Schwienhorst , Christof Biebricher , Björn Lindemann , Esteban Domingo , John Holland , Karsten Henco
发明人： Manfred Eigen , Andreas Schwienhorst , Christof Biebricher , Björn Lindemann , Esteban Domingo , John Holland , Karsten Henco
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12N15/11 , A61K48/00 , A61K2039/525 , C12N7/00 , C12N15/00 , C12N2740/16011 , C12N2795/18111 , Y10T436/143333
摘要： A process for instabilizing viral quasi-species-distributions under avoidance of resistance phenomena by replication of the nucleic acids of the viruses present in the quasi-species-distribution by of a defective replication system, a) whereby the defective replication system has a rate of misincorporation for nucleotides above the rate of misincorporation of the viral wild-type-replication system and, whereby the viruses are replicated by the replication system having the higher rate of misincorporation at least as effectively as it is done by the replication system of the wild-type virus, b) and/or negative influence of the replication of the consensus-sequence (nucleic acid sequence of the wild-type virus) in relation to other replicatable nucleic acids.

7. 发明授权

US06423516B1 Process and agent for instabilizing viral quasi-species-distributions avoiding resistance phenomena 失效
标题翻译：不稳定病毒准物种分布的过程和试剂，避免了阻力现象
公开(公告)号：US06423516B1
公开(公告)日：2002-07-23
申请号：US08362604
申请日：1996-03-22
申请人： Manfred Eigen , Andreas Schwienhorst , Christof Biebricher , Björn Lindemann , Esteban Domingo , John Holland , Karsten Henco
发明人： Manfred Eigen , Andreas Schwienhorst , Christof Biebricher , Björn Lindemann , Esteban Domingo , John Holland , Karsten Henco
IPC分类号： C12P1934
CPC分类号： C12N15/11 , A61K48/00 , A61K2039/525 , C12N7/00 , C12N15/00 , C12N2740/16011 , C12N2795/18111 , Y10T436/143333
摘要： A process for instabilizing viral quasi-species-distributions under avoidance of resistance phenomena by replication of the nucleic acids of the viruses present in the quasi-species-distribution by of a defective replication system, a) whereby the defective replication system has a rate of misincorporation for nucleotides above the rate of misincorporation of the viral wild-type-replication system and, whereby the viruses are replicated by the replication system having the higher rate of misincorporation at least as effectively as it is done by the replication system of the wild-type virus, b) and/or negative influence of the replication of the consensus-sequence (nucleic acid sequence of the wild-type virus) in relation to other replicatable nucleic acids.
摘要翻译：一种通过利用有缺陷的复制系统复制存在于准物种分布中的病毒的核酸来避免抗性现象来阻止病毒准物种分布的方法，其中缺陷复制系统的速率为对于高于病毒野生型复制系统错配的速率的核苷酸的错配，并且其中病毒由具有较高错配率的复制系统复制至少与野生型复制系统的复制系统一样有效地复制，类型病毒，b）和/或共有序列（野生型病毒的核酸序列）相对于其他可重复核酸的复制的负面影响。

8. 发明授权

US5871908A Process for the determination of in vitro amplified nucleic acids 失效
标题翻译：测定体外扩增核酸的方法
公开(公告)号：US5871908A
公开(公告)日：1999-02-16
申请号：US157195
申请日：1993-12-08
申请人： Karsten Henco , Manfred Eigen , Detlev Riesner
发明人： Karsten Henco , Manfred Eigen , Detlev Riesner
IPC分类号： B01L7/00 , C12Q1/68 , C12P19/34
CPC分类号： B01L7/52 , C12Q1/6825 , C12Q1/686
摘要： A process for the qualitative and quantitative determination of at least one in vitro amplified nucleic acid in a sealed reaction chamber,wherein during or subsequent to the amplification of the nucleic acid at least one substance (probe) is present which interacts with the nucleic acid to be detected;wherein spectroscopically measurable parameters of said substance (probe) are subject to variation, creating a measurable signal;wherein the sample to be measured is exposed to the action of a gradient capable of at least partially denaturing nucleic acids;with detection of the measurable parameter undergoing variation through the action of the gradient; andthe entire amplification reaction, including qualitative and quantitative determination, may be carried out in a sealed reaction chamber (measuring compartment) without intermittent opening,permitting to automatically operate the diagnostic method of DNA and RNA amplification in qualitative and quantitative fashion on large series of samples.
摘要翻译： PCT No.PCT / EP93 / 00254 Sec。 371日期：1993年12月8日 102（e）日期1993年12月8日PCT提交1993年2月4日PCT公布。公开号WO93 / 16194 日期1993年8月19日一种在密封反应室中定性和定量测定至少一种体外扩增的核酸的方法，其中在核酸扩增期间或之后存在至少一种物质（探针），其与与待检测的核酸; 其中所述物质（探针）的光谱可测量参数经历变化，产生可测量的信号; 其中要测量的样品暴露于能够至少部分变性核酸的梯度的作用; 通过梯度的作用检测可测量的参数变化; 并且包括定性和定量测定的整个扩增反应可以在密封的反应室（测量室）中进行，而不间断地打开，允许以定性和定量的方式自动操作DNA和RNA扩增的诊断方法样品。

9. 发明授权

US5849545A Substrate material for simultaneously binding genotypic and phenotypic substances 失效
标题翻译：用于同时结合基因型和表型物质的底物材料
公开(公告)号：US5849545A
公开(公告)日：1998-12-15
申请号：US834834
申请日：1997-04-10
申请人： Karsten Henco , Manfred Eigen
发明人： Karsten Henco , Manfred Eigen
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6834
摘要： Described is a support material that can simultaneously bind both genotypic and phenotypic substances. The respective areas, which can have surface-modifying matter such as anionic exchangers and/or affinity ligands, simultaneously bind, for example, nucleic acids and proteins or peptides. The support materials described can be used in processes for evolutive optimization of biopolymers, wherein genotype and phenotype can be bound at the same time so as to furnish them for further analysis.
摘要翻译：描述了可同时结合基因型和表型物质的支持材料。可以具有表面改性物质如阴离子交换剂和/或亲和配体的各个区域同时结合例如核酸和蛋白质或肽。所描述的载体材料可用于生物聚合物的进化优化的方法，其中基因型和表型可以同时结合，以便进一步分析。

10. 发明授权

US5677147A HIV-2 virus variants 失效
公开(公告)号：US5677147A
公开(公告)日：1997-10-14
申请号：US684682
申请日：1996-07-22
申请人： Karsten Henco , Hagen von Briesen , Andreas Immelmann , Herbert Kuhnel , Ursula Dietrich , Helga Rubsamen-Waigmann , Michalina Adamski
发明人： Karsten Henco , Hagen von Briesen , Andreas Immelmann , Herbert Kuhnel , Ursula Dietrich , Helga Rubsamen-Waigmann , Michalina Adamski
IPC分类号： G01N33/569 , A61K38/00 , A61K39/21 , A61K39/395 , C07K14/005 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/195 , C07K14/705 , C07K16/00 , C07K16/10 , C07K19/00 , C12N5/00 , C12N5/10 , C12N7/00 , C12N15/48 , C12N15/49 , C12R1/92 , G01N33/577
CPC分类号： C12N7/00 , C07K14/005 , C07K16/1045 , A61K38/00 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , Y10S435/974 , Y10S530/81 , Y10S530/815 , Y10S530/826
摘要： HIV-2 virus variants, namely virus HIV D194 and virus HIV D205, which can be cloned from the corresponding virus isolate HIV D194 (ECACC V 87122303) or from the infected cell line HUT 194 (ECACC V 87122306) or from the virus isolate HIV D205 (ECACC V 87122304), respectively, and their RNA or RNA-fragments and DNA and DNA-fragments derived therefrom and/or proteins and the use thereof for diagnostics and therapy.

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