专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090017011A1 MODULATION OF VEGF-C/VEGFR-3 INTERACTIONS IN THE TREATMENT OF RHEUMATOID ARTHRITIS 审中-公开
标题翻译： VEGF-C / VEGFR-3相互作用在治疗恶病质中的调节作用
公开(公告)号：US20090017011A1
公开(公告)日：2009-01-15
申请号：US12139102
申请日：2008-06-13
申请人： Kari Alitalo , Karri Paavonen , Yrjo Konttinen
发明人： Kari Alitalo , Karri Paavonen , Yrjo Konttinen
IPC分类号： A61K39/395 , A61K38/02 , A61K38/16 , A61K31/7088 , A61P19/02
CPC分类号： C07K16/2863 , A61K2039/505 , G01N33/74
摘要： The present invention relates to methods for treating an individual exhibiting symptoms of chronic arthridites, as identified by an elevated level of VEGF-C expression at synovial sites, and provides materials and methods for the modulation of VEGF-C/VEGFR-3 ligand-receptor interactions as a treatment for chronic arthridites.
摘要翻译：本发明涉及通过在滑膜部位升高的VEGF-C表达水平鉴定的慢性arthridite症状的个体的治疗方法，并且提供调节VEGF-C / VEGFR-3配体受体的材料和方法相互作用作为慢性arthridites的治疗。

2. 发明申请

US20070224194A1 Methods for Inhibiting Angiogenesis and/or Lymphangiogenesis 审中-公开
标题翻译：抑制血管生成和/或淋巴管生成的方法
公开(公告)号：US20070224194A1
公开(公告)日：2007-09-27
申请号：US11566195
申请日：2006-12-01
申请人： Bradley McColl , Steven Stacker , Marc Achen , Karri Paavonen
发明人： Bradley McColl , Steven Stacker , Marc Achen , Karri Paavonen
IPC分类号： A61K31/7052 , A61K39/395
CPC分类号： C07K14/4703 , C07K5/1027 , C12N15/113
摘要： Proprotein convertase inhibitor has been found to block proteolytic processing and activation of VEGF-C and VEGF-D and inhibit angiogenesis and/or lymphangiogenesis. Method and composition are disclosed for inhibiting angiogenesis and/or lymphangiogenesis, and for treating conditions associated with excessive angiogenesis, such as tumors and/or retinopathies, as well as conditions associated with lymphangiogenesis, such as the metastatic spread of malignancies, macular degeneration, inflammatory mediated diseases, rheumatoid arthritis, diabetic retinopathy and psoriasis in a patient. The inventive method and composition utilize proprotein convertase antagonist selected from the group consisting of an anti-proprotein convertase antibody, an antisense nucleic acid molecule against a polynucleotide coding for a proprotein convertase, and an siRNA for inhibiting proprotein convertase expression, as well as proprotein convertase inhibitors.
摘要翻译：已经发现前蛋白转化酶抑制剂阻断VEGF-C和VEGF-D的蛋白水解加工和活化并抑制血管生成和/或淋巴管生成。公开了用于抑制血管发生和/或淋巴管生成的方法和组合，以及用于治疗与过度血管发生相关的病症，例如肿瘤和/或视网膜病变，以及与淋巴管生成相关的病症，例如恶性肿瘤的转移性扩散，黄斑变性，炎性介导的疾病，类风湿性关节炎，糖尿病性视网膜病变和银屑病。本发明的方法和组合物使用选自抗前体蛋白转化酶抗体，针对编码前蛋白转化酶的多核苷酸的反义核酸分子和用于抑制前蛋白转化酶表达的siRNA以及前蛋白转化酶抑制剂。

3. 发明申请

US20070212390A1 Protease-resistant forms of VEGF-D, method of making and method of use 审中-公开
标题翻译：蛋白酶抗性形式的VEGF-D，制备方法和使用方法
公开(公告)号：US20070212390A1
公开(公告)日：2007-09-13
申请号：US11517290
申请日：2006-09-08
申请人： Karri Paavonen , Steven Stacker , Marc Achen
发明人： Karri Paavonen , Steven Stacker , Marc Achen
IPC分类号： A61K38/18 , C07K14/475 , C07H21/04 , C12P21/06
CPC分类号： C07K14/52
摘要： The present invention provides modified VEGF-D polypeptide variants that are resistant to serine protease processing and methods of making and using the same, as well pharmaceutical compositions comprising the peptide or a polynucleotide encoding the same. The VEGF-D variants comprise a VEGF homology domain, and at least one of (1) a C-terminal propeptide that is not cleavable by a serine protease, and (2) an N-terminal propeptide that is not cleavable by a serine protease. The VEGF-D variants can be made using site-directed mutagenesis. The VEGF-D variants are useful for the treatment of diseases such as cardiovascular disease and primary and secondary lymphedema, and for the prevention of stenosis and restenosis of blood vessels.
摘要翻译：本发明提供了对丝氨酸蛋白酶加工具有抗性的修饰的VEGF-D多肽变体及其制备和使用方法，以及包含该肽或编码该肽的多核苷酸的药物组合物。 VEGF-D变体包含VEGF同源结构域，和（1）不能被丝氨酸蛋白酶切割的C-末端前肽中的至少一种，和（2）不能被丝氨酸蛋白酶切割的N-末端前肽。 VEGF-D变体可以使用定点突变来制备。 VEGF-D变体可用于治疗诸如心血管疾病和原发性和继发性淋巴水肿的疾病，以及用于预防血管狭窄和再狭窄。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式