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1. 发明授权

US07006280B2 Multi-stage filtered optical amplifier 有权
标题翻译：多级滤波光放大器
公开(公告)号：US07006280B2
公开(公告)日：2006-02-28
申请号：US10726458
申请日：2003-12-03
申请人： Kao-Yang Huang , John R. Costelloe , Richard Williams
发明人： Kao-Yang Huang , John R. Costelloe , Richard Williams
IPC分类号： H04B10/12
CPC分类号： H01S3/06754 , H01S3/10023 , H01S2301/04
摘要： A multistage amplifier is disclosed for amplifying light over a wavelength band. A first and second span of amplifying fiber are optically coupled and a gain flattening filter (GFF) in-line with one of two spans of amplifying fiber is provided for attenuating certain wavelengths of amplified light. A first gain spectral response of the first and second spans of amplifying fiber including the GFF are measured over the wavelength band, and the shape of a ripple that oscillates as a function of wavelength in the form of a plurality of peaks or maxima and valleys in the form of minima occur at a plurality of different wavelengths, each different wavelength corresponding to a different channel. A second filter is provided finishing or compensating filter having a second spectral response that has a second plurality of peaks in the form of maxima and valleys in the form of minima is provided. The second filter is designed so that the second spectral response is absent at least 50% of four most predominant peaks or valleys at channels where peaks or valleys, respectively, were present in the first spectral response. The maximum ripple amplitude in the second spectral response is less than a maximum ripple amplitude in the first gain spectral response. This arrangement lessens unwanted effects of systematic error occurring when filters having similar ripple responses with wavelength are cascaded.
摘要翻译：公开了一种用于在波长带上放大光的多级放大器。放大光纤的第一和第二跨度是光学耦合的，并且提供与两个放大光纤的跨距之一成对的增益平坦化滤光器（GFF），用于衰减某些波长的放大光。在波长带上测量包括GFF的放大光纤的第一和第二跨度的第一增益光谱响应，以及以多个峰值或最大值和谷值形式的波长的函数振荡的纹波的形状最小的形式出现在多个不同的波长处，每个不同的波长对应于不同的通道。提供了第二滤光器，其具有第二光谱响应的精加工或补偿滤光器，所述第二光谱响应具有以最小值形式的最大值和谷值形式的第二多个峰值。第二个滤光片被设计成使得第二光谱响应在第一光谱响应中分别存在峰或谷的通道处不存在四个最主要的峰或谷中的至少50％。第二光谱响应中的最大纹波幅度小于第一增益光谱响应中的最大纹波幅度。当具有波长相似的波纹响应的滤波器级联时，这种布置减少了发生的系统误差的不期望的影响。

2. 发明授权

US10583939B2 Deployed electromagnetic radiation deflector shield (DERDS) which creates a zone of minimum radiation and magnetic/plasma effects for spacecraft and extra-planetary base station protection 有权
公开(公告)号：US10583939B2
公开(公告)日：2020-03-10
申请号：US15477115
申请日：2017-04-02
申请人： Richard Williams
发明人： Richard Williams
IPC分类号： B64G1/54 , B64G1/42
摘要： Example aspects of a deployed electromagnetic radiation deflector shield and a method for using a deployed electromagnetic radiation deflector shield are disclosed. The deployed electromagnetic radiation deflector shield can comprise a power supply; and an electromagnet configured to generate a magnetic field to deflect radiation; wherein the deployed electromagnetic radiation deflector shield is deployed at a distance away from one of a spacecraft and a base station to minimize an effect of the magnetic field on the one of the spacecraft and base station.

3. 发明授权

US09071139B2 High current switching converter for LED applications 有权
标题翻译：用于LED应用的大电流开关转换器
公开(公告)号：US09071139B2
公开(公告)日：2015-06-30
申请号：US12194411
申请日：2008-08-19
申请人： Richard Williams
发明人： Richard Williams
IPC分类号： H02M3/158 , H05B37/02 , H05B33/08
CPC分类号： H02M3/158 , H05B33/0815 , H05B37/02
摘要： A step-up switching voltage regulator includes two or more inductors and a switching network. A control circuit drives the switching network in a repeating sequence that includes: a magnetizing phase where the inductors are connected in series between an input voltage and ground; and a charge transfer phase where the inductors are connected in parallel to provide current to an output node with at least one of the inductors is connected between ground and the output node.
摘要翻译：升压开关电压调节器包括两个或更多个电感器和开关网络。控制电路以重复序列驱动交换网络，该重复序列包括：电感器串联连接在输入电压和地之间的磁化阶段; 以及电荷转移阶段，其中电感器并联连接以将电流提供给输出节点，其中至少一个电感器连接在地和输出节点之间。

4. 发明申请

US20130066676A1 SYSTEMS AND METHODS OF ENHANCING LEADS 有权
标题翻译：增强领导力的系统和方法
公开(公告)号：US20130066676A1
公开(公告)日：2013-03-14
申请号：US13608733
申请日：2012-09-10
申请人： Richard Williams , Jacob Kong , Lawrence J. Hughes , Damodar Panigrahi , Maria Luisa Kirgan , Rasoul Hajikhani
发明人： Richard Williams , Jacob Kong , Lawrence J. Hughes , Damodar Panigrahi , Maria Luisa Kirgan , Rasoul Hajikhani
IPC分类号： G06Q30/02
CPC分类号： G06Q30/0201 , G06Q30/00 , G06Q30/0202
摘要： A client transmits one or more lead records to a lead enhancement module that is configured to enhance the received lead records and return enhanced lead records to the client. The lead enhancement module may return a contactability score for each lead record, indicating a likelihood that the individual identified in the lead may be contacted using the contact information provided in the lead record and/or additional contract information located by the lead enhancement module. The lead enhancement module may also receive additional data items associated with leads from one or more data sources. Additionally, statistical models that may be customized for each client may be applied to information associated with lead records in order to determine one or more propensity scores for each of the lead records, where a propensity score indicates a likelihood that an individual will take a particular action, such as purchasing particular goods or services.
摘要翻译：客户端将一个或多个引导记录传送到引导增强模块，引导增强模块被配置为增强接收到的引导记录并将增强的引导记录返回给客户端。潜在客户增强模块可以返回每个潜在客户记录的可接触性评分，指示可以使用在领先记录中提供的联系信息和/或由引导增强模块定位的附加合同信息来联系领先者中识别的个体。引线增强模块还可以接收与来自一个或多个数据源的引线相关联的附加数据项。另外，可以针对每个客户端定制的统计模型可以应用于与铅记录相关联的信息，以便确定每个潜在记录的一个或多个倾向得分，其中倾向得分指示个体将采取特定的可能性行动，如购买特定商品或服务。

5. 发明授权

US08329025B2 Analyte determination method and analyte meter 有权
标题翻译：分析物测定方法和分析仪
公开(公告)号：US08329025B2
公开(公告)日：2012-12-11
申请号：US13106361
申请日：2011-05-12
申请人： Ian Harding , Richard Williams , Sridhar Iyengar
发明人： Ian Harding , Richard Williams , Sridhar Iyengar
IPC分类号： G01N27/26
CPC分类号： G01N27/3274 , C12Q1/006 , G01N27/307 , G01N27/327 , G01N27/3272 , G01N27/3273
摘要： The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.
摘要翻译：在施加到使用还原介体的电化学测试条的样品中的氧或红细胞的存在通过作为样品的温度的函数确定的添加剂校正因子来校正，并且反映样品的氧气承载能力。测量的氧气承载能力也可用于确定血细胞比容并区分血液样本和应用于测试条的对照溶液。

6. 发明授权

US08211933B2 3.3.0 bicyclic GlyT1 inhibitors and methods of making and using same 失效
标题翻译： 3.3.0双环GlyT1抑制剂及其制备和使用方法
公开(公告)号：US08211933B2
公开(公告)日：2012-07-03
申请号：US12636099
申请日：2009-12-11
申请人： Craig W. Lindsley , P. Jeffrey Conn , Richard Williams , Douglas J. Sheffler
发明人： Craig W. Lindsley , P. Jeffrey Conn , Richard Williams , Douglas J. Sheffler
IPC分类号： A61K31/4035 , C07D209/44
CPC分类号： C07D209/52 , C07D403/12
摘要： In one aspect, the invention relates to compounds which are useful as as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：一方面，本发明涉及作为甘氨酸1型转运蛋白（GlyT1）活性的抑制剂有用的化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物治疗与甘氨酸1型转运蛋白（GlyT1）活性相关的病症的方法。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

7. 发明授权

US08192610B2 Error detection in analyte measurements based on measurement of system resistance 有权
标题翻译：基于测量系统电阻的分析物测量中的误差检测
公开(公告)号：US08192610B2
公开(公告)日：2012-06-05
申请号：US12961654
申请日：2010-12-07
申请人： Steven Diamond , Ian Harding , Richard Williams
发明人： Steven Diamond , Ian Harding , Richard Williams
IPC分类号： G01N27/327
CPC分类号： G01N27/3274
摘要： Measurement of the series track resistance of a working and counter electrode pair in an electrochemical test strip provide error detection for multiple variations in the quality of the test strip, as well as the operation of strip in the test meter. In particular, a single measurement of series resistance can be used to detect and generate an error message when an incorrect reading is likely to result due to (1) damaged electrode tracks, (2) fouled electrode surfaces, (3) dirty strip contacts, or (4) short circuit between the electrodes.
摘要翻译：在电化学测试条中测量工作电极对和对电极对的串联轨道电阻可以提供测试条质量的多种变化的错误检测以及测试仪中条带的操作。特别地，当由于（1）损坏的电极轨迹，（2）污染的电极表面，（3）脏的带状接触，或者（3））导致不正确的读数时，可以使用串联电阻的单次测量来检测并产生错误信息，或（4）电极之间的短路。

8. 发明申请

US20120028956A1 BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME 审中-公开
公开(公告)号：US20120028956A1
公开(公告)日：2012-02-02
申请号：US13269977
申请日：2011-10-10
申请人： P. Jeffrey Conn , Craig W. Lindsley , Charles David Weaver , Alice L. Rodriguez , Colleen M. Niswender , Carrie K. Jones , Richard Williams
发明人： P. Jeffrey Conn , Craig W. Lindsley , Charles David Weaver , Alice L. Rodriguez , Colleen M. Niswender , Carrie K. Jones , Richard Williams
IPC分类号： A61K31/4725 , A61K31/496 , A61K31/4375 , A61K31/472 , C07D413/06 , C07D401/06 , C07D471/04 , C07D217/24 , A61P25/24 , C07D401/12 , A61P25/28 , A61P25/00 , A61P25/18 , A61P25/30 , A61P25/08 , A61P25/06 , A61P3/10 , A61P3/04 , A61P3/00 , A61P25/20 , A61P25/22 , A61K31/5377
CPC分类号： A61K31/397 , A61K31/4704 , A61K31/5377 , C07D209/46 , C07D209/48 , C07D217/24 , C07D401/06
摘要： In one aspect, the invention relates to bicyclic mGluR5 positive allosteric modulators, for example 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

9. 发明授权

US07846321B2 Error detection in analyte measurements based on measurement of system resistance 有权
标题翻译：基于测量系统电阻的分析物测量中的误差检测
公开(公告)号：US07846321B2
公开(公告)日：2010-12-07
申请号：US11874766
申请日：2007-10-18
申请人： Steven Diamond , Ian Harding , Richard Williams
发明人： Steven Diamond , Ian Harding , Richard Williams
IPC分类号： C12Q1/00 , C12M1/00
CPC分类号： G01N27/3274
摘要： Measurement of the series track resistance of a working and counter electrode pair in an electrochemical test strip provide error detection for multiple variations in the quality of the test strip, as well as the operation of strip in the test meter. In particular, a single measurement of series resistance can be used to detect and generate an error message when an incorrect reading is likely to result due to (1) damaged electrode tracks, (2) fouled electrode surfaces, (3) dirty strip contacts, or (4) short circuit between the electrodes.
摘要翻译：在电化学测试条中测量工作电极对和对电极对的串联轨道电阻可以提供测试条质量的多种变化的错误检测以及测试仪中条带的操作。特别地，当由于（1）损坏的电极轨迹，（2）污染的电极表面，（3）脏的带状接触，或者（3））导致不正确的读数时，可以使用串联电阻的单次测量来检测并产生错误信息，或（4）电极之间的短路。

10. 发明授权

US07837941B2 Method and apparatus for monitoring alteration of flow characteristics in a liquid sample 有权
标题翻译：监测液体样品中流动特性变化的方法和装置
公开(公告)号：US07837941B2
公开(公告)日：2010-11-23
申请号：US11279044
申请日：2006-04-07
申请人： Ian Harding , Sridhar G. Iyengar , Ha Nguyen , Richard Williams
发明人： Ian Harding , Sridhar G. Iyengar , Ha Nguyen , Richard Williams
IPC分类号： G01N33/49
CPC分类号： G01N27/26 , G01N33/4905 , G01N33/86
摘要： A device for measuring blood coagulation time is formed from a first substrate; a second substrate; a spacer layer disposed between the first and second substrates, said spacer layer having an opening formed therein defining a sample receiving chamber, a vented sink chamber, and an elongated reservoir forming a conduit for liquid movement between the sample receiving chamber and the sink chamber; a first electrode disposed on the first substrate, said first electrode being exposed in the reservoir portion through a first opening in the spacer layer; and a second electrode disposed on the second substrate, said second electrode being exposed in the reservoir portion through a second opening in the spacer layer. The device of the invention is used in combination with an apparatus that is connected to the first and second electrodes for measuring current flow between the first and second electrodes. Changes in observed current are indicative of flow through the device, and a cessation of flow indicates coagulation.
摘要翻译：用于测量凝血时间的装置由第一基底形成; 第二基板; 间隔层，其设置在所述第一和第二基板之间，所述间隔层具有形成在其中的开口，所述隔离件限定了样品接收室，通气的宿室和形成用于液体在样品接收室和宿室之间移动的导管的细长储存器; 设置在所述第一基板上的第一电极，所述第一电极通过所述间隔层中的第一开口暴露在所述储存部分中; 以及设置在所述第二基板上的第二电极，所述第二电极通过所述间隔层中的第二开口暴露在所述储存部分中。本发明的装置与连接到第一和第二电极的装置结合使用，用于测量第一和第二电极之间的电流。观察到的电流的变化表示通过该装置的流动，并且停止流动表示凝结。

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