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1. 发明授权

US08992708B2 Use of synthetic adhesives in the manufacture of corrugated fiberboard 有权
标题翻译：使用合成胶粘剂制造瓦楞纸板
公开(公告)号：US08992708B2
公开(公告)日：2015-03-31
申请号：US13083028
申请日：2011-04-08
申请人： Karl-Heinz Schumacher , Gledison Fonseca , Rabie Al-Hellani , Wolfgang Gaschler , Ellen Krüger , Andrea Herold , Hildegard Stein , Oliver Hartz , Hubertus Kröner
发明人： Karl-Heinz Schumacher , Gledison Fonseca , Rabie Al-Hellani , Wolfgang Gaschler , Ellen Krüger , Andrea Herold , Hildegard Stein , Oliver Hartz , Hubertus Kröner
IPC分类号： B31F1/20 , B31F1/28 , C08F212/08 , C09D103/02 , D21H17/37 , B29C53/22 , C08F220/06 , C08F222/04 , D21H27/10 , D21H17/36
CPC分类号： B31F1/2809 , B29C53/22 , C08F212/08 , C08F220/06 , C08F222/04 , C09D103/02 , C09J125/14 , D21H17/36 , D21H17/37 , D21H27/10 , Y10T156/1016 , Y10T156/1025 , C08L35/06 , C08F2220/1825 , C08F218/08 , C08F2220/1891 , C08F222/02 , C08F236/10 , C08F2/38 , C08F2/22
摘要： Described is the use of synthetic adhesives in the manufacture of corrugated fiberboard at relatively low temperatures and high lineal speeds. The corrugated fiberboard includes a corrugated sheet of paper and a flat linerboard and the corrugation of the corrugated sheet of paper is produced at paper temperatures below 95° C. and at a lineal speed above 150 m/min. The production of the corrugation of a corrugated sheet of paper is immediately followed by a continuous operation in which a preferably unheated corrugated board adhesive is applied and the corrugated sheet of paper is adhered to at least one first linerboard. The corrugated board adhesive used is an aqueous adhesive dispersion based on at least one synthetic, dispersed polymer having preferably more than 40% by weight solids content, selected from acrylate copolymers, copolymers of vinylaromatics and conjugated aliphatic dienes and vinyl acetate-alkylene copolymers, wherein the glass transition temperatures of the polymers are above 20° C. and (preferably at least 5° C.) below the surface temperature of the corrugated sheet of paper to which they are applied.
摘要翻译：描述了在相对低的温度和较高的线速下制造瓦楞纸板的合成粘合剂的用途。瓦楞纸板包括波纹纸和平板纸板，波纹纸的波纹在低于95℃的纸张温度下以高于150米/分的线速度产生。波纹纸的波纹的生产紧随其后是连续操作，其中施加优选不加热的波纹板粘合剂，并且波纹纸粘附到至少一个第一衬板。使用的波纹板粘合剂是基于至少一种合成的分散聚合物的水性粘合剂分散体，其具有优选大于40重量％的固体含量，选自丙烯酸酯共聚物，乙烯基芳族化合物和共轭脂族二烯的共聚物和乙酸乙烯酯 - 亚烷基共聚物，其中聚合物的玻璃化转变温度高于其应用它们的波纹纸的表面温度的20℃以下（优选至少5℃）。

2. 发明申请

US20110247746A1 USE OF SYNTHETIC ADHESIVES IN THE MANUFACTURE OF CORRUGATED FIBERBOARD 有权
标题翻译：合成胶粘剂在腐蚀性纤维板的制造中的应用
公开(公告)号：US20110247746A1
公开(公告)日：2011-10-13
申请号：US13083028
申请日：2011-04-08
申请人： Karl-Heinz SCHUMACHER , Gledison Fonseca , Rabie Al-Hellani , Wolfgang Gaschler , Ellen Krüger , Andrea Herold , Hildegard Stein , Oliver Hartz , Hubertus Kröner
发明人： Karl-Heinz SCHUMACHER , Gledison Fonseca , Rabie Al-Hellani , Wolfgang Gaschler , Ellen Krüger , Andrea Herold , Hildegard Stein , Oliver Hartz , Hubertus Kröner
IPC分类号： B31F1/20 , B32B37/12
CPC分类号： B31F1/2809 , B29C53/22 , C08F212/08 , C08F220/06 , C08F222/04 , C09D103/02 , C09J125/14 , D21H17/36 , D21H17/37 , D21H27/10 , Y10T156/1016 , Y10T156/1025 , C08L35/06 , C08F2220/1825 , C08F218/08 , C08F2220/1891 , C08F222/02 , C08F236/10 , C08F2/38 , C08F2/22
摘要： Described is the use of synthetic adhesives in the manufacture of corrugated fiberboard at relatively low temperatures and high lineal speeds. The corrugated fiberboard includes a corrugated sheet of paper and a flat linerboard and the corrugation of the corrugated sheet of paper is produced at paper temperatures below 95° C. and at a lineal speed above 150 m/min. The production of the corrugation of a corrugated sheet of paper is immediately followed by a continuous operation in which a preferably unheated corrugated board adhesive is applied and the corrugated sheet of paper is adhered to at least one first linerboard. The corrugated board adhesive used is an aqueous adhesive dispersion based on at least one synthetic, dispersed polymer having preferably more than 40% by weight solids content, selected from acrylate copolymers, copolymers of vinylaromatics and conjugated aliphatic dienes and vinyl acetate-alkylene copolymers, wherein the glass transition temperatures of the polymers are above 20° C. and (preferably at least 5° C.) below the surface temperature of the corrugated sheet of paper to which they are applied.
摘要翻译：描述了在相对低的温度和较高的线速下制造瓦楞纸板的合成粘合剂的用途。瓦楞纸板包括波纹纸和平板纸板，波纹纸的波纹在低于95℃的纸张温度下以高于150米/分的线速度产生。波纹纸的波纹的生产紧随其后是连续操作，其中施加优选不加热的波纹板粘合剂，并且波纹纸粘附到至少一个第一衬板。使用的波纹板粘合剂是基于至少一种合成的分散聚合物的水性粘合剂分散体，其具有优选大于40重量％的固体含量，选自丙烯酸酯共聚物，乙烯基芳族化合物和共轭脂族二烯的共聚物和乙酸乙烯酯 - 亚烷基共聚物，其中聚合物的玻璃化转变温度高于其应用它们的波纹纸的表面温度的20℃以下（优选至少5℃）。

3. 发明授权

US08399214B2 Use of dimethyl disulfide for methionine production in microoraganisms 有权
标题翻译：用二甲基二硫化物在微生物激素中生产甲硫氨酸
公开(公告)号：US08399214B2
公开(公告)日：2013-03-19
申请号：US11988971
申请日：2006-07-18
申请人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
发明人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
IPC分类号： C12P1/00
CPC分类号： C12P13/12
摘要： The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ΔmetF organism or a ΔmetE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/MetE and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ΔmetF ΔmetB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.
摘要翻译：本发明的特征在于用于生产甲硫氨酸的改进方法和生物体。本发明证明，一种有机蛋白（MetF）生物体或一种具有谷氨酸棒状杆菌或大肠杆菌的突变体的MetE生物体可以使用例如二甲基二硫醚（DMDS）的甲基封端硫化物源作为硫和甲基，绕过MetH / MetE和MetF活性的需要，需要还原硫酸盐，用于合成甲硫氨酸。该专利中还描述的是涉及MetY（也称为MetZ）作为将甲基封端的硫化物源例如DMDS掺入甲硫氨酸的酶的数据。 A＆Dgr; metF＆Dgr;谷氨酸棒杆菌的metB菌株可以使用甲基封端的硫化物源，例如DMDS，作为硫化物和甲基的来源。此外，通过加入甲基封端的硫化物源（例如DMDS），改善过量产生O-乙酰高丝氨酸的工程化原养殖生物体的甲硫氨酸生产。

4. 发明申请

US20100003727A1 Coryneform Bacteria with Formate-THF-Synthetase and/or Glycine Cleavage Activity 审中-公开
标题翻译：具有甲酸-THF合成酶和/或甘氨酸裂解活性的棒状杆菌细菌
公开(公告)号：US20100003727A1
公开(公告)日：2010-01-07
申请号：US12519909
申请日：2008-02-14
申请人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , Thomas A. Patterson , R. Rogers Yocum , Janice G. Pero
发明人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , Thomas A. Patterson , R. Rogers Yocum , Janice G. Pero
IPC分类号： C12P13/12 , C12N1/21
CPC分类号： C12P13/12 , C12N15/52
摘要： The present invention relates to microorganisms, in particular C. glutamicum in which the formation of N5,N10-methylene-THF is increased.The present invention also relates to the use of such microorganisms for producing methionine.
摘要翻译：本发明涉及增加N5，N10-亚甲基-THF的形成的微生物，特别是谷氨酸棒杆菌。本发明还涉及这种微生物用于产生甲硫氨酸的用途。

5. 发明申请

US20090298136A1 Methionine producing recombinant microorganisms 审中-公开
标题翻译：产生甲硫氨酸的重组微生物
公开(公告)号：US20090298136A1
公开(公告)日：2009-12-03
申请号：US11988962
申请日：2006-07-18
申请人： Oskar Zelder , Stefan Haefner , Corinna Klopprogge , Hartwig Schroder , Andrea Herold , Thomas A. Patterson , Theron Hermann , R. Rogers Yocum , Mark K. William , Janice G. Pero
发明人： Oskar Zelder , Stefan Haefner , Corinna Klopprogge , Hartwig Schroder , Andrea Herold , Thomas A. Patterson , Theron Hermann , R. Rogers Yocum , Mark K. William , Janice G. Pero
IPC分类号： C12P13/12 , C12N1/21
CPC分类号： C12P13/12 , C12N15/52
摘要： This invention relates to methionine producing recombinant microorganisms. Specifically, this invention relates to recombinant strains of Corynebacterium that produce increased levels of methionine compared to their wild-type counterparts and further to methods of generating such microorganisms.
摘要翻译：本发明涉及产生甲硫氨酸的重组微生物。具体而言，本发明涉及棒状杆菌的重组菌株，其与野生型对应物相比产生较高水平的甲硫氨酸，并且还涉及产生这种微生物的方法。

6. 发明申请

US20080268502A1 Multiple Promoters and the Use Thereof For Gene Expression 有权
标题翻译：多重启动子及其用于基因表达的用途
公开(公告)号：US20080268502A1
公开(公告)日：2008-10-30
申请号：US12048599
申请日：2008-03-14
申请人： Stefan Haefner , Hartwig Schroder , Oskar Zelder , Corinna Klopprogge , Andrea Herold
发明人： Stefan Haefner , Hartwig Schroder , Oskar Zelder , Corinna Klopprogge , Andrea Herold
IPC分类号： C12P21/04 , C12N15/11 , C12N15/00 , C12P19/34 , C12P7/64 , C12N15/74 , C12P13/04 , C12N1/20 , C12P1/00
CPC分类号： C07K14/34 , C12N15/77
摘要： The present invention relates to multiple promoters and to expression units comprising them; to the use thereof for regulating transcription and expression of genes; to expression cassettes which comprise multiple promoters or expression units of this kind; to vectors which comprise such expression cassettes; to genetically modified microorganisms which comprise vectors and/or expression units of this kind; and to processes for preparing biosynthetic products by culturing said genetically modified microorganisms.
摘要翻译：本发明涉及多种启动子和包含它们的表达单元; 用于调节基因的转录和表达; 包括多种启动子或这种表达单位的表达盒; 包含这种表达盒的载体; 涉及包含这种载体和/或表达单元的转基因微生物; 以及通过培养所述转基因微生物来制备生物合成产物的方法。

7. 发明申请

US20120288901A1 Method of Producing Methionine in Corynebacteria by Over-Expressing Enzymes of the Pentose Phosphate Pathway 审中-公开
标题翻译：通过过表达戊糖磷酸途径的酶在棒状杆菌中产生甲硫氨酸的方法
公开(公告)号：US20120288901A1
公开(公告)日：2012-11-15
申请号：US12527476
申请日：2008-02-13
申请人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold
发明人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold
IPC分类号： C12P13/12 , C12N1/21
CPC分类号： C12N9/1022 , C12N9/0006 , C12P13/12
摘要： The present invention relates to a method of producing methionine in Coryneform bacteria in which enzymes of the pentose phosphate pathway are over-expressed. The present invention also relates to Coryneform bacteria for producing methionine in which at least two enzymes of the pentose phosphate pathway are over-expressed.
摘要翻译：本发明涉及一种在棒状细菌中产生甲硫氨酸的方法，其中戊糖磷酸途径的酶被过度表达。本发明还涉及用于产生甲硫氨酸的棒状细菌，其中戊糖磷酸途径的至少两种酶被过度表达。

8. 发明授权

US08252555B2 Nucleic acid encoding a cobalamin-dependent methionine synthase polypeptide 失效
标题翻译：编码钴胺素依赖性甲硫氨酸合成酶多肽的核酸
公开(公告)号：US08252555B2
公开(公告)日：2012-08-28
申请号：US12521141
申请日：2007-12-21
申请人： Oskar Zelder , Wolfgang Grabarse , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Anja Knietsch , Andrea Herold
发明人： Oskar Zelder , Wolfgang Grabarse , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Anja Knietsch , Andrea Herold
IPC分类号： C12P21/06
CPC分类号： C12N9/0091 , C12P13/12
摘要： The present invention relates to nucleotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof that are modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host cells comprising such nucleotide sequences. Furthermore, the present invention relates to methods for producing methionine in host organisms by making use of such nucleotide sequences.
摘要翻译：本发明涉及编码酶促活性钴胺素 - 甲硫氨酸合成酶的核苷酸序列及其功能片段，其与相应的野生型酶相比被修饰，使得所述酶显示产品对甲硫氨酸的抑制作用降低。本发明还涉及由该核苷酸序列编码的多肽和包含该核苷酸序列的宿主细胞。此外，本发明涉及通过利用这种核苷酸序列在宿主生物体中产生甲硫氨酸的方法。

9. 发明申请

US20110003963A1 METHOD FOR THE PRODUCTION OF DIPICOLINATE 审中-公开
标题翻译：二氯化碳生产方法
公开(公告)号：US20110003963A1
公开(公告)日：2011-01-06
申请号：US12865895
申请日：2009-02-04
申请人： Oskar Zelder , Weol Kyu Jeong , Corinna Klopprogge , Andrea Herold , Hartwig Schröder
发明人： Oskar Zelder , Weol Kyu Jeong , Corinna Klopprogge , Andrea Herold , Hartwig Schröder
IPC分类号： C08G69/08 , C12P17/12 , C07H21/04 , C12N15/63 , C12N1/21
CPC分类号： C12P17/12 , C12N9/001
摘要： The present invention relates to a novel method for the fermentative production of dipicolinate by cultivating a recombinant microorganism expressing an enzyme having dipicolinate synthetase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as a method of preparing polyester or polyamide copolymers making use of dipicolinate as obtained by fermentative production.
摘要翻译：本发明涉及通过培养表达具有吡啶二羧酸合成酶活性的酶的重组微生物来发酵吡啶硫酸盐的新方法。本发明还涉及适用于制备这种宿主的相应的重组宿主，重组载体，表达盒和核酸以及使用通过发酵生产得到的吡啶二酸盐制备聚酯或聚酰胺共聚物的方法。

10. 发明申请

US20090325244A1 METHOD OF INCREASING GENE EXPRESSION USING MODIFIED CODON USAGE 审中-公开
标题翻译：使用改性CODON使用增加基因表达的方法
公开(公告)号：US20090325244A1
公开(公告)日：2009-12-31
申请号：US12446809
申请日：2007-10-18
申请人： Andrea Herold , Corinna Klopprogge , Hartwig Schröder , Oskar Zelder , Weol Kyu Jeong
发明人： Andrea Herold , Corinna Klopprogge , Hartwig Schröder , Oskar Zelder , Weol Kyu Jeong
IPC分类号： C12P13/12 , C12N15/87 , C12N15/82 , C12N15/11 , C12N15/00 , C12N1/21 , C12P13/04 , C12P13/08 , C12P7/64
CPC分类号： C12N15/67 , C12N15/77
摘要： The present invention relates to a method of increasing the amount of at least one polypeptide in the host cell by expressing a modified nucleotide sequence encoding for a polypeptide in a host cell with said modified nucleotide sequence being derived from a different non-modified nucleotide sequence encoding for a polypeptide of identical amino acid sequence such that the codon usage of the modified nucleotide sequence is adjusted to the codon usage of abundant proteins in the host cell.
摘要翻译：本发明涉及一种通过在宿主细胞中表达编码多肽的修饰的核苷酸序列来增加宿主细胞中至少一种多肽的量的方法，所述修饰的核苷酸序列来自编码的不同的未修饰的核苷酸序列对于相同氨基酸序列的多肽，使得修饰的核苷酸序列的密码子使用被调节为宿主细胞中丰富蛋白质的密码子使用。

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