专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06531617B2 Process for preparing hydroxychomanones and cis-aminochromanols 失效
标题翻译：制备羟基胆碱和顺式氨基色甘醇的方法
公开(公告)号：US06531617B2
公开(公告)日：2003-03-11
申请号：US10001369
申请日：2001-10-24
申请人： Karl Hansen , Paul Devine , Philippe M. Rabbat
发明人： Karl Hansen , Paul Devine , Philippe M. Rabbat
IPC分类号： C07D31122
CPC分类号： C07D311/22
摘要： Enantiomerically enriched hydroxychromanones are obtained by the AlCl3-catalyzed intramolecular Friedel-Crafts acylation of the corresponding 3-phenoxy-2-alkylcarbonyloxy-propionic acid followed by cleavage of the carboxylate in the presence of an alkali metal peroxide or hydroperoxide. Enantiomerically enriched cis-aminochromanols can then be prepared by treating the hydroxychromanones with a hydroxylamine and hydrogenating the resulting oxime. The cis-aminochromanols can be employed as intermediates in the production of HIV protease inhibitors which are useful for treating HIV infection and AIDS.
摘要翻译：通过相应的3-苯氧基-2-烷基羰氧基 - 丙酸的AlCl 3催化的分子内Friedel-Crafts酰化，然后在碱金属过氧化物或氢过氧化物的存在下裂解羧酸酯，获得对映异构体富集的羟基色满酮。然后可以通过用羟胺处理羟基色满酮并氢化所得肟来制备对映异构体富集的顺式氨基色甘醇。顺式 - 氨基苯并二氢吡喃醇可用作生产可用于治疗HIV感染和艾滋病的HIV蛋白酶抑制剂的中间体。

2. 发明授权

US06384244B2 Process for preparing cis- aminochromanols 失效
标题翻译：顺式氨基色甘醇的制备方法
公开(公告)号：US06384244B2
公开(公告)日：2002-05-07
申请号：US09853796
申请日：2001-05-11
申请人： Ian Davies , Karl Hansen , Paul N. Devine , Louis Matty, Jr. , Yuan Cheng , Philippe M. Rabbat
发明人： Ian Davies , Karl Hansen , Paul N. Devine , Louis Matty, Jr. , Yuan Cheng , Philippe M. Rabbat
IPC分类号： C07D31104
CPC分类号： C07D311/68
摘要： cis-aminochromanols are obtained in high yield and with high selectivity over their trans counterparts by hydrogenating the corresponding oximes in the presence of a catalyst and an acid selected from HBr, HCl, and organic sulfonic acid. The cis-aminochromanols can be employed as intermediates in the production of HIV protease inhibitors which are useful for treating HIV infection and AIDS.
摘要翻译：通过在催化剂和选自HBr，HCl和有机磺酸的酸的存在下氢化相应的肟，以高产率和高反应性获得顺式 - 氨基色甘醇。顺式 - 氨基苯并二氢吡喃醇可用作生产可用于治疗HIV感染和艾滋病的HIV蛋白酶抑制剂的中间体。

3. 发明申请

US20080276412A1 External Filter Chamber 有权
标题翻译：外部过滤室
公开(公告)号：US20080276412A1
公开(公告)日：2008-11-13
申请号：US12043945
申请日：2008-03-06
申请人： Kurt Clarence Adelman , Karl Hansen
发明人： Kurt Clarence Adelman , Karl Hansen
IPC分类号： A47L9/10 , B01D39/00
CPC分类号： A47L11/4013 , A47L11/4027 , E01H1/0827
摘要： An external filter box for a surface maintenance machine having a hopper with selective communication being provided between the filter box and the hopper to permit dusty air to flow from the hopper to the filter box and to permit dust and debris captured by the filter box to flow into the hopper. In one example, the hopper includes a prefilter assembly which is coupled to an inlet of the filter box during a sweeping operation and which is removed away from the filter box during a hopper dump procedure.
摘要翻译：一种用于表面维护机的外部过滤箱，其具有在过滤箱和料斗之间具有选择性连通的料斗，以允许多尘的空气从料斗流入过滤箱，并允许由过滤箱捕获的灰尘和碎屑流动进入料斗。在一个示例中，料斗包括预过滤器组件，其在清扫操作期间联接到过滤箱的入口，并且在料斗倾倒过程期间将其从过滤箱中移走。

4. 发明申请

US20060287528A1 Novel crystalline forms of a phosphoric acid salt of a dipeptidyl peptidase-iv inhibitor 审中-公开
标题翻译：二肽基肽酶-IV抑制剂的磷酸盐的新型结晶形式
公开(公告)号：US20060287528A1
公开(公告)日：2006-12-21
申请号：US10569566
申请日：2004-08-27
申请人： Robert Wenslow , Joseph Armstrong , Alex Chen , Stephen Cypes , Russell Ferlita , Karl Hansen , Christopher Lindemann , Evangelia Spartalis
发明人： Robert Wenslow , Joseph Armstrong , Alex Chen , Stephen Cypes , Russell Ferlita , Karl Hansen , Christopher Lindemann , Evangelia Spartalis
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to crystalline anhydrate polymorphs of the dihydrogenphosphate salt of (2R)4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-α]pyrazin-7(8H) yl]-1-(2,4,5-trifluorophenyl)butan-2-amine as well as a process for their preparation, pharmaceutical compositions containing these novel forms, and methods of use of the novel forms and pharmaceutical compositions for the treatment of diabetes, obesity, and high blood pressure. The invention also concerns novel crystalline solvates of the dihydrogenphosphate salt of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]tria-zolo [4,3-α]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine as well as a crystalline desolvated polymorph and their use for the preparation of the anhydrate polymorphs of the present invention.
摘要翻译：本发明涉及（2R）-4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4]三唑并[4,3-a]吡嗪的磷酸二氢盐的晶体无水物多晶型物 -7（8H）基] -1-（2,4,5-三氟苯基）丁-2-胺以及它们的制备方法，含有这些新形式的药物组合物，以及新型形式和药物的使用方法用于治疗糖尿病，肥胖和高血压的组合物。本发明还涉及（2R）-4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4]三唑并[4,3-a]的磷酸二氢盐的新结晶溶剂合物 ]吡嗪-7（8H） - 基] -1-（2,4,5-三氟苯基）丁-2-胺以及晶体脱溶化多晶型物及其用于制备本发明的无水物多晶型物的用途。

5. 发明授权

US07662199B2 Cyclonic filter for surface maintenance machine 有权
标题翻译：表面维护机用旋转式过滤器
公开(公告)号：US07662199B2
公开(公告)日：2010-02-16
申请号：US12044874
申请日：2008-03-07
申请人： Richard William Wellens , Michael Thomas Basham , Karl Hansen
发明人： Richard William Wellens , Michael Thomas Basham , Karl Hansen
IPC分类号： B01D59/50
CPC分类号： B01D50/002 , A47L11/4013 , A47L11/4027 , B01D45/12 , B01D46/0075 , B01D46/2403 , B01D46/521 , B01D2279/55
摘要： A filter system for a surface maintenance machine having a hopper assembly for receiving brush-thrown debris including a cyclonic separator for separating dust and debris from air drawn through the hopper via vacuum action. The cyclonic separator may include multiple cyclone and may be in fluid communication with the hopper assembly so as to periodically receive dust and debris exiting the filter system.
摘要翻译：一种用于表面维护机器的过滤器系统，其具有用于接收刷子抛掷碎屑的料斗组件，所述料斗组件包括用于通过真空动作从通过料斗抽吸的空气分离灰尘和碎屑的旋风分离器。旋风分离器可以包括多个旋风分离器，并且可以与料斗组件流体连通，以便周期性地接收离开过滤器系统的灰尘和碎屑。

6. 发明授权

US06401608B1 Printing press with perfecting station 有权
标题翻译：印刷机与完善的车站
公开(公告)号：US06401608B1
公开(公告)日：2002-06-11
申请号：US09565319
申请日：2000-05-05
申请人： Donald F. Lyon , Roger D. Star , Karl Hansen , Michael I. Tilman , Salvatore DiRosa
发明人： Donald F. Lyon , Roger D. Star , Karl Hansen , Michael I. Tilman , Salvatore DiRosa
IPC分类号： B41F502
CPC分类号： B41F7/025 , B41F7/10 , B41F13/70 , B41F23/044
摘要： A printing press including a frame and a central impression drum rotatably supported on the frame. A plurality of first side printing stations is circumferentially spaced about the central impression drum and in communication therewith. Each of the plurality of printing first side printing stations is adapted to print an image on a first side of a substrate. A perfecting printing station is disposed at a position about the central impression drum. The perfecting printing station includes a multi-purpose drum having a substrate retainer for securing the substrate thereto. The multi-purpose drum forms an impression cylinder and is in communication with an image transfer cylinder for imparting an image on a second side of the substrate. An ink fixing unit is disposed between the first side printing stations and the perfecting station. The ink fixing unit fixes the image on the first side of the substrate prior to the image being imparted on the second side of the substrate by the perfecting station.
摘要翻译：一种印刷机，包括可旋转地支撑在框架上的框架和中央印版滚筒。多个第一侧印刷台围绕中央印版滚筒周向隔开并与之连通。多个打印第一侧打印站中的每一个适于在基板的第一侧上打印图像。一个完美的印刷站位于围绕中央印版滚筒的位置。完善的印刷站包括具有用于固定基板的基板保持器的多功能滚筒。多功能滚筒形成压印滚筒，并与图像传送滚筒连通，用于在基板的第二面上施加图像。油墨定影单元设置在第一侧印刷台和精加工台之间。油墨定影单元在通过精加工站在图像被施加到基板的第二侧之前将图像固定在基板的第一侧上。

7. 发明授权

US08099828B2 External filter chamber 有权
标题翻译：外部过滤室
公开(公告)号：US08099828B2
公开(公告)日：2012-01-24
申请号：US12043945
申请日：2008-03-06
申请人： Kurt Clarence Adelman , Karl Hansen
发明人： Kurt Clarence Adelman , Karl Hansen
IPC分类号： A47L9/10
CPC分类号： A47L11/4013 , A47L11/4027 , E01H1/0827
摘要： An external filter box for a surface maintenance machine having a hopper with selective communication being provided between the filter box and the hopper to permit dusty air to flow from the hopper to the filter box and to permit dust and debris captured by the filter box to flow into the hopper. In one example, the hopper includes a prefilter assembly which is coupled to an inlet of the filter box during a sweeping operation and which is removed away from the filter box during a hopper dump procedure.
摘要翻译：一种用于表面维护机的外部过滤箱，其具有在过滤箱和料斗之间具有选择性连通的料斗，以允许多尘的空气从料斗流入过滤箱，并允许由过滤箱捕获的灰尘和碎屑流动进入料斗。在一个示例中，料斗包括预过滤器组件，其在清扫操作期间联接到过滤箱的入口，并且在料斗倾倒过程期间将其从过滤箱中移走。

8. 发明授权

US07326708B2 Phosphoric acid salt of a dipeptidyl peptidase-IV inhibitor 有权
标题翻译：二肽基肽酶-IV抑制剂的磷酸盐
公开(公告)号：US07326708B2
公开(公告)日：2008-02-05
申请号：US10874992
申请日：2004-06-23
申请人： Stephen Howard Cypes , Alex Minhua Chen , Russell R. Ferlita , Karl Hansen , Ivan Lee , Vicky K. Vydra , Robert M. Wenslow, Jr.
发明人： Stephen Howard Cypes , Alex Minhua Chen , Russell R. Ferlita , Karl Hansen , Ivan Lee , Vicky K. Vydra , Robert M. Wenslow, Jr.
IPC分类号： A61K31/495 , C07D471/04
CPC分类号： C07D487/04
摘要： The dihydrogenphosphate salt of 4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine is a potent inhibitor of dipeptidyl peptidase-IV and is useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as type 2 diabetes. The invention also relates to a crystalline monohydrate of the dihydrogenphosphate salt as well as a process for its preparation, pharmaceutical compositions containing this novel form and methods of use for the treatment of diabetes, obesity, and high blood pressure.
摘要翻译： 4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4]三唑并[4,3-a]吡嗪-7（8H） - 基] -1-（ 2,4,5-三氟苯基）丁-2-胺是二肽基肽酶-IV的有效抑制剂，可用于预防和/或治疗非胰岛素依赖性糖尿病，也称为2型糖尿病。本发明还涉及磷酸二氢盐的结晶一水合物及其制备方法，含有这种新型形式的药物组合物和用于治疗糖尿病，肥胖症和高血压的方法。

9. 发明申请

US20080271420A1 Cyclonic Filter For Surface Maintenance Machine 有权
标题翻译：表面维护机用旋风过滤器
公开(公告)号：US20080271420A1
公开(公告)日：2008-11-06
申请号：US12044874
申请日：2008-03-07
申请人： Richard William Wellens , Michael Thomas Basham , Karl Hansen
发明人： Richard William Wellens , Michael Thomas Basham , Karl Hansen
IPC分类号： B01D50/00
CPC分类号： B01D50/002 , A47L11/4013 , A47L11/4027 , B01D45/12 , B01D46/0075 , B01D46/2403 , B01D46/521 , B01D2279/55
摘要： A filter system for a surface maintenance machine having a hopper assembly for receiving brush-thrown debris including a cyclonic separator for separating dust and debris from air drawn through the hopper via vacuum action. The cyclonic separator may include multiple cyclone and may be in fluid communication with the hopper assembly so as to periodically receive dust and debris exiting the filter system.
摘要翻译：一种用于表面维护机器的过滤器系统，其具有用于接收刷子抛掷碎屑的料斗组件，所述料斗组件包括用于通过真空动作从通过料斗抽吸的空气分离灰尘和碎屑的旋风分离器。旋风分离器可以包括多个旋风分离器，并且可以与料斗组件流体连通，以便周期性地接收离开过滤器系统的灰尘和碎屑。

10. 发明申请

US20080227786A1 Novel Crystalline Salts of a Dipeptidyl Peptidase-IV Inhibitor 审中-公开
标题翻译：二肽基肽酶-IV抑制剂的新型结晶盐
公开(公告)号：US20080227786A1
公开(公告)日：2008-09-18
申请号：US10585603
申请日：2005-01-12
申请人： Russell R. Ferlita , Karl Hansen , Vicky K. Vydra , Yaling Wang , Christopher M. Lindemann
发明人： Russell R. Ferlita , Karl Hansen , Vicky K. Vydra , Yaling Wang , Christopher M. Lindemann
IPC分类号： A61K31/4985 , C07D487/02 , A61P3/10
CPC分类号： C07D487/04
摘要： Novel crystalline salts of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-&agr; amine are potent inhibitors of dipeptidyl peptidase-IV and are useful for the treatment of non-insulin dependent (Type 2) diabetes mellitus. The invention also relates to pharmaceutical compositions containing these novel salts, processes to prepare these salts and their pharmaceutical compositions as well as uses thereof for the treatment of Type 2 diabetes.
摘要翻译：（2R）-4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4]三唑并[4,3-a]吡嗪-7（8H） - 基] -1-（2,4,5-三氟苯基）丁烷-2-α胺是二肽基肽酶-IV的有效抑制剂，可用于治疗非胰岛素依赖型（2型）糖尿病。本发明还涉及含有这些新型盐的药物组合物，制备这些盐的方法及其药物组合物及其用于治疗2型糖尿病的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式