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1. 发明授权

US06248841B1 Elastomer treatment process to decrease peroxide levels 有权
标题翻译：弹性体处理工艺降低过氧化物的含量
公开(公告)号：US06248841B1
公开(公告)日：2001-06-19
申请号：US09355693
申请日：1999-09-30
申请人： Karl M. Gelotte , Joseph D'Silva
发明人： Karl M. Gelotte , Joseph D'Silva
IPC分类号： C08F800
CPC分类号： C08F6/28 , C08F8/04 , C08F210/18 , C08F210/06 , C08F236/20
摘要： A novel process has been developed for the treatment of crosslinked ethylene-propylene diene monomer (EPDM) elastomer material to decrease its residual peroxide levels. EPDM is used to form the seats and neck gaskets of metering valves used in metered-dose inhalers (MDI). For filled and inverted MDI units these EPDM components are in direct contact with the pharmaceutical formulation media. The process involves exposing the EPDM valve components to a solution of 2-mercaptoethanol, a chemical reducing agent. The 2-mercaptoethanol greatly diminishes the residual peroxide levels in EPDM by reducing the peroxide functional groups to the corresponding hydroxyl groups. EPDM components treated in this manner have demonstrated very low peroxide levels and, consequently, greatly improved compatibility with the pharmaceutical formulation in the inhaler. An advantage of this approach is that the treated EPDM would likely retain its favorable physical properties and its good performance in metering valves. In this work 2-mercaptoethanol was used as the model reducing agent. It is believed, however, that similar positive results can be obtained using other reducing agents, notably other volatile compounds containing sulfur in one of its lower valence states (i.e. other thiol compounds or sulfur dioxide).
摘要翻译：已经开发了一种用于处理交联的乙烯 - 丙烯二烯单体（EPDM）弹性体材料以降低其剩余过氧化物水平的新方法。 EPDM用于形成用于计量吸入器（MDI）的计量阀座和颈垫。对于填充和倒置的MDI单元，这些EPDM组分与药物制剂介质直接接触。该方法包括将EPDM阀组件暴露于2-巯基乙醇（化学还原剂）的溶液中。 2-巯基乙醇通过将过氧化物官能团还原成相应的羟基，大大降低了EPDM中的过氧化物残余量。以这种方式处理的EPDM组分已经表现出非常低的过氧化物水平，因此显着提高了与吸入器中药物制剂的相容性。该方法的优点是经处理的EPDM可能保持其有利的物理性能和在计量阀中的良好性能。在这项工作中，使用2-巯基乙醇作为模型还原剂。然而，据信可以使用其它还原剂，特别是其中低价态硫（即其它硫醇化合物或二氧化硫）中含有硫的其它挥发性化合物可获得类似的阳性结果。

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