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1. 发明授权

US5110508A Process and apparatus for making a heat-sensitive material 失效
标题翻译：制造热敏材料的工艺和装置
公开(公告)号：US5110508A
公开(公告)日：1992-05-05
申请号：US340977
申请日：1989-04-20
申请人： Karl-Heinz Buettgen , Bernhard Gutsche , Friedrich Hommers , Wilhelm Johannisbauer , Eberhard Peukert , Reinhold Sedelies
发明人： Karl-Heinz Buettgen , Bernhard Gutsche , Friedrich Hommers , Wilhelm Johannisbauer , Eberhard Peukert , Reinhold Sedelies
IPC分类号： B01D1/22 , B01D3/00 , B01J14/00 , B01J19/00 , B01J19/18 , C07C67/08
CPC分类号： B01D3/009 , B01J14/00 , B01J19/0013 , B01J19/1881 , B01J2219/0009 , B01J2219/00101
摘要： The invention relates to a process, more especially a discontinuous process, for conducting a reaction taking place at elevated temperature in which heat-sensitive products are formed. To increase the volume-time yield, a heat transfer unit independent of the reactor is used for heating. The invention also relates to an apparatus for the production of heat-sensitive products at elevated temperatures. This apparatus comprises a reactor and a heating system. To increase the volume-time yield, the heating system comprises at least one heat transfer unit arranged outside and connected to the reactor.
摘要翻译：本发明涉及一种用于进行在其中形成热敏产物的升高的温度下进行的反应的方法，更特别是不连续的方法。为了增加体积 - 时间产率，独立于反应器的传热装置被用于加热。本发明还涉及一种用于在高温下生产热敏产品的装置。该装置包括反应器和加热系统。为了增加体积 - 时间产量，加热系统包括布置在外部并连接到反应器的至少一个传热单元。

2. 发明授权

US5527974A Process for the purification of glycerol water 失效
标题翻译：纯化甘油水的方法
公开(公告)号：US5527974A
公开(公告)日：1996-06-18
申请号：US284531
申请日：1994-09-29
申请人： Lutz Jeromin , Wilhelm Johannisbauer , Stefan Blum , Reinhold Sedelies , Heinrich Moormann , Bernd Holfoth , Juergen Plachenka
发明人： Lutz Jeromin , Wilhelm Johannisbauer , Stefan Blum , Reinhold Sedelies , Heinrich Moormann , Bernd Holfoth , Juergen Plachenka
IPC分类号： B01D17/02 , B01D61/16 , C02F1/44 , C07C29/76 , C07C31/22
CPC分类号： B01D17/0211 , B01D17/02 , B01D61/147 , B01D61/16 , C02F1/444 , C07C29/76 , C07C31/225 , C12C11/02 , B01D2311/04
摘要： The glycerol water (sweet water) accumulating in the high-pressure hydrolysis of natural fats and oils with steam into fatty acid and glycerol is continuously purified. Fats larger than 100 .mu.m in diameter are separated from the aqueous phase in a plate-type phase separator and are returned to the high-pressure hydrolysis process. The aqueous phase thus prepurified is passed through a cross-flow filtration membrane, more particularly a microfiltration membrane, and the concentrate is returned to the entrance of the plate-phase separator. Large product streams of glycerol water can be purified continuously, effectively and particularly economically despite frequent changes of provenance.
摘要翻译：将天然脂肪和油中蒸汽高压水解的甘油水（甜水）持续纯化。在板式相分离器中将直径大于100μm的脂肪与水相分离，并返回到高压水解过程。将如此预纯化的水相通过交叉流过滤膜，更特别是微滤膜，并将浓缩物返回到板相分离器的入口。甘油水的大量产物流可以连续，有效和特别经济地纯化，尽管原产地频繁变化。

3. 发明授权

US5128070A Process for the acid-catalyzed cleavage of fatty acid glycerides and apparatus therefor 失效
标题翻译：脂肪酸甘油酸的酸性催化清除方法及其设备
公开(公告)号：US5128070A
公开(公告)日：1992-07-07
申请号：US388206
申请日：1989-08-01
申请人： Reinhold Sedelies , Wilhelm Johannisbauer , Guenter Wozny , Lutz Jeromin , Gerhard Dieckelm , Manfred Lindemann , Gerd Matrong
发明人： Reinhold Sedelies , Wilhelm Johannisbauer , Guenter Wozny , Lutz Jeromin , Gerhard Dieckelm , Manfred Lindemann , Gerd Matrong
IPC分类号： C07C27/02 , C11C1/04
CPC分类号： C11C1/04
摘要： Process for the acid-catalyzed hydrolysis of fatty acid glycerides, wherein the process is carried out continuously with the glyceride and the water being moved countercurrent to each other, and apparatus therefor.
摘要翻译：脂肪酸甘油酯的酸催化水解的方法，其中该方法与甘油酯和水相互逆流地连续进行，以及其装置。

4. 发明授权

US08404468B2 Efficient astaxanthin production strains derived from Haematococcus pluvialis 有权
标题翻译：来源于红球藻的高效虾青素生产菌株
公开(公告)号：US08404468B2
公开(公告)日：2013-03-26
申请号：US12601471
申请日：2008-05-14
申请人： Martin Lucia , Irina Obraztsova , Baldomero F. Cordero , Angeles M. Vargas , Albrecht Weiss , Bernhard Gutsche , Wilhelm Johannisbauer , Herminia Rodriguez
发明人： Martin Lucia , Irina Obraztsova , Baldomero F. Cordero , Angeles M. Vargas , Albrecht Weiss , Bernhard Gutsche , Wilhelm Johannisbauer , Herminia Rodriguez
IPC分类号： C12P1/02 , C12N15/01 , C12N1/15
CPC分类号： C12P1/02 , C12N15/79 , C12P23/00
摘要： The present invention pertains to a method for the efficient production of carotenoids. In particular, the present invention is directed to a method for producing carotenoid and carotenoid-containing cells, especially astaxanthin and astaxanthin-containing cells, by generating mutant microorganisms belonging to the photoautotrophic algae of the Class Chlorophyceae and culturing same. The present invention further relates to methods of generating microorganisms producing high yields of carotenoids, in particular astaxanthin, products containing said microorganisms or said carotenoids, and the use of said carotenoids produced by the microorganisms according to the present invention and deposited mutant strains generated from said microorganisms.
摘要翻译：本发明涉及一种有效生产类胡萝卜素的方法。特别地，本发明涉及通过产生属于类绿藻的光自养藻类的突变微生物并进行培养的方法来生产含有类胡萝卜素和类胡萝卜素的细胞，特别是虾青素和含虾青素的细胞。本发明还涉及产生高产量的类胡萝卜素，特别是虾青素，含有所述微生物或所述类胡萝卜素的产品的微生物的生产方法，以及由本发明的微生物产生的所述类胡萝卜素的用途以及由所述微生物产生的沉积的突变菌株微生物。

5. 发明申请

US20070196893A1 Process for obtaining lutein from algae 失效
标题翻译：从藻类中获得叶黄素的方法
公开(公告)号：US20070196893A1
公开(公告)日：2007-08-23
申请号：US11651792
申请日：2007-01-10
申请人： Albrecht Weiss , Wilhelm Johannisbauer , Bernhard Gutsche , Baldomero Cordero , Lucia Martin , Herminia Rodriguez , M. Angeles Vargas , Irina Obraztsova
发明人： Albrecht Weiss , Wilhelm Johannisbauer , Bernhard Gutsche , Baldomero Cordero , Lucia Martin , Herminia Rodriguez , M. Angeles Vargas , Irina Obraztsova
IPC分类号： C07C35/18 , C12P23/00
CPC分类号： C12P23/00 , A23K20/179 , A23L5/46 , A23L33/105 , A61K8/9706 , A61K2800/522 , A61Q19/00
摘要： A process of obtaining lutein in a high yield from green algae is described. Lutein and lutein-enriched products obtained by the process, which are suitable for use as dietary supplements and/or food additives, or cosmetic or pharmaceutical raw materials, are also described.
摘要翻译：描述了从绿藻中获得高产量的叶黄素的方法。还描述了通过该方法获得的适合用作膳食补充剂和/或食品添加剂的化妆品或药物原料的叶黄素和富含叶黄素的产品。

6. 发明授权

US5646311A Recovery of tocopherols 失效
标题翻译：恢复生育酚
公开(公告)号：US5646311A
公开(公告)日：1997-07-08
申请号：US654483
申请日：1996-05-28
申请人： Tracy K. Hunt , Lutz Jeromin , Wilhelm Johannisbauer , Bernhard Gutsche , Volkmar Jordon , Herbert Wogatzki
发明人： Tracy K. Hunt , Lutz Jeromin , Wilhelm Johannisbauer , Bernhard Gutsche , Volkmar Jordon , Herbert Wogatzki
IPC分类号： B01J31/02 , B01J31/08 , C07C67/03 , C07C67/54 , C07D311/72 , C07C69/24
CPC分类号： C07D311/72 , C07C67/03 , C07C67/54
摘要： Starting from a mixture containing tocopherol, fats and/or fat derivatives, more particularly fatty acids, and optionally sterol and/or sterol derivatives, the free fatty acids present in the mixture are esterified with an alcohol. The mixture is then transesterified with an alcohol in the presence of a basic catalyst. After the transesterification, the excess lower alcohol is distilled off from the reaction mixture. The transesterification catalyst and the glycerol present, if any, are removed and the fatty acid alkyl ester is distilled off from the mixture. Distillation of fatty acid alkyl esters can be accomplished with a packed column in sequence with a wiped film evaporator. The simultaneous recovery of tocopherol and sterol is possible. Tocopherols and sterols can be separated by the crystallization of sterols from a blend of organic solvents.
摘要翻译：从含有生育酚，脂肪和/或脂肪衍生物，更特别是脂肪酸和任选的固醇和/或固醇衍生物的混合物开始，混合物中存在的游离脂肪酸被醇酯化。然后将混合物在碱性催化剂存在下用醇酯交换。酯交换后，从反应混合物中蒸馏出多余的低级醇。酯交换催化剂和存在的甘油（如果有的话）被除去，并从混合物中蒸出脂肪酸烷基酯。脂肪酸烷基酯的蒸馏可以用填充柱依次用擦膜蒸发器完成。生育酚和甾醇的同时回收是可能的。生育酚和甾醇可以通过固醇与有机溶剂的混合物的结晶分离。

7. 发明申请

US20070190595A1 Process for obtaining zeaxanthin from algae 审中-公开
标题翻译：从藻类中获得玉米黄质的方法
公开(公告)号：US20070190595A1
公开(公告)日：2007-08-16
申请号：US11650264
申请日：2007-01-05
申请人： Albrecht Weiss , Wilhelm Johannisbauer , Bernhard Gutsche , Baldomero Cordero , Lucia Martin , Herminia Rodriguez , M. Angeles Vargas , Irina Obraztsova
发明人： Albrecht Weiss , Wilhelm Johannisbauer , Bernhard Gutsche , Baldomero Cordero , Lucia Martin , Herminia Rodriguez , M. Angeles Vargas , Irina Obraztsova
IPC分类号： C12P1/00
CPC分类号： C12P23/00
摘要： A process of obtaining zeaxanthin in a high yield from blue-green algae is de-scribed. Zeaxanthin and zeaxanthin-enriched products obtained by the process, which are suitable for use as dietary supplements and/or food additives, are also described.
摘要翻译：描述了从蓝绿色藻类获得高产量的玉米黄质的方法。还描述了通过该方法获得的适合用作膳食补充剂和/或食品添加剂的玉米黄质和富含玉米黄质的产品。

8. 发明申请

US20050150380A1 Method for separating supercritical or near critical mixtures 失效
标题翻译：分离超临界或近临界混合物的方法
公开(公告)号：US20050150380A1
公开(公告)日：2005-07-14
申请号：US10511039
申请日：2003-04-02
申请人： Bernhard Gutsche , Wilhelm Johannisbauer , Harald Roessler , Magnus Topphoff
发明人： Bernhard Gutsche , Wilhelm Johannisbauer , Harald Roessler , Magnus Topphoff
IPC分类号： C07C29/76 , B01D19/00
CPC分类号： C07C29/76 , Y02P20/544 , C07C31/04 , C07C31/125 , C07C33/025
摘要： Processes for separating supercritical or near-critical mixtures containing hydrogen, a solvent gas, methanol and a fatty alcohol under an initial pressure of from 100 to 300 bar are described, wherein the processes comprise: (a) reducing the pressure of such a mixture in a first stage to a pressure of from 50 to 150 bar to form a first recycle gas and a first partially-separated intermediate mixture, wherein the reduced pressure in the first stage is at least below the initial pressure; (b) reducing the pressure of the first partially-separated intermediate mixture in a second stage to a pressure of from 10 to 50 bar to form a second recycle gas and a second partially-separated intermediate mixture; and (c) reducing the pressure of the second partially-separated intermediate mixture in a third stage to a pressure of from 1 to 10 bar to form a third recycle gas and a fatty alcohol product.
摘要翻译：描述了在100至300巴的初始压力下分离含有氢，溶剂气体，甲醇和脂肪醇的超临界或近临界混合物的方法，其中所述方法包括：（a）将这种混合物的压力降低第一阶段至50至150巴的压力以形成第一再循环气体和第一部分分离的中间体混合物，其中第一阶段中的减压至少低于初始压力; （b）将第二阶段中的第一部分分离的中间体混合物的压力降低至10至50巴的压力以形成第二再循环气体和第二部分分离的中间体混合物; 和（c）将第三阶段中的第二部分分离的中间体混合物的压力降低至1至10巴的压力以形成第三循环气体和脂肪醇产物。

9. 发明授权

US5627289A Recovery of tocopherol and sterol from tocopherol and sterol containing mixtures of fats and fat derivatives 失效
标题翻译：从生育酚和含有脂肪和脂肪衍生物混合物的固醇中回收生育酚和固醇
公开(公告)号：US5627289A
公开(公告)日：1997-05-06
申请号：US387933
申请日：1995-02-27
申请人： Lutz Jeromin , Wilhelm Johannisbauer , Bernhard Gutsche , Volkmar Jordan , Herbert Wogatzki
发明人： Lutz Jeromin , Wilhelm Johannisbauer , Bernhard Gutsche , Volkmar Jordan , Herbert Wogatzki
IPC分类号： A23L3/3544 , C07D311/72 , C07J9/00 , C07J75/00 , C11B3/02 , C11B7/00 , C11C3/10
CPC分类号： A23L3/3544 , C07D311/72
摘要： A process is provided for simultaneously recovering tocopherol and sterol from a mixture containing tocopherol, fats and/or fat derivatives, more particularly fatty acids, and sterol and/or sterol derivatives, more particularly from a steamer distillate of natural oils and fats. The steps of said process comprise:free fatty acids present in the mixture are esterified with a lower alcohol, preferably methanol, 0.4 to 1.6 and more particularly 1 to 1.5 parts by volume of mixture being esterified with 1 part by volume of the lower alcohol,the mixture is subsequently transesterified with the lower alcohol in the presence of a basic catalyst,the excess lower alcohol is distilled off from the reaction mixture after the transesterification,the transesterification catalyst and the glycerol optionally present are removed, more particularly by washing,the fatty acid alkyl ester is distilled off from the mixture, more particularly after removal of the transesterification catalyst, andif desired, tocopherol and sterol are separated by methods known per se. After the transesterification reaction, the alkali catalyst is preferably neutralized with an inorganic acid and the mixture is then washed with water.
摘要翻译： PCT No.PCT / EP93 / 02207 Sec。 371日期：1995年2月27日 102（e）1995年2月27日PCT PCT 1993年8月18日PCT公布。公开号WO94 / 00650 PCT 日期1994年5月17日提供了一种从含有生育酚，脂肪和/或脂肪衍生物，特别是脂肪酸和甾醇和/或固醇衍生物的混合物中同时回收生育酚和固醇的方法，更特别是来自天然油的蒸馏馏分和脂肪所述方法的步骤包括：混合物中存在的游离脂肪酸用低级醇优选甲醇酯化，优选甲醇为0.4至1.6，更特别为1至1.5体积份的混合物与1体积份低级醇酯化，该混合物随后在碱性催化剂的存在下与低级醇进行酯交换，在酯交换反应后，从反应混合物中蒸出过量的低级醇，任选存在的酯交换催化剂和甘油被去除，更特别是通过洗涤除去脂肪从混合物中蒸馏掉酸性烷基酯，更特别是在除去酯交换催化剂后，如果需要，通过本身已知的方法分离生育酚和固醇。酯交换反应后，碱催化剂优选用无机酸中和，然后将混合物用水洗涤。

10. 发明授权

US08357510B2 Process for obtaining lutein from algae 失效
标题翻译：从藻类中获得叶黄素的方法
公开(公告)号：US08357510B2
公开(公告)日：2013-01-22
申请号：US11651792
申请日：2007-01-10
申请人： Albrecht Weiss , Wilhelm Johannisbauer , Bernhard Gutsche , Baldomero F. Cordero , Lucia Martin , Herminia Rodriguez , M. Angeles Vargas , Irina Obraztsova
发明人： Albrecht Weiss , Wilhelm Johannisbauer , Bernhard Gutsche , Baldomero F. Cordero , Lucia Martin , Herminia Rodriguez , M. Angeles Vargas , Irina Obraztsova
IPC分类号： C12P23/00
CPC分类号： C12P23/00 , A23K20/179 , A23L5/46 , A23L33/105 , A61K8/9706 , A61K2800/522 , A61Q19/00
摘要： A process of obtaining lutein in a high yield from green algae is described. Lutein and lutein-enriched products obtained by the process, which are suitable for use as dietary supplements and/or food additives, or cosmetic or pharmaceutical raw materials, are also described.
摘要翻译：描述了从绿藻中获得高产量的叶黄素的方法。还描述了通过该方法获得的适合用作膳食补充剂和/或食品添加剂的化妆品或药物原料的叶黄素和富含叶黄素的产品。

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