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1. 发明授权

US4529582A Titration of group C streptococcal antibody 失效
标题翻译： C组链球菌抗体滴定
公开(公告)号：US4529582A
公开(公告)日：1985-07-16
申请号：US454908
申请日：1982-12-30
申请人： Karen K. Brown , Sharon A. Bryant
发明人： Karen K. Brown , Sharon A. Bryant
IPC分类号： A61K49/00 , G01N33/569 , G01N33/48 , G01N33/54
CPC分类号： A61K49/00 , G01N33/56944
摘要： Group C streptococcal antibody levels in a serum sample can be determined via passive protection test in susceptible animals. Test is based on property of protective antibody in the serum sample to reduce the virulence of a group C streptococcal challenge and provides a means for detecting whether an animal (e.g. horse) is susceptible to infection by group C streptococcal organism.
摘要翻译：血清样品中C组链球菌抗体水平可以通过易感动物的被动保护试验来测定。测试基于血清样品中保护性抗体的性质，以降低C组链球菌攻击的毒力，并提供检测动物（例如马）是否易受C组链球菌生物感染的方法。

2. 发明授权

US5316926A Method for the microbiological production of non-antigenic hyaluronic acid 失效
标题翻译：非抗原性透明质酸微生物生产方法
公开(公告)号：US5316926A
公开(公告)日：1994-05-31
申请号：US796178
申请日：1991-11-22
申请人： Karen K. Brown , Linda L. C. Ruiz , Ivo van de Rijn , Nathan D. Greene , Sandy L. Trump , Curtis D. Wilson , Sharon A. Bryant
发明人： Karen K. Brown , Linda L. C. Ruiz , Ivo van de Rijn , Nathan D. Greene , Sandy L. Trump , Curtis D. Wilson , Sharon A. Bryant
IPC分类号： C08B37/08 , C12P19/26 , G12P19/04 , G12N15/01 , G12N1/20
CPC分类号： C08B37/0072 , C12P19/26 , Y10S435/885
摘要： The present disclosure is concerned with the production of high molecular weight hyaluronic acid suitable for medicinal administration to mammals without provoking an immune response from microbiological fermentation. The cultures may be prepared from specially developed strains of hyaluronic acid generating bacteria obtained by passaging in serologically negative host animal blood. The cultures are kept in log phase growth for an extended period by appropriate temperature, pH and glucose content adjustments. If the cultured strain is not hyaluronidase negative the hyaluronidase activity is inhibited. The hyaluronic acid is precipitated from the culture by the sequential addition of an anionic surfactant and then a cationic surfactant and extended from the precipitate with a high molarity aqueous calcium ion solution. The isolated aqueous hyaluronic acid solution may then be purified by passage through a nitrocellulose filter. Its pyrogenicity may be alleviated by treatment with a strong acid washed activated carbon.
摘要翻译：本公开涉及适合于向哺乳动物药物施用而不引起微生物发酵的免疫应答的高分子量透明质酸的生产。培养物可以通过在血清学阴性宿主动物血液中传代获得的特别开发的透明质酸产生细菌菌株制备。通过适当的温度，pH和葡萄糖含量调节，培养物长时间保持对数期生长。如果培养的菌株不是透明质酸酶阴性，则透明质酸酶活性被抑制。透明质酸通过依次加入阴离子表面活性剂然后阳离子表面活性剂并从沉淀物中以高摩尔浓度的钙离子溶液延伸从培养物中沉淀出来。然后可以通过穿过硝酸纤维素过滤器来纯化分离的透明质酸水溶液。其致热原性可以通过用强酸洗涤的活性炭处理来缓解。

3. 发明授权

US4944942A Intranasal vaccination of horses with inactivated microorganisms or antigenic material 失效
标题翻译：用灭活的微生物或抗原物质对马进行鼻内接种
公开(公告)号：US4944942A
公开(公告)日：1990-07-31
申请号：US90272
申请日：1987-08-27
申请人： Karen K. Brown , Sharon A. Bryant
发明人： Karen K. Brown , Sharon A. Bryant
IPC分类号： A61K39/02 , A61K9/00 , A61K9/72 , A61K39/09 , A61K39/145 , A61K39/295 , A61P31/04
CPC分类号： A61K9/0043 , A61K39/092 , A61K2039/521 , A61K2039/543 , A61K2039/552 , A61K2039/55511 , A61K2039/55555 , A61K2039/55583 , Y10S424/829
摘要： Horses can be immunized by the intranasal administration of antigenic material which provokes the proliferation of antibodies which reduce or neutralize the virulence of invasive microorganisms. These antigenic materials may be inactivated whole organisms, extracts from such organisms, or recombinant DNA or synthetic peptide antigens. This antigenic material can be combined with adjuvants and transdermal carriers or it can just be carried in sterile water. The intranasal vaccination may be part of a total regimen that includes other routes of administration such as intramuscular injection.
摘要翻译：可以通过鼻内施用抗原材料来免疫马，其会引起减少或中和侵入性微生物毒力的抗体增殖。这些抗原性材料可以是灭活的全生物，这些生物的提取物，或重组DNA或合成肽抗原。这种抗原性材料可以与佐剂和透皮载体组合，也可以在无菌水中携带。鼻内接种可以是包括其它给药途径如肌内注射的总方案的一部分。

4. 发明授权

US4582798A Preparation and use of enzyme-detergent extracted Streptococcus equi vaccine 失效
标题翻译：制备和使用酶洗涤剂提取的马链球菌疫苗
公开(公告)号：US4582798A
公开(公告)日：1986-04-15
申请号：US674449
申请日：1984-11-23
申请人： Karen K. Brown , Sharon A. Bryant , Kenneth S. Lewis
发明人： Karen K. Brown , Sharon A. Bryant , Kenneth S. Lewis
IPC分类号： C12N1/20 , A61K20060101 , A61K39/09 , C07K14/005 , C07K14/195 , C07K14/41 , C12N1/06 , C12P21/00 , C12P21/08
CPC分类号： A61K39/092 , Y10S435/885 , Y10S530/806 , Y10S530/825
摘要： Immunogenic protein material obtained from Streptococcus equi bacteria via enzymatic digestion and detergent treatment and useful as a vaccine.
摘要翻译：通过酶消化和洗涤剂处理从马链球菌获得的免疫原性蛋白质材料，可用作疫苗。

5. 发明授权

US06387378B1 Device for storage and mucosal delivery of biological or pharmaceutical materials to animals 失效
标题翻译：用于将生物或药物材料储存和粘膜递送给动物的装置
公开(公告)号：US06387378B1
公开(公告)日：2002-05-14
申请号：US08118905
申请日：1993-09-09
申请人： George P. Shibley , Karen K. Brown , Leszek J. Choromanski , Sharon A. Bryant
发明人： George P. Shibley , Karen K. Brown , Leszek J. Choromanski , Sharon A. Bryant
IPC分类号： A61K39012
CPC分类号： A61D7/00
摘要： Disclosed herein is a device for storing and/or delivering an effective amount of biological or pharmaceutical material to an animal comprising a tube disposed to contain said biological or pharmaceutical material and sealed at its ends and adapted to provide an opening through which the biological or pharmaceutical material exits and is administered to an intended site of the animal.
摘要翻译：本文公开了一种用于向动物存储和/或递送有效量的生物或药物材料的装置，包括设置为容纳所述生物或药物材料并且在其端部密封并适于提供开口的管，生物或药物材料出口并施用于动物的预期部位。

6. 发明授权

US5583014A Preparation and use of enzyme-detergent extracted Streptococcus zoopidemicus vaccine 失效
标题翻译：制备和使用酶洗涤剂提取的链球菌疫苗
公开(公告)号：US5583014A
公开(公告)日：1996-12-10
申请号：US547733
申请日：1990-07-03
申请人： Karen K. Brown , Sharon A. Bryant , Richard C. Stewart , Richard E. Parizek
发明人： Karen K. Brown , Sharon A. Bryant , Richard C. Stewart , Richard E. Parizek
IPC分类号： A61K39/09 , C12N1/20 , C12P21/00
CPC分类号： A61K39/092 , Y10S435/885 , Y10S530/806 , Y10S530/826
摘要： A vaccine effective against S. zooepidemicus-caused infections is made by enzymatic digestion of S. zooepidemicus and subsequent detergent treatment of the product of this digestion. The antigenic material thus obtained is then combined with an appropriate adjuvant.
摘要翻译：通过酶消化动物疫苗和随后的消化产物的洗涤剂处理，可以有效地对动物疫苗引起的感染的疫苗。然后将由此获得的抗原物质与合适的佐剂组合。

7. 发明授权

US4529581A Determining potency of streptococcal preparations 失效
标题翻译：测定链球菌制剂的效力
公开(公告)号：US4529581A
公开(公告)日：1985-07-16
申请号：US454906
申请日：1982-12-30
申请人： Karen K. Brown , Sharon A. Bryant
发明人： Karen K. Brown , Sharon A. Bryant
IPC分类号： G01N33/569 , A61K49/00 , G01N33/48 , G01N33/54
CPC分类号： G01N33/56944
摘要： Antigenicity of streptococcal preparations useful for inducing anti-streptococcal immunity in animals can be determined using a combining power technique. Method involves incubating serial dilutions of the antigen preparation with known amounts of anti-streptococcal antiserum, thereby lessening, in serial manner, the combining power of the antiserum. The serial reaction products are then incubated with serial dilutions of streptococcal preparations having known activity and the effects of the serial reaction products on such activity are then determined by in vivo means. Those determinations can be related to a standard for determining potency of the streptococcal preparation. Assay technique is especially useful in determining potency of Streptococcus equi bacterins or bacterin derivatives.
摘要翻译：用于诱导动物中抗链球菌免疫的链球菌制剂的抗原性可以使用组合功能技术来确定。方法包括用已知量的抗链球菌抗血清孵育抗原制剂的系列稀释液，从而以一致的方式减少抗血清的结合力。然后将连续反应产物与具有已知活性的链球菌制剂的系列稀释液一起温育，然后通过体内方法测定连续反应产物对这种活性的影响。这些测定可以与确定链球菌制剂效力的标准相关。测定技术在确定马链球菌或菌苗衍生物的效力方面特别有用。

8. 发明授权

US5093487A Low viscosity high molecular weight filter sterilizable hyaluronic acid 失效
标题翻译：低粘度高分子量过滤器无菌的羟丙酸
公开(公告)号：US5093487A
公开(公告)日：1992-03-03
申请号：US816548
申请日：1986-01-06
申请人： Karen K. Brown , Nathan D. Greene , Sandy L. Trump , Sharon A. Bryant
发明人： Karen K. Brown , Nathan D. Greene , Sandy L. Trump , Sharon A. Bryant
IPC分类号： C08B37/08
CPC分类号： C08B37/0072
摘要： The present disclosure is concerned with procedures for adjusting the average molecular weight, the molecular weight distribution and the viscosity in solution of hyaluronic acid and its salts (HA), particularly its sodium and potassium salts. The average molecular weight can be increased and the molecular weight distribution can be narrowed by precipitating this material into a bath of a non-solvent containing a continuously moving device to which it can adhere as it precipitates. The solution viscosity of this or any high molecular weight, high viscosity HA can be reduced without substantially effecting its molecular weight by either a moderate temperature heat treatment or passage through a fine (one micron or less) pore filter as a one weight percent or stronger aqueous solution. The disclosure is also concerned with the high molecular weight low solution viscosity HA so obtained.
摘要翻译：本公开涉及调节透明质酸及其盐（HA）的溶液中的平均分子量，分子量分布和粘度的方法，特别是其钠盐和钾盐。可以增加平均分子量并且通过将该材料沉淀到含有其沉淀时可以粘附的连续移动装置的非溶剂的浴中而使分子量分布变窄。这种或任何高分子量，高粘度的HA的溶液粘度可以通过中等温度热处理或通过细（1微米或更小）的孔过滤器作为一重量百分比或更强而基本上不影响其分子量而降低水溶液。本公开还涉及如此获得的高分子量低溶液粘度HA。

9. 发明授权

US5053022A Applicator for intranasal administration of vaccines to horses 失效
标题翻译：针对马的疫苗鼻内给药者
公开(公告)号：US5053022A
公开(公告)日：1991-10-01
申请号：US546210
申请日：1990-06-28
申请人： Sharon A. Bryant , Karen K. Brown , Richard E. Parizek , Larry F. Moore , Louis J. Travalent
发明人： Sharon A. Bryant , Karen K. Brown , Richard E. Parizek , Larry F. Moore , Louis J. Travalent
IPC分类号： A61D7/00
CPC分类号： A61D7/00
摘要： A device for administering antigenic material to a horse intranasally. This device is composed of a hollow tube and a blocking device. The hollow tube is long enough to reach the tonsilor tissue of a horse. This tube has a sealed end and a tapered open end. At least one opening, preferably openings along the length of this tube are positioned in a manner such that antigenic material which exits through them will reach the tonsilor tissue of the horse. The blocking device sits on the hollow tube at the point where the tapering of the open end begins. A syringe containing antigenic material is positioned at the tapered open end of the hollow tube and the antigenic material is then released in the form of small droplets on the tonsilor tissue of the horse.
摘要翻译：用于向鼻内施用抗原材料的装置。该装置由中空管和阻塞装置组成。中空管足够长以到达马的扁桃体组织。该管具有密封端和锥形开口端。至少一个开口，优选沿着该管的长度的开口被定位成使得通过它们离开的抗原材料将到达马的扁桃体组织。阻塞装置位于开口端逐渐变细的点处的中空管上。含有抗原材料的注射器位于中空管的锥形开口端，然后抗原物质以小液滴的形式在马的扁桃体组织上释放。

10. 发明授权

US09913906B2 Hyaluronic acid stabilizer 有权
公开(公告)号：US09913906B2
公开(公告)日：2018-03-13
申请号：US14995325
申请日：2016-01-14
申请人： Karen K. Brown
发明人： Karen K. Brown
IPC分类号： A61K31/728 , A61K47/12 , C08B37/08 , A61K9/00 , A61K47/02 , A61K9/06 , C08L5/08 , A61K8/04 , A61K8/365 , A61K8/73 , A61K9/08 , A61Q11/00 , A61Q19/00 , A61K47/22 , A61K47/46
CPC分类号： A61K47/12 , A61K8/042 , A61K8/365 , A61K8/735 , A61K9/0014 , A61K9/06 , A61K9/08 , A61K31/728 , A61K47/02 , A61K47/22 , A61K47/46 , A61K2800/524 , A61Q11/00 , A61Q19/00 , C08B37/0072 , C08L5/08
摘要： An embodiment of the present disclosure provides a composition that comprises hyaluronic acid, or its salt or derivative thereof, and an antimicrobial agent, such as zinc citrate, that does not degrade the hyaluronic acid molecule.

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