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1. 发明授权

US4545993A 1,2-Benzopyran-6-yl acetic acid compound and pharmaceutical compositions containing said compounds 失效
标题翻译： 1,2-苯并吡喃-6-基乙酸化合物和含有所述化合物的药物组合物
公开(公告)号：US4545993A
公开(公告)日：1985-10-08
申请号：US400029
申请日：1982-07-20
申请人： Kaoru Okamoto , Masaki Hamada , Teikichi Kurosaki
发明人： Kaoru Okamoto , Masaki Hamada , Teikichi Kurosaki
IPC分类号： A61K31/35 , A61K31/352 , A61P25/04 , A61P29/00 , C07D311/58 , C07D311/64 , C07D409/06 , C07D311/70
CPC分类号： C07D409/06 , C07D311/58 , C07D311/64
摘要： Heterocyclic compounds comprising the formula (I): ##STR1## wherein: R.sub.1, R.sub.2, R.sub.4 and R.sub.5 each are hydrogen or a lower alkyl group;R.sub.3 is hydrogen, a halogen, an alkyl group, a haloalkyl group, an alkoxy group, an alkenyl group, an alkenyloxy group, an aryl group, an aryloxy group, an acyl group or a nitro group;and the broken line connotes a single or double bond at the C.sub.3 -C.sub.4 position, provided that when the broken line connotes a single bond, R.sub.3 is other than hydrogen; and pharmaceutically acceptable salts thereof,exhibiting antiinflammatory, antipyretic and analgesic action.
摘要翻译：包含式（I）的杂环化合物：其中：R 1，R 2，R 4和R 5各自为氢或低级烷基; R3是氢，卤素，烷基，卤代烷基，烷氧基，烯基，烯氧基，芳基，芳氧基，酰基或硝基; 且虚线表示在C3-C4位置的单键或双键，条件是当虚线表示单键时，R 3不是氢; 和其药学上可接受的盐，具有抗炎，解热和镇痛作用。

2. 发明授权

US4189474A Dextrin hydroxycarboxylato polyiron (III) olated complex and process for the manufacture thereof 失效
标题翻译：糊精羟基羧酸酯多铁（III）复合物及其制备方法
公开(公告)号：US4189474A
公开(公告)日：1980-02-19
申请号：US755649
申请日：1976-12-30
申请人： Teikichi Kurosaki , Kanzo Ohta , Hirohide Matsuura , Katsumi Sawada
发明人： Teikichi Kurosaki , Kanzo Ohta , Hirohide Matsuura , Katsumi Sawada
IPC分类号： A61K31/19 , A61K31/715 , A61K33/26 , A61P7/06 , C08B31/00 , C08B37/16 , C08B37/02
CPC分类号： C08B31/00 , A61K31/715 , C08B37/0012 , Y10S514/814
摘要： The present invention is directed to an iron complex used in treatment of iron-deficiency anemia. The complex is formed by reacting a reactive polyiron (III) olated compound with dextrin and at least one hydroxycarboxylic acid. A dextrin-hydroxycarboxylato-polyiron (III) olated complex is produced. The reaction product contains substantially no free iron. Iron concentration is between about 35 and 47%. The complex can be administered non-orally.The compound of the subject invention has advantages over prior art compounds. Specifically, the subject complex has a high iron content, is thermally stable, and can be preserved. It may be administered intravenously without accumulating in the blood of an animal or damaging its tissue. No serious side effects result from use of the subject complex.
摘要翻译：本发明涉及用于治疗缺铁性贫血的铁络合物。络合物通过使反应性聚铁（III）醇化化合物与糊精和至少一种羟基羧酸反应形成。产生糊精 - 羟基羧基 - 多铁（III）络合物。反应产物基本上不含有游离铁。铁浓度介于约35％至47％之间。复合物可以非口服给药。本发明的化合物具有优于现有技术化合物的优点。具体地说，本发明复合物具有高铁含量，是热稳定的并且可以被保存。它可以静脉内施用而不积聚在动物的血液中或损坏其组织。没有使用主题复合物造成严重的副作用。

3. 发明授权

US3946012A 6-L-dihydroxyethyl-2,4,7-trioxo-8-D-ribityl pteridine and process for producing the same 失效
标题翻译： 6-L-二羟乙基-2,4,7-三氧代-8-D-核苷基蝶啶及其制备方法
公开(公告)号：US3946012A
公开(公告)日：1976-03-23
申请号：US396810
申请日：1973-09-13
申请人： Masuichi Takino , Teikichi Kurosaki , Munehiko Odaka
发明人： Masuichi Takino , Teikichi Kurosaki , Munehiko Odaka
IPC分类号： A61K31/505 , A61K31/519 , A61P25/04 , A61P29/00 , C07D475/02
CPC分类号： C07D475/02
摘要： Trioxopteridine derivatives of the formula ##SPC1##, wherein R.sub.1 is a normal alkyl group having 0 to 6 hydroxyl groups and R.sub.2 is hydrogen or a normal lower alkyl group having 0 to 5 hydroxyl groups, are prepared by catalytically hydrogenating a 6-substituted-5-nitro-2,4-dioxopyrimidine to give a 6-substituted-5-amino-2,4-dioxopyrimidine, and then reacting the latter compound with a compound of the formula R.sub.2 --A--COOR.sub.3, wherein R.sub.3 is hydrogen, lower alkyl, an alkali metal or an alkaline earth metal and A is carbonyl or a group of the formula ##EQU1## wherein R.sub.4 is lower alkyl. The resulting trioxopteridine derivatives have analgesic and antiphlogistic properties and are therefore useful as pharmaceutical medicaments.
摘要翻译：通过催化氢化6-取代-5-硝基哒嗪衍生物，其中R1是具有0至6个羟基的正烷基，R2是氢或具有0至5个羟基的正常低级烷基， 2,4-二氧代嘧啶，得到6-取代-5-氨基-2,4-二氧代嘧啶，然后使后一化合物与式R2-A-COOR3的化合物反应，其中R3是氢，低级烷基，碱金属或碱土金属，A是羰基或式| R4O-C-OH的基团，其中R4是低级烷基。所得的三氟opter啶衍生物具有止痛和消炎性质，因此可用作药物药物。

4. 发明授权

US4277474A Treatment of allergic symptoms with propanone derivatives 失效
标题翻译：用丙酮衍生物治疗过敏症状
公开(公告)号：US4277474A
公开(公告)日：1981-07-07
申请号：US79460
申请日：1979-09-27
申请人： Akihide Kohda , Teikichi Kurosaki
发明人： Akihide Kohda , Teikichi Kurosaki
IPC分类号： A61K31/535 , A61K31/135 , A61K31/40 , A61K31/445 , A61K31/452 , A61K31/495 , A61K31/5375 , A61P11/00 , A61P17/00 , A61P27/16 , A61P37/08 , A61P43/00 , C07C221/00 , C07C225/16 , C07C225/18 , C07D211/14 , C07D227/04 , C07D265/30 , C07D295/10 , C07D295/104 , C07D295/108 , C07D333/56 , C07D333/58
CPC分类号： C07D295/108 , C07D295/104 , C07D333/58 , Y10S514/826 , Y10S514/861
摘要： New propanone derivatives, useful for treating allergic diseases, the pharmacologically allowable salts thereof, their manufacturing process and pharmaceutical composition containing at least one of them as the active ingredient.
摘要翻译：用于治疗过敏性疾病的新的丙酮衍生物，其药理学上允许的盐，其制备方法和含有至少一种作为活性成分的药物组合物。

5. 发明授权

US4046893A Trioxopteridine derivatives suitable as medicament 失效
标题翻译：适合作为药物的三氟opter啶衍生物
公开(公告)号：US4046893A
公开(公告)日：1977-09-06
申请号：US650749
申请日：1976-01-20
申请人： Masuichi Takino , Teikichi Kurosaki , Munehiko Odaka
发明人： Masuichi Takino , Teikichi Kurosaki , Munehiko Odaka
IPC分类号： A61K31/505
摘要： Trioxopteridine derivatives of the formula ##STR1## , wherein R.sub.1 is a normal alkyl group having 0 to 6 hydroxyl groups and R.sub.2 is hydrogen or a normal lower alkyl group having 0 to 5 hydroxyl groups, are prepared by catalytically hydrogenating a 6-substituted-5-nitro-2,4-dioxopyrimidine to give a 6-substituted-5-amino-2,4-dioxopyrimidine, and then reacting the latter compound with a compound of the formula R.sub.2 --A--COOR.sub.3, wherein R.sub.3 is hydrogen, lower alkyl, an alkali metal or an alkaline earth metal and A is carbonyl or a group of the formula ##STR2## wherein R.sub.4 is lower alkyl. The resulting trioxopteridine derivatives have analgesic and antiphlogistic properties and are therefore useful as pharmaceutical medicaments.
摘要翻译：其中R1是具有0至6个羟基并且R2是氢的正烷基或具有0至5个羟基的正常低级烷基，其通过催化氢化6-取代-5 - 硝基-2,4-二氧代嘧啶，得到6-取代-5-氨基-2,4-二氧代嘧啶，然后使后一化合物与式R2-A-COOR3的化合物反应，其中R3是氢，低级烷基碱金属或碱土金属，A为羰基或式为“IMAGE”的基团，其中R4为低级烷基。所得的三氟opter啶衍生物具有止痛和消炎性质，因此可用作药物药物。

6. 发明授权

US4563454A Propanone derivatives in antiallergic compositions 失效
标题翻译：丙酸衍生物在抗过敏组合物中
公开(公告)号：US4563454A
公开(公告)日：1986-01-07
申请号：US693838
申请日：1985-01-24
申请人： Akihide Kohda , Teikichi Kurosaki
发明人： Akihide Kohda , Teikichi Kurosaki
IPC分类号： A61K31/535 , A61K31/135 , A61K31/40 , A61K31/445 , A61K31/452 , A61K31/495 , A61K31/5375 , A61P11/00 , A61P17/00 , A61P27/16 , A61P37/08 , A61P43/00 , C07C221/00 , C07C225/16 , C07C225/18 , C07D211/14 , C07D227/04 , C07D265/30 , C07D295/10 , C07D295/104 , C07D295/108 , C07D333/56 , C07D333/58
CPC分类号： C07D295/108 , C07D295/104 , C07D333/58 , Y10S514/826 , Y10S514/861
摘要： New propanone derivatives, the pharmacologically allowable salts thereof, their manufacturing process and pharmaceutical composition containing at least one of them as the active ingredient.

7. 发明授权

US4555513A 1,2 Dihydro- and 1,2,3,4-tetrahydro quinolylacetic acids and analgesic use thereof 失效
标题翻译： 1,2二氢 - 和1,2,3,4-四氢喹啉基乙酸及其止痛用途
公开(公告)号：US4555513A
公开(公告)日：1985-11-26
申请号：US452146
申请日：1982-12-22
申请人： Masaaki Hamada , Kaoru Okamaoto , Teikichi Kurosaki
发明人： Masaaki Hamada , Kaoru Okamaoto , Teikichi Kurosaki
IPC分类号： C07D215/14 , A61K31/47 , A61P25/04 , A61P29/00 , C07D215/06 , C07D215/08 , C07D215/12 , C07D215/18 , C07D215/22 , C07D215/233
CPC分类号： C07D215/233 , C07D215/06 , C07D215/08 , C07D215/12 , C07D215/18
摘要： Novel quinolylacetic acid compounds of the formula (I): ##STR1## wherein R.sub.1 is a member selected from the group consisting of hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms, and a lower alkyl group having 1 to 4 carbon atoms substituted with an aromatic group having a substituent;R.sub.2 is a member selected from the group consisting of hydrogen atom and a lower alkyl group having 1 to 4 carbon atoms;R.sub.3 is a member selected from the group consisting of hydrogen, a halogen atom, an alkyl group having 1 to 8 carbon atoms, and an alkenyl group having 2 to 8 carbon atoms;R.sub.4 and R.sub.5, carpable of cyclization, are each a member selected from the group consisting of hydrogen atom and a lower alkyl group having 1 to 4 carbon atoms;R.sub.6 is a member selected from the group consisting of hydrogen atom an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 5 carbon atoms, an alkynyl group having 3 to 8 carbon atoms, an aralkyl group, a substituted aralkyl group, an aliphatic or aromatic acyl group, and a substituted aliphatic or aromatic acyl group; andA is a member selected from the group consisting of hydrogen atom and an oxo group;the broken line denoting a second bond or no bond when A is a hydrogen atom and denoting no bond when A is an oxo group, and pharmaceutically acceptable salts thereof.
摘要翻译：式（I）的新型喹啉基乙酸化合物：其中R 1是选自氢原子，具有1至4个碳原子的低级烷基和具有1至4个碳原子的低级烷基的成员 4个碳原子被具有取代基的芳基取代; R2为选自氢原子和碳原子数为1〜4的低级烷基的成员; R3为选自氢，卤素原子，碳原子数为1〜8的烷基和碳原子数为2〜8的烯基的成员; 可环化的R 4和R 5各自是选自氢原子和具有1至4个碳原子的低级烷基的成员; R6为选自氢原子，碳原子数1〜8的烷基，碳原子数2〜5的烯基，碳原子数3〜8的炔基，芳烷基，取代芳烷基脂族或芳族酰基，和取代的脂族或芳族酰基; A为选自氢原子和氧代基的成员; 当A是氢原子并且当A是氧代基时不表示键时，表示第二个键或无键的虚线及其药学上可接受的盐。

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